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Silica exposure and chronic virus infection synergistically promote lupus-like systemic autoimmunity in mice with low genetic predisposition.

Gonzalez-Quintial R, Mayeux JM, Kono DH, Theofilopoulos AN, Pollard KM, Baccala R.

Clin Immunol. 2019 Jun 5. pii: S1521-6616(19)30293-1. doi: 10.1016/j.clim.2019.06.003. [Epub ahead of print]


Mercury-induced inflammation and autoimmunity.

Pollard KM, Cauvi DM, Toomey CB, Hultman P, Kono DH.

Biochim Biophys Acta Gen Subj. 2019 Feb 10. pii: S0304-4165(19)30027-3. doi: 10.1016/j.bbagen.2019.02.001. [Epub ahead of print] Review.


Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition.

Gonzalez-Quintial R, Nguyen A, Kono DH, Oldstone MBA, Theofilopoulos AN, Baccala R.

PLoS One. 2018 Sep 10;13(9):e0203118. doi: 10.1371/journal.pone.0203118. eCollection 2018.


Silicosis and Silica-Induced Autoimmunity in the Diversity Outbred Mouse.

Mayeux JM, Escalante GM, Christy JM, Pawar RD, Kono DH, Pollard KM.

Front Immunol. 2018 Apr 26;9:874. doi: 10.3389/fimmu.2018.00874. eCollection 2018.


Environmental Xenobiotic Exposure and Autoimmunity.

Pollard KM, Christy JM, Cauvi DM, Kono DH.

Curr Opin Toxicol. 2018 Aug;10:15-22. doi: 10.1016/j.cotox.2017.11.009. Epub 2017 Nov 21.


Induction of Systemic Autoimmunity by a Xenobiotic Requires Endosomal TLR Trafficking and Signaling from the Late Endosome and Endolysosome but Not Type I IFN.

Pollard KM, Escalante GM, Huang H, Haraldsson KM, Hultman P, Christy JM, Pawar RD, Mayeux JM, Gonzalez-Quintial R, Baccala R, Beutler B, Theofilopoulos AN, Kono DH.

J Immunol. 2017 Dec 1;199(11):3739-3747. doi: 10.4049/jimmunol.1700332. Epub 2017 Oct 20.


The multiple pathways to autoimmunity.

Theofilopoulos AN, Kono DH, Baccala R.

Nat Immunol. 2017 Jun 20;18(7):716-724. doi: 10.1038/ni.3731. Review.


Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation.

Lawson BR, Gonzalez-Quintial R, Eleftheriadis T, Farrar MA, Miller SD, Sauer K, McGavern DB, Kono DH, Baccala R, Theofilopoulos AN.

Clin Immunol. 2015 Dec;161(2):260-9. doi: 10.1016/j.clim.2015.08.007. Epub 2015 Aug 25.


The effect of the autoimmunity-associated gene, PTPN22, on a BXSB-derived model of lupus.

Maine CJ, Marquardt K, Scatizzi JC, Pollard KM, Kono DH, Sherman LA.

Clin Immunol. 2015 Jan;156(1):65-73. doi: 10.1016/j.clim.2014.11.003. Epub 2014 Nov 11.


A tandem repeat in decay accelerating factor 1 is associated with severity of murine mercury-induced autoimmunity.

Cauvi DM, Gabriel R, Kono DH, Hultman P, Pollard KM.

Autoimmune Dis. 2014;2014:260613. doi: 10.1155/2014/260613. Epub 2014 Apr 10.


Requirements for "Fire and ICE" differ between animal models of autoimmunity: comment on the article by Kahlenberg et al.

Pollard KM, Kono DH.

Arthritis Rheumatol. 2014 Aug;66(8):2310-1. doi: 10.1002/art.38678. No abstract available.


TLRs and interferons: a central paradigm in autoimmunity.

Kono DH, Baccala R, Theofilopoulos AN.

Curr Opin Immunol. 2013 Dec;25(6):720-7. doi: 10.1016/j.coi.2013.10.006. Epub 2013 Nov 16. Review.


Interferon-γ and systemic autoimmunity.

Pollard KM, Cauvi DM, Toomey CB, Morris KV, Kono DH.

Discov Med. 2013 Sep;16(87):123-31. Review.


Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells.

Koh YT, Scatizzi JC, Gahan JD, Lawson BR, Baccala R, Pollard KM, Beutler BA, Theofilopoulos AN, Kono DH.

J Immunol. 2013 May 15;190(10):4982-90. doi: 10.4049/jimmunol.1202986. Epub 2013 Apr 15.


Critical role of transmethylation in TLR signaling and systemic lupus erythematosus.

Tardif V, Manenkova Y, Berger M, Hoebe K, Zuo JP, Yuan C, Kono DH, Theofilopoulos AN, Lawson BR.

Clin Immunol. 2013 May;147(2):133-43. doi: 10.1016/j.clim.2013.02.018. Epub 2013 Mar 5.


