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Items: 1 to 50 of 113

1.

Design, selection and optimization of an anti-TRAIL-R2/anti-CD3 bispecific antibody able to educate T cells to recognize and destroy cancer cells.

Satta A, Mezzanzanica D, Caroli F, Frigerio B, Nicola MD, Kontermann RE, Iacovelli F, Desideri A, Anichini A, Canevari S, Gianni AM, Figini M.

MAbs. 2018 Jul 11. doi: 10.1080/19420862.2018.1494105. [Epub ahead of print]

PMID:
29993310
2.

IgG-single-chain TRAIL fusion proteins for tumour therapy.

Siegemund M, Schneider F, Hutt M, Seifert O, Müller I, Kulms D, Pfizenmaier K, Kontermann RE.

Sci Rep. 2018 May 17;8(1):7808. doi: 10.1038/s41598-018-24450-8.

3.

Endoglin based in vivo near-infrared fluorescence imaging of tumor models in mice using activatable liposomes.

Tansi FL, Rüger R, Kollmeier AM, Rabenhold M, Steiniger F, Kontermann RE, Teichgraeber UK, Fahr A, Hilger I.

Biochim Biophys Acta. 2018 Jun;1862(6):1389-1400. doi: 10.1016/j.bbagen.2018.03.012. Epub 2018 Mar 13.

4.

Targeting scFv-Fc-scTRAIL fusion proteins to tumor cells.

Hutt M, Fellermeier-Kopf S, Seifert O, Schmitt LC, Pfizenmaier K, Kontermann RE.

Oncotarget. 2018 Jan 31;9(13):11322-11335. doi: 10.18632/oncotarget.24379. eCollection 2018 Feb 16.

5.

Transcytosis of payloads that are non-covalently complexed to bispecific antibodies across the hCMEC/D3 blood-brain barrier model.

Schmid D, Buntz A, Hanh Phan TN, Mayer K, Hoffmann E, Thorey I, Niewöhner J, Vasters K, Sircar R, Mundigl O, Kontermann RE, Brinkmann U.

Biol Chem. 2018 Jun 27;399(7):711-721. doi: 10.1515/hsz-2017-0311.

PMID:
29466231
6.

Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis.

Fischer R, Proske M, Duffey M, Stangl H, Martinez GF, Peters N, Kraske A, Straub RH, Bethea JR, Kontermann RE, Pfizenmaier K.

Arthritis Rheumatol. 2018 May;70(5):722-735. doi: 10.1002/art.40413. Epub 2018 Mar 11.

PMID:
29342501
7.

Corrigendum to "Bispecific antibodies" [Drug Discov. Today 20 (July (7)) (2015) 838-847].

Kontermann RE, Brinkmann U.

Drug Discov Today. 2018 Jan 5. pii: S1359-6446(17)30598-6. doi: 10.1016/j.drudis.2017.12.004. [Epub ahead of print] No abstract available.

PMID:
29309739
8.

Superior Properties of Fc-comprising scTRAIL Fusion Proteins.

Hutt M, Marquardt L, Seifert O, Siegemund M, Müller I, Kulms D, Pfizenmaier K, Kontermann RE.

Mol Cancer Ther. 2017 Dec;16(12):2792-2802. doi: 10.1158/1535-7163.MCT-17-0551. Epub 2017 Sep 13.

PMID:
28904131
9.

Novel strategies to mimic transmembrane tumor necrosis factor-dependent activation of tumor necrosis factor receptor 2.

Fischer R, Marsal J, Guttà C, Eisler SA, Peters N, Bethea JR, Pfizenmaier K, Kontermann RE.

Sci Rep. 2017 Jul 26;7(1):6607. doi: 10.1038/s41598-017-06993-4.

10.

Antitumor Activity of a Mesenchymal Stem Cell Line Stably Secreting a Tumor-Targeted TNF-Related Apoptosis-Inducing Ligand Fusion Protein.

Marini I, Siegemund M, Hutt M, Kontermann RE, Pfizenmaier K.

Front Immunol. 2017 May 11;8:536. doi: 10.3389/fimmu.2017.00536. eCollection 2017.

11.

Inhibition of HER3 activation and tumor growth with a human antibody binding to a conserved epitope formed by domain III and IV.

Schmitt LC, Rau A, Seifert O, Honer J, Hutt M, Schmid S, Zantow J, Hust M, Dübel S, Olayioye MA, Kontermann RE.

MAbs. 2017 Jul;9(5):831-843. doi: 10.1080/19420862.2017.1319023. Epub 2017 Apr 19.

12.

Activatable bispecific liposomes bearing fibroblast activation protein directed single chain fragment/Trastuzumab deliver encapsulated cargo into the nuclei of tumor cells and the tumor microenvironment simultaneously.

