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Response to 'Detecting right ventricular dysfunction in patients diagnosed with low-risk pulmonary embolism: is routine computed tomographic pulmonary angiography sufficient?'

Barco S, Konstantinides SV, Lankeit M.

Eur Heart J. 2019 Sep 20. pii: ehz656. doi: 10.1093/eurheartj/ehz656. [Epub ahead of print] No abstract available.


2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS).

Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jiménez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Ní Áinle F, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL; ESC Scientific Document Group .

Eur Heart J. 2019 Aug 31. pii: ehz405. doi: 10.1093/eurheartj/ehz405. [Epub ahead of print] No abstract available.


Sex-specific differences in Chronic Thromboembolic Pulmonary Hypertension. Results from the European CTEPH Registry.

Barco S, Klok FA, Konstantinides SV, Dartevelle P, Fadel E, Jenkins D, Kim NH, Madani M, Matsubara H, Mayer E, Pepke-Zaba J, Simonneau G, Delcroix M, Lang IM.

J Thromb Haemost. 2019 Sep 3. doi: 10.1111/jth.14629. [Epub ahead of print]


2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS): The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC).

Authors/Task Force Members:, Konstantinides SV, Meyer G, Becattini C, Bueno H, Geersing GJ, Harjola VP, Huisman MV, Humbert M, Jennings CS, Jiménez D, Kucher N, Lang IM, Lankeit M, Lorusso R, Mazzolai L, Meneveau N, Áinle FN, Prandoni P, Pruszczyk P, Righini M, Torbicki A, Van Belle E, Zamorano JL; Document Reviewers: Nazzareno Galié (CPG Review Coordinator) (Italy), J. Simon R. Gibbs (CPG Review Coordinator) (United Kingdom), Victor Aboyans (France), Walter Ageno (Italy), Stefan Agewall (Norway), Ana G. Almeida (Portugal), Felicita Andreotti (Italy), Emanuele Barbato (Italy), Johann Bauersachs (Germany), Andreas Baumbach (United Kingdom), Farzin Beygui (France), Jørn Carlsen (Denmark), Marco De Carlo (Italy), Marion Delcroix (Belgium), Victoria Delgado (Netherlands), Pilar Escribano Subias (Spain), Donna Fitzsimons (United Kingdom), Sean Gaine (Ireland), Samuel Z. Goldhaber (United States of America), Deepa Gopalan (United Kingdom), Gilbert Habib (France), Sigrun Halvorsen (Norway), David Jenkins (United Kingdom), Hugo A. Katus (Germany), Barbro Kjellström (Sweden), Mitja Lainscak (Slovenia), Patrizio Lancellotti (Belgium), Geraldine Lee (United Kingdom), Grégoire Le Gal (Canada), Emmanuel Messas (France), Joao Morais (Portugal), Steffen E. Petersen (United Kingdom), Anna Sonia Petronio (Italy), Massimo Francesco Piepoli (Italy), Susanna Price (United Kingdom), Marco Roffi (Switzerland), Aldo Salvi (Italy), Olivier Sanchez (France), Evgeny Shlyakhto (Russian Federation), Iain A. Simpson (United Kingdom), Stefan Stortecky (Switzerland), Matthias Thielmann (Germany), Anton Vonk Noordegraaf (Netherlands); Document Reviewers:.

Eur Respir J. 2019 Aug 31. pii: 1901647. doi: 10.1183/13993003.01647-2019. [Epub ahead of print] No abstract available.


A prospective cohort study to identify and evaluate endotypes of venous thromboembolism: Rationale and design of the Genotyping and Molecular Phenotyping in Venous ThromboEmbolism project (GMP-VTE).

Ten Cate V, Koeck T, Panova-Noeva M, Rapp S, Prochaska JH, Lenz M, Schulz A, Eggebrecht L, Hermanns MI, Heitmeier S, Krahn T, Laux V, Münzel T, Leineweber K, Konstantinides SV, Wild PS; Collaborators: Investigators FOCUS BioSeq Study and VTEval Study.

