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An Excimer Clamp for Measuring Damaged-Base Excision by the DNA Repair Enzyme NTH1.

Jun YW, Wilson DL, Kietrys AM, Lotsof ER, Conlon SG, David SS, Kool ET.

Angew Chem Int Ed Engl. 2020 Feb 28. doi: 10.1002/anie.202001516. [Epub ahead of print]


A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.

Jun YW, Hebenbrock M, Kool ET.

Chem Commun (Camb). 2019 Dec 19;56(2):317-320. doi: 10.1039/c9cc08458d.


Ultrafast Oxime Formation Enables Efficient Fluorescence Light-up Measurement of DNA Base Excision.

Wilson DL, Kool ET.

J Am Chem Soc. 2019 Dec 11;141(49):19379-19388. doi: 10.1021/jacs.9b09812. Epub 2019 Nov 27.


The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors.

Samaranayake GJ, Troccoli CI, Zhang L, Huynh M, Jayaraj CJ, Ji D, McPherson L, Onishi Y, Nguyen DM, Robbins DJ, Karbaschi M, Cooke MS, Barrientos A, Kool ET, Rai P.

Mol Cancer Ther. 2020 Feb;19(2):432-446. doi: 10.1158/1535-7163.MCT-19-0437. Epub 2019 Nov 19.


Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1.

Tahara YK, Kietrys AM, Hebenbrock M, Lee Y, Wilson DL, Kool ET.

ACS Chem Biol. 2019 Dec 20;14(12):2606-2615. doi: 10.1021/acschembio.9b00490. Epub 2019 Oct 29.


Polymerase synthesis of four-base DNA from two stable dimeric nucleotides.

Mohsen MG, Ji D, Kool ET.

Nucleic Acids Res. 2019 Oct 10;47(18):9495-9501. doi: 10.1093/nar/gkz741.


What constitutes a reasonable compensation for non-commercial oocyte donors: an analogy with living organ donation and medical research participation.

Kool E, van der Graaf R, Bos A, Fauser B, Bredenoord A.

J Med Ethics. 2019 Nov;45(11):736-741. doi: 10.1136/medethics-2019-105474. Epub 2019 Aug 2.


Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue.

McPherson LA, Troccoli CI, Ji D, Bowles AE, Gardiner ML, Mohsen MG, Nagathihalli NS, Nguyen DM, Robbins DJ, Merchant NB, Kool ET, Rai P, Ford JM.

DNA Repair (Amst). 2019 Nov;83:102644. doi: 10.1016/j.dnarep.2019.102644. Epub 2019 Jul 5.


Polyacetate and Polycarbonate RNA: Acylating Reagents and Properties.

Habibian M, Velema WA, Kietrys AM, Onishi Y, Kool ET.

Org Lett. 2019 Jul 19;21(14):5413-5416. doi: 10.1021/acs.orglett.9b01526. Epub 2019 Jul 3.


Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in RNA and DNA.

Mohsen MG, Ji D, Kool ET.

Chem Sci. 2019 Jan 30;10(11):3264-3270. doi: 10.1039/c8sc03901a. eCollection 2019 Mar 21.


Simple alkanoyl acylating agents for reversible RNA functionalization and control.

Park HS, Kietrys AM, Kool ET.

Chem Commun (Camb). 2019 Apr 25;55(35):5135-5138. doi: 10.1039/c9cc01598a.


Stakeholders views on the ethical aspects of oocyte banking for third-party assisted reproduction: a qualitative interview study with donors, recipients and professionals.

Kool EM, van der Graaf R, Bos AME, Pieters JJPM, Custers IM, Fauser BCJM, Bredenoord AL.

Hum Reprod. 2019 May 1;34(5):842-850. doi: 10.1093/humrep/dez032.


RNA structure maps across mammalian cellular compartments.

Sun L, Fazal FM, Li P, Broughton JP, Lee B, Tang L, Huang W, Kool ET, Chang HY, Zhang QC.

Nat Struct Mol Biol. 2019 Apr;26(4):322-330. doi: 10.1038/s41594-019-0200-7. Epub 2019 Mar 18.


Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.

Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD.

PLoS One. 2019 Feb 27;14(2):e0208341. doi: 10.1371/journal.pone.0208341. eCollection 2019.


Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNA.

Velema WA, Kool ET.

Org Lett. 2018 Oct 19;20(20):6587-6590. doi: 10.1021/acs.orglett.8b02938. Epub 2018 Oct 9.


Fluorescence Probes for ALKBH2 Allow the Measurement of DNA Alkylation Repair and Drug Resistance Responses.

Wilson DL, Beharry AA, Srivastava A, O'Connor TR, Kool ET.

