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[Efficacy of TS-1 as a Late-Line Treatment for Metastatic Breast Cancer].

Murazawa C, Kontani K, Hashimoto S, Hashimoto N, Norimura S, Ohtani M, Date M, Yokomise H.

Gan To Kagaku Ryoho. 2019 Sep;46(9):1461-1463. Japanese.


Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1.

Toyama Y, Kontani K, Katada T, Shimada I.

Sci Adv. 2019 Aug 7;5(8):eaax1595. doi: 10.1126/sciadv.aax1595. eCollection 2019 Aug.


Did kindergarteners who experienced the Great East Japan earthquake as infants develop traumatic symptoms? Series of questionnaire-based cross-sectional surveys: A concise and informative title: traumatic symptoms of kindergarteners who experienced disasters as infants.

Usami M, Iwadare Y, Ushijima H, Inazaki K, Tanaka T, Kodaira M, Watanabe K, Kawahara K, Morikawa M, Kontani K, Murakami K, Ogata R, Okamoto S, Sekine K, Sato M, Sasaki Y, Tanaka H, Harada M, Imagi S, Matsuda K, Katsumi C, Aoki M, Makino K, Saito K.

Asian J Psychiatr. 2019 Jul 5;44:38-44. doi: 10.1016/j.ajp.2019.07.011. [Epub ahead of print]


Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos.

Hashimoto K, Yamaguchi Y, Kishi Y, Kikko Y, Takasaki K, Maeda Y, Matsumoto Y, Oka M, Miura M, Ohata S, Katada T, Kontani K.

Genes Cells. 2019 Jun;24(6):436-448. doi: 10.1111/gtc.12687. Epub 2019 May 26.


Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR.

Toyama Y, Kontani K, Katada T, Shimada I.

Sci Adv. 2019 Mar 13;5(3):eaav8945. doi: 10.1126/sciadv.aav8945. eCollection 2019 Mar.


ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.

Saitoh SI, Saitoh YM, Kontani K, Sato K, Miyake K.

Int Immunol. 2019 Mar 28;31(4):225-237. doi: 10.1093/intimm/dxy084.


[Utility of Prophylactic Administration of Pegfilgrastim in Breast Cancer Chemotherapy].

Norimura S, Kontani K, Morishita A, Kubo T, Murazawa C, Hashimoto S, Hashimoto N, Kenzaki K, Miura K, Yokomise H.

Gan To Kagaku Ryoho. 2018 Dec;45(12):1729-1732. Japanese.


GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism.

Shimizu H, Toma-Fukai S, Kontani K, Katada T, Shimizu T.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9563-9568. doi: 10.1073/pnas.1804740115. Epub 2018 Sep 6.


Hypertension and Proteinuria as Predictive Factors of Effects of Bevacizumab on Advanced Breast Cancer in Japan.

Tanaka H, Takahashi K, Yamaguchi K, Kontani K, Motoki T, Asakura M, Kosaka S, Yokomise H, Houchi H.

Biol Pharm Bull. 2018;41(4):644-648. doi: 10.1248/bpb.b17-00605.


Candidate biomarkers predictive of anthracycline and taxane efficacy against breast cancer.

Norimura S, Kontani K, Kubo T, Hashimoto SI, Murazawa C, Kenzaki K, Liu D, Tamaki M, Aki F, Miura K, Yoshizawa K, Tangoku A, Yokomise H.

J Cancer Res Ther. 2018 Jan-Mar;14(2):409-415. doi: 10.4103/jcrt.JCRT_1053_16.


Acute Pericarditis Following Acute Pulmonary Thromboembolism.

Nakata A, Aburadani I, Kontani K, Hirota S.

Int Heart J. 2017 Dec 12;58(6):1028-1033. doi: 10.1536/ihj.17-035. Epub 2017 Nov 17.


TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells.

Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, Miyake K.

Nat Commun. 2017 Nov 17;8(1):1592. doi: 10.1038/s41467-017-01687-x.


Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos.

Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T, Kontani K.

J Cell Sci. 2017 Oct 15;130(20):3568-3577. doi: 10.1242/jcs.200519. Epub 2017 Aug 21.


Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding.

Shimizu H, Toma-Fukai S, Saijo S, Shimizu N, Kontani K, Katada T, Shimizu T.

J Biol Chem. 2017 Aug 11;292(32):13441-13448. doi: 10.1074/jbc.M117.792556. Epub 2017 Jun 19.


Predictive biomarkers and effectiveness of MUC1-targeted dendritic-cell-based vaccine in patients with refractory non-small cell lung cancer.

