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Items: 1 to 50 of 317

1.

Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients.

Rimpelä JM, Pörsti IH, Jula A, Lehtimäki T, Niiranen TJ, Oikarinen L, Porthan K, Tikkakoski A, Virolainen J, Kontula KK, Hiltunen TP.

BMC Med Genet. 2018 Jul 4;19(1):110. doi: 10.1186/s12881-018-0624-7.

2.

Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population.

Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM, Kurki M, Ganna A, Graham D, Glaser B, Peter I, Atzmon G, Barzilai N, Levine AP, Schiff E, Pontikos N, Weisburd B, Lek M, Karczewski KJ, Bloom J, Minikel EV, Petersen BS, Beaugerie L, Seksik P, Cosnes J, Schreiber S, Bokemeyer B, Bethge J; International IBD Genetics Consortium; NIDDK IBD Genetics Consortium; T2D-GENES Consortium, Heap G, Ahmad T, Plagnol V, Segal AW, Targan S, Turner D, Saavalainen P, Farkkila M, Kontula K, Palotie A, Brant SR, Duerr RH, Silverberg MS, Rioux JD, Weersma RK, Franke A, Jostins L, Anderson CA, Barrett JC, MacArthur DG, Jalas C, Sokol H, Xavier RJ, Pulver A, Cho JH, McGovern DPB, Daly MJ.

PLoS Genet. 2018 May 24;14(5):e1007329. doi: 10.1371/journal.pgen.1007329. eCollection 2018 May.

3.

Clinical and molecular genetic risk determinants in adult long QT syndrome type 1 and 2 patients : Koponen et al. Follow-up of adult LQTS patients.

Koponen M, Havulinna AS, Marjamaa A, Tuiskula AM, Salomaa V, Laitinen-Forsblom PJ, Piippo K, Toivonen L, Kontula K, Viitasalo M, Swan H.

BMC Med Genet. 2018 Apr 5;19(1):56. doi: 10.1186/s12881-018-0574-0.

4.

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study.

Ala-Mutka EM, Rimpelä JM, Fyhrquist F, Kontula KK, Hiltunen TP.

Pharmacogenomics. 2018 Apr;19(6):517-527. doi: 10.2217/pgs-2017-0184. Epub 2018 Mar 27.

PMID:
29580174
5.

The outcome and timing of death of 17,767 nosocomial bloodstream infections in acute care hospitals in Finland during 1999-2014.

Kontula KSK, Skogberg K, Ollgren J, Järvinen A, Lyytikäinen O.

Eur J Clin Microbiol Infect Dis. 2018 May;37(5):945-952. doi: 10.1007/s10096-018-3211-0. Epub 2018 Feb 17.

PMID:
29455272
6.

Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension.

Hiltunen TP, Rimpelä JM, Mohney RP, Stirdivant SM, Kontula KK.

PLoS One. 2017 Nov 9;12(11):e0187729. doi: 10.1371/journal.pone.0187729. eCollection 2017.

7.

The genetics underlying idiopathic ventricular fibrillation: A special role for catecholaminergic polymorphic ventricular tachycardia?

Leinonen JT, Crotti L, Djupsjöbacka A, Castelletti S, Junna N, Ghidoni A, Tuiskula AM, Spazzolini C, Dagradi F, Viitasalo M, Kontula K, Kotta MC, Widén E, Swan H, Schwartz PJ.

Int J Cardiol. 2018 Jan 1;250:139-145. doi: 10.1016/j.ijcard.2017.10.016. Epub 2017 Oct 5.

PMID:
29032884
8.

Bloodstream infections following different types of surgery in a Finnish tertiary care hospital, 2009-2014.

Skogberg K, Kontula KSK, Järvinen A, Lyytikäinen O.

J Hosp Infect. 2018 May;99(1):89-93. doi: 10.1016/j.jhin.2017.10.005. Epub 2017 Oct 12.

PMID:
29031864
9.

Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses.

Rimpelä JM, Kontula KK, Fyhrquist F, Donner KM, Tuiskula AM, Sarin AP, Mohney RP, Stirdivant SM, Hiltunen TP.

Pharmacogenomics. 2017 Apr;18(5):445-458. doi: 10.2217/pgs-2016-0204. Epub 2017 Mar 29.

