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Items: 1 to 50 of 79


Genetic determinants of genus-level glycan diversity in a bacterial protein glycosylation system.

Hadjineophytou C, Anonsen JH, Wang N, Ma KC, Viburiene R, Vik Å, Harrison OB, Maiden MCJ, Grad YH, Koomey M.

PLoS Genet. 2019 Dec 23;15(12):e1008532. doi: 10.1371/journal.pgen.1008532. eCollection 2019 Dec.


A Broad Spectrum Protein Glycosylation System Influences Type II Protein Secretion and Associated Phenotypes in Vibrio cholerae.

Vorkapic D, Mitterer F, Pressler K, Leitner DR, Anonsen JH, Liesinger L, Mauerhofer LM, Kuehnast T, Toeglhofer M, Schulze A, Zingl FG, Feldman MF, Reidl J, Birner-Gruenberger R, Koomey M, Schild S.

Front Microbiol. 2019 Dec 3;10:2780. doi: 10.3389/fmicb.2019.02780. eCollection 2019.


O-linked protein glycosylation in bacteria: snapshots and current perspectives.

Koomey M.

Curr Opin Struct Biol. 2019 Jun;56:198-203. doi: 10.1016/ Epub 2019 May 9. Review.


Global biochemical and structural analysis of the type IV pilus from the Gram-positive bacterium Streptococcus sanguinis.

Berry JL, Gurung I, Anonsen JH, Spielman I, Harper E, Hall AMJ, Goosens VJ, Raynaud C, Koomey M, Biais N, Matthews S, Pelicic V.

J Biol Chem. 2019 Apr 26;294(17):6796-6808. doi: 10.1074/jbc.RA118.006917. Epub 2019 Mar 5.


Type IV Pilin Post-Translational Modifications Modulate Material Properties of Bacterial Colonies.

Zöllner R, Cronenberg T, Kouzel N, Welker A, Koomey M, Maier B.

Biophys J. 2019 Mar 5;116(5):938-947. doi: 10.1016/j.bpj.2019.01.020. Epub 2019 Jan 29.


Disrupted Synthesis of a Di-N-acetylated Sugar Perturbs Mature Glycoform Structure and Microheterogeneity in the O-Linked Protein Glycosylation System of Neisseria elongata subsp. glycolytica.

Wang N, Anonsen JH, Viburiene R, Lam JS, Vik Å, Koomey M.

J Bacteriol. 2018 Dec 7;201(1). pii: e00522-18. doi: 10.1128/JB.00522-18. Print 2019 Jan 1.


Structural and genetic analyses of glycan O-acetylation in a bacterial protein glycosylation system: evidence for differential effects on glycan chain length.

Anonsen JH, Børud B, Vik Å, Viburiene R, Koomey M.

Glycobiology. 2017 Sep 1;27(9):888-899. doi: 10.1093/glycob/cwx032.


Sweet New Roles for Protein Glycosylation in Prokaryotes.

Eichler J, Koomey M.

Trends Microbiol. 2017 Aug;25(8):662-672. doi: 10.1016/j.tim.2017.03.001. Epub 2017 Mar 21. Review.


Characterization of a Unique Tetrasaccharide and Distinct Glycoproteome in the O-Linked Protein Glycosylation System of Neisseria elongata subsp. glycolytica.

Anonsen JH, Vik Å, Børud B, Viburiene R, Aas FE, Kidd SW, Aspholm M, Koomey M.

J Bacteriol. 2015 Oct 19;198(2):256-67. doi: 10.1128/JB.00620-15. Print 2016 Jan 15.


Cytochrome c-based domain modularity governs genus-level diversification of electron transfer to dissimilatory nitrite reduction.

Aas FE, Li X, Edwards J, Hongrø Solbakken M, Deeudom M, Vik Å, Moir J, Koomey M, Aspholm M.

Environ Microbiol. 2015 Jun;17(6):2114-32. doi: 10.1111/1462-2920.12661. Epub 2014 Dec 11.