Tansi FL, Rüger R, Böhm C, Steiniger F, Kontermann RE, Teichgraeber UK, Fahr A, Hilger I.

Acta Biomater. 2017 May;54:281-293. doi: 10.1016/j.actbio.2017.03.033. Epub 2017 Mar 24.

13.

A fast and effective determination of the biodistribution and subcellular localization of fluorescent immunoliposomes in freshly excised animal organs.

Tansi FL, Rüger R, Kollmeier AM, Böhm C, Kontermann RE, Teichgraeber UK, Fahr A, Hilger I.

BMC Biotechnol. 2017 Jan 18;17(1):8. doi: 10.1186/s12896-017-0327-8.

14.

The making of bispecific antibodies.

Brinkmann U, Kontermann RE.

MAbs. 2017 Feb/Mar;9(2):182-212. doi: 10.1080/19420862.2016.1268307. Review.

15.

Advancing targeted co-stimulation with antibody-fusion proteins by introducing TNF superfamily members in a single-chain format.

Fellermeier S, Beha N, Meyer JE, Ring S, Bader S, Kontermann RE, Müller D.

Oncoimmunology. 2016 Sep 27;5(11):e1238540. doi: 10.1080/2162402X.2016.1238540. eCollection 2016.

16.

Essential protective role of tumor necrosis factor receptor 2 in neurodegeneration.

Dong Y, Fischer R, Naudé PJ, Maier O, Nyakas C, Duffey M, Van der Zee EA, Dekens D, Douwenga W, Herrmann A, Guenzi E, Kontermann RE, Pfizenmaier K, Eisel UL.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12304-12309. Epub 2016 Oct 10.

17.

Dataset on FAP-induced emergence of spontaneous metastases and on the preparation of activatable FAP-targeting immunoliposomes to detect the metastases.

Tansi FL, Rüger R, Böhm C, Kontermann RE, Teichgraeber UK, Fahr A, Hilger I.

Data Brief. 2016 Sep 3;9:143-8. doi: 10.1016/j.dib.2016.08.058. eCollection 2016 Dec.

18.

An optimized antibody-single-chain TRAIL fusion protein for cancer therapy.

Siegemund M, Seifert O, Zarani M, Džinić T, De Leo V, Göttsch D, Münkel S, Hutt M, Pfizenmaier K, Kontermann RE.

MAbs. 2016 Jul;8(5):879-91. doi: 10.1080/19420862.2016.1172163. Epub 2016 Apr 11.

19.

Half-life extended biotherapeutics.

Kontermann RE.

Expert Opin Biol Ther. 2016 Jul;16(7):903-15. doi: 10.1517/14712598.2016.1165661. Epub 2016 Apr 18. Review. Erratum in: Expert Opin Biol Ther. 2016 Sep;16(9):1179.

PMID:
26967759
20.

Potential of activatable FAP-targeting immunoliposomes in intraoperative imaging of spontaneous metastases.

Tansi FL, Rüger R, Böhm C, Kontermann RE, Teichgraeber UK, Fahr A, Hilger I.

Biomaterials. 2016 May;88:70-82. doi: 10.1016/j.biomaterials.2016.02.028. Epub 2016 Feb 23.

21.

Pharmacokinetic properties of IgG and various Fc fusion proteins in mice.

Unverdorben F, Richter F, Hutt M, Seifert O, Malinge P, Fischer N, Kontermann RE.

MAbs. 2016;8(1):120-8. doi: 10.1080/19420862.2015.1113360.

22.

A Fab-Selective Immunoglobulin-Binding Domain from Streptococcal Protein G with Improved Half-Life Extension Properties.

Unverdorben F, Hutt M, Seifert O, Kontermann RE.

PLoS One. 2015 Oct 2;10(10):e0139838. doi: 10.1371/journal.pone.0139838. eCollection 2015.

23.

Immunoliposomes for Targeted Delivery of an Antifibrotic Drug.

Schuster L, Seifert O, Vollmer S, Kontermann RE, Schlosshauer B, Hartmann H.

Mol Pharm. 2015 Sep 8;12(9):3146-57. doi: 10.1021/acs.molpharmaceut.5b00012. Epub 2015 Jul 28.

PMID:
26181293
24.

Bispecific antibodies.

Kontermann RE, Brinkmann U.

Drug Discov Today. 2015 Jul;20(7):838-47. doi: 10.1016/j.drudis.2015.02.008. Epub 2015 Feb 26. Review. Erratum in: Drug Discov Today. 2018 Jan 5;:.

25.

Tailoring the stealth properties of biocompatible polysaccharide nanocontainers.

Kang B, Okwieka P, Schöttler S, Seifert O, Kontermann RE, Pfizenmaier K, Musyanovych A, Meyer R, Diken M, Sahin U, Mailänder V, Wurm FR, Landfester K.