Angew Chem Int Ed Engl. 2018 Sep 24;57(39):12896-12900. doi: 10.1002/anie.201807593. Epub 2018 Sep 3.


Exceptionally rapid oxime and hydrazone formation promoted by catalytic amine buffers with low toxicity.

Larsen D, Kietrys AM, Clark SA, Park HS, Ekebergh A, Kool ET.

Chem Sci. 2018 May 21;9(23):5252-5259. doi: 10.1039/c8sc01082j. eCollection 2018 Jun 21.


Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes.

Saiki JP, Cao H, Van Wassenhove LD, Viswanathan V, Bloomstein J, Nambiar DK, Mattingly AJ, Jiang D, Chen CH, Stevens MC, Simmons AL, Park HS, von Eyben R, Kool ET, Sirjani D, Knox SM, Le QT, Mochly-Rosen D.

Proc Natl Acad Sci U S A. 2018 Jun 12;115(24):6279-6284. doi: 10.1073/pnas.1802184115. Epub 2018 May 24.


Ethics of oocyte banking for third-party assisted reproduction: a systematic review.

Kool EM, Bos AME, van der Graaf R, Fauser BCJM, Bredenoord AL.

Hum Reprod Update. 2018 Sep 1;24(5):615-635. doi: 10.1093/humupd/dmy016.


ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase.

Ji D, Kietrys AM, Lee Y, Kool ET.

Bioconjug Chem. 2018 May 16;29(5):1614-1621. doi: 10.1021/acs.bioconjchem.8b00124. Epub 2018 Mar 29.


RNA Control by Photoreversible Acylation.

Velema WA, Kietrys AM, Kool ET.

J Am Chem Soc. 2018 Mar 14;140(10):3491-3495. doi: 10.1021/jacs.7b12408. Epub 2018 Mar 1.


Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase.

Tahara YK, Auld D, Ji D, Beharry AA, Kietrys AM, Wilson DL, Jimenez M, King D, Nguyen Z, Kool ET.

J Am Chem Soc. 2018 Feb 14;140(6):2105-2114. doi: 10.1021/jacs.7b09316. Epub 2018 Feb 5.


RNA Cloaking by Reversible Acylation.

Kadina A, Kietrys AM, Kool ET.

Angew Chem Int Ed Engl. 2018 Mar 12;57(12):3059-3063. doi: 10.1002/anie.201708696. Epub 2018 Feb 22.


Fluorescent Probes of DNA Repair.

Wilson DL, Kool ET.

ACS Chem Biol. 2018 Jul 20;13(7):1721-1733. doi: 10.1021/acschembio.7b00919. Epub 2017 Nov 30. Review.


Fingerprints of Modified RNA Bases from Deep Sequencing Profiles.

Kietrys AM, Velema WA, Kool ET.

J Am Chem Soc. 2017 Nov 29;139(47):17074-17081. doi: 10.1021/jacs.7b07914. Epub 2017 Nov 17.


Fluorescent nucleobases as tools for studying DNA and RNA.

Xu W, Chan KM, Kool ET.

Nat Chem. 2017 Nov;9(11):1043-1055. doi: 10.1038/nchem.2859. Epub 2017 Oct 16. Review.


Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera.

Ji D, Stepchenkova EI, Cui J, Menezes MR, Pavlov YI, Kool ET.

Nucleic Acids Res. 2017 Nov 16;45(20):11515-11524. doi: 10.1093/nar/gkx774.


Luminescent Carbon Dot Mimics Assembled on DNA.

Chan KM, Xu W, Kwon H, Kietrys AM, Kool ET.

J Am Chem Soc. 2017 Sep 20;139(37):13147-13155. doi: 10.1021/jacs.7b07420. Epub 2017 Sep 12.


Oximes and Hydrazones in Bioconjugation: Mechanism and Catalysis.

Kölmel DK, Kool ET.

Chem Rev. 2017 Aug 9;117(15):10358-10376. doi: 10.1021/acs.chemrev.7b00090. Epub 2017 Jun 22. Review.


Color-Change Photoswitching of an Alkynylpyrene Excimer Dye.

Chan KM, Kölmel DK, Wang S, Kool ET.

Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6497-6501. doi: 10.1002/anie.201701235. Epub 2017 May 5.


Fluorogenic Templated Reaction Cascades for RNA Detection.

Velema WA, Kool ET.

J Am Chem Soc. 2017 Apr 19;139(15):5405-5411. doi: 10.1021/jacs.7b00466. Epub 2017 Apr 5.


DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobases.

Kwon H, Chan KM, Kool ET.

