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Items: 6


Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.

Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM.

Mol Cell. 2019 Dec 5;76(5):784-796.e6. doi: 10.1016/j.molcel.2019.09.010. Epub 2019 Oct 3.


TEFM regulates both transcription elongation and RNA processing in mitochondria.

Jiang S, Koolmeister C, Misic J, Siira S, Kühl I, Silva Ramos E, Miranda M, Jiang M, Posse V, Lytovchenko O, Atanassov I, Schober FA, Wibom R, Hultenby K, Milenkovic D, Gustafsson CM, Filipovska A, Larsson NG.

EMBO Rep. 2019 Jun;20(6). pii: e48101. doi: 10.15252/embr.201948101. Epub 2019 Apr 29.


Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse.

Filograna R, Koolmeister C, Upadhyay M, Pajak A, Clemente P, Wibom R, Simard ML, Wredenberg A, Freyer C, Stewart JB, Larsson NG.

Sci Adv. 2019 Apr 3;5(4):eaav9824. doi: 10.1126/sciadv.aav9824. eCollection 2019 Apr.


POLRMT does not transcribe nuclear genes.

Kühl I, Kukat C, Ruzzenente B, Milenkovic D, Mourier A, Miranda M, Koolmeister C, Falkenberg M, Larsson NG.

Nature. 2014 Oct 9;514(7521):E7-11. doi: 10.1038/nature13690. No abstract available.


The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation.

Posse V, Hoberg E, Dierckx A, Shahzad S, Koolmeister C, Larsson NG, Wilhelmsson LM, Hällberg BM, Gustafsson CM.

Nucleic Acids Res. 2014 Apr;42(6):3638-47. doi: 10.1093/nar/gkt1397. Epub 2014 Jan 20.


Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.

Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF.

Nat Genet. 2012 Nov;44(11):1282-5. doi: 10.1038/ng.2427. Epub 2012 Oct 7.

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