Requirements for innate immune pathways in environmentally induced autoimmunity.

Pollard KM, Kono DH.

BMC Med. 2013 Apr 4;11:100. doi: 10.1186/1741-7015-11-100. Review.


Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus.

Baccala R, Gonzalez-Quintial R, Blasius AL, Rimann I, Ozato K, Kono DH, Beutler B, Theofilopoulos AN.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2940-5. doi: 10.1073/pnas.1222798110. Epub 2013 Feb 4.


Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice.

Baccala R, Gonzalez-Quintial R, Schreiber RD, Lawson BR, Kono DH, Theofilopoulos AN.

J Immunol. 2012 Dec 15;189(12):5976-84. doi: 10.4049/jimmunol.1201477. Epub 2012 Nov 21.


MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses.

Grönwall C, Chen Y, Vas J, Khanna S, Thiel S, Corr M, Kono DH, Silverman GJ.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19745-50. doi: 10.1073/pnas.1211868109. Epub 2012 Nov 8.


Animal models used to examine the role of the environment in the development of autoimmune disease: findings from an NIEHS Expert Panel Workshop.

Germolec D, Kono DH, Pfau JC, Pollard KM.

J Autoimmun. 2012 Dec;39(4):285-93. doi: 10.1016/j.jaut.2012.05.020. Epub 2012 Jun 27. Review.


Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity.

Pollard KM, Hultman P, Toomey CB, Cauvi DM, Hoffman HM, Hamel JC, Kono DH.

J Autoimmun. 2012 Dec;39(4):323-31. doi: 10.1016/j.jaut.2012.04.003. Epub 2012 May 10.


The Lbw2 locus promotes autoimmune hemolytic anemia.

Scatizzi JC, Haraldsson MK, Pollard KM, Theofilopoulos AN, Kono DH.

J Immunol. 2012 Apr 1;188(7):3307-14. doi: 10.4049/jimmunol.1103561. Epub 2012 Feb 27.


Transmethylation in immunity and autoimmunity.

Lawson BR, Eleftheriadis T, Tardif V, Gonzalez-Quintial R, Baccala R, Kono DH, Theofilopoulos AN.

Clin Immunol. 2012 Apr;143(1):8-21. doi: 10.1016/j.clim.2011.10.007. Epub 2011 Dec 24. Review.


Systemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7Rα blockade.

Gonzalez-Quintial R, Lawson BR, Scatizzi JC, Craft J, Kono DH, Baccala R, Theofilopoulos AN.

PLoS One. 2011;6(11):e27528. doi: 10.1371/journal.pone.0027528. Epub 2011 Nov 10.


Intracellular nucleic acid sensors and autoimmunity.

Theofilopoulos AN, Kono DH, Beutler B, Baccala R.

J Interferon Cytokine Res. 2011 Dec;31(12):867-86. doi: 10.1089/jir.2011.0092. Epub 2011 Oct 27. Review.


β2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity.

Pollard KM, Hultman P, Toomey CB, Cauvi DM, Kono DH.

J Immunotoxicol. 2011 Jul-Sep;8(3):228-37. doi: 10.3109/1547691X.2011.583614. Erratum in: J Immunotoxicol. 2011 Oct-Dec;8(4):398. Konoc, Dwight H [corrected to Kono, Dwight H].


Mast cell function is not altered by Coronin-1A deficiency.

Arandjelovic S, Wickramarachchi D, Hemmers S, Leming SS, Kono DH, Mowen KA.

J Leukoc Biol. 2010 Oct;88(4):737-45. doi: 10.1189/jlb.0310131. Epub 2010 Jul 19.


Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.

Aït-Azzouzene D, Kono DH, Gonzalez-Quintial R, McHeyzer-Williams LJ, Lim M, Wickramarachchi D, Gerdes T, Gavin AL, Skog P, McHeyzer-Williams MG, Nemazee D, Theofilopoulos AN.

J Immunol. 2010 Jul 15;185(2):1015-27. doi: 10.4049/jimmunol.1000698. Epub 2010 Jun 16.


Sensors of the innate immune system: their link to rheumatic diseases.

Theofilopoulos AN, Gonzalez-Quintial R, Lawson BR, Koh YT, Stern ME, Kono DH, Beutler B, Baccala R.

Nat Rev Rheumatol. 2010 Mar;6(3):146-56. doi: 10.1038/nrrheum.2009.278. Epub 2010 Feb 9. Review.


Toxicology of autoimmune diseases.

Pollard KM, Hultman P, Kono DH.

Chem Res Toxicol. 2010 Mar 15;23(3):455-66. doi: 10.1021/tx9003787. Review.


Immune pathology associated with altered actin cytoskeleton regulation.

Wickramarachchi DC, Theofilopoulos AN, Kono DH.