10.

Response by Crotti et al to Letter Regarding Article, "Genetic Modifiers for the Long-QT Syndrome: How Important Is the Role of Variants in the 3' Untranslated Region of KCNQ1?"

Crotti L, Lahtinen AM, Spazzolini C, Mastantuono E, Cristina Monti M, Morassutto C, Parati G, Heradien M, Goosen A, Lichtner P, Meitinger T, Brink PA, Kontula K, Swan H, Schwartz PJ.

Circ Cardiovasc Genet. 2016 Dec;9(6):581-582. doi: 10.1161/CIRCGENETICS.116.001635. No abstract available.

PMID:
27998949
11.

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L, Melum E, Kumasaka N, Atkinson EJ, Schlicht EM, Liu JZ, Shah T, Gutierrez-Achury J, Boberg KM, Bergquist A, Vermeire S, Eksteen B, Durie PR, Farkkila M, Müller T, Schramm C, Sterneck M, Weismüller TJ, Gotthardt DN, Ellinghaus D, Braun F, Teufel A, Laudes M, Lieb W, Jacobs G, Beuers U, Weersma RK, Wijmenga C, Marschall HU, Milkiewicz P, Pares A, Kontula K, Chazouillères O, Invernizzi P, Goode E, Spiess K, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J, Floreani A, Gulamhusein AF, Eaton JE, Schreiber S, Coltescu C, Bowlus CL, Luketic VA, Odin JA, Chopra KB, Kowdley KV, Chalasani N, Manns MP, Srivastava B, Mells G, Sandford RN, Alexander G, Gaffney DJ, Chapman RW, Hirschfield GM, de Andrade M; UK-PSC Consortium; International IBD Genetics Consortium; International PSC Study Group, Rushbrook SM, Franke A, Karlsen TH, Lazaridis KN, Anderson CA.

Nat Genet. 2017 Feb;49(2):269-273. doi: 10.1038/ng.3745. Epub 2016 Dec 19.

12.

Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.

Salvi E, Wang Z, Rizzi F, Gong Y, McDonough CW, Padmanabhan S, Hiltunen TP, Lanzani C, Zaninello R, Chittani M, Bailey KR, Sarin AP, Barcella M, Melander O, Chapman AB, Manunta P, Kontula KK, Glorioso N, Cusi D, Dominiczak AF, Johnson JA, Barlassina C, Boerwinkle E, Cooper-DeHoff RM, Turner ST.

Hypertension. 2017 Jan;69(1):51-59. Epub 2016 Oct 31. Review.

13.

Erratum: A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium, MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ.

Nat Commun. 2016 Sep 13;7:12869. doi: 10.1038/ncomms12869. No abstract available.

14.

Genetic Modifiers for the Long-QT Syndrome: How Important Is the Role of Variants in the 3' Untranslated Region of KCNQ1?

Crotti L, Lahtinen AM, Spazzolini C, Mastantuono E, Monti MC, Morassutto C, Parati G, Heradien M, Goosen A, Lichtner P, Meitinger T, Brink PA, Kontula K, Swan H, Schwartz PJ.

Circ Cardiovasc Genet. 2016 Aug;9(4):330-9. doi: 10.1161/CIRCGENETICS.116.001419.

PMID:
27531917
15.

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

Rivas MA, Graham D, Sulem P, Stevens C, Desch AN, Goyette P, Gudbjartsson D, Jonsdottir I, Thorsteinsdottir U, Degenhardt F, Mucha S, Kurki MI, Li D, D'Amato M, Annese V, Vermeire S, Weersma RK, Halfvarson J, Paavola-Sakki P, Lappalainen M, Lek M, Cummings B, Tukiainen T, Haritunians T, Halme L, Koskinen LL, Ananthakrishnan AN, Luo Y, Heap GA, Visschedijk MC; UK IBD Genetics Consortium; NIDDK IBD Genetics Consortium, MacArthur DG, Neale BM, Ahmad T, Anderson CA, Brant SR, Duerr RH, Silverberg MS, Cho JH, Palotie A, Saavalainen P, Kontula K, Färkkilä M, McGovern DP, Franke A, Stefansson K, Rioux JD, Xavier RJ, Daly MJ, Barrett J, de Lane K, Edwards C, Hart A, Hawkey C, Jostins L, Kennedy N, Lamb C, Lee J, Lees C, Mansfield J, Mathew C, Mowatt C, Newman B, Nimmo E, Parkes M, Pollard M, Prescott N, Randall J, Rice D, Satsangi J, Simmons A, Tremelling M, Uhlig H, Wilson D, Abraham C, Achkar JP, Bitton A, Boucher G, Croitoru K, Fleshner P, Glas J, Kugathasan S, Limbergen JV, Milgrom R, Proctor D, Regueiro M, Schumm PL, Sharma Y, Stempak JM, Targan SR, Wang MH.

