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Items: 1 to 50 of 111

1.

High-Dose Vitamin D3 Administration Is Associated With Increases in Hemoglobin Concentrations in Mechanically Ventilated Critically Ill Adults: A Pilot Double-Blind, Randomized, Placebo-Controlled Trial.

Smith EM, Jones JL, Han JE, Alvarez JA, Sloan JH, Konrad RJ, Zughaier SM, Martin GS, Ziegler TR, Tangpricha V.

JPEN J Parenter Enteral Nutr. 2018 Jan;42(1):87-94. doi: 10.1177/0148607116678197. Epub 2017 Dec 11.

2.

Analysis of angiogenesis biomarkers for ramucirumab efficacy in patients with metastatic colorectal cancer from RAISE, a global, randomized, double-blind, phase III study.

Tabernero J, Hozak RR, Yoshino T, Cohn AL, Obermannova R, Bodoky G, Garcia-Carbonero R, Ciuleanu TE, Portnoy DC, Prausová J, Muro K, Siegel RW, Konrad RJ, Ouyang H, Melemed SA, Ferry D, Nasroulah F, Van Cutsem E.

Ann Oncol. 2018 Mar 1;29(3):602-609. doi: 10.1093/annonc/mdx767.

3.

Cytokeratin-18 and enhanced liver fibrosis scores in type 1 and type 2 diabetes and effects of two different insulins.

Sanyal A, Cusi K, Hartman ML, Zhang S, Bastyr EJ 3rd, Bue-Valleskey JM, Chang AM, Haupt A, Jacober SJ, Konrad RJ, Zhang Q, Hoogwerf BJ.

J Investig Med. 2018 Mar;66(3):661-668. doi: 10.1136/jim-2017-000609. Epub 2017 Nov 21.

PMID:
29167192
4.

Clinical Outcomes of Patients with Diabetes Who Exhibit Upper-Quartile Insulin Antibody Responses After Treatment with LY2963016 or Lantus® Insulin Glargine.

Ilag LL, Costigan TM, Deeg MA, Pollom RK, Chang CL, Konrad RJ, Prince MJ.

Diabetes Ther. 2017 Jun;8(3):545-554. doi: 10.1007/s13300-017-0253-8. Epub 2017 Mar 30.

5.

An innovative and highly drug-tolerant approach for detecting neutralizing antibodies directed to therapeutic antibodies.

Sloan JH, Conway RG, Pottanat TG, Troutt JS, Higgs RE, Konrad RJ, Qian YW.

Bioanalysis. 2016 Oct;8(20):2157-68. doi: 10.4155/bio-2016-0161. Epub 2016 Sep 5.

PMID:
27593891
6.

Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease.

Avin KG, Chen NX, Organ JM, Zarse C, O'Neill K, Conway RG, Konrad RJ, Bacallao RL, Allen MR, Moe SM.

PLoS One. 2016 Aug 3;11(8):e0159411. doi: 10.1371/journal.pone.0159411. eCollection 2016.

7.

High-dose vitamin D3 reduces circulating hepcidin concentrations: A pilot, randomized, double-blind, placebo-controlled trial in healthy adults.

Smith EM, Alvarez JA, Kearns MD, Hao L, Sloan JH, Konrad RJ, Ziegler TR, Zughaier SM, Tangpricha V.

Clin Nutr. 2017 Aug;36(4):980-985. doi: 10.1016/j.clnu.2016.06.015. Epub 2016 Jun 27.

8.

Phase 3 Trials of Ixekizumab in Moderate-to-Severe Plaque Psoriasis.

Gordon KB, Blauvelt A, Papp KA, Langley RG, Luger T, Ohtsuki M, Reich K, Amato D, Ball SG, Braun DK, Cameron GS, Erickson J, Konrad RJ, Muram TM, Nickoloff BJ, Osuntokun OO, Secrest RJ, Zhao F, Mallbris L, Leonardi CL; UNCOVER-1 Study Group; UNCOVER-2 Study Group; UNCOVER-3 Study Group.

N Engl J Med. 2016 Jul 28;375(4):345-56. doi: 10.1056/NEJMoa1512711. Epub 2016 Jun 8.

9.

A dual-monoclonal, sandwich immunoassay specific for glucagon like peptide-19-36/7 (GLP-19-36/7).