Autoimmunity. 2010 Feb;43(1):64-75. doi: 10.3109/08916930903374634. Review.


Sensors of the innate immune system: their mode of action.

Baccala R, Gonzalez-Quintial R, Lawson BR, Stern ME, Kono DH, Beutler B, Theofilopoulos AN.

Nat Rev Rheumatol. 2009 Aug;5(8):448-56. doi: 10.1038/nrrheum.2009.136. Epub 2009 Jul 14. Review.


Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus.

Kono DH, Haraldsson MK, Lawson BR, Pollard KM, Koh YT, Du X, Arnold CN, Baccala R, Silverman GJ, Beutler BA, Theofilopoulos AN.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12061-6. doi: 10.1073/pnas.0905441106. Epub 2009 Jul 2.


Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis.

Chen Y, Khanna S, Goodyear CS, Park YB, Raz E, Thiel S, Grönwall C, Vas J, Boyle DL, Corr M, Kono DH, Silverman GJ.

J Immunol. 2009 Jul 15;183(2):1346-59. doi: 10.4049/jimmunol.0900948. Epub 2009 Jun 29.


ICOS controls effector function but not trafficking receptor expression of kidney-infiltrating effector T cells in murine lupus.

Odegard JM, DiPlacido LD, Greenwald L, Kashgarian M, Kono DH, Dong C, Flavell RA, Craft J.

J Immunol. 2009 Apr 1;182(7):4076-84. doi: 10.4049/jimmunol.0800758.


ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity.

Odegard JM, Marks BR, DiPlacido LD, Poholek AC, Kono DH, Dong C, Flavell RA, Craft J.

J Exp Med. 2008 Nov 24;205(12):2873-86. doi: 10.1084/jem.20080840. Epub 2008 Nov 3.


The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.

Haraldsson MK, Louis-Dit-Sully CA, Lawson BR, Sternik G, Santiago-Raber ML, Gascoigne NR, Theofilopoulos AN, Kono DH.

Immunity. 2008 Jan;28(1):40-51. doi: 10.1016/j.immuni.2007.11.023.


Characterization of reciprocal Lmb1-4 interval MRL-Faslpr and C57BL/6-Faslpr congenic mice reveals significant effects from Lmb3.

Santiago-Raber ML, Haraldsson MK, Theofilopoulos AN, Kono DH.

J Immunol. 2007 Jun 15;178(12):8195-202.


TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity.

Baccala R, Hoebe K, Kono DH, Beutler B, Theofilopoulos AN.

Nat Med. 2007 May;13(5):543-51. Review.


Genetics of SLE in mice.

Kono DH, Theofilopoulos AN.

Springer Semin Immunopathol. 2006 Oct;28(2):83-96. Epub 2006 Sep 14. Review.


Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.

Watson LC, Moffatt-Blue CS, McDonald RZ, Kompfner E, Ait-Azzouzene D, Nemazee D, Theofilopoulos AN, Kono DH, Feeney AJ.

J Immunol. 2006 Jul 15;177(2):1120-8.


Immunology and genetics of induced systemic autoimmunity.

Pollard KM, Hultman P, Kono DH.

Autoimmun Rev. 2005 Jun;4(5):282-8. Epub 2005 Jan 11. Review.


Autoimmune alterations induced by the New Zealand Black Lbw2 locus in BWF1 mice.

Haraldsson MK, dela Paz NG, Kuan JG, Gilkeson GS, Theofilopoulos AN, Kono DH.

J Immunol. 2005 Apr 15;174(8):5065-73.


Interferons as pathogenic effectors in autoimmunity.

Baccala R, Kono DH, Theofilopoulos AN.

Immunol Rev. 2005 Apr;204:9-26. Review.


Type I interferons (alpha/beta) in immunity and autoimmunity.

Theofilopoulos AN, Baccala R, Beutler B, Kono DH.

Annu Rev Immunol. 2005;23:307-36. Review.


Costimulation requirements of induced murine systemic autoimmune disease.

Pollard KM, Arnush M, Hultman P, Kono DH.

J Immunol. 2004 Nov 1;173(9):5880-7.


Terminal deoxynucleotidyltransferase deficiency decreases autoimmune disease in diabetes-prone nonobese diabetic mice and lupus-prone MRL-Fas(lpr) mice.

Robey IF, Peterson M, Horwitz MS, Kono DH, Stratmann T, Theofilopoulos AN, Sarvetnick N, Teyton L, Feeney AJ.

J Immunol. 2004 Apr 1;172(7):4624-9.


Inhibition of lupus by genetic alteration of the interferon-alpha/beta receptor.

Kono DH, Baccala R, Theofilopoulos AN.

Autoimmunity. 2003 Dec;36(8):503-10. Review.


Genetic complementation in female (BXSB x NZW)F2 mice.

Kono DH, Park MS, Theofilopoulos AN.

J Immunol. 2003 Dec 15;171(12):6442-7.

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