Nat Commun. 2016 Aug 9;7:12342. doi: 10.1038/ncomms12342. Erratum in: Nat Commun. 2016 Sep 13;7:12869.

16.

Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes.

Kuusela J, Kujala VJ, Kiviaho A, Ojala M, Swan H, Kontula K, Aalto-Setälä K.

Springerplus. 2016 Feb 29;5:234. doi: 10.1186/s40064-016-1889-y. eCollection 2016.

17.

Antiarrhythmic Action of Flecainide in Polymorphic Ventricular Arrhythmias Caused by a Gain-of-Function Mutation in the Nav 1.5 Sodium Channel.

Amarouch MY, Swan H, Leinonen J, Marjamaa A, Lahtinen AM, Kontula K, Toivonen L, Widen E, Abriel H.

Ann Noninvasive Electrocardiol. 2016 Jul;21(4):343-51. doi: 10.1111/anec.12312. Epub 2015 Oct 7.

PMID:
26965448
18.

Early deaths in bloodstream infections: a population-based case series.

Kontula KS, Skogberg K, Ollgren J, Järvinen A, Lyytikäinen O.

Infect Dis (Lond). 2016;48(5):379-85. doi: 10.3109/23744235.2015.1131329. Epub 2016 Jan 14.

PMID:
26763410
19.

Slowed depolarization and irregular repolarization in catecholaminergic polymorphic ventricular tachycardia: a study from cellular Ca2+ transients and action potentials to clinical monophasic action potentials and electrocardiography.

Paavola J, Väänänen H, Larsson K, Penttinen K, Toivonen L, Kontula K, Laine M, Aalto-Setälä K, Swan H, Viitasalo M.

Europace. 2016 Oct;18(10):1599-1607. Epub 2015 Dec 24.

PMID:
26705554
20.

Endoplasmic reticulum stress increases AT1R mRNA expression via TIA-1-dependent mechanism.

Backlund M, Paukku K, Kontula KK, Lehtonen JY.

Nucleic Acids Res. 2016 Apr 20;44(7):3095-104. doi: 10.1093/nar/gkv1368. Epub 2015 Dec 17.

21.

Prediction of sudden cardiac death with automated high-throughput analysis of heterogeneity in standard resting 12-lead electrocardiograms.

Kenttä TV, Nearing BD, Porthan K, Tikkanen JT, Viitasalo M, Nieminen MS, Salomaa V, Oikarinen L, Jula A, Kontula K, Newton-Cheh C, Huikuri HV, Verrier RL.

Heart Rhythm. 2016 Mar;13(3):713-20. doi: 10.1016/j.hrthm.2015.11.035. Epub 2015 Nov 23.

PMID:
26616400
22.

PTPRD gene associated with blood pressure response to atenolol and resistant hypertension.

Gong Y, McDonough CW, Beitelshees AL, El Rouby N, Hiltunen TP, O'Connell JR, Padmanabhan S, Langaee TY, Hall K, Schmidt SO, Curry RW Jr, Gums JG, Donner KM, Kontula KK, Bailey KR, Boerwinkle E, Takahashi A, Tanaka T, Kubo M, Chapman AB, Turner ST, Pepine CJ, Cooper-DeHoff RM, Johnson JA.

J Hypertens. 2015 Nov;33(11):2278-85. doi: 10.1097/HJH.0000000000000714.

23.

Correction: Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K.

PLoS One. 2015 Jul 31;10(7):e0134746. doi: 10.1371/journal.pone.0134746. eCollection 2015. No abstract available.

24.

Follow-up of 316 molecularly defined pediatric long-QT syndrome patients: clinical course, treatments, and side effects.