Osborne RI, Ming W, Troutt JS, Siegel RW, Konrad RJ.

Clin Biochem. 2016 Aug;49(12):897-902. doi: 10.1016/j.clinbiochem.2016.03.014. Epub 2016 May 18.

PMID:
27208557
10.

Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material.

van der Vorm LN, Hendriks JC, Laarakkers CM, Klaver S, Armitage AE, Bamberg A, Geurts-Moespot AJ, Girelli D, Herkert M, Itkonen O, Konrad RJ, Tomosugi N, Westerman M, Bansal SS, Campostrini N, Drakesmith H, Fillet M, Olbina G, Pasricha SR, Pitts KR, Sloan JH, Tagliaro F, Weykamp CW, Swinkels DW.

Clin Chem. 2016 Jul;62(7):993-1001. doi: 10.1373/clinchem.2016.256768. Epub 2016 May 12.

11.

A Highly Sensitive and Drug-Tolerant Anti-Drug Antibody Screening Assay for Ixekizumab using Affinity Capture Elution.

Muram TM, Sloan JH, Chain JS, Komocsar WJ, Meiklejohn BI, Blauvelt A, Papp K, Heffernan MP, Qian YW, Konrad RJ.

J Invest Dermatol. 2016 Jul;136(7):1513-1515. doi: 10.1016/j.jid.2016.01.040. Epub 2016 Mar 30. No abstract available.

12.

Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk Factors.

Leander K, Mälarstig A, Van't Hooft FM, Hyde C, Hellénius ML, Troutt JS, Konrad RJ, Öhrvik J, Hamsten A, de Faire U.

Circulation. 2016 Mar 29;133(13):1230-9. doi: 10.1161/CIRCULATIONAHA.115.018531. Epub 2016 Feb 19.

PMID:
26896437
13.

Affinity capture elution bridging assay: A novel immunoassay format for detection of anti-therapeutic protein antibodies.

Chen YQ, Pottanat TG, Carter QL, Troutt JS, Konrad RJ, Sloan JH.

J Immunol Methods. 2016 Apr;431:45-51. doi: 10.1016/j.jim.2016.02.008. Epub 2016 Feb 10.

PMID:
26874304
14.

Circulating Hepcidin-25 Is Reduced by Endogenous Estrogen in Humans.

Lehtihet M, Bonde Y, Beckman L, Berinder K, Hoybye C, Rudling M, Sloan JH, Konrad RJ, Angelin B.

PLoS One. 2016 Feb 11;11(2):e0148802. doi: 10.1371/journal.pone.0148802. eCollection 2016.

15.

Low incidence of anti-drug antibodies in patients with type 2 diabetes treated with once-weekly glucagon-like peptide-1 receptor agonist dulaglutide.

Milicevic Z, Anglin G, Harper K, Konrad RJ, Skrivanek Z, Glaesner W, Karanikas CA, Mace K.

Diabetes Obes Metab. 2016 May;18(5):533-6. doi: 10.1111/dom.12640. Epub 2016 Mar 4.

PMID:
26847401
16.

Evaluation of immunogenicity of LY2963016 insulin glargine compared with Lantus® insulin glargine in patients with type 1 or type 2 diabetes mellitus.

Ilag LL, Deeg MA, Costigan T, Hollander P, Blevins TC, Edelman SV, Konrad RJ, Ortmann RA, Pollom RK, Huster WJ, Zielonka JS, Prince MJ.

Diabetes Obes Metab. 2016 Feb;18(2):159-68. doi: 10.1111/dom.12584. Epub 2016 Jan 8.

17.

Endogenous GLP-1 mediates postprandial reductions in activation in central reward and satiety areas in patients with type 2 diabetes.

ten Kulve JS, Veltman DJ, van Bloemendaal L, Barkhof F, Deacon CF, Holst JJ, Konrad RJ, Sloan JH, Drent ML, Diamant M, IJzerman RG.

Diabetologia. 2015 Dec;58(12):2688-98. doi: 10.1007/s00125-015-3754-x. Epub 2015 Sep 18.

18.

The Effect of Discontinuing Treatment With Blosozumab: Follow-up Results of a Phase 2 Randomized Clinical Trial in Postmenopausal Women With Low Bone Mineral Density.