Thromb Res. 2019 Sep;181:84-91. doi: 10.1016/j.thromres.2019.07.019. Epub 2019 Jul 25.


Quality of life and functional limitations after pulmonary embolism and its prognostic relevance.

Keller K, Tesche C, Gerhold-Ay A, Nickels S, Klok FA, Rappold L, Hasenfuß G, Dellas C, Konstantinides SV, Lankeit M.

J Thromb Haemost. 2019 Jul 25. doi: 10.1111/jth.14589. [Epub ahead of print]


Increased Lymphangiogenesis and Lymphangiogenic Growth Factor Expression in Perivascular Adipose Tissue of Patients with Coronary Artery Disease.

Drosos I, Pavlaki M, Ortega Carrillo MDP, Kourkouli A, Buschmann K, Konstantinou F, Gogiraju R, Bochenek ML, Chalikias G, Tortopidis C, Vahl CF, Mikroulis D, Tziakas D, Münzel T, Konstantinides S, Schäfer K.

J Clin Med. 2019 Jul 9;8(7). pii: E1000. doi: 10.3390/jcm8071000.


Evaluation of the predictive value of the bleeding prediction score VTE-BLEED for recurrent venous thromboembolism.

Klok FA, Presles E, Tromeur C, Barco S, Konstantinides SV, Sanchez O, Pernod G, Raj L, Robin P, Le Roux PY, Hoffman C, Mélac S, Bertoletti L, Girard P, Laporte S, Mismetti P, Meyer G, Leroyer C, Couturaud F; PADIS‐PE Investigators.

Res Pract Thromb Haemost. 2019 May 25;3(3):364-371. doi: 10.1002/rth2.12214. eCollection 2019 Jul.


[Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6th World Symposium on Pulmonary Hypertension].

Rosenkranz S, Diller GP, Dumitrescu D, Ewert R, Ghofrani HA, Grünig E, Halank M, Held M, Kaemmerer H, Klose H, Kovacs G, Konstantinides S, Lang IM, Lange TJ, Leuchte H, Mayer E, Olschewski A, Olschewski H, Olsson KM, Opitz C, Schermuly RT, Seeger W, Wilkens H, Hoeper MM.

Dtsch Med Wochenschr. 2019 Jul 5. doi: 10.1055/a-0918-3772. [Epub ahead of print] German.


Recurrence Risk after First Symptomatic Distal versus Proximal Deep Vein Thrombosis According to Baseline Risk Factors.

Valerio L, Ambaglio C, Barone M, Ciola M, Konstantinides SV, Mahmoudpour SH, Picchi C, Pieresca C, Trinchero A, Barco S.

TH Open. 2019 Mar 11;3(1):e58-e63. doi: 10.1055/s-0039-1683374. eCollection 2019 Jan.


Center for Thrombosis and Hemostasis Mainz.

Konstantinides SV, Münzel T, Ruf W.

Eur Heart J. 2019 Jun 14;40(23):1827-1829. doi: 10.1093/eurheartj/ehz380. No abstract available.


Potential Involvement of Osteopontin in Inflammatory and Fibrotic Processes in Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension.

Kölmel S, Hobohm L, Käberich A, Krieg VJ, Bochenek ML, Wenzel P, Wiedenroth CB, Liebetrau C, Hasenfuß G, Mayer E, Konstantinides SV, Schäfer K, Guth S, Lankeit M.

Thromb Haemost. 2019 Aug;119(8):1332-1346. doi: 10.1055/s-0039-1692174. Epub 2019 Jun 10.


Early discharge and home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban: an international multicentre single-arm clinical trial.

