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Items: 1 to 50 of 128

1.

The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response.

Svoboda M, Konvalinka J, Trempe JF, Grantz Saskova K.

DNA Repair (Amst). 2019 Jun 27;80:45-51. doi: 10.1016/j.dnarep.2019.06.008. [Epub ahead of print]

2.

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.

Zima V, Albiñana CB, Rojíková K, Pokorná J, Pachl P, Řezáčová P, Hudlicky J, Navrátil V, Majer P, Konvalinka J, Kožíšek M, Machara A.

Bioorg Med Chem. 2019 Jul 1;27(13):2935-2947. doi: 10.1016/j.bmc.2019.05.024. Epub 2019 May 17.

PMID:
31128993
3.

Exploiting the unique features of Zika and Dengue proteases for inhibitor design.

Majerová T, Novotný P, Krýsová E, Konvalinka J.

Biochimie. 2019 May 9. pii: S0300-9084(19)30143-9. doi: 10.1016/j.biochi.2019.05.004. [Epub ahead of print] Review.

PMID:
31077760
4.

GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond.

Vorlova B, Knedlik T, Tykvart J, Konvalinka J.

Front Biosci (Landmark Ed). 2019 Mar 1;24:648-687. Review.

PMID:
30844704
5.

Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy.

Srb P, Svoboda M, Benda L, Lepšík M, Tarábek J, Šícha V, Grüner B, Grantz-Šašková K, Brynda J, Řezáčová P, Konvalinka J, Veverka V.

Phys Chem Chem Phys. 2019 Mar 6;21(10):5661-5673. doi: 10.1039/c9cp00416e.

PMID:
30794275
6.

Identification of Protein Targets of Bioactive Small Molecules Using Randomly Photomodified Probes.

Šimon P, Knedlík T, Blažková K, Dvořáková P, Březinová A, Kostka L, Šubr V, Konvalinka J, Šácha P.

ACS Chem Biol. 2018 Dec 21;13(12):3333-3342. doi: 10.1021/acschembio.8b00791. Epub 2018 Dec 7.

PMID:
30489064
7.

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors.

Kožíšek M, Navrátil V, Rojíková K, Pokorná J, Berenguer Albiñana C, Pachl P, Zemanová J, Machara A, Šácha P, Hudlický J, Císařová I, Řezáčová P, Konvalinka J.

Biochem J. 2018 Dec 10;475(23):3847-3860. doi: 10.1042/BCJ20180764.

8.

A novel PSMA/GCPII-deficient mouse model shows enlarged seminal vesicles upon aging.

Vorlová B, Sedlák F, Kašpárek P, Šrámková K, Malý M, Zámečník J, Šácha P, Konvalinka J.

Prostate. 2019 Feb;79(2):126-139. doi: 10.1002/pros.23717. Epub 2018 Sep 5.

PMID:
30256431
9.

The calcium-binding site of human glutamate carboxypeptidase II is critical for dimerization, thermal stability, and enzymatic activity.

Ptacek J, Nedvedova J, Navratil M, Havlinova B, Konvalinka J, Barinka C.

Protein Sci. 2018 Sep;27(9):1575-1584. doi: 10.1002/pro.3460.

PMID:
30168215
10.

Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation.

Humpolíčková J, Weber J, Starková J, Mašínová E, Günterová J, Flaisigová I, Konvalinka J, Majerová T.

Sci Rep. 2018 Jul 11;8(1):10438. doi: 10.1038/s41598-018-28638-w.

11.

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.

Pokorná J, Pachl P, Karlukova E, Hejdánek J, Řezáčová P, Machara A, Hudlický J, Konvalinka J, Kožíšek M.

Viruses. 2018 Jun 21;10(7). pii: E339. doi: 10.3390/v10070339.

12.

Inhibitor-GCPII Interaction: Selective and Robust System for Targeting Cancer Cells with Structurally Diverse Nanoparticles.

Neburkova J, Sedlak F, Zackova Suchanova J, Kostka L, Sacha P, Subr V, Etrych T, Simon P, Barinkova J, Krystufek R, Spanielova H, Forstova J, Konvalinka J, Cigler P.

Mol Pharm. 2018 Aug 6;15(8):2932-2945. doi: 10.1021/acs.molpharmaceut.7b00889. Epub 2018 Feb 13.

PMID:
29389139
13.

Label-free determination of prostate specific membrane antigen in human whole blood at nanomolar levels by magnetically assisted surface enhanced Raman spectroscopy.

Chaloupková Z, Balzerová A, Bařinková J, Medříková Z, Šácha P, Beneš P, Ranc V, Konvalinka J, Zbořil R.

