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Items: 1 to 50 of 98

1.

Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.

Rodenko B, Wanner MJ, Alkhaldi AA, Ebiloma GU, Barnes RL, Kaiser M, Brun R, McCulloch R, Koomen GJ, de Koning HP.

Antimicrob Agents Chemother. 2015 Nov;59(11):6708-16. doi: 10.1128/AAC.00596-15. Epub 2015 Aug 17.

2.

Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.

Ghisaidoobe AT, van den Berg RJ, Butt SS, Strijland A, Donker-Koopman WE, Scheij S, van den Nieuwendijk AM, Koomen GJ, van Loevezijn A, Leemhuis M, Wennekes T, van der Stelt M, van der Marel GA, van Boeckel CA, Aerts JM, Overkleeft HS.

J Med Chem. 2014 Nov 13;57(21):9096-104. doi: 10.1021/jm501181z. Epub 2014 Oct 17.

PMID:
25250725
3.

Pancreatitis and a sudden loss of sight.

Wielsma S, Gerrits AM, Koomen GJ, Witteman B.

Neth J Med. 2013 Apr;71(3):137-41. No abstract available.

4.

Synthesis of marine-derived 3-alkylpyridinium alkaloids with potent antiprotozoal activity.

Rodenko B, Al-Salabi MI, Teka IA, Ho W, El-Sabbagh N, Ali JA, Ibrahim HM, Wanner MJ, Koomen GJ, de Koning HP.

ACS Med Chem Lett. 2011 Oct 5;2(12):901-6. doi: 10.1021/ml200160k. eCollection 2011 Dec 8.

5.

Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites.

Läppchen T, Pinas VA, Hartog AF, Koomen GJ, Schaffner-Barbero C, Andreu JM, Trambaiolo D, Löwe J, Juhem A, Popov AV, den Blaauwen T.

Chem Biol. 2008 Feb;15(2):189-99. doi: 10.1016/j.chembiol.2007.12.013.

6.

2,N6-disubstituted adenosine analogs with antitrypanosomal and antimalarial activities.

Rodenko B, van der Burg AM, Wanner MJ, Kaiser M, Brun R, Gould M, de Koning HP, Koomen GJ.

Antimicrob Agents Chemother. 2007 Nov;51(11):3796-802. Epub 2007 Aug 13.

7.

ABCG2 (breast cancer resistance protein/mitoxantrone resistance-associated protein) ATPase assay: a useful tool to detect drug-transporter interactions.

Glavinas H, Kis E, Pál A, Kovács R, Jani M, Vági E, Molnár E, Bánsághi S, Kele Z, Janáky T, Báthori G, von Richter O, Koomen GJ, Krajcsi P.

Drug Metab Dispos. 2007 Sep;35(9):1533-42. Epub 2007 May 30.

PMID:
17537873
8.

Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues.

Rodenko B, Detz RJ, Pinas VA, Lambertucci C, Brun R, Wanner MJ, Koomen GJ.

Bioorg Med Chem. 2006 Mar 1;14(5):1618-29. Epub 2005 Oct 24.

PMID:
16249090
9.

GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin.

Läppchen T, Hartog AF, Pinas VA, Koomen GJ, den Blaauwen T.

Biochemistry. 2005 May 31;44(21):7879-84.

PMID:
15910002
10.

The mechanism of selective purine C-nitration revealed: NMR studies demonstrate formation and radical rearrangement of an N7-nitramine intermediate.

Rodenko B, Koch M, van der Burg AM, Wanner MJ, Koomen GJ.

J Am Chem Soc. 2005 Apr 27;127(16):5957-63.

PMID:
15839695
12.

New (1-deaza)purine derivatives via efficient C-2 nitration of the (1-deaza)purine ring.

Wanner MJ, Rodenko B, Koch M, Koomen GJ.

Nucleosides Nucleotides Nucleic Acids. 2004 Oct;23(8-9):1313-20.

PMID:
15571251
13.

Function-dependent conformational changes of the ABCG2 multidrug transporter modify its interaction with a monoclonal antibody on the cell surface.

Ozvegy-Laczka C, Várady G, Köblös G, Ujhelly O, Cervenak J, Schuetz JD, Sorrentino BP, Koomen GJ, Váradi A, Német K, Sarkadi B.

J Biol Chem. 2005 Feb 11;280(6):4219-27. Epub 2004 Nov 22.

14.

N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor.

Beukers MW, Wanner MJ, Von Frijtag Drabbe Künzel JK, Klaasse EC, IJzerman AP, Koomen GJ.

J Med Chem. 2003 Apr 10;46(8):1492-503.

PMID:
12672250
15.

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

Allen JD, van Loevezijn A, Lakhai JM, van der Valk M, van Tellingen O, Reid G, Schellens JH, Koomen GJ, Schinkel AH.

Mol Cancer Ther. 2002 Apr;1(6):417-25.