Barco S, Schmidtmann I, Ageno W, Bauersachs RM, Becattini C, Bernardi E, Beyer-Westendorf J, Bonacchini L, Brachmann J, Christ M, Czihal M, Duerschmied D, Empen K, Espinola-Klein C, Ficker JH, Fonseca C, Genth-Zotz S, Jiménez D, Harjola VP, Held M, Iogna Prat L, Lange TJ, Manolis A, Meyer A, Mustonen P, Rauch-Kroehnert U, Ruiz-Artacho P, Schellong S, Schwaiblmair M, Stahrenberg R, Westerweel PE, Wild PS, Konstantinides SV, Lankeit M; HoT-PE Investigators .

Eur Heart J. 2019 May 23. pii: ehz367. doi: 10.1093/eurheartj/ehz367. [Epub ahead of print]


Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany.

Keller K, Hobohm L, Ebner M, Kresoja KP, Münzel T, Konstantinides SV, Lankeit M.

Eur Heart J. 2019 May 18. pii: ehz236. doi: 10.1093/eurheartj/ehz236. [Epub ahead of print]


Safety of low-dose subcutaneous recombinant interleukin-2: systematic review and meta-analysis of randomized controlled trials.

Mahmoudpour SH, Jankowski M, Valerio L, Becker C, Espinola-Klein C, Konstantinides S, Quitzau K, Barco S.

Sci Rep. 2019 May 9;9(1):7145. doi: 10.1038/s41598-019-43530-x.


Temporal trends in management and outcome of pulmonary embolism: a single-centre experience.

Ebner M, Kresoja KP, Keller K, Hobohm L, Rogge NIJ, Hasenfuß G, Pieske B, Konstantinides SV, Lankeit M.

Clin Res Cardiol. 2019 May 7. doi: 10.1007/s00392-019-01489-9. [Epub ahead of print]


Sex-specific differences in pulmonary embolism.

Keller K, Rappold L, Gerhold-Ay A, Hobohm L, Hasenfuß G, Konstantinides SV, Dellas C, Lankeit M.

Thromb Res. 2019 Jun;178:173-181. doi: 10.1016/j.thromres.2019.04.020. Epub 2019 Apr 23.


High cardiovascular risk in mixed connective tissue disease: evaluation of macrovascular involvement and its predictors by aortic pulse wave velocity.

Triantafyllias K, de Blasi M, Lütgendorf F, Cavagna L, Stortz M, Weinmann-Menke J, Konstantinides S, Galle PR, Schwarting A.

Clin Exp Rheumatol. 2019 Apr 2. [Epub ahead of print]


Prediction and prognostic importance of in-hospital major bleeding in a real-world cohort of patients with pulmonary embolism.

Kresoja KP, Ebner M, Rogge NIJ, Sentler C, Keller K, Hobohm L, Hasenfuß G, Konstantinides SV, Pieske B, Lankeit M.

Int J Cardiol. 2019 Sep 1;290:144-149. doi: 10.1016/j.ijcard.2019.03.017. Epub 2019 Mar 16.


Therapeutic Advances in Emergency Cardiology: Acute Pulmonary Embolism.

Petriş AO, Konstantinides S, Tint D, Cimpoeşu D, Pop C.

Am J Ther. 2019 Mar/Apr;26(2):e248-e256. doi: 10.1097/MJT.0000000000000917. Review.


Lysed Erythrocyte Membranes Promote Vascular Calcification.

Tziakas DN, Chalikias G, Pavlaki M, Kareli D, Gogiraju R, Hubert A, Böhm E, Stamoulis P, Drosos I, Kikas P, Mikroulis D, Giatromanolaki A, Georgiadis GS, Konstantinou F, Argyriou C, Münzel T, Konstantinides SV, Schäfer K.

Circulation. 2019 Apr 23;139(17):2032-2048. doi: 10.1161/CIRCULATIONAHA.118.037166.


Long-term impact of acute kidney injury on prognosis in patients with acute myocardial infarction.

Chalikias G, Serif L, Kikas P, Thomaidis A, Stakos D, Makrygiannis D, Chatzikyriakou S, Papoulidis N, Voudris V, Lantzouraki A, Müller M, Arampatzis S, Konstantinides S, Tziakas D.