Teramoto K, Ozaki Y, Hanaoka J, Sawai S, Tezuka N, Fujino S, Daigo Y, Kontani K.

Ther Adv Med Oncol. 2017 Mar;9(3):147-157. doi: 10.1177/1758834016678375. Epub 2016 Nov 24.


Regulation of ciliary retrograde protein trafficking by the Joubert syndrome proteins ARL13B and INPP5E.

Nozaki S, Katoh Y, Terada M, Michisaka S, Funabashi T, Takahashi S, Kontani K, Nakayama K.

J Cell Sci. 2017 Feb 1;130(3):563-576. doi: 10.1242/jcs.197004. Epub 2016 Dec 7.


Retrospective analysis of the survival benefit of chemotherapy for recurrent or advanced epithelial ovarian carcinoma in patients previously treated with paclitaxel plus platinum-based chemotherapy.

Nishikawa A, Hashimoto H, Takeda M, Kontani K, Miyatake T, Mimura M, Nagamatsu M, Yokoi T.

Eur J Gynaecol Oncol. 2016 Aug;37(4):451-454.


Indication of metronomic chemotherapy for metastatic breast cancer: Clinical outcomes and responsive subtypes.

Kontani K, Hashimoto SI, Murazawa C, Norimura S, Tanaka H, Ohtani M, Fujiwara-Honjo N, Date M, Teramoto K, Houchi H, Yokomise H.

Mol Clin Oncol. 2016 Jun;4(6):947-953. Epub 2016 Mar 30.


Variegated RHOA mutations in adult T-cell leukemia/lymphoma.

Nagata Y, Kontani K, Enami T, Kataoka K, Ishii R, Totoki Y, Kataoka TR, Hirata M, Aoki K, Nakano K, Kitanaka A, Sakata-Yanagimoto M, Egami S, Shiraishi Y, Chiba K, Tanaka H, Shiozawa Y, Yoshizato T, Suzuki H, Kon A, Yoshida K, Sato Y, Sato-Otsubo A, Sanada M, Munakata W, Nakamura H, Hama N, Miyano S, Nureki O, Shibata T, Haga H, Shimoda K, Katada T, Chiba S, Watanabe T, Ogawa S.

Blood. 2016 Feb 4;127(5):596-604. doi: 10.1182/blood-2015-06-644948. Epub 2015 Nov 16.


Di-Ras2 Protein Forms a Complex with SmgGDS Protein in Brain Cytosol in Order to Be in a Low Affinity State for Guanine Nucleotides.

Ogita Y, Egami S, Ebihara A, Ueda N, Katada T, Kontani K.

J Biol Chem. 2015 Aug 14;290(33):20245-56. doi: 10.1074/jbc.M115.637769. Epub 2015 Jul 6.


The C. elegans Hypodermis Couples Progenitor Cell Quiescence to the Dietary State.

Fukuyama M, Kontani K, Katada T, Rougvie AE.

Curr Biol. 2015 May 4;25(9):1241-8. doi: 10.1016/j.cub.2015.03.016. Epub 2015 Apr 16.


Factors responsible for long-term survival in metastatic breast cancer.

Kontani K, Hashimoto S, Murazawa C, Norimura S, Tanaka H, Ohtani M, Fujiwara-Honjo N, Date M, Teramoto K, Houchi H, Yokomise H.

World J Surg Oncol. 2014 Nov 14;12:344. doi: 10.1186/1477-7819-12-344.


Tranilast inhibits the function of cancer-associated fibroblasts responsible for the induction of immune suppressor cell types.

Ohshio Y, Hanaoka J, Kontani K, Teramoto K.

Scand J Immunol. 2014 Dec;80(6):408-16. doi: 10.1111/sji.12242.


Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export.

Saito K, Yamashiro K, Shimazu N, Tanabe T, Kontani K, Katada T.

J Cell Biol. 2014 Sep 15;206(6):751-62. doi: 10.1083/jcb.201312062. Epub 2014 Sep 8.


[Regulation of membrane dynamics by ARF-like GTPase].

Kontani K.

Seikagaku. 2014 Feb;86(1):98-102. Review. Japanese. No abstract available.


Metronomic chemotherapy for metastatic breast cancer to prolong time to treatment failure to 12 months or more.

Kontani K, Hashimoto SI, Murazawa C, Norimura S, Tanaka H, Ohtani M, Fujiwara-Honjo N, Date M, Houchi H, Yokomise H.

Mol Clin Oncol. 2013 Mar;1(2):225-230. Epub 2012 Dec 10.