16.

Inhibition of BCRP-mediated drug efflux by fumitremorgin-type indolyl diketopiperazines.

van Loevezijn A, Allen JD, Schinkel AH, Koomen GJ.

Bioorg Med Chem Lett. 2001 Jan 8;11(1):29-32.

PMID:
11140726
17.

2-Nitro analogues of adenosine and 1-deazaadenosine: synthesis and binding studies at the adenosine A1, A2A and A3 receptor subtypes.

Wanner MJ, Von Frijtag Drabbe Künzel JK, Ijzerman AP, Koomen GJ.

Bioorg Med Chem Lett. 2000 Sep 18;10(18):2141-4.

PMID:
10999489
18.

Enantiopure Tetrahydro-beta-carbolines via Pictet-Spengler Reactions with N-Sulfinyl Tryptamines.

Gremmen C, Willemse B, Wanner MJ, Koomen GJ.

Org Lett. 2000 Jun 29;2(13):1955-1958.

PMID:
10891200
19.

Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase.

Overkleeft HS, Renkema GH, Neele J, Vianello P, Hung IO, Strijland A, van der Burg AM, Koomen GJ, Pandit UK, Aerts JM.

J Biol Chem. 1998 Oct 9;273(41):26522-7.

20.

Trans/cis (Z/E) photoisomerization of the chromophore of photoactive yellow protein is not a prerequisite for the initiation of the photocycle of this photoreceptor protein.

Cordfunke R, Kort R, Pierik A, Gobets B, Koomen GJ, Verhoeven JW, Hellingwerf KJ.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7396-401.

21.

Contribution of tubular anion and cation secretion to residual renal function in chronic dialysis patients.

van Olden RW, van Acker BA, Koomen GC, Krediet RT, Arisz L.

Clin Nephrol. 1998 Mar;49(3):167-72.

PMID:
9543598
22.

Day-to-day variability of fluid and solute transport in upright and recumbent positions during CAPD.

Imholz AL, Koomen GC, Voorn WJ, Struijk DG, Arisz L, Krediet RT.

Nephrol Dial Transplant. 1998 Jan;13(1):146-53.

PMID:
9481731
23.

Clearance ratios of amylase isoenzymes and IgG subclasses: do they reflect glomerular charge selectivity?

Buis B, Wever PC, Koomen GC, van Acker BA, Groothoff JW, Krediet RT, Arisz L.

Nephron. 1997;75(4):444-50.

PMID:
9127332
24.

Spectral tuning, fluorescence, and photoactivity in hybrids of photoactive yellow protein, reconstituted with native or modified chromophores.

Kroon AR, Hoff WD, Fennema HP, Gijzen J, Koomen GJ, Verhoeven JW, Crielaard W, Hellingwerf KJ.

J Biol Chem. 1996 Dec 13;271(50):31949-56.

25.

Effect of electric charge on the transperitoneal transport of plasma proteins during CAPD.

Buis B, Koomen GC, Imholz AL, Struijk DG, Reddingius RE, Arisz L, Krediet RT.

Nephrol Dial Transplant. 1996 Jun;11(6):1113-20.

PMID:
8671978
26.

IgG subclasses in CAPD patients.

Krediet RT, Koomen GC, Vlug A, Struijk DG, Buis B, van Olden RW, Imholz AL.

Perit Dial Int. 1996 May-Jun;16(3):288-94.

PMID:
8761543
27.

Circadian rhythm in glomerular transport of macromolecules through large pores and shunt pathway.

Koopman MG, Koomen GC, van Acker BA, Arisz L.

Kidney Int. 1996 May;49(5):1242-9.

28.

Fluid kinetics in CAPD patients during dialysis with a bicarbonate-based hypoosmolar solution.

Struijk DG, Krediet RT, Imholz AL, Koomen GC, Arisz L.

Blood Purif. 1996;14(3):217-26.

PMID:
8738535
29.

Markers of peritoneal membrane status.

Krediet RT, Pannekeet MM, Zemel D, Koomen GC, Struijk DG, Hoek FJ.

Perit Dial Int. 1996;16 Suppl 1:S42-9. Review. No abstract available.

PMID:
8728161
30.

Inhibition of pig kidney diamine oxidase by nazlinin and nazlinin derivatives.

Cheng E, Dekker HL, van Gelder BF, Koomen GJ.

Biochim Biophys Acta. 1995 Dec 6;1253(2):189-92.

PMID:
8519801
31.

Time course of inulin and creatinine clearance in the interval between two haemodialysis treatments.

van Olden RW, van Acker BA, Koomen GC, Krediet RT, Arisz L.

Nephrol Dial Transplant. 1995 Dec;10(12):2274-80.

PMID:
8808225
32.

Dialysate CA125 in stable CAPD patients: no relation with transport parameters.

Pannekeet MM, Koomen GC, Struijk DG, Krediet RT.