Anal Chim Acta. 2018 Jan 2;997:44-51. doi: 10.1016/j.aca.2017.10.008. Epub 2017 Oct 17.

PMID:
29149993
14.

Random protein sequences can form defined secondary structures and are well-tolerated in vivo.

Tretyachenko V, Vymětal J, Bednárová L, Kopecký V Jr, Hofbauerová K, Jindrová H, Hubálek M, Souček R, Konvalinka J, Vondrášek J, Hlouchová K.

Sci Rep. 2017 Nov 13;7(1):15449. doi: 10.1038/s41598-017-15635-8.

15.

Inhibitor-Decorated Polymer Conjugates Targeting Fibroblast Activation Protein.

Dvořáková P, Bušek P, Knedlík T, Schimer J, Etrych T, Kostka L, Stollinová Šromová L, Šubr V, Šácha P, Šedo A, Konvalinka J.

J Med Chem. 2017 Oct 26;60(20):8385-8393. doi: 10.1021/acs.jmedchem.7b00767. Epub 2017 Oct 16.

PMID:
28953383
16.

Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII.

Knedlík T, Vorlová B, Navrátil V, Tykvart J, Sedlák F, Vaculín Š, Franěk M, Šácha P, Konvalinka J.

FEBS Open Bio. 2017 Aug 29;7(9):1362-1378. doi: 10.1002/2211-5463.12276. eCollection 2017 Sep.

17.

DNA-linked Inhibitor Antibody Assay (DIANA) for sensitive and selective enzyme detection and inhibitor screening.

Navrátil V, Schimer J, Tykvart J, Knedlík T, Vik V, Majer P, Konvalinka J, Šácha P.

Nucleic Acids Res. 2017 Jan 25;45(2):e10. doi: 10.1093/nar/gkw853. Epub 2016 Sep 26.

18.

Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family.

Trempe JF, Šašková KG, Sivá M, Ratcliffe CD, Veverka V, Hoegl A, Ménade M, Feng X, Shenker S, Svoboda M, Kožíšek M, Konvalinka J, Gehring K.

Sci Rep. 2016 Sep 20;6:33671. doi: 10.1038/srep33671.

19.

Stimulated Emission Depletion Nanoscopy Reveals Time-Course of Human Immunodeficiency Virus Proteolytic Maturation.

Hanne J, Göttfert F, Schimer J, Anders-Össwein M, Konvalinka J, Engelhardt J, Müller B, Hell SW, Kräusslich HG.

ACS Nano. 2016 Sep 27;10(9):8215-22. doi: 10.1021/acsnano.6b03850. Epub 2016 Aug 16.

PMID:
27517329
20.

Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog.

Sivá M, Svoboda M, Veverka V, Trempe JF, Hofmann K, Kožíšek M, Hexnerová R, Sedlák F, Belza J, Brynda J, Šácha P, Hubálek M, Starková J, Flaisigová I, Konvalinka J, Šašková KG.

Sci Rep. 2016 Jul 27;6:30443. doi: 10.1038/srep30443.

21.

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly.

Kožíšek M, Štěpánek O, Parkan K, Berenguer Albiñana C, Pávová M, Weber J, Krӓusslich HG, Konvalinka J, Machara A.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3487-90. doi: 10.1016/j.bmcl.2016.06.039. Epub 2016 Jun 16.

22.

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza.

Albiñana CB, Machara A, Řezáčová P, Pachl P, Konvalinka J, Kožíšek M.

Eur J Med Chem. 2016 Oct 4;121:100-109. doi: 10.1016/j.ejmech.2016.05.016. Epub 2016 May 7.

PMID:
27236066
23.

Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities.

Navrátil M, Tykvart J, Schimer J, Pachl P, Navrátil V, Rokob TA, Hlouchová K, Rulíšek L, Konvalinka J.

FEBS J. 2016 Jul;283(13):2528-45. doi: 10.1111/febs.13761. Epub 2016 Jun 6.

24.

iBodies: Modular Synthetic Antibody Mimetics Based on Hydrophilic Polymers Decorated with Functional Moieties.

Šácha P, Knedlík T, Schimer J, Tykvart J, Parolek J, Navrátil V, Dvořáková P, Sedlák F, Ulbrich K, Strohalm J, Majer P, Šubr V, Konvalinka J.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2356-60. doi: 10.1002/anie.201508642. Epub 2016 Jan 8.

25.

Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds.

