Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 786

1.

Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking.

Guillot A, Ren T, Jourdan T, Pawlosky RJ, Han E, Kim SJ, Zhang L, Koob GF, Gao B.

Proc Natl Acad Sci U S A. 2019 Dec 2. pii: 201908137. doi: 10.1073/pnas.1908137116. [Epub ahead of print]

PMID:
31792171
2.

PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease.

Lee JS, Mukhopadhyay P, Matyas C, Trojnar E, Paloczi J, Yang YR, Blank BA, Savage C, Sorokin AV, Mehta NN, Vendruscolo JCM, Koob GF, Vendruscolo LF, Pacher P, Lohoff FW.

Sci Rep. 2019 Nov 20;9(1):17167. doi: 10.1038/s41598-019-53603-6.

3.

A Light in the Darkness: Repetitive Transcranial Magnetic Stimulation (rTMS) to Treat the Hedonic Dysregulation of Addiction.

Pettorruso M, di Giannantonio M, De Risio L, Martinotti G, Koob GF.

J Addict Med. 2019 Nov 12. doi: 10.1097/ADM.0000000000000575. [Epub ahead of print]

PMID:
31725426
4.

Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder?

Tunstall BJ, Lorrai I, McConnell SA, Gazo KL, Zallar LJ, de Guglielmo G, Hoang I, Haass-Koffler CL, Repunte-Canonigo V, Koob GF, Vendruscolo LF, Sanna PP.

Alcohol Alcohol. 2019 Jan 9;54(5):497-502. doi: 10.1093/alcalc/agz054.

PMID:
31535696
5.

Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency.

Zorrilla EP, Koob GF.

Front Behav Neurosci. 2019 Aug 27;13:188. doi: 10.3389/fnbeh.2019.00188. eCollection 2019.

6.

Larry Stein: pioneer neuropsychopharmacology researcher, mentor, and friend.

Koob GF.

Neuropsychopharmacology. 2019 Dec;44(13):2294-2295. doi: 10.1038/s41386-019-0509-2. Epub 2019 Sep 9. No abstract available.

PMID:
31501525
7.

Refractory dependence on opioid analgesics.

Ballantyne JC, Sullivan MD, Koob GF.

Pain. 2019 Dec;160(12):2655-2660. doi: 10.1097/j.pain.0000000000001680. No abstract available.

PMID:
31408053
8.

Neurobiology of Opioid Addiction: Opponent Process, Hyperkatifeia, and Negative Reinforcement.

Koob GF.

Biol Psychiatry. 2020 Jan 1;87(1):44-53. doi: 10.1016/j.biopsych.2019.05.023. Epub 2019 Jun 12. Review.

PMID:
31400808
9.

Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency.

Zorrilla EP, Koob GF.

Front Behav Neurosci. 2019 Jun 25;13:136. doi: 10.3389/fnbeh.2019.00136. eCollection 2019. Review. Erratum in: Front Behav Neurosci. 2019 Aug 27;13:188.

10.

Alcohol use disorder and sleep disturbances: a feed-forward allostatic framework.

Koob GF, Colrain IM.

Neuropsychopharmacology. 2020 Jan;45(1):141-165. doi: 10.1038/s41386-019-0446-0. Epub 2019 Jun 24. Review.

PMID:
31234199
11.

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala.

Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF.

PLoS Biol. 2019 Apr 16;17(4):e2006421. doi: 10.1371/journal.pbio.2006421. eCollection 2019 Apr.

12.

Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology.

George DT, Ameli R, Koob GF.

Trends Neurosci. 2019 May;42(5):349-360. doi: 10.1016/j.tins.2019.03.004. Epub 2019 Apr 4. Review.

PMID:
30955857
13.

Heroin addiction engages negative emotional learning brain circuits in rats.

Carmack SA, Keeley RJ, Vendruscolo JCM, Lowery-Gionta EG, Lu H, Koob GF, Stein EA, Vendruscolo LF.

J Clin Invest. 2019 Mar 26;129(6):2480-2484. doi: 10.1172/JCI125534.

14.

Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats.

de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O.

Nat Commun. 2019 Mar 18;10(1):1238. doi: 10.1038/s41467-019-09183-0.

15.

Male and female mice develop escalation of heroin intake and dependence following extended access.

Towers EB, Tunstall BJ, McCracken ML, Vendruscolo LF, Koob GF.