Extended glycan diversity in a bacterial protein glycosylation system linked to allelic polymorphisms and minimal genetic alterations in a glycosyltransferase gene.

Børud B, Anonsen JH, Viburiene R, Cohen EH, Samuelsen AB, Koomey M.

Mol Microbiol. 2014 Nov;94(3):688-99. doi: 10.1111/mmi.12789. Epub 2014 Sep 29.


Type IV pilus assembly proficiency and dynamics influence pilin subunit phospho-form macro- and microheterogeneity in Neisseria gonorrhoeae.

Vik Å, Anonsen JH, Aas FE, Hegge FT, Roos N, Koomey M, Aspholm M.

PLoS One. 2014 May 5;9(5):e96419. doi: 10.1371/journal.pone.0096419. eCollection 2014.


Concerted spatio-temporal dynamics of imported DNA and ComE DNA uptake protein during gonococcal transformation.

Gangel H, Hepp C, Müller S, Oldewurtel ER, Aas FE, Koomey M, Maier B.

PLoS Pathog. 2014 Apr 24;10(4):e1004043. doi: 10.1371/journal.ppat.1004043. eCollection 2014 Apr.


Allelic variation in a simple sequence repeat element of neisserial pglB2 and its consequences for protein expression and protein glycosylation.

Viburiene R, Vik Å, Koomey M, Børud B.

J Bacteriol. 2013 Aug;195(15):3476-85. doi: 10.1128/JB.00276-13. Epub 2013 May 31.


An extended spectrum of target proteins and modification sites in the general O-linked protein glycosylation system in Neisseria gonorrhoeae.

Anonsen JH, Vik Å, Egge-Jacobsen W, Koomey M.

J Proteome Res. 2012 Dec 7;11(12):5781-93. doi: 10.1021/pr300584x. Epub 2012 Oct 29.


Insights into type IV pilus biogenesis and dynamics from genetic analysis of a C-terminally tagged pilin: a role for O-linked glycosylation.

Vik Å, Aspholm M, Anonsen JH, Børud B, Roos N, Koomey M.

Mol Microbiol. 2012 Sep;85(6):1166-78. doi: 10.1111/j.1365-2958.2012.08166.x. Epub 2012 Aug 13.


Hypomorphic glycosyltransferase alleles and recoding at contingency loci influence glycan microheterogeneity in the protein glycosylation system of Neisseria species.

Johannessen C, Koomey M, Børud B.

J Bacteriol. 2012 Sep;194(18):5034-43. doi: 10.1128/JB.00950-12. Epub 2012 Jul 13.


Characterization of exogenous bacterial oligosaccharyltransferases in Escherichia coli reveals the potential for O-linked protein glycosylation in Vibrio cholerae and Burkholderia thailandensis.

Gebhart C, Ielmini MV, Reiz B, Price NL, Aas FE, Koomey M, Feldman MF.

Glycobiology. 2012 Jul;22(7):962-74. doi: 10.1093/glycob/cws059. Epub 2012 Mar 5.


Novel protein substrates of the phospho-form modification system in Neisseria gonorrhoeae and their connection to O-linked protein glycosylation.

Anonsen JH, Egge-Jacobsen W, Aas FE, Børud B, Koomey M, Vik A.

Infect Immun. 2012 Jan;80(1):22-30. doi: 10.1128/IAI.05920-11. Epub 2011 Nov 14.


O-linked glycosylation of the PilA pilin protein of Francisella tularensis: identification of the endogenous protein-targeting oligosaccharyltransferase and characterization of the native oligosaccharide.

Egge-Jacobsen W, Salomonsson EN, Aas FE, Forslund AL, Winther-Larsen HC, Maier J, Macellaro A, Kuoppa K, Oyston PC, Titball RW, Thomas RM, Forsberg Å, Prior JL, Koomey M.

J Bacteriol. 2011 Oct;193(19):5487-97. doi: 10.1128/JB.00383-11. Epub 2011 Jul 29.


Kiss and run - phosphoglycerol modifications of N. Meningitidis pili mediate detachment.

Tønjum T, Koomey M.