Machara A, Lux V, Kožíšek M, Grantz Šašková K, Štěpánek O, Kotora M, Parkan K, Pávová M, Glass B, Sehr P, Lewis J, Müller B, Kräusslich HG, Konvalinka J.

J Med Chem. 2016 Jan 28;59(2):545-58. doi: 10.1021/acs.jmedchem.5b01089. Epub 2016 Jan 6.

PMID:
26685880
26.

Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II.

Tykvart J, Schimer J, Jančařík A, Bařinková J, Navrátil V, Starková J, Šrámková K, Konvalinka J, Majer P, Šácha P.

J Med Chem. 2015 May 28;58(10):4357-63. doi: 10.1021/acs.jmedchem.5b00278. Epub 2015 May 7.

PMID:
25923815
27.

Retroviral proteases and their roles in virion maturation.

Konvalinka J, Kräusslich HG, Müller B.

Virology. 2015 May;479-480:403-17. doi: 10.1016/j.virol.2015.03.021. Epub 2015 Mar 26. Review.

28.

Inhibitor and substrate binding induced stability of HIV-1 protease against sequential dissociation and unfolding revealed by high pressure spectroscopy and kinetics.

Ingr M, Lange R, Halabalová V, Yehya A, Hrnčiřík J, Chevalier-Lucia D, Palmade L, Blayo C, Konvalinka J, Dumay E.

PLoS One. 2015 Mar 17;10(3):e0119099. doi: 10.1371/journal.pone.0119099. eCollection 2015.

29.

Structural and biochemical characterization of a novel aminopeptidase from human intestine.

Tykvart J, Bařinka C, Svoboda M, Navrátil V, Souček R, Hubálek M, Hradilek M, Šácha P, Lubkowski J, Konvalinka J.

J Biol Chem. 2015 May 1;290(18):11321-36. doi: 10.1074/jbc.M114.628149. Epub 2015 Mar 9.

30.

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor.

Schimer J, Pávová M, Anders M, Pachl P, Šácha P, Cígler P, Weber J, Majer P, Řezáčová P, Kräusslich HG, Müller B, Konvalinka J.

Nat Commun. 2015 Mar 9;6:6461. doi: 10.1038/ncomms7461.

31.

Malonate-based inhibitors of mammalian serine racemase: kinetic characterization and structure-based computational study.

Vorlová B, Nachtigallová D, Jirásková-Vaníčková J, Ajani H, Jansa P, Rezáč J, Fanfrlík J, Otyepka M, Hobza P, Konvalinka J, Lepšík M.

Eur J Med Chem. 2015 Jan 7;89:189-97. doi: 10.1016/j.ejmech.2014.10.043. Epub 2014 Oct 16.

PMID:
25462239
32.

Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA).

Tykvart J, Navrátil V, Sedlák F, Corey E, Colombatti M, Fracasso G, Koukolík F, Bařinka C, Sácha P, Konvalinka J.

Prostate. 2014 Dec;74(16):1674-90. doi: 10.1002/pros.22887. Epub 2014 Sep 27.

PMID:
25262926
33.

Induced maturation of human immunodeficiency virus.

Mattei S, Anders M, Konvalinka J, Kräusslich HG, Briggs JA, Müller B.

J Virol. 2014 Dec;88(23):13722-31. doi: 10.1128/JVI.02271-14. Epub 2014 Sep 17.

34.

Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery.

Tykvart J, Schimer J, Bařinková J, Pachl P, Poštová-Slavětínská L, Majer P, Konvalinka J, Šácha P.

Bioorg Med Chem. 2014 Aug 1;22(15):4099-108. doi: 10.1016/j.bmc.2014.05.061. Epub 2014 Jun 5.

PMID:
24954515
35.

Structural and biochemical characterization of the folyl-poly-γ-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.

Navrátil M, Ptáček J, Šácha P, Starková J, Lubkowski J, Bařinka C, Konvalinka J.

FEBS J. 2014 Jul;281(14):3228-42. doi: 10.1111/febs.12857. Epub 2014 Jun 17.

36.

Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases.

Kožíšek M, Lepšík M, Grantz Šašková K, Brynda J, Konvalinka J, Rezáčová P.

FEBS J. 2014 Apr;281(7):1834-47. doi: 10.1111/febs.12743.

37.

Detection and quantitation of glutamate carboxypeptidase II in human blood.

Knedlík T, Navrátil V, Vik V, Pacík D, Šácha P, Konvalinka J.

Prostate. 2014 May;74(7):768-80. doi: 10.1002/pros.22796. Epub 2014 Mar 20.

PMID:
24647901
38.