Neuropharmacology. 2019 Jun;151:189-194. doi: 10.1016/j.neuropharm.2019.03.019. Epub 2019 Mar 14.

PMID:
30880124
16.

Detecting neuroinflammation in the brain following chronic alcohol exposure in rats: A comparison between in vivo and in vitro TSPO radioligand binding.

Tyler RE, Kim SW, Guo M, Jang YJ, Damadzic R, Stodden T, Vendruscolo LF, Koob GF, Wang GJ, Wiers CE, Volkow ND.

Eur J Neurosci. 2019 Jul;50(1):1831-1842. doi: 10.1111/ejn.14392. Epub 2019 Mar 25.

PMID:
30803059
17.

The NIH Blueprint for Neuroscience Research Seeks Community Input on Future Neuroscience Investments.

Mott MC, Austin CP, Bianchi DW, Cashion AK, Gordon JA, Heemskerk JE, Hodes RJ, Koob GF, Riley WT, Sieving PA, Shurtleff D, Somerman MJ, Volkow ND, Anderson KC, Owens DF, Koroshetz WJ.

J Neurosci. 2019 Jan 30;39(5):774-775. doi: 10.1523/JNEUROSCI.2742-18.2018. No abstract available.

18.

The neurobiology of addiction.

Uhl GR, Koob GF, Cable J.

Ann N Y Acad Sci. 2019 Sep;1451(1):5-28. doi: 10.1111/nyas.13989. Epub 2019 Jan 15.

19.

Neurofunctional Domains Derived From Deep Behavioral Phenotyping in Alcohol Use Disorder.

Kwako LE, Schwandt ML, Ramchandani VA, Diazgranados N, Koob GF, Volkow ND, Blanco C, Goldman D.

Am J Psychiatry. 2019 Sep 1;176(9):744-753. doi: 10.1176/appi.ajp.2018.18030357. Epub 2019 Jan 4. Erratum in: Am J Psychiatry. 2019 Jun 1;176(6):489.

PMID:
30606047
20.

Neuroethics for the National Institutes of Health BRAIN Initiative.

Bianchi DW, Cooper JA, Gordon JA, Heemskerk J, Hodes R, Koob GF, Koroshetz WJ, Shurtleff D, Sieving PA, Volkow ND, Churchill JD, Ramos KM.

J Neurosci. 2018 Dec 12;38(50):10583-10585. doi: 10.1523/JNEUROSCI.2091-18.2018. No abstract available.

21.

Larry Parsons: Researcher, mentor, and friend.

Frantz K, Roberto M, Mason B, Koob GF, Volkow N, Rodriguez de Fonseca F.

Addict Biol. 2018 Nov;23(6):1204-1206. doi: 10.1111/adb.12686. No abstract available.

PMID:
30485629
22.

Ghrelin receptor deletion reduces binge-like alcohol drinking in rats.

Zallar LJ, Beurmann S, Tunstall BJ, Fraser CM, Koob GF, Vendruscolo LF, Leggio L.

J Neuroendocrinol. 2019 Jul;31(7):e12663. doi: 10.1111/jne.12663. Epub 2019 Jan 16.

PMID:
30456835
23.

Cocaine-induced ischemia in prefrontal cortex is associated with escalation of cocaine intake in rodents.

Du C, Volkow ND, You J, Park K, Allen CP, Koob GF, Pan Y.

Mol Psychiatry. 2018 Oct 3. doi: 10.1038/s41380-018-0261-8. [Epub ahead of print]

24.

Addiction and stress: An allostatic view.

Koob GF, Schulkin J.

Neurosci Biobehav Rev. 2019 Nov;106:245-262. doi: 10.1016/j.neubiorev.2018.09.008. Epub 2018 Sep 15. Review.

PMID:
30227143
25.

Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence.

Somkuwar SS, Quach LW, Quigley JA, Purohit DC, Fannon MJ, Koob GF, Mandyam CD.

Brain Sci. 2018 Jun 26;8(7). pii: E119. doi: 10.3390/brainsci8070119.

26.

Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use.

Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C.

Mol Psychiatry. 2018 Dec;23(12):2266-2276. doi: 10.1038/s41380-018-0080-y. Epub 2018 Jun 7.

PMID:
29880881
27.

Promoting Wellness in Older Adults with Mental Illnesses and Substance Use Disorders: Call to Action to All Stakeholders.