Front Microbiol. 2011 Apr 27;2:82. doi: 10.3389/fmicb.2011.00082. eCollection 2011. No abstract available.


Genetic and molecular analyses reveal an evolutionary trajectory for glycan synthesis in a bacterial protein glycosylation system.

Børud B, Viburiene R, Hartley MD, Paulsen BS, Egge-Jacobsen W, Imperiali B, Koomey M.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9643-8. doi: 10.1073/pnas.1103321108. Epub 2011 May 23.


Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.

Hartley MD, Morrison MJ, Aas FE, Børud B, Koomey M, Imperiali B.

Biochemistry. 2011 Jun 7;50(22):4936-48. doi: 10.1021/bi2003372. Epub 2011 May 12.


Structural alterations in a component of cytochrome c oxidase and molecular evolution of pathogenic Neisseria in humans.

Aspholm M, Aas FE, Harrison OB, Quinn D, Vik A, Viburiene R, Tønjum T, Moir J, Maiden MC, Koomey M.

PLoS Pathog. 2010 Aug 19;6(8):e1001055. doi: 10.1371/journal.ppat.1001055.


Multiple pilus motors cooperate for persistent bacterial movement in two dimensions.

Holz C, Opitz D, Greune L, Kurre R, Koomey M, Schmidt MA, Maier B.

Phys Rev Lett. 2010 Apr 30;104(17):178104. Epub 2010 Apr 28.


Genetic, structural, and antigenic analyses of glycan diversity in the O-linked protein glycosylation systems of human Neisseria species.

Børud B, Aas FE, Vik A, Winther-Larsen HC, Egge-Jacobsen W, Koomey M.

J Bacteriol. 2010 Jun;192(11):2816-29. doi: 10.1128/JB.00101-10. Epub 2010 Apr 2.


Infection of human mucosal tissue by Pseudomonas aeruginosa requires sequential and mutually dependent virulence factors and a novel pilus-associated adhesin.

Heiniger RW, Winther-Larsen HC, Pickles RJ, Koomey M, Wolfgang MC.

Cell Microbiol. 2010 Aug;12(8):1158-73. doi: 10.1111/j.1462-5822.2010.01461.x. Epub 2010 Mar 12.


Functional analyses of pilin-like proteins from Francisella tularensis: complementation of type IV pilus phenotypes in Neisseria gonorrhoeae.

Salomonsson E, Forsberg A, Roos N, Holz C, Maier B, Koomey M, Winther-Larsen HC.

Microbiology. 2009 Aug;155(Pt 8):2546-59. doi: 10.1099/mic.0.028183-0. Epub 2009 May 7.


Broad spectrum O-linked protein glycosylation in the human pathogen Neisseria gonorrhoeae.

Vik A, Aas FE, Anonsen JH, Bilsborough S, Schneider A, Egge-Jacobsen W, Koomey M.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4447-52. doi: 10.1073/pnas.0809504106. Epub 2009 Feb 26.


Dynamics of type IV pili is controlled by switching between multiple states.

Clausen M, Koomey M, Maier B.

Biophys J. 2009 Feb;96(3):1169-77. doi: 10.1016/j.bpj.2008.10.017.


Roles of c-type cytochromes in respiration in Neisseria meningitidis.

Deeudom M, Koomey M, Moir JWB.

Microbiology. 2008 Sep;154(Pt 9):2857-2864. doi: 10.1099/mic.0.2008/020339-0.


Genetic and functional analyses of PptA, a phospho-form transferase targeting type IV pili in Neisseria gonorrhoeae.

Naessan CL, Egge-Jacobsen W, Heiniger RW, Wolfgang MC, Aas FE, Røhr A, Winther-Larsen HC, Koomey M.

J Bacteriol. 2008 Jan;190(1):387-400. Epub 2007 Oct 19.


Neisseria gonorrhoeae O-linked pilin glycosylation: functional analyses define both the biosynthetic pathway and glycan structure.

Aas FE, Vik A, Vedde J, Koomey M, Egge-Jacobsen W.