Int J Cardiol. 2019 May 15;283:48-54. doi: 10.1016/j.ijcard.2019.01.070. Epub 2019 Jan 26.


Incidence and in-hospital safety outcomes of patients undergoing percutaneous mitral valve edge-to-edge repair using MitraClip: five-year German national patient sample including 13,575 implants.

von Bardeleben RS, Hobohm L, Kreidel F, Ostad MA, Schulz E, Konstantinides S, Lankeit M, Feldman T, Münzel T, Keller K.

EuroIntervention. 2019 Apr 20;14(17):1725-1732. doi: 10.4244/EIJ-D-18-00961.


Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling.

Gogiraju R, Hubert A, Fahrer J, Straub BK, Brandt M, Wenzel P, Münzel T, Konstantinides S, Hasenfuss G, Schäfer K.

Circ Heart Fail. 2019 Jan;12(1):e005622. doi: 10.1161/CIRCHEARTFAILURE.118.005622.


The Prognostic Value of Renal Function in Acute Pulmonary Embolism-A Multi-Centre Cohort Study.

Kostrubiec M, Pływaczewska M, Jiménez D, Lankeit M, Ciurzynski M, Konstantinides S, Pruszczyk P.

Thromb Haemost. 2019 Jan;119(1):140-148. doi: 10.1055/s-0038-1676522. Epub 2018 Dec 31.


Prognostic value of right ventricular dysfunction or elevated cardiac biomarkers in patients with low-risk pulmonary embolism: a systematic review and meta-analysis.

Barco S, Mahmoudpour SH, Planquette B, Sanchez O, Konstantinides SV, Meyer G.

Eur Heart J. 2019 Mar 14;40(11):902-910. doi: 10.1093/eurheartj/ehy873.


Incomplete echocardiographic recovery at 6 months predicts long-term sequelae after intermediate-risk pulmonary embolism. A post-hoc analysis of the Pulmonary Embolism Thrombolysis (PEITHO) trial.

Barco S, Russo M, Vicaut E, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Danays T, Dellas C, Duerschmied D, Empen K, Ferrari E, Galiè N, Jiménez D, Klok FA, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N, Palazzini M, Pruszczyk P, Rugolotto M, Salvi A, Sanchez O, Schellong S, Sobkowicz B, Meyer G, Konstantinides SV.

Clin Res Cardiol. 2019 Jul;108(7):772-778. doi: 10.1007/s00392-018-1405-1. Epub 2018 Dec 18.


Magnetic resonance direct thrombus imaging for pre-operative assessment of acute thrombosis in chronic thromboembolic pulmonary hypertension.

Klok FA, Pruefer D, Rolf A, Konstantinides SV.

Eur Heart J. 2019 Mar 14;40(11):944. doi: 10.1093/eurheartj/ehy786. No abstract available.


Determinants of diagnostic delay in chronic thromboembolic pulmonary hypertension: results from the European CTEPH Registry.

Klok FA, Barco S, Konstantinides SV, Dartevelle P, Fadel E, Jenkins D, Kim NH, Madani M, Matsubara H, Mayer E, Pepke-Zaba J, Delcroix M, Lang IM.

Eur Respir J. 2018 Dec 6;52(6). pii: 1801687. doi: 10.1183/13993003.01687-2018. Print 2018 Dec. No abstract available.


Pulmonary Embolism: Contemporary Medical Management and Future Perspectives.

Barco S, Konstantinides SV.

Ann Vasc Dis. 2018 Sep 25;11(3):265-276. doi: 10.3400/avd.ra.18-00054.


Duration of interventricular septal shift toward the left ventricle is associated with poor clinical outcome in precapillary pulmonary hypertension: A cardiac magnetic resonance study.