Active transport and diffusion barriers restrict Joubert Syndrome-associated ARL13B/ARL-13 to an Inv-like ciliary membrane subdomain.

Cevik S, Sanders AA, Van Wijk E, Boldt K, Clarke L, van Reeuwijk J, Hori Y, Horn N, Hetterschijt L, Wdowicz A, Mullins A, Kida K, Kaplan OI, van Beersum SE, Man Wu K, Letteboer SJ, Mans DA, Katada T, Kontani K, Ueffing M, Roepman R, Kremer H, Blacque OE.

PLoS Genet. 2013;9(12):e1003977. doi: 10.1371/journal.pgen.1003977. Epub 2013 Dec 5.


Genetically encoded calcium indicator illuminates calcium dynamics in primary cilia.

Su S, Phua SC, DeRose R, Chiba S, Narita K, Kalugin PN, Katada T, Kontani K, Takeda S, Inoue T.

Nat Methods. 2013 Nov;10(11):1105-7. doi: 10.1038/nmeth.2647. Epub 2013 Sep 22.


Inhibition of transforming growth factor-β release from tumor cells reduces their motility associated with epithelial-mesenchymal transition.

Ohshio Y, Teramoto K, Hashimoto M, Kitamura S, Hanaoka J, Kontani K.

Oncol Rep. 2013 Aug;30(2):1000-6. doi: 10.3892/or.2013.2505. Epub 2013 May 28.


The microRNA miR-235 couples blast-cell quiescence to the nutritional state.

Kasuga H, Fukuyama M, Kitazawa A, Kontani K, Katada T.

Nature. 2013 May 23;497(7450):503-6. doi: 10.1038/nature12117. Epub 2013 May 5.


Arl8/ARL-8 functions in apoptotic cell removal by mediating phagolysosome formation in Caenorhabditis elegans.

Sasaki A, Nakae I, Nagasawa M, Hashimoto K, Abe F, Saito K, Fukuyama M, Gengyo-Ando K, Mitani S, Katada T, Kontani K.

Mol Biol Cell. 2013 May;24(10):1584-92. doi: 10.1091/mbc.E12-08-0628. Epub 2013 Mar 13.


Behavior of bone marrow-derived cells following in vivo transplantation: differentiation into stromal cells with roles in organ maintenance.

Taguchi O, Tsujimura K, Kontani K, Harada Y, Nomura S, Ikeda H, Morita A, Sugiura H, Hayashi N, Yatabe Y, Seto M, Tatematsu M, Takahashi T, Fukushima A.

Am J Pathol. 2013 Apr;182(4):1255-62. doi: 10.1016/j.ajpath.2012.12.034. Epub 2013 Feb 12.


Simultaneous activation of T helper function can augment the potency of dendritic cell-based cancer immunotherapy.

Teramoto K, Ohshio Y, Fujita T, Hanaoka J, Kontani K.

J Cancer Res Clin Oncol. 2013 May;139(5):861-70. doi: 10.1007/s00432-013-1394-4. Epub 2013 Feb 15.


Transforming mutations of RAC guanosine triphosphatases in human cancers.

Kawazu M, Ueno T, Kontani K, Ogita Y, Ando M, Fukumura K, Yamato A, Soda M, Takeuchi K, Miki Y, Yamaguchi H, Yasuda T, Naoe T, Yamashita Y, Katada T, Choi YL, Mano H.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3029-34. doi: 10.1073/pnas.1216141110. Epub 2013 Feb 4.


Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine.

Takasuga S, Horie Y, Sasaki J, Sun-Wada GH, Kawamura N, Iizuka R, Mizuno K, Eguchi S, Kofuji S, Kimura H, Yamazaki M, Horie C, Odanaga E, Sato Y, Chida S, Kontani K, Harada A, Katada T, Suzuki A, Wada Y, Ohnishi H, Sasaki T.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1726-31. doi: 10.1073/pnas.1213212110. Epub 2013 Jan 15.


C. elegans AMPKs promote survival and arrest germline development during nutrient stress.

Fukuyama M, Sakuma K, Park R, Kasuga H, Nagaya R, Atsumi Y, Shimomura Y, Takahashi S, Kajiho H, Rougvie A, Kontani K, Katada T.

Biol Open. 2012 Oct 15;1(10):929-36. doi: 10.1242/bio.2012836. Epub 2012 Aug 2.


Clinical usefulness of human epidermal growth factor receptor-2 extracellular domain as a biomarker for monitoring cancer status and predicting the therapeutic efficacy in breast cancer.