Mol Microbiol. 2007 Aug;65(3):607-24. Epub 2007 Jun 29.


Pseudomonas aeruginosa Type IV pilus expression in Neisseria gonorrhoeae: effects of pilin subunit composition on function and organelle dynamics.

Winther-Larsen HC, Wolfgang MC, van Putten JP, Roos N, Aas FE, Egge-Jacobsen WM, Maier B, Koomey M.

J Bacteriol. 2007 Sep;189(18):6676-85. Epub 2007 Jun 15.


Microbial genome dynamics in CNS pathogenesis.

Davidsen T, Koomey M, Tønjum T.

Neuroscience. 2007 Apr 14;145(4):1375-87. Epub 2007 Mar 23. Review.


Substitutions in the N-terminal alpha helical spine of Neisseria gonorrhoeae pilin affect Type IV pilus assembly, dynamics and associated functions.

Aas FE, Winther-Larsen HC, Wolfgang M, Frye S, Løvold C, Roos N, van Putten JP, Koomey M.

Mol Microbiol. 2007 Jan;63(1):69-85. Epub 2006 Nov 27.


Release of host-derived membrane vesicles following pilus-mediated adhesion of Neisseria gonorrhoeae.

Gill DB, Spitzer D, Koomey M, Heuser JE, Atkinson JP.

Cell Microbiol. 2005 Nov;7(11):1672-83.


A conserved set of pilin-like molecules controls type IV pilus dynamics and organelle-associated functions in Neisseria gonorrhoeae.

Winther-Larsen HC, Wolfgang M, Dunham S, van Putten JP, Dorward D, Løvold C, Aas FE, Koomey M.

Mol Microbiol. 2005 May;56(4):903-17.


A force-dependent switch reverses type IV pilus retraction.

Maier B, Koomey M, Sheetz MP.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10961-6. Epub 2004 Jul 15.


Unique modifications with phosphocholine and phosphoethanolamine define alternate antigenic forms of Neisseria gonorrhoeae type IV pili.

Hegge FT, Hitchen PG, Aas FE, Kristiansen H, Løvold C, Egge-Jacobsen W, Panico M, Leong WY, Bull V, Virji M, Morris HR, Dell A, Koomey M.

Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10798-803. Epub 2004 Jul 12.


Type IV pilus retraction in pathogenic Neisseria is regulated by the PilC proteins.

Morand PC, Bille E, Morelle S, Eugène E, Beretti JL, Wolfgang M, Meyer TF, Koomey M, Nassif X.

EMBO J. 2004 May 5;23(9):2009-17. Epub 2004 Apr 22.


Transformation and DNA repair: linkage by DNA recombination.

Tønjum T, Håvarstein LS, Koomey M, Seeberg E.

Trends Microbiol. 2004 Jan;12(1):1-4. Review.


Down-regulation of CD46 by piliated Neisseria gonorrhoeae.

Gill DB, Koomey M, Cannon JG, Atkinson JP.

J Exp Med. 2003 Nov 3;198(9):1313-22.


Competence for natural transformation in Neisseria gonorrhoeae: components of DNA binding and uptake linked to type IV pilus expression.

Aas FE, Wolfgang M, Frye S, Dunham S, Løvold C, Koomey M.

Mol Microbiol. 2002 Nov;46(3):749-60.


Transcriptional, chemosensory and cell-contact-dependent regulation of type IV pilus expression.

Winther-Larsen HC, Koomey M.

Curr Opin Microbiol. 2002 Apr;5(2):173-8. Review.


Neisseria gonorrhoeae PilV, a type IV pilus-associated protein essential to human epithelial cell adherence.

Winther-Larsen HC, Hegge FT, Wolfgang M, Hayes SF, van Putten JP, Koomey M.

Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15276-81.


Structural alterations in a type IV pilus subunit protein result in concurrent defects in multicellular behaviour and adherence to host tissue.

Park HS, Wolfgang M, van Putten JP, Dorward D, Hayes SF, Koomey M.

Mol Microbiol. 2001 Oct;42(2):293-307.

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