Koponen M, Marjamaa A, Hiippala A, Happonen JM, Havulinna AS, Salomaa V, Lahtinen AM, Hintsa T, Viitasalo M, Toivonen L, Kontula K, Swan H.

Circ Arrhythm Electrophysiol. 2015 Aug;8(4):815-23. doi: 10.1161/CIRCEP.114.002654. Epub 2015 Jun 10.

PMID:
26063740
25.

Antiarrhythmic Effects of Dantrolene in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia and Replication of the Responses Using iPSC Models.

Penttinen K, Swan H, Vanninen S, Paavola J, Lahtinen AM, Kontula K, Aalto-Setälä K.

PLoS One. 2015 May 8;10(5):e0125366. doi: 10.1371/journal.pone.0125366. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0134746.

26.

Helsinki alert of biodiversity and health.

von Hertzen L, Beutler B, Bienenstock J, Blaser M, Cani PD, Eriksson J, Färkkilä M, Haahtela T, Hanski I, Jenmalm MC, Kere J, Knip M, Kontula K, Koskenvuo M, Ling C, Mandrup-Poulsen T, von Mutius E, Mäkelä MJ, Paunio T, Pershagen G, Renz H, Rook G, Saarela M, Vaarala O, Veldhoen M, de Vos WM.

Ann Med. 2015 May;47(3):218-25. doi: 10.3109/07853890.2015.1010226. Epub 2015 Apr 23. Review.

27.

TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives.

Chittani M, Zaninello R, Lanzani C, Frau F, Ortu MF, Salvi E, Fresu G, Citterio L, Braga D, Piras DA, Carpini SD, Velayutham D, Simonini M, Argiolas G, Pozzoli S, Troffa C, Glorioso V, Kontula KK, Hiltunen TP, Donner KM, Turner ST, Boerwinkle E, Chapman AB, Padmanabhan S, Dominiczak AF, Melander O, Johnson JA, Cooper-Dehoff RM, Gong Y, Rivera NV, Condorelli G, Trimarco B, Manunta P, Cusi D, Glorioso N, Barlassina C.

J Hypertens. 2015 Jun;33(6):1301-9. doi: 10.1097/HJH.0000000000000541.

28.

Pharmacogenomics of hypertension: a genome‐wide, placebo‐controlled cross‐over study, using four classes of antihypertensive drugs.

Hiltunen TP, Donner KM, Sarin AP, Saarela J, Ripatti S, Chapman AB, Gums JG, Gong Y, Cooper-DeHoff RM, Frau F, Glorioso V, Zaninello R, Salvi E, Glorioso N, Boerwinkle E, Turner ST, Johnson JA, Kontula KK.

J Am Heart Assoc. 2015 Jan 26;4(1):e001521. doi: 10.1161/JAHA.115.001778.

29.

Prevalence and clinical correlates of familial hypercholesterolemia founder mutations in the general population.

Lahtinen AM, Havulinna AS, Jula A, Salomaa V, Kontula K.

Atherosclerosis. 2015 Jan;238(1):64-9. doi: 10.1016/j.atherosclerosis.2014.11.015. Epub 2014 Nov 18.

PMID:
25437892
30.

Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study.

Frau F, Zaninello R, Salvi E, Ortu MF, Braga D, Velayutham D, Argiolas G, Fresu G, Troffa C, Bulla E, Bulla P, Pitzoi S, Piras DA, Glorioso V, Chittani M, Bernini G, Bardini M, Fallo F, Malatino L, Stancanelli B, Regolisti G, Ferri C, Desideri G, Scioli GA, Galletti F, Sciacqua A, Perticone F, Degli Esposti E, Sturani A, Semplicini A, Veglio F, Mulatero P, Williams TA, Lanzani C, Hiltunen TP, Kontula K, Boerwinkle E, Turner ST, Manunta P, Barlassina C, Cusi D, Glorioso N.

Pharmacogenomics. 2014 Sep;15(13):1643-52. doi: 10.2217/pgs.14.119.

PMID:
25410890
31.

Gain-of-function mutation of the SCN5A gene causes exercise-induced polymorphic ventricular arrhythmias.

Swan H, Amarouch MY, Leinonen J, Marjamaa A, Kucera JP, Laitinen-Forsblom PJ, Lahtinen AM, Palotie A, Kontula K, Toivonen L, Abriel H, Widen E.