Clin Nephrol. 1995 Oct;44(4):248-54.

PMID:
8575125
33.

The standard peritoneal permeability analysis: a tool for the assessment of peritoneal permeability characteristics in CAPD patients.

Pannekeet MM, Imholz AL, Struijk DG, Koomen GC, Langedijk MJ, Schouten N, de Waart R, Hiralall J, Krediet RT.

Kidney Int. 1995 Sep;48(3):866-75.

34.

Dialysate markers of peritoneal tissue during peritonitis and in stable CAPD.

Pannekeet MM, Zemel D, Koomen GC, Struijk DG, Krediet RT.

Perit Dial Int. 1995 Jul-Sep;15(6):217-25.

PMID:
7578497
35.

Drawbacks of the constant-infusion technique for measurement of renal function.

Van Acker BA, Koomen GC, Arisz L.

Am J Physiol. 1995 Apr;268(4 Pt 2):F543-52.

PMID:
7733310
36.

Nitrate in stable CAPD patients and during peritonitis.

Douma CE, de Waart DR, Zemel D, Imholz AL, Koomen GC, Struijk DG, Krediet RT.

Adv Perit Dial. 1995;11:36-40.

PMID:
8534733
37.

Cancer antigen 125: a bulk marker for the mesothelial mass in stable peritoneal dialysis patients.

Visser CE, Brouwer-Steenbergen JJ, Betjes MG, Koomen GC, Beelen RH, Krediet RT.

Nephrol Dial Transplant. 1995;10(1):64-9.

PMID:
7724031
38.

Radiation reduces cyclooxygenase activity in cultured human endothelial cells at low doses.

Verheij M, Koomen GC, van Mourik JA, Dewit L.

Prostaglandins. 1994 Dec;48(6):351-66.

PMID:
7892507
39.

Practical methods for assessing dialysis efficiency during peritoneal dialysis.

Krediet RT, Koomen GC, Struijk DG, van Olden RW, Imholz AL, Boeschoten EW.

Kidney Int Suppl. 1994 Dec;48:S7-13. Review. No abstract available.

PMID:
7700044
40.

Fluid and solute transport in CAPD patients using ultralow sodium dialysate.

Imholz AL, Koomen GC, Struijk DG, Arisz L, Krediet RT.

Kidney Int. 1994 Aug;46(2):333-40.

41.

A prospective study of peritoneal transport in CAPD patients.

Struijk DG, Krediet RT, Koomen GC, Boeschoten EW, Hoek FJ, Arisz L.

Kidney Int. 1994 Jun;45(6):1739-44.

43.

Urinary sodium excretion in patients with nephrotic syndrome, and its circadian variation.

Koopman MG, Koomen GC, van Acker BA, Arisz L.

Q J Med. 1994 Feb;87(2):109-17.

PMID:
8153287
44.

Measurement of peritoneal fluid handling in children on continuous ambulatory peritoneal dialysis using autologous hemoglobin.

Reddingius RE, Schröder CH, Willems HL, van den Brandt FC, Koomen GC, Krediet RT, Monnens LA.

Perit Dial Int. 1994;14(1):42-7.

PMID:
8312413
45.

Interleukin-8 during peritonitis in patients treated with CAPD; an in-vivo model of acute inflammation.

Zemel D, Krediet RT, Koomen GC, Kortekaas WM, Geertzen HG, ten Berge RJ.

Nephrol Dial Transplant. 1994;9(2):169-74.

PMID:
8190331
46.

Cancer antigen 125 is locally produced in the peritoneal cavity during continuous ambulatory peritoneal dialysis.

Koomen GC, Betjes MG, Zemel D, Krediet RT, Hoek FJ.

Perit Dial Int. 1994;14(2):132-6.

PMID:
8043665
47.

The effect of serum albumin at the start of continuous ambulatory peritoneal dialysis treatment on patient survival.

Struijk DG, Krediet RT, Koomen GC, Boeschoten EW, Arisz L.

Perit Dial Int. 1994;14(2):121-6.

PMID:
8043663
48.

The use of peptides in peritoneal dialysis fluids.

Krediet RT, Imholz AL, Lameire N, Faict D, Koomen GC, Martis L.

Perit Dial Int. 1994;14 Suppl 3:S152-7. Review. No abstract available.

PMID:
7948265
49.

Evaluation of short-chain polypeptides as an osmotic agent in continuous ambulatory peritoneal dialysis patients.

Imholz AL, Lameire N, Faict D, Koomen GC, Krediet RT, Martis L.

Perit Dial Int. 1994;14(3):215-22.

PMID:
7948230
50.

Circadian rhythm of glomerular filtration rate in patients after kidney transplantation.

Buijsen JG, van Acker BA, Koomen GC, Koopman MG, Arisz L.

Nephrol Dial Transplant. 1994;9(9):1330-3.

PMID:
7816301

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