GS-8374, a prototype phosphonate-containing inhibitor of HIV-1 protease, effectively inhibits protease mutants with amino acid insertions.

Grantz Šašková K, Kozíšek M, Stray K, de Jong D, Rezáová P, Brynda J, van Maarseveen NM, Nijhuis M, Cihlár T, Konvalinka J.

J Virol. 2014 Mar;88(6):3586-90. doi: 10.1128/JVI.02688-13. Epub 2013 Dec 26.

39.

Unorthodox inhibitors of HIV protease: looking beyond active-site-directed peptidomimetics.

Schimer J, Konvalinka J.

Curr Pharm Des. 2014;20(21):3389-97. Review.

PMID:
24001229
40.

Ion specific effects of alkali cations on the catalytic activity of HIV-1 protease.

Pokorná J, Heyda J, Konvalinka J.

Faraday Discuss. 2013;160:359-70; discussion 389-403.

PMID:
23795510
41.

Glutamate carboxypeptidase II does not process amyloid-β peptide.

Sedlák F, Šácha P, Blechová M, Březinová A, Šafařík M, Šebestík J, Konvalinka J.

FASEB J. 2013 Jul;27(7):2626-32. doi: 10.1096/fj.12-225094. Epub 2013 Mar 23.

PMID:
23525279
42.

Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.

Schimer J, Cígler P, Veselý J, Grantz Šašková K, Lepšík M, Brynda J, Rezáčová P, Kožíšek M, Císařová I, Oberwinkler H, Kraeusslich HG, Konvalinka J.

J Med Chem. 2012 Nov 26;55(22):10130-5. doi: 10.1021/jm301249q. Epub 2012 Oct 23.

PMID:
23050738
43.

Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease.

Kozísek M, Henke S, Sasková KG, Jacobs GB, Schuch A, Buchholz B, Müller V, Kräusslich HG, Rezácová P, Konvalinka J, Bodem J.

Antimicrob Agents Chemother. 2012 Aug;56(8):4320-30. doi: 10.1128/AAC.00465-12. Epub 2012 May 29.

44.

GCPII variants, paralogs and orthologs.

Hlouchová K, Navrátil V, Tykvart J, Sácha P, Konvalinka J.

Curr Med Chem. 2012;19(9):1316-22. Review.

PMID:
22304710
45.

Efficient and versatile one-step affinity purification of in vivo biotinylated proteins: expression, characterization and structure analysis of recombinant human glutamate carboxypeptidase II.

Tykvart J, Sácha P, Bařinka C, Knedlík T, Starková J, Lubkowski J, Konvalinka J.

Protein Expr Purif. 2012 Mar;82(1):106-15. doi: 10.1016/j.pep.2011.11.016. Epub 2011 Dec 8.

46.

Novel substrate-based inhibitors of human glutamate carboxypeptidase II with enhanced lipophilicity.

Plechanovová A, Byun Y, Alquicer G, Skultétyová L, Mlčochová P, Němcová A, Kim HJ, Navrátil M, Mease R, Lubkowski J, Pomper M, Konvalinka J, Rulíšek L, Bařinka C.

J Med Chem. 2011 Nov 10;54(21):7535-46. doi: 10.1021/jm200807m. Epub 2011 Oct 11.

47.

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat.

Fun A, van Maarseveen NM, Pokorná J, Maas RE, Schipper PJ, Konvalinka J, Nijhuis M.

Retrovirology. 2011 Aug 24;8:70. doi: 10.1186/1742-4690-8-70.

48.

Urea and guanidinium induced denaturation of a Trp-cage miniprotein.

Heyda J, Kožíšek M, Bednárova L, Thompson G, Konvalinka J, Vondrášek J, Jungwirth P.

J Phys Chem B. 2011 Jul 21;115(28):8910-24. doi: 10.1021/jp200790h. Epub 2011 Jun 2.

PMID:
21634379
49.

Inhibition of human serine racemase, an emerging target for medicinal chemistry.

Jirásková-Vaníčková J, Ettrich R, Vorlová B, Hoffman HE, Lepšík M, Jansa P, Konvalinka J.

Curr Drug Targets. 2011 Jun;12(7):1037-55. Review.

PMID:
21291385
50.

A reliable docking/scoring scheme based on the semiempirical quantum mechanical PM6-DH2 method accurately covering dispersion and H-bonding: HIV-1 protease with 22 ligands.

Fanfrlík J, Bronowska AK, Rezác J, Prenosil O, Konvalinka J, Hobza P.

J Phys Chem B. 2010 Oct 7;114(39):12666-78. doi: 10.1021/jp1032965.

PMID:
20839830

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