Circ Cardiovasc Genet. 2014 Dec;7(6):771-81. doi: 10.1161/CIRCGENETICS.114.000703. Epub 2014 Sep 10.

32.

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Arking DE, Pulit SL, Crotti L, van der Harst P, Munroe PB, Koopmann TT, Sotoodehnia N, Rossin EJ, Morley M, Wang X, Johnson AD, Lundby A, Gudbjartsson DF, Noseworthy PA, Eijgelsheim M, Bradford Y, Tarasov KV, Dörr M, Müller-Nurasyid M, Lahtinen AM, Nolte IM, Smith AV, Bis JC, Isaacs A, Newhouse SJ, Evans DS, Post WS, Waggott D, Lyytikäinen LP, Hicks AA, Eisele L, Ellinghaus D, Hayward C, Navarro P, Ulivi S, Tanaka T, Tester DJ, Chatel S, Gustafsson S, Kumari M, Morris RW, Naluai ÅT, Padmanabhan S, Kluttig A, Strohmer B, Panayiotou AG, Torres M, Knoflach M, Hubacek JA, Slowikowski K, Raychaudhuri S, Kumar RD, Harris TB, Launer LJ, Shuldiner AR, Alonso A, Bader JS, Ehret G, Huang H, Kao WH, Strait JB, Macfarlane PW, Brown M, Caulfield MJ, Samani NJ, Kronenberg F, Willeit J; CARe Consortium; COGENT Consortium, Smith JG, Greiser KH, Meyer Zu Schwabedissen H, Werdan K, Carella M, Zelante L, Heckbert SR, Psaty BM, Rotter JI, Kolcic I, Polašek O, Wright AF, Griffin M, Daly MJ; DCCT/EDIC, Arnar DO, Hólm H, Thorsteinsdottir U; eMERGE Consortium, Denny JC, Roden DM, Zuvich RL, Emilsson V, Plump AS, Larson MG, O'Donnell CJ, Yin X, Bobbo M, D'Adamo AP, Iorio A, Sinagra G, Carracedo A, Cummings SR, Nalls MA, Jula A, Kontula KK, Marjamaa A, Oikarinen L, Perola M, Porthan K, Erbel R, Hoffmann P, Jöckel KH, Kälsch H, Nöthen MM; HRGEN Consortium, den Hoed M, Loos RJ, Thelle DS, Gieger C, Meitinger T, Perz S, Peters A, Prucha H, Sinner MF, Waldenberger M, de Boer RA, Franke L, van der Vleuten PA, Beckmann BM, Martens E, Bardai A, Hofman N, Wilde AA, Behr ER, Dalageorgou C, Giudicessi JR, Medeiros-Domingo A, Barc J, Kyndt F, Probst V, Ghidoni A, Insolia R, Hamilton RM, Scherer SW, Brandimarto J, Margulies K, Moravec CE, del Greco M F, Fuchsberger C, O'Connell JR, Lee WK, Watt GC, Campbell H, Wild SH, El Mokhtari NE, Frey N, Asselbergs FW, Mateo Leach I, Navis G, van den Berg MP, van Veldhuisen DJ, Kellis M, Krijthe BP, Franco OH, Hofman A, Kors JA, Uitterlinden AG, Witteman JC, Kedenko L, Lamina C, Oostra BA, Abecasis GR, Lakatta EG, Mulas A, Orrú M, Schlessinger D, Uda M, Markus MR, Völker U, Snieder H, Spector TD, Ärnlöv J, Lind L, Sundström J, Syvänen AC, Kivimaki M, Kähönen M, Mononen N, Raitakari OT, Viikari JS, Adamkova V, Kiechl S, Brion M, Nicolaides AN, Paulweber B, Haerting J, Dominiczak AF, Nyberg F, Whincup PH, Hingorani AD, Schott JJ, Bezzina CR, Ingelsson E, Ferrucci L, Gasparini P, Wilson JF, Rudan I, Franke A, Mühleisen TW, Pramstaller PP, Lehtimäki TJ, Paterson AD, Parsa A, Liu Y, van Duijn CM, Siscovick DS, Gudnason V, Jamshidi Y, Salomaa V, Felix SB, Sanna S, Ritchie MD, Stricker BH, Stefansson K, Boyer LA, Cappola TP, Olsen JV, Lage K, Schwartz PJ, Kääb S, Chakravarti A, Ackerman MJ, Pfeufer A, de Bakker PI, Newton-Cheh C.