Jeste DV, Peschin S, Buckwalter K, Blazer DG, McGuire MH, Moutier C, Doederlein A, Niederehe G, Altman B, Borenstein J, Saks E, Norquist G, Koob GF, Compton WM, Sperling A, Bain L, Glorioso D, Paul IH, Reynolds CF 3rd.

Am J Geriatr Psychiatry. 2018 Jun;26(6):617-630. doi: 10.1016/j.jagp.2018.03.011. Epub 2018 Apr 26. No abstract available.

28.

Influence of alcoholism and cholesterol on TSPO binding in brain: PET [11C]PBR28 studies in humans and rodents.

Kim SW, Wiers CE, Tyler R, Shokri-Kojori E, Jang YJ, Zehra A, Freeman C, Ramirez V, Lindgren E, Miller G, Cabrera EA, Stodden T, Guo M, Demiral ŞB, Diazgranados N, Park L, Liow JS, Pike V, Morse C, Vendruscolo LF, Innis RB, Koob GF, Tomasi D, Wang GJ, Volkow ND.

Neuropsychopharmacology. 2018 Aug;43(9):1832-1839. doi: 10.1038/s41386-018-0085-x. Epub 2018 May 3.

29.

Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats.

Schmeichel BE, Matzeu A, Koebel P, Vendruscolo LF, Sidhu H, Shahryari R, Kieffer BL, Koob GF, Martin-Fardon R, Contet C.

Neuropsychopharmacology. 2018 Nov;43(12):2373-2382. doi: 10.1038/s41386-018-0054-4. Epub 2018 Apr 6.

30.

Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou.

Kenny PJ, Hoyer D, Koob GF.

Biol Psychiatry. 2018 Jun 1;83(11):940-946. doi: 10.1016/j.biopsych.2018.02.009. Epub 2018 Feb 22. Review.

PMID:
29602521
31.

Age, Alcohol Use, and Brain Function: Yoda Says, "With Age and Alcohol, Confused Is the Force".

Koob GF.

JAMA Psychiatry. 2018 May 1;75(5):422. doi: 10.1001/jamapsychiatry.2018.0009. No abstract available.

PMID:
29541767
32.

Enhanced neuronal and blunted hemodynamic reactivity to cocaine in the prefrontal cortex following extended cocaine access: optical imaging study in anesthetized rats.

Allen CP, Park K, Li A, Volkow ND, Koob GF, Pan Y, Hu XT, Du C.

Addict Biol. 2019 May;24(3):485-497. doi: 10.1111/adb.12615. Epub 2018 Mar 5.

PMID:
29504647
33.

Evaluation of Alcohol Preference and Drinking in msP Rats Bearing a Crhr1 Promoter Polymorphism.

Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP.

Front Psychiatry. 2018 Feb 15;9:28. doi: 10.3389/fpsyt.2018.00028. eCollection 2018.

34.

Development and initial characterization of a novel ghrelin receptor CRISPR/Cas9 knockout wistar rat model.

Zallar LJ, Tunstall BJ, Richie CT, Zhang YJ, You ZB, Gardner EL, Heilig M, Pickel J, Koob GF, Vendruscolo LF, Harvey BK, Leggio L.

Int J Obes (Lond). 2019 Feb;43(2):344-354. doi: 10.1038/s41366-018-0013-5. Epub 2018 Jan 30.

35.

Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake.

Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR.

Biol Psychiatry. 2018 Jun 15;83(12):1024-1035. doi: 10.1016/j.biopsych.2017.10.031. Epub 2017 Nov 20.

36.

Blockade of TRPV1 Inhibits Methamphetamine-induced Rewarding Effects.

Tian YH, Ma SX, Lee KW, Wee S, Koob GF, Lee SY, Jang CG.

Sci Rep. 2018 Jan 17;8(1):882. doi: 10.1038/s41598-018-19207-2.

37.

Individual differences in the neuropsychopathology of addiction.

George O, Koob GF.

Dialogues Clin Neurosci. 2017 Sep;19(3):217-229. Review.

38.

Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.

Tunstall BJ, Ho CP, Cao J, Vendruscolo JCM, Schmeichel BE, Slack RD, Tanda G, Gadiano AJ, Rais R, Slusher BS, Koob GF, Newman AH, Vendruscolo LF.

Neuropharmacology. 2018 Mar 15;131:96-103. doi: 10.1016/j.neuropharm.2017.12.006. Epub 2017 Dec 5.