Biomaterials. 2015 May;49:125-34. doi: 10.1016/j.biomaterials.2015.01.042. Epub 2015 Feb 16.

PMID:
25725561
26.

Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously.

Rabenhold M, Steiniger F, Fahr A, Kontermann RE, Rüger R.

J Control Release. 2015 Mar 10;201:56-67. doi: 10.1016/j.jconrel.2015.01.022. Epub 2015 Jan 21.

PMID:
25617725
27.

Tumor-antigen-binding bispecific antibodies for cancer treatment.

Weidle UH, Kontermann RE, Brinkmann U.

Semin Oncol. 2014 Oct;41(5):653-60. doi: 10.1053/j.seminoncol.2014.08.004. Epub 2014 Aug 12. Review.

28.

An EGF receptor targeting Ranpirnase-diabody fusion protein mediates potent antitumour activity in vitro and in vivo.

Kiesgen S, Arndt MAE, Körber C, Arnold U, Weber T, Halama N, Keller A, Bötticher B, Schlegelmilch A, Liebers N, Cremer M, Herold-Mende C, Dyckhoff G, Federspil PA, Jensen AD, Jäger D, Kontermann RE, Mier W, Krauss J.

Cancer Lett. 2015 Feb 1;357(1):364-373. doi: 10.1016/j.canlet.2014.11.054. Epub 2014 Nov 27.

PMID:
25434798
29.

Genetic delivery of an immunoRNase by an oncolytic adenovirus enhances anticancer activity.

Fernández-Ulibarri I, Hammer K, Arndt MA, Kaufmann JK, Dorer D, Engelhardt S, Kontermann RE, Hess J, Allgayer H, Krauss J, Nettelbeck DM.

Int J Cancer. 2015 May 1;136(9):2228-40. doi: 10.1002/ijc.29258. Epub 2014 Nov 12.

30.

A fusogenic dengue virus-derived peptide enhances antitumor efficacy of an antibody-ribonuclease fusion protein targeting the EGF receptor.

Kiesgen S, Liebers N, Cremer M, Arnold U, Weber T, Keller A, Herold-Mende C, Dyckhoff G, Jäger D, Kontermann RE, Arndt MA, Krauss J.

Protein Eng Des Sel. 2014 Oct;27(10):331-7. doi: 10.1093/protein/gzu040.

PMID:
25301960
31.

In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes.

Rüger R, Tansi FL, Rabenhold M, Steiniger F, Kontermann RE, Fahr A, Hilger I.

J Control Release. 2014 Jul 28;186:1-10. doi: 10.1016/j.jconrel.2014.04.050. Epub 2014 May 5.

PMID:
24810115
32.

Immuno-LipoTRAIL: Targeted delivery of TRAIL-functionalized liposomal nanoparticles.

Seifert O, Pollak N, Nusser A, Steiniger F, Rüger R, Pfizenmaier K, Kontermann RE.

Bioconjug Chem. 2014 May 21;25(5):879-87. doi: 10.1021/bc400517j. Epub 2014 May 7.

PMID:
24766622
33.

Expression and purification of recombinant antibody formats and antibody fusion proteins.

Siegemund M, Richter F, Seifert O, Unverdorben F, Kontermann RE.

Methods Mol Biol. 2014;1131:273-95. doi: 10.1007/978-1-62703-992-5_18.

PMID:
24515473
34.

Generation of “LYmph Node Derived Antibody Libraries” (LYNDAL) for selecting fully human antibody fragments with therapeutic potential.

Diebolder P, Keller A, Haase S, Schlegelmilch A, Kiefer JD, Karimi T, Weber T, Moldenhauer G, Kehm R, Eis-Hübinger AM, Jäger D, Federspil PA, Herold-Mende C, Dyckhoff G, Kontermann RE, Arndt MA, Krauss J.

MAbs. 2014 Jan-Feb;6(1):130-42.

35.

Combining antibody-directed presentation of IL-15 and 4-1BBL in a trifunctional fusion protein for cancer immunotherapy.

Kermer V, Hornig N, Harder M, Bondarieva A, Kontermann RE, Müller D.

Mol Cancer Ther. 2014 Jan;13(1):112-21. doi: 10.1158/1535-7163.MCT-13-0282. Epub 2013 Nov 6.

36.

Tetravalent antibody-scTRAIL fusion proteins with improved properties.

Seifert O, Plappert A, Fellermeier S, Siegemund M, Pfizenmaier K, Kontermann RE.

Mol Cancer Ther. 2014 Jan;13(1):101-11. doi: 10.1158/1535-7163.MCT-13-0396. Epub 2013 Oct 3.

37.

An anti-TNFR1 scFv-HSA fusion protein as selective antagonist of TNF action.