Mouratoglou SA, Kallifatidis A, Pitsiou G, Grosomanidis V, Kamperidis V, Chalikias G, Kristo D, Tziakas D, Konstantinides S, Hadjimiltiades S, Karvounis H, Giannakoulas G.

Hellenic J Cardiol. 2018 Oct 30. pii: S1109-9666(18)30367-1. doi: 10.1016/j.hjc.2018.10.007. [Epub ahead of print]


Impact of sex, age, and risk factors for venous thromboembolism on the initial presentation of first isolated symptomatic acute deep vein thrombosis.

Barco S, Klok FA, Mahé I, Marchena PJ, Ballaz A, Rubio CM, Adarraga MD, Mastroiacovo D, Konstantinides SV, Monreal M; RIETE Investigators.

Thromb Res. 2019 Jan;173:166-171. doi: 10.1016/j.thromres.2018.09.056. Epub 2018 Sep 27.


Sex-specific differences in the distal versus proximal presenting location of acute deep vein thrombosis.

Trinchero A, Scheres LJJ, Prochaska JH, Ambaglio C, Wild PS, Middeldorp S, Konstantinides SV, Barco S.

Thromb Res. 2018 Dec;172:74-79. doi: 10.1016/j.thromres.2018.10.025. Epub 2018 Oct 26.


Differential impact of syncope on the prognosis of patients with acute pulmonary embolism: a systematic review and meta-analysis.

Barco S, Ende-Verhaar YM, Becattini C, Jimenez D, Lankeit M, Huisman MV, Konstantinides SV, Klok FA.

Eur Heart J. 2018 Dec 14;39(47):4186-4195. doi: 10.1093/eurheartj/ehy631.


Optimizing the Personalized, Risk-Adjusted Management of Pulmonary Embolism: An Integrated Clinical Trial Programme.

Barco S, Konstantinides SV.

Hamostaseologie. 2019 Jun;39(2):117-127. doi: 10.1055/s-0038-1673413. Epub 2018 Oct 18.


Power of the Wilcoxon-Mann-Whitney test for non-inferiority in the presence of death-censored observations.

Schmidtmann I, Konstantinides S, Binder H.

Biom J. 2019 Sep;61(5):1187-1200. doi: 10.1002/bimj.201700296. Epub 2018 Sep 19.


Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018.

Wilkens H, Konstantinides S, Lang IM, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohé C, Guth S, Held M, Hinrichs JB, Hoeper MM, Klepetko W, Kramm T, Krüger U, Lankeit M, Meyer BC, Olsson KM, Schäfers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E.

Int J Cardiol. 2018 Dec 1;272S:69-78. doi: 10.1016/j.ijcard.2018.08.079. Epub 2018 Aug 28. Review.


A five-year, single-centre experience on ultrasound-assisted, catheter-directed thrombolysis in patients with pulmonary embolism at high risk and intermediate to high risk.

Kaymaz C, Akbal OY, Hakgor A, Tokgoz HC, Karagoz A, Tanboga IH, Tanyeri S, Keskin B, Turkday S, Demir D, Dogan C, Bayram Z, Acar RD, Guvendi B, Ozdemir N, Tapson VF, Konstantinides S.

EuroIntervention. 2018 Nov 20;14(10):1136-1143. doi: 10.4244/EIJ-D-18-00371.


Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis.

Sacco C, Zane F, Granziera S, Holm K, Creemers-Schild D, Hotz MA, Turpini E, Valentini A, Righini C, Karkos PD, Verhamme P, Di Nisio M, Konstantinides S, Pecci A, Barco S; Lemierre Study Group .

Hamostaseologie. 2019 Feb;39(1):76-86. doi: 10.1055/s-0038-1654720. Epub 2018 Aug 2.


Global public awareness about atrial fibrillation.

Wendelboe AM, Raskob GE, Angchaisuksiri P, Blanco AN, Büller H, Ddungu H, Dvorak JD, Hunt BJ, Hylek EM, Kakkar A, Konstantinides SV, McCumber M, McLintock C, Urano T, Weitz JI.