Nat Genet. 2014 Aug;46(8):826-36. doi: 10.1038/ng.3014. Epub 2014 Jun 22.

33.

Stressful life events and depressive symptoms among symptomatic long QT syndrome patients.

Hintsa T, Jokela M, Elovainio M, Määttänen I, Swan H, Hintsanen M, Toivonen L, Kontula K, Keltikangas-Järvinen L.

J Health Psychol. 2016 Apr;21(4):505-12. doi: 10.1177/1359105314530450. Epub 2014 Apr 24.

PMID:
24764285
34.

Work stress and the long QT syndrome: high job strain and effort-reward imbalance at work associated with arrhythmic risk in the long QT syndrome.

Hintsa T, Määttänen I, Hintsanen M, Swan H, Toivonen L, Kontula K, Keltikangas-Järvinen L.

J Occup Environ Med. 2013 Dec;55(12):1387-93. doi: 10.1097/JOM.0000000000000026.

PMID:
24270299
35.

Identification of a KCNQ1 polymorphism acting as a protective modifier against arrhythmic risk in long-QT syndrome.

Duchatelet S, Crotti L, Peat RA, Denjoy I, Itoh H, Berthet M, Ohno S, Fressart V, Monti MC, Crocamo C, Pedrazzini M, Dagradi F, Vicentini A, Klug D, Brink PA, Goosen A, Swan H, Toivonen L, Lahtinen AM, Kontula K, Shimizu W, Horie M, George AL Jr, Trégouët DA, Guicheney P, Schwartz PJ.

Circ Cardiovasc Genet. 2013 Aug;6(4):354-61. doi: 10.1161/CIRCGENETICS.113.000023. Epub 2013 Jul 15.

36.

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.

Turner ST, Boerwinkle E, O'Connell JR, Bailey KR, Gong Y, Chapman AB, McDonough CW, Beitelshees AL, Schwartz GL, Gums JG, Padmanabhan S, Hiltunen TP, Citterio L, Donner KM, Hedner T, Lanzani C, Melander O, Saarela J, Ripatti S, Wahlstrand B, Manunta P, Kontula K, Dominiczak AF, Cooper-DeHoff RM, Johnson JA.

Hypertension. 2013 Aug;62(2):391-7. doi: 10.1161/HYPERTENSIONAHA.111.00436. Epub 2013 Jun 10.

37.

Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population.

Lahtinen AM, Havulinna AS, Noseworthy PA, Jula A, Karhunen PJ, Perola M, Newton-Cheh C, Salomaa V, Kontula K.

Ann Med. 2013 Jun;45(4):328-35. doi: 10.3109/07853890.2013.783995. Epub 2013 May 8.

38.

A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals.

Havulinna AS, Kettunen J, Ukkola O, Osmond C, Eriksson JG, Kesäniemi YA, Jula A, Peltonen L, Kontula K, Salomaa V, Newton-Cheh C.

Hypertension. 2013 May;61(5):987-94. doi: 10.1161/HYPERTENSIONAHA.111.00649. Epub 2013 Mar 18.

39.

Telomere length is associated with ACE I/D polymorphism in hypertensive patients with left ventricular hypertrophy.

Fyhrquist F, Eriksson A, Saijonmaa O, Nordestgaard BG, Kontula K, de Faire U, Ibsen H, Kjeldsen S, Os I, Dahlöf B.

J Renin Angiotensin Aldosterone Syst. 2013 Sep;14(3):227-34. doi: 10.1177/1470320312460292. Epub 2012 Oct 17.

PMID:
23077078
40.

Generalized glucocorticoid resistance caused by a novel two-nucleotide deletion in the hormone-binding domain of the glucocorticoid receptor gene NR3C1.

Donner KM, Hiltunen TP, Jänne OA, Sane T, Kontula K.

Eur J Endocrinol. 2012 Dec 10;168(1):K9-K18. doi: 10.1530/EJE-12-0532. Print 2013 Jan.

PMID:
23076843
41.