Recknor CP, Recker RR, Benson CT, Robins DA, Chiang AY, Alam J, Hu L, Matsumoto T, Sowa H, Sloan JH, Konrad RJ, Mitlak BH, Sipos AA.

J Bone Miner Res. 2015 Sep;30(9):1717-25. doi: 10.1002/jbmr.2489. Epub 2015 Jun 11.

19.

Novel sandwich immunoassays for the measurement of total and active FGF21.

Umberger TS, Sloan JH, Chen J, Cheng C, Siegel RW, Qian Y, Troutt JS, Konrad RJ.

Bioanalysis. 2014;6(24):3283-93. doi: 10.4155/bio.14.241.

PMID:
25534786
20.

The role of vitamin D in regulating the iron-hepcidin-ferroportin axis in monocytes.

Zughaier SM, Alvarez JA, Sloan JH, Konrad RJ, Tangpricha V.

J Clin Transl Endocrinol. 2014 Mar 21;1(1):19-25.

21.

GLP-1 receptor activation modulates appetite- and reward-related brain areas in humans.

van Bloemendaal L, IJzerman RG, Ten Kulve JS, Barkhof F, Konrad RJ, Drent ML, Veltman DJ, Diamant M.

Diabetes. 2014 Dec;63(12):4186-96. doi: 10.2337/db14-0849. Epub 2014 Jul 28.

22.

Isolation and characterization of the circulating truncated form of PCSK9.

Han B, Eacho PI, Knierman MD, Troutt JS, Konrad RJ, Yu X, Schroeder KM.

J Lipid Res. 2014 Jul;55(7):1505-14. doi: 10.1194/jlr.M049346. Epub 2014 Apr 28.

24.

Circulating PCSK9 is a strong determinant of plasma triacylglycerols and total cholesterol in homozygous carriers of apolipoprotein ε2.

Brouwers MC, van Greevenbroek MM, Konrad RJ, Troutt JS, Schaper NC, Stehouwer CD.

Clin Sci (Lond). 2014 May;126(9):679-84. doi: 10.1042/CS20130556.

PMID:
24308640
25.

Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung.

Holzer TR, Fulford AD, Nedderman DM, Umberger TS, Hozak RR, Joshi A, Melemed SA, Benjamin LE, Plowman GD, Schade AE, Ackermann BL, Konrad RJ, Nasir A.

PLoS One. 2013 Nov 14;8(11):e80292. doi: 10.1371/journal.pone.0080292. eCollection 2013.

26.
27.

Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometry.

Chen Y, Yurek DA, Yu L, Wang H, Ehsani ME, Qian YW, Konrad RJ, Jiang XC, Kuo MS, Cao G, Wang J.

Anal Biochem. 2013 Jul 1;438(1):61-6. doi: 10.1016/j.ab.2013.03.016. Epub 2013 Mar 25.

PMID:
23535273
28.

Serum hepcidin levels are associated with obesity but not liver disease.

Vuppalanchi R, Troutt JS, Konrad RJ, Ghabril M, Saxena R, Bell LN, Kowdley KV, Chalasani N.

Obesity (Silver Spring). 2014 Mar;22(3):836-41. doi: 10.1002/oby.20403. Epub 2013 Dec 17.

29.

Plasma proprotein convertase subtilisin kexin type 9 levels are related to markers of cholesterol synthesis in familial combined hyperlipidemia.

Brouwers MC, Konrad RJ, van Himbergen TM, Isaacs A, Otokozawa S, Troutt JS, Schaefer EJ, van Greevenbroek MM, Stalenhoef AF, de Graaf J.

Nutr Metab Cardiovasc Dis. 2013 Nov;23(11):1115-21. doi: 10.1016/j.numecd.2012.11.008. Epub 2013 Jan 18.

PMID:
23333725
30.

Validation of assays for measurement of amyloid-β peptides in cerebrospinal fluid and plasma specimens from patients with Alzheimer's disease treated with solanezumab.

Lachno DR, Evert BA, Vanderstichele H, Robertson M, Demattos RB, Konrad RJ, Talbot JA, Racke MM, Dean RA.

J Alzheimers Dis. 2013;34(4):897-910. doi: 10.3233/JAD-122317.

PMID:
23302661
31.