Res Pract Thromb Haemost. 2017 Oct 25;2(1):49-57. doi: 10.1002/rth2.12051. eCollection 2018 Jan.


What's new in severe pulmonary embolism?

Aissaoui N, Konstantinides S, Meyer G.

Intensive Care Med. 2019 Jan;45(1):75-77. doi: 10.1007/s00134-018-5199-4. Epub 2018 Jun 15. No abstract available.


The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice.

Bochenek ML, Bauer T, Gogiraju R, Nadir Y, Mann A, Schönfelder T, Hünig L, Brenner B, Münzel T, Wenzel P, Konstantinides S, Schäfer K.

Blood Adv. 2018 Jun 12;2(11):1300-1314. doi: 10.1182/bloodadvances.2017014050.


Diagnosis of Cerebral Venous Thrombosis: The Complementary Value of Imaging Methods.

Konstantinides SV.

Thromb Haemost. 2018 Jun;118(6):956. doi: 10.1055/s-0038-1653969. Epub 2018 May 30. No abstract available.


Pulmonary embolism.

Huisman MV, Barco S, Cannegieter SC, Le Gal G, Konstantinides SV, Reitsma PH, Rodger M, Vonk Noordegraaf A, Klok FA.

Nat Rev Dis Primers. 2018 May 17;4:18028. doi: 10.1038/nrdp.2018.28. Review.


Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study.

Hellenkamp K, Pruszczyk P, Jiménez D, Wyzgał A, Barrios D, Ciurzyński M, Morillo R, Hobohm L, Keller K, Kurnicka K, Kostrubiec M, Wachter R, Hasenfuß G, Konstantinides S, Lankeit M.

Eur Respir J. 2018 Apr 19;51(4). pii: 1702037. doi: 10.1183/13993003.02037-2017. Print 2018 Apr.


Detection and treatment of chronic thromboembolic pulmonary hypertension: Still a lot of homework to do.

Konstantinides SV.

Hellenic J Cardiol. 2018 Jan - Feb;59(1):24-25. doi: 10.1016/j.hjc.2018.02.012. Epub 2018 Mar 2. No abstract available.


Evaluation of VTE-BLEED for predicting intracranial or fatal bleeding in stable anticoagulated patients with venous thromboembolism.

Klok FA, Barco S, Konstantinides SV.

Eur Respir J. 2018 Apr 19;51(4). pii: 1800077. doi: 10.1183/13993003.00077-2018. Print 2018 Apr. No abstract available.


Initial strides for invent-VTE: Towards global collaboration to accelerate clinical research in venous thromboembolism.

Rodger M, Langlois N, Middeldorp S, Kahn S, Sandset PM, Brighton T, Huisman MV, Meyer G, Konstantinides S, Ageno W, Morange P, Garcia D, Kreuziger LB, Young L, Key N, Monreal M, Jiménez D.

Thromb Res. 2018 Mar;163:128-131. doi: 10.1016/j.thromres.2018.01.050. Epub 2018 Jan 31.


Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials.

Barco S, Vicaut E, Klok FA, Lankeit M, Meyer G, Konstantinides SV; PEITHO Investigators.

Eur Respir J. 2018 Jan 18;51(1). pii: 1701775. doi: 10.1183/13993003.01775-2017. Print 2018 Jan. No abstract available.


Role of CYP4F2, CYP2C19, and CYP1A2 polymorphisms on acenocoumarol pharmacogenomic algorithm accuracy improvement in the Greek population: need for sub-phenotype analysis.

Ragia G, Karantza IM, Kelli-Kota E, Kolovou V, Kolovou G, Konstantinides S, Maltezos E, Tavridou A, Tziakas D, Maitland-van der Zee AH, Manolopoulos VG.

Drug Metab Pers Ther. 2017 Dec 20;32(4):183-190. doi: 10.1515/dmpt-2017-0034.


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