Kontani K, Kuroda N, Hashimoto S, Murazawa C, Norimura S, Tanaka H, Ohtani M, Fujiwara-Honjo N, Kushida Y, Date M, Haba R, Houchi H, Yamauchi A, Yokomise H.

Cancer Biol Ther. 2013 Jan;14(1):20-8. doi: 10.4161/cbt.22626. Epub 2012 Oct 31.


Neuronally expressed Ras-family GTPase Di-Ras modulates synaptic activity in Caenorhabditis elegans.

Tada M, Gengyo-Ando K, Kobayashi T, Fukuyama M, Mitani S, Kontani K, Katada T.

Genes Cells. 2012 Sep;17(9):778-89. doi: 10.1111/j.1365-2443.2012.01627.x. Epub 2012 Aug 16.


RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin.

Kajiho H, Fukushima S, Kontani K, Katada T.

PLoS One. 2012;7(1):e30575. doi: 10.1371/journal.pone.0030575. Epub 2012 Jan 23.


Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.

Kajiho H, Sakurai K, Minoda T, Yoshikawa M, Nakagawa S, Fukushima S, Kontani K, Katada T.

J Biol Chem. 2011 Jul 8;286(27):24364-73. doi: 10.1074/jbc.M110.172445. Epub 2011 May 17.


cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites.

Saito K, Yamashiro K, Ichikawa Y, Erlmann P, Kontani K, Malhotra V, Katada T.

Mol Biol Cell. 2011 Jul 1;22(13):2301-8. doi: 10.1091/mbc.E11-02-0143. Epub 2011 Apr 27.


RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK7.

Takahashi S, Ebihara A, Kajiho H, Kontani K, Nishina H, Katada T.

Cell Death Differ. 2011 Apr;18(4):645-55. doi: 10.1038/cdd.2010.137. Epub 2010 Nov 19.


RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs.

Takahashi S, Sakurai K, Ebihara A, Kajiho H, Saito K, Kontani K, Nishina H, Katada T.

Nucleic Acids Res. 2011 Apr;39(8):3446-57. doi: 10.1093/nar/gkq1302. Epub 2011 Jan 6.


Study of the measurement of serum extracellular domain of HER-2/neu protein with CLIA method.

Kuroda N, Kontani K, Kajikawa T, Taminato T.

Rinsho Byori. 2010 Jun;58(6):541-52.


Fiber formation of a synthetic spider peptide derived from Nephila clavata.

Hidaka Y, Kontani K, Taniguchi R, Saiki M, Yokoi S, Yukuhiro K, Yamaguchi H, Miyazawa M.

Biopolymers. 2011;96(2):222-7. doi: 10.1002/bip.21402.


An Arf-like small G protein, ARL-8, promotes the axonal transport of presynaptic cargoes by suppressing vesicle aggregation.

Klassen MP, Wu YE, Maeder CI, Nakae I, Cueva JG, Lehrman EK, Tada M, Gengyo-Ando K, Wang GJ, Goodman M, Mitani S, Kontani K, Katada T, Shen K.

Neuron. 2010 Jun 10;66(5):710-23. doi: 10.1016/j.neuron.2010.04.033.


The arf-like GTPase Arl8 mediates delivery of endocytosed macromolecules to lysosomes in Caenorhabditis elegans.

Nakae I, Fujino T, Kobayashi T, Sasaki A, Kikko Y, Fukuyama M, Gengyo-Ando K, Mitani S, Kontani K, Katada T.

Mol Biol Cell. 2010 Jul 15;21(14):2434-42. doi: 10.1091/mbc.E09-12-1010. Epub 2010 May 19.


Indication for skin-sparing mastectomy with or without nipple preservation for primary breast cancer.

Kontani K, Murazawa C, Norimura S, Yamashita K, Fujiwara-Honjo N, Ohtani M, Date M, Kushida Y, Muneuchi G, Haba R, Yokomise H, Yamauchi A.

Int Surg. 2010 Jan-Mar;95(1):12-20.


Joubert syndrome Arl13b functions at ciliary membranes and stabilizes protein transport in Caenorhabditis elegans.

Cevik S, Hori Y, Kaplan OI, Kida K, Toivenon T, Foley-Fisher C, Cottell D, Katada T, Kontani K, Blacque OE.

J Cell Biol. 2010 Mar 22;188(6):953-69. doi: 10.1083/jcb.200908133. Epub 2010 Mar 15. Erratum in: J Cell Biol. 2010 Apr 5;189(1):187.

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