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Items: 1 to 50 of 168


MATRIEX imaging: multiarea two-photon real-time in vivo explorer.

Yang M, Zhou Z, Zhang J, Jia S, Li T, Guan J, Liao X, Leng B, Lyu J, Zhang K, Li M, Gong Y, Zhu Z, Yan J, Zhou Y, Liu JK, Varga Z, Konnerth A, Tang Y, Gao J, Chen X, Jia H.

Light Sci Appl. 2019 Nov 28;8:109. doi: 10.1038/s41377-019-0219-x. eCollection 2019.


Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity.

Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T.

Nat Neurosci. 2019 Oct;22(10):1731-1742. doi: 10.1038/s41593-019-0479-z. Epub 2019 Sep 9.


A vicious cycle of β amyloid-dependent neuronal hyperactivation.

Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A.

Science. 2019 Aug 9;365(6453):559-565. doi: 10.1126/science.aay0198.


Two types of functionally distinct Ca2+ stores in hippocampal neurons.

Chen-Engerer HJ, Hartmann J, Karl RM, Yang J, Feske S, Konnerth A.

Nat Commun. 2019 Jul 19;10(1):3223. doi: 10.1038/s41467-019-11207-8.


High-performance calcium sensors for imaging activity in neuronal populations and microcompartments.

Dana H, Sun Y, Mohar B, Hulse BK, Kerlin AM, Hasseman JP, Tsegaye G, Tsang A, Wong A, Patel R, Macklin JJ, Chen Y, Konnerth A, Jayaraman V, Looger LL, Schreiter ER, Svoboda K, Kim DS.

Nat Methods. 2019 Jul;16(7):649-657. doi: 10.1038/s41592-019-0435-6. Epub 2019 Jun 17.


Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.

Hammelmann V, Stieglitz MS, Hülle H, Le Meur K, Kass J, Brümmer M, Gruner C, Rötzer RD, Fenske S, Hartmann J, Zott B, Lüthi A, Spahn S, Moser M, Isbrandt D, Ludwig A, Konnerth A, Wahl-Schott C, Biel M.

JCI Insight. 2019 May 2;4(9). pii: 126418. doi: 10.1172/jci.insight.126418. eCollection 2019 May 2.


In Vivo Functional Mapping of a Cortical Column at Single-Neuron Resolution.

Tischbirek CH, Noda T, Tohmi M, Birkner A, Nelken I, Konnerth A.

Cell Rep. 2019 Apr 30;27(5):1319-1326.e5. doi: 10.1016/j.celrep.2019.04.007.


Deep Two-Photon Imaging In Vivo with a Red-Shifted Calcium Indicator.

Birkner A, Konnerth A.

Methods Mol Biol. 2019;1929:15-26. doi: 10.1007/978-1-4939-9030-6_2.


What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Zott B, Busche MA, Sperling RA, Konnerth A.

Annu Rev Neurosci. 2018 Jul 8;41:277-297. doi: 10.1146/annurev-neuro-080317-061725. Review.


A Visual-Cue-Dependent Memory Circuit for Place Navigation.

Qin H, Fu L, Hu B, Liao X, Lu J, He W, Liang S, Zhang K, Li R, Yao J, Yan J, Chen H, Jia H, Zott B, Konnerth A, Chen X.

Neuron. 2018 Jul 11;99(1):47-55.e4. doi: 10.1016/j.neuron.2018.05.021. Epub 2018 Jun 14.


BACE inhibition-dependent repair of Alzheimer's pathophysiology.

Keskin AD, Kekuš M, Adelsberger H, Neumann U, Shimshek DR, Song B, Zott B, Peng T, Förstl H, Staufenbiel M, Nelken I, Sakmann B, Konnerth A, Busche MA.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8631-8636. doi: 10.1073/pnas.1708106114. Epub 2017 Jul 24.


Identification of Highly Specific scFvs against Total Adiponectin for Diagnostic Purposes.

Wilton P, Steidel M, Krczal G, Hermanns I, Pfützner A, Konnerth A, Boonrod K.

Biology (Basel). 2017 Apr 26;6(2). pii: E26. doi: 10.3390/biology6020026.


Improved deep two-photon calcium imaging in vivo.

Birkner A, Tischbirek CH, Konnerth A.

Cell Calcium. 2017 Jun;64:29-35. doi: 10.1016/j.ceca.2016.12.005. Epub 2016 Dec 21.


In vivo deep two-photon imaging of neural circuits with the fluorescent Ca2+ indicator Cal-590.

Tischbirek CH, Birkner A, Konnerth A.

J Physiol. 2017 May 15;595(10):3097-3105. doi: 10.1113/JP272790. Epub 2017 Feb 5. Review.


Immunodominant membrane proteins of phytoplasmas.

Konnerth A, Krczal G, Boonrod K.

Microbiology. 2016 Aug;162(8):1267-1273. doi: 10.1099/mic.0.000331. Epub 2016 Jul 5. Review.


Impairments of neural circuit function in Alzheimer's disease.

Busche MA, Konnerth A.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150429. doi: 10.1098/rstb.2015.0429. Review.


Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models.

Busche MA, Grienberger C, Keskin AD, Song B, Neumann U, Staufenbiel M, Förstl H, Konnerth A.

Nat Neurosci. 2015 Dec;18(12):1725-7. doi: 10.1038/nn.4163. Epub 2015 Nov 9.


Rescue of long-range circuit dysfunction in Alzheimer's disease models.

Busche MA, Kekuš M, Adelsberger H, Noda T, Förstl H, Nelken I, Konnerth A.

Nat Neurosci. 2015 Nov;18(11):1623-30. doi: 10.1038/nn.4137. Epub 2015 Oct 12.


η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C.

Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.


Deep two-photon brain imaging with a red-shifted fluorometric Ca2+ indicator.

Tischbirek C, Birkner A, Jia H, Sakmann B, Konnerth A.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):11377-82. doi: 10.1073/pnas.1514209112. Epub 2015 Aug 24.


Synaptic dynamics and neuronal network connectivity are reflected in the distribution of times in Up states.

Dao Duc K, Parutto P, Chen X, Epsztein J, Konnerth A, Holcman D.

Front Comput Neurosci. 2015 Jul 29;9:96. doi: 10.3389/fncom.2015.00096. eCollection 2015.


Imaging Submillisecond Membrane Potential Changes from Individual Regions of Single Axons, Dendrites and Spines.

Popovic M, Vogt K, Holthoff K, Konnerth A, Salzberg BM, Grinvald A, Antic SD, Canepari M, Zecevic D.

Adv Exp Med Biol. 2015;859:57-101. doi: 10.1007/978-3-319-17641-3_3. Review.


TRPC3-dependent synaptic transmission in central mammalian neurons.

Hartmann J, Konnerth A.

J Mol Med (Berl). 2015 Sep;93(9):983-9. doi: 10.1007/s00109-015-1298-7. Epub 2015 Jun 5. Review.


Neuronal hyperactivity--A key defect in Alzheimer's disease?

Busche MA, Konnerth A.

Bioessays. 2015 Jun;37(6):624-32. doi: 10.1002/bies.201500004. Epub 2015 Mar 14.


Dendritic function in vivo.

Grienberger C, Chen X, Konnerth A.

Trends Neurosci. 2015 Jan;38(1):45-54. doi: 10.1016/j.tins.2014.11.002. Epub 2014 Nov 