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Items: 6


β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.

Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM.

Nat Commun. 2019 Jun 18;10(1):2685. doi: 10.1038/s41467-019-10555-9.


Point mutations in the tri-helix bundle of the M-domain of cardiac myosin binding protein-C influence systolic duration and delay cardiac relaxation.

van Dijk SJ, Kooiker KB, Napierski NC, Touma KD, Mazzalupo S, Harris SP.

J Mol Cell Cardiol. 2018 Jun;119:116-124. doi: 10.1016/j.yjmcc.2018.05.001. Epub 2018 May 3.


miR-21 is associated with fibrosis and right ventricular failure.

Reddy S, Hu DQ, Zhao M, Blay E Jr, Sandeep N, Ong SG, Jung G, Kooiker KB, Coronado M, Fajardo G, Bernstein D.

JCI Insight. 2017 May 4;2(9). pii: 91625. doi: 10.1172/jci.insight.91625. eCollection 2017 May 4.


Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.

Adhikari AS, Kooiker KB, Sarkar SS, Liu C, Bernstein D, Spudich JA, Ruppel KM.

Cell Rep. 2016 Dec 13;17(11):2857-2864. doi: 10.1016/j.celrep.2016.11.040.


Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes.

McNamara JW, Li A, Smith NJ, Lal S, Graham RM, Kooiker KB, van Dijk SJ, Remedios CGD, Harris SP, Cooke R.

J Mol Cell Cardiol. 2016 May;94:65-71. doi: 10.1016/j.yjmcc.2016.03.009. Epub 2016 Mar 26.


Time-dependent evolution of functional vs. remodeling signaling in induced pluripotent stem cell-derived cardiomyocytes and induced maturation with biomechanical stimulation.

Jung G, Fajardo G, Ribeiro AJ, Kooiker KB, Coronado M, Zhao M, Hu DQ, Reddy S, Kodo K, Sriram K, Insel PA, Wu JC, Pruitt BL, Bernstein D.

FASEB J. 2016 Apr;30(4):1464-79. doi: 10.1096/fj.15-280982. Epub 2015 Dec 16.

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