Org Biomol Chem. 2017 Feb 22;15(8):1801-1809. doi: 10.1039/c6ob02830f.


Correction to "Genetically Encoded Multispectral Labeling of Proteins with Polyfluorophores on a DNA Backbone".

Singh V, Wang S, Chan KM, Clark SA, Kool ET.

J Am Chem Soc. 2017 Feb 8;139(5):2118. doi: 10.1021/jacs.6b11085. Epub 2017 Jan 27. No abstract available.


Chemical and structural effects of base modifications in messenger RNA.

Harcourt EM, Kietrys AM, Kool ET.

Nature. 2017 Jan 18;541(7637):339-346. doi: 10.1038/nature21351. Review.


Light-Up "Channel Dyes" for Haloalkane-Based Protein Labeling in Vitro and in Bacterial Cells.

Clark SA, Singh V, Vega Mendoza D, Margolin W, Kool ET.

Bioconjug Chem. 2016 Dec 21;27(12):2839-2843. doi: 10.1021/acs.bioconjchem.6b00613. Epub 2016 Dec 1.


Comparison of SHAPE reagents for mapping RNA structures inside living cells.

Lee B, Flynn RA, Kadina A, Guo JK, Kool ET, Chang HY.

RNA. 2017 Feb;23(2):169-174. doi: 10.1261/rna.058784.116. Epub 2016 Nov 22.


DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides.

Kent T, Rusanov TD, Hoang TM, Velema WA, Krueger AT, Copeland WC, Kool ET, Pomerantz RT.

Nucleic Acids Res. 2016 Nov 2;44(19):9381-9392. Epub 2016 Sep 2.


The Discovery of Rolling Circle Amplification and Rolling Circle Transcription.

Mohsen MG, Kool ET.

Acc Chem Res. 2016 Nov 15;49(11):2540-2550. Epub 2016 Oct 24.


A Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target.

Ji D, Beharry AA, Ford JM, Kool ET.

J Am Chem Soc. 2016 Jul 27;138(29):9005-8. doi: 10.1021/jacs.6b02895. Epub 2016 Jul 18.


Dark Hydrazone Fluorescence Labeling Agents Enable Imaging of Cellular Aldehydic Load.

Yuen LH, Saxena NS, Park HS, Weinberg K, Kool ET.

ACS Chem Biol. 2016 Aug 19;11(8):2312-9. doi: 10.1021/acschembio.6b00269. Epub 2016 Jun 24.


Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores.

Kölmel DK, Barandun LJ, Kool ET.

Org Biomol Chem. 2016 Jul 6;14(27):6407-12. doi: 10.1039/c6ob01199c.


Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution.

Hwang CS, Xu L, Wang W, Ulrich S, Zhang L, Chong J, Shin JH, Huang X, Kool ET, McKenna CE, Wang D.

Nucleic Acids Res. 2016 May 5;44(8):3820-8. doi: 10.1093/nar/gkw220. Epub 2016 Apr 7.


Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity.

Oertell K, Harcourt EM, Mohsen MG, Petruska J, Kool ET, Goodman MF.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2277-85. doi: 10.1073/pnas.1600279113. Epub 2016 Apr 4.


Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response.

Beharry AA, Nagel ZD, Samson LD, Kool ET.

PLoS One. 2016 Apr 1;11(4):e0152684. doi: 10.1371/journal.pone.0152684. eCollection 2016.


Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker.

Beharry AA, Lacoste S, O'Connor TR, Kool ET.

J Am Chem Soc. 2016 Mar 23;138(11):3647-50. doi: 10.1021/jacs.6b00986. Epub 2016 Mar 15.


Epigenetics: A new methyl mark on messengers.

Kietrys AM, Kool ET.

Nature. 2016 Feb 25;530(7591):423-4. doi: 10.1038/530423a. No abstract available.


7SK-BAF axis controls pervasive transcription at enhancers.

Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY.

Nat Struct Mol Biol. 2016 Mar;23(3):231-8. doi: 10.1038/nsmb.3176. Epub 2016 Feb 15.


ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling.

Ji D, Mohsen MG, Harcourt EM, Kool ET.

Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2087-91. doi: 10.1002/anie.201509131. Epub 2016 Jan 6.


Corrigendum: Organocatalytic removal of formaldehyde adducts from RNA and DNA bases.

Karmakar S, Harcourt EM, Hewings DS, Scherer F, Lovejoy AF, Kurtz DM, Ehrenschwender T, Barandun LJ, Roost C, Alizadeh AA, Kool ET.

Nat Chem. 2015 Dec;7(12):1033. doi: 10.1038/nchem.2401. No abstract available.


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