Determination of cathepsin S abundance and activity in human plasma and implications for clinical investigation.

Cox JM, Troutt JS, Knierman MD, Siegel RW, Qian YW, Ackermann BL, Konrad RJ.

Anal Biochem. 2012 Nov 15;430(2):130-7. doi: 10.1016/j.ab.2012.08.011. Epub 2012 Aug 23.

PMID:
22922382
32.

A novel high-sensitivity electrochemiluminescence (ECL) sandwich immunoassay for the specific quantitative measurement of plasma glucagon.

Sloan JH, Siegel RW, Ivanova-Cox YT, Watson DE, Deeg MA, Konrad RJ.

Clin Biochem. 2012 Dec;45(18):1640-4. doi: 10.1016/j.clinbiochem.2012.07.111. Epub 2012 Aug 4.

PMID:
22890005
33.

Validation of a multiplex assay for simultaneous quantification of amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer's disease therapeutics.

Lachno DR, Emerson JK, Vanderstichele H, Gonzales C, Martényi F, Konrad RJ, Talbot JA, Lowe SL, Oefinger PE, Dean RA.

J Alzheimers Dis. 2012;32(4):905-18. doi: 10.3233/JAD-2012-121075.

PMID:
22886018
34.

Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration.

Troutt JS, Rudling M, Persson L, Ståhle L, Angelin B, Butterfield AM, Schade AE, Cao G, Konrad RJ.

Clin Chem. 2012 Aug;58(8):1225-32. doi: 10.1373/clinchem.2012.186866. Epub 2012 Jun 7.

35.

Common and low-frequency genetic variants in the PCSK9 locus influence circulating PCSK9 levels.

Chernogubova E, Strawbridge R, Mahdessian H, Mälarstig A, Krapivner S, Gigante B, Hellénius ML, de Faire U, Franco-Cereceda A, Syvänen AC, Troutt JS, Konrad RJ, Eriksson P, Hamsten A, van 't Hooft FM.

Arterioscler Thromb Vasc Biol. 2012 Jun;32(6):1526-34. doi: 10.1161/ATVBAHA.111.240549. Epub 2012 Mar 29.

PMID:
22460556
36.

Glycerolipid acyltransferases in triglyceride metabolism and energy homeostasis-potential as drug targets.

Cao G, Konrad RJ, Li SD, Hammond C.

Endocr Metab Immune Disord Drug Targets. 2012 Jun;12(2):197-206. Review.

PMID:
22385114
37.

A novel, high-sensitivity and drug-tolerant sandwich immunoassay for the quantitative measurement of circulating proteins.

Sloan JH, Ackermann BL, Carpenter JW, Nguyen HT, Stopa K, Siegel RW, Konrad RJ.

Bioanalysis. 2012 Feb;4(3):241-8. doi: 10.4155/bio.11.312.

PMID:
22303828
38.

Development of a novel radioimmunoassay to detect autoantibodies to amyloid beta peptides in the presence of a cross-reactive therapeutic antibody.

Sloan JH, Ackermann BJ, O'Dell M, Bowsher RR, Dean RA, Konrad RJ.

J Pharm Biomed Anal. 2011 Dec 15;56(5):1029-34. doi: 10.1016/j.jpba.2011.08.006. Epub 2011 Aug 10.

PMID:
21868184
39.

Validation of ELISA methods for quantification of total tau and phosporylated-tau181 in human cerebrospinal fluid with measurement in specimens from two Alzheimer's disease studies.

Lachno DR, Romeo MJ, Siemers ER, Vanderstichele H, Coart E, Konrad RJ, Zajac JJ, Talbot JA, Jensen HF, Sethuraman G, Demattos RB, May PC, Dean RA.

J Alzheimers Dis. 2011;26(3):531-41. doi: 10.3233/JAD-2011-110296.

PMID:
21694458
40.

Plasma proprotein convertase subtilisin kexin type 9 is a heritable trait of familial combined hyperlipidaemia.

Brouwers MC, van Greevenbroek MM, Troutt JS, Bonner Freeman A, Lu A, Schaper NC, Konrad RJ, Stehouwer CD.

Clin Sci (Lond). 2011 Nov;121(9):397-403. doi: 10.1042/CS20110129.

PMID:
21539517
41.