Berger V, Richter F, Zettlitz K, Unverdorben F, Scheurich P, Herrmann A, Pfizenmaier K, Kontermann RE.

Protein Eng Des Sel. 2013 Oct;26(10):581-7. doi: 10.1093/protein/gzt044. Epub 2013 Sep 4.

PMID:
24006371
38.

Antagonistic TNF receptor one-specific antibody (ATROSAB): receptor binding and in vitro bioactivity.

Richter F, Liebig T, Guenzi E, Herrmann A, Scheurich P, Pfizenmaier K, Kontermann RE.

PLoS One. 2013 Aug 19;8(8):e72156. doi: 10.1371/journal.pone.0072156. eCollection 2013.

39.

Specific gene delivery to liver sinusoidal and artery endothelial cells.

Abel T, El Filali E, Waern J, Schneider IC, Yuan Q, Münch RC, Hick M, Warnecke G, Madrahimov N, Kontermann RE, Schüttrumpf J, Müller UC, Seppen J, Ott M, Buchholz CJ.

Blood. 2013 Sep 19;122(12):2030-8. doi: 10.1182/blood-2012-11-468579. Epub 2013 Jul 24.

40.

Evaluating combinations of costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy.

Hornig N, Reinhardt K, Kermer V, Kontermann RE, Müller D.

Cancer Immunol Immunother. 2013 Aug;62(8):1369-80. doi: 10.1007/s00262-013-1441-7. Epub 2013 May 30.

PMID:
23715927
41.

8(th) Annual European Antibody Congress 2012: November 27-28, 2012, Geneva, Switzerland.

Beck A, Carter PJ, Gerber HP, Lugovskoy AA, Wurch T, Junutula JR, Kontermann RE, Mabry R.

MAbs. 2013 May-Jun;5(3):339-57. doi: 10.4161/mabs.24105. Epub 2013 Mar 14.

42.

The IgM CH2 domain as covalently linked homodimerization module for the generation of fusion proteins with dual specificity.

Seifert O, Plappert A, Heidel N, Fellermeier S, Messerschmidt SK, Richter F, Kontermann RE.

Protein Eng Des Sel. 2012 Oct;25(10):603-12. Epub 2012 Sep 17.

PMID:
22988132
43.

Combination of a bispecific antibody and costimulatory antibody-ligand fusion proteins for targeted cancer immunotherapy.

Hornig N, Kermer V, Frey K, Diebolder P, Kontermann RE, Müller D.

J Immunother. 2012 Jun;35(5):418-29. doi: 10.1097/CJI.0b013e3182594387.

PMID:
22576347
44.

Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity.

Siegemund M, Pollak N, Seifert O, Wahl K, Hanak K, Vogel A, Nussler AK, Göttsch D, Münkel S, Bantel H, Kontermann RE, Pfizenmaier K.

Cell Death Dis. 2012 Apr 12;3:e295. doi: 10.1038/cddis.2012.29.

45.

An antibody fusion protein for cancer immunotherapy mimicking IL-15 trans-presentation at the tumor site.

Kermer V, Baum V, Hornig N, Kontermann RE, Müller D.

Mol Cancer Ther. 2012 Jun;11(6):1279-88. doi: 10.1158/1535-7163.MCT-12-0019. Epub 2012 Apr 6.

46.

Dual targeting strategies with bispecific antibodies.

Kontermann RE.

MAbs. 2012 Mar-Apr;4(2):182-97. doi: 10.4161/mabs.4.2.19000. Epub 2012 Mar 1. Review.

47.

Antibody-cytokine fusion proteins.

Kontermann RE.

Arch Biochem Biophys. 2012 Oct 15;526(2):194-205. doi: 10.1016/j.abb.2012.03.001. Epub 2012 Mar 16. Review.

PMID:
22445675
48.

Half-life extension of a single-chain diabody by fusion to domain B of staphylococcal protein A.

Unverdorben F, Färber-Schwarz A, Richter F, Hutt M, Kontermann RE.

Protein Eng Des Sel. 2012 Feb;25(2):81-8. doi: 10.1093/protein/gzr061. Epub 2012 Jan 11.

PMID:
22238430
49.

Plasma half-life extension of small recombinant antibodies by fusion to immunoglobulin-binding domains.

Hutt M, Färber-Schwarz A, Unverdorben F, Richter F, Kontermann RE.

J Biol Chem. 2012 Feb 10;287(7):4462-9. doi: 10.1074/jbc.M111.311522. Epub 2011 Dec 6.

50.

Strategies for extended serum half-life of protein therapeutics.

Kontermann RE.

Curr Opin Biotechnol. 2011 Dec;22(6):868-76. doi: 10.1016/j.copbio.2011.06.012. Epub 2011 Aug 20. Review.

PMID:
21862310

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