39.

The conception of the ABCD study: From substance use to a broad NIH collaboration.

Volkow ND, Koob GF, Croyle RT, Bianchi DW, Gordon JA, Koroshetz WJ, Pérez-Stable EJ, Riley WT, Bloch MH, Conway K, Deeds BG, Dowling GJ, Grant S, Howlett KD, Matochik JA, Morgan GD, Murray MM, Noronha A, Spong CY, Wargo EM, Warren KR, Weiss SRB.

Dev Cogn Neurosci. 2018 Aug;32:4-7. doi: 10.1016/j.dcn.2017.10.002. Epub 2017 Oct 10. Review.

40.

Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST).

Francesconi W, Szücs A, Berton F, Koob GF, Vendruscolo LF, Sanna PP.

Psychopharmacology (Berl). 2017 Dec;234(23-24):3485-3498. doi: 10.1007/s00213-017-4732-4. Epub 2017 Oct 6.

41.

Neuroscience of Compulsive Eating Behavior.

Moore CF, Sabino V, Koob GF, Cottone P.

Front Neurosci. 2017 Aug 24;11:469. doi: 10.3389/fnins.2017.00469. eCollection 2017. Review.

42.

Methylomic profiling and replication implicates deregulation of PCSK9 in alcohol use disorder.

Lohoff FW, Sorcher JL, Rosen AD, Mauro KL, Fanelli RR, Momenan R, Hodgkinson CA, Vendruscolo LF, Koob GF, Schwandt M, George DT, Jones IS, Holmes A, Zhou Z, Xu MJ, Gao B, Sun H, Phillips MJ, Muench C, Kaminsky ZA.

Mol Psychiatry. 2018 Sep;23(9):1900-1910. doi: 10.1038/mp.2017.168. Epub 2017 Aug 29.

43.

Compulsive-Like Sufentanil Vapor Self-Administration in Rats.

Vendruscolo JCM, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater SA, Taffe MA, Koob GF, Vendruscolo LF.

Neuropsychopharmacology. 2018 Mar;43(4):801-809. doi: 10.1038/npp.2017.172. Epub 2017 Aug 16.

44.

Neuroclinical Framework for the Role of Stress in Addiction.

Kwako LE, Koob GF.

Chronic Stress (Thousand Oaks). 2017 Feb;1. doi: 10.1177/2470547017698140. Epub 2017 Apr 10.

45.

The future is now: A 2020 view of alcoholism research.

Harris RA, Koob GF.

Neuropharmacology. 2017 Aug 1;122:1-2. doi: 10.1016/j.neuropharm.2017.06.001. No abstract available.

46.

Dysregulation of Brain Stress Systems Mediates Compulsive Alcohol Drinking.

Tunstall BJ, Carmack SA, Koob GF, Vendruscolo LF.

Curr Opin Behav Sci. 2017 Feb;13:85-90. doi: 10.1016/j.cobeha.2016.10.006. Epub 2016 Nov 19.

47.

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans.

Aoun EG, Jimenez VA, Vendruscolo LF, Walter NAR, Barbier E, Ferrulli A, Haass-Koffler CL, Darakjian P, Lee MR, Addolorato G, Heilig M, Hitzemann R, Koob GF, Grant KA, Leggio L.

Mol Psychiatry. 2018 Jun;23(6):1466-1473. doi: 10.1038/mp.2017.97. Epub 2017 May 2.

48.

A new nomenclature for classifying psychotropic drugs.

Caraci F, Enna SJ, Zohar J, Racagni G, Zalsman G, van den Brink W, Kasper S, Koob GF, Pariante CM, Piazza PV, Yamada K, Spedding M, Drago F.

Br J Clin Pharmacol. 2017 Aug;83(8):1614-1616. doi: 10.1111/bcp.13302. Epub 2017 May 24.

49.

Titrating Tipsy Targets: The Neurobiology of Low-Dose Alcohol.

Cui C, Koob GF.

Trends Pharmacol Sci. 2017 Jun;38(6):556-568. doi: 10.1016/j.tips.2017.03.002. Epub 2017 Mar 31. Review.

50.

A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse.

Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD.

Mol Psychiatry. 2018 Mar;23(3):629-638. doi: 10.1038/mp.2017.46. Epub 2017 Mar 28.

Supplemental Content

Support Center