Dual-monoclonal, sandwich immunoassay specific for glucose-dependent insulinotropic peptide1-42, the active form of the incretin hormone.

Troutt JS, Siegel RW, Chen J, Sloan JH, Deeg MA, Cao G, Konrad RJ.

Clin Chem. 2011 Jun;57(6):849-55. doi: 10.1373/clinchem.2010.159954. Epub 2011 Apr 22.

42.

Plasma proprotein convertase subtilisin kexin type 9 is not altered in subjects with impaired glucose metabolism and type 2 diabetes mellitus, but its relationship with non-HDL cholesterol and apolipoprotein B may be modified by type 2 diabetes mellitus: The CODAM study.

Brouwers MC, Troutt JS, van Greevenbroek MM, Ferreira I, Feskens EJ, van der Kallen CJ, Schaper NC, Schalkwijk CG, Konrad RJ, Stehouwer CD.

Atherosclerosis. 2011 Jul;217(1):263-7. doi: 10.1016/j.atherosclerosis.2011.03.023. Epub 2011 Mar 25.

43.

Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents.

Konrad RJ, Troutt JS, Cao G.

Lipids Health Dis. 2011 Feb 28;10:38. doi: 10.1186/1476-511X-10-38.

44.

The role of apolipoprotein A5 in non-alcoholic fatty liver disease.

Ress C, Moschen AR, Sausgruber N, Tschoner A, Graziadei I, Weiss H, Schgoer W, Ebenbichler CF, Konrad RJ, Patsch JR, Tilg H, Kaser S.

Gut. 2011 Jul;60(7):985-91. doi: 10.1136/gut.2010.222224. Epub 2011 Feb 21.

PMID:
21339203
45.

The acyl coenzymeA:monoacylglycerol acyltransferase 3 (MGAT3) gene is a pseudogene in mice but encodes a functional enzyme in rats.

Yue YG, Chen YQ, Zhang Y, Wang H, Qian YW, Arnold JS, Calley JN, Li SD, Perry WL 3rd, Zhang HY, Konrad RJ, Cao G.

Lipids. 2011 Jun;46(6):513-20. doi: 10.1007/s11745-011-3537-1. Epub 2011 Feb 11.

PMID:
21312067
46.

Comparison of assay formats for drug-tolerant immunogenicity testing.

Butterfield AM, Chain JS, Ackermann BL, Konrad RJ.

Bioanalysis. 2010 Dec;2(12):1961-9. doi: 10.4155/bio.10.136.

PMID:
21110740
47.

Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population.

Cui Q, Ju X, Yang T, Zhang M, Tang W, Chen Q, Hu Y, Haas JV, Troutt JS, Pickard RT, Darling R, Konrad RJ, Zhou H, Cao G.

Atherosclerosis. 2010 Dec;213(2):632-6. doi: 10.1016/j.atherosclerosis.2010.09.027. Epub 2010 Oct 30.

PMID:
21040917
48.

Circulating proprotein convertase subtilisin kexin type 9 has a diurnal rhythm synchronous with cholesterol synthesis and is reduced by fasting in humans.

Persson L, Cao G, Ståhle L, Sjöberg BG, Troutt JS, Konrad RJ, Gälman C, Wallén H, Eriksson M, Hafström I, Lind S, Dahlin M, Amark P, Angelin B, Rudling M.

Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2666-72. doi: 10.1161/ATVBAHA.110.214130. Epub 2010 Sep 30.

PMID:
20884874
49.

A dual-monoclonal sandwich ELISA specific for hepcidin-25.

Butterfield AM, Luan P, Witcher DR, Manetta J, Murphy AT, Wroblewski VJ, Konrad RJ.

Clin Chem. 2010 Nov;56(11):1725-32. doi: 10.1373/clinchem.2010.151522. Epub 2010 Sep 16.

50.

Development of a novel sandwich ELISA for measuring cell lysate ABCA1 protein levels.

Troutt JS, Alborn WE, Bellinger MA, Cox KL, Ehsani ME, Wang X, Qian YW, Sloan JH, Willey MB, Cao G, Konrad RJ.

Lipids. 2010 Aug;45(8):757-64. doi: 10.1007/s11745-010-3448-6. Epub 2010 Jul 17.

PMID:
20640528

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