Association study of FUT2 (rs601338) with celiac disease and inflammatory bowel disease in the Finnish population.

Parmar AS, Alakulppi N, Paavola-Sakki P, Kurppa K, Halme L, Färkkilä M, Turunen U, Lappalainen M, Kontula K, Kaukinen K, Mäki M, Lindfors K, Partanen J, Sistonen P, Mättö J, Wacklin P, Saavalainen P, Einarsdottir E.

Tissue Antigens. 2012 Dec;80(6):488-93. doi: 10.1111/tan.12016. Epub 2012 Oct 18.

PMID:
23075394
42.

Cell model of catecholaminergic polymorphic ventricular tachycardia reveals early and delayed afterdepolarizations.

Kujala K, Paavola J, Lahti A, Larsson K, Pekkanen-Mattila M, Viitasalo M, Lahtinen AM, Toivonen L, Kontula K, Swan H, Laine M, Silvennoinen O, Aalto-Setälä K.

PLoS One. 2012;7(9):e44660. doi: 10.1371/journal.pone.0044660. Epub 2012 Sep 4.

43.

Stress proneness in molecularly defined long QT syndrome: a study using temperament assessment by behavioural inhibition system scale.

Määttänen I, Keltikangas-Järvinen L, Swan H, Toivonen L, Kontula K, Hintsanen M, Alatupa S, Hintsa T.

Stress Health. 2013 Apr;29(2):150-5. doi: 10.1002/smi.2441. Epub 2012 Aug 30.

PMID:
22936642
44.

Common genetic variants associated with sudden cardiac death: the FinSCDgen study.

Lahtinen AM, Noseworthy PA, Havulinna AS, Jula A, Karhunen PJ, Kettunen J, Perola M, Kontula K, Newton-Cheh C, Salomaa V.

PLoS One. 2012;7(7):e41675. doi: 10.1371/journal.pone.0041675. Epub 2012 Jul 23.

45.

Clinical and molecular approaches to individualize antihypertensive drug therapy.

Hiltunen TP, Kontula K.

Ann Med. 2012 Jun;44 Suppl 1:S23-9. doi: 10.3109/07853890.2012.679960. Review.

PMID:
22713145
46.

Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients.

Parmar AS, Lappalainen M, Paavola-Sakki P, Halme L, Färkkilä M, Turunen U, Kontula K, Aromaa A, Salomaa V, Peltonen L, Halfvarson J, Törkvist L, D'Amato M, Saavalainen P, Einarsdottir E.

Genes Immun. 2012 Sep;13(6):474-80. doi: 10.1038/gene.2012.21. Epub 2012 May 17.

PMID:
22592522
47.

Regulation of AT1R expression through HuR by insulin.

Paukku K, Backlund M, De Boer RA, Kalkkinen N, Kontula KK, Lehtonen JY.

Nucleic Acids Res. 2012 Jul;40(12):5250-61. doi: 10.1093/nar/gks170. Epub 2012 Feb 23.

48.

A common variant near the KCNJ2 gene is associated with T-peak to T-end interval.

Marjamaa A, Oikarinen L, Porthan K, Ripatti S, Peloso G, Noseworthy PA, Viitasalo M, Nieminen MS, Toivonen L, Kontula K, Peltonen L, Havulinna AS, Jula A, O'Donnell CJ, Newton-Cheh C, Perola M, Salomaa V.

Heart Rhythm. 2012 Jul;9(7):1099-103. doi: 10.1016/j.hrthm.2012.02.019. Epub 2012 Feb 15.

49.

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture.

Lahti AL, Kujala VJ, Chapman H, Koivisto AP, Pekkanen-Mattila M, Kerkelä E, Hyttinen J, Kontula K, Swan H, Conklin BR, Yamanaka S, Silvennoinen O, Aalto-Setälä K.

Dis Model Mech. 2012 Mar;5(2):220-30. doi: 10.1242/dmm.008409. Epub 2011 Nov 3.

50.

STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men.

Donner KM, Hiltunen TP, Hannila-Handelberg T, Suonsyrjä T, Kontula K.

Hypertens Res. 2012 Jan;35(1):107-14. doi: 10.1038/hr.2011.166. Epub 2011 Oct 13.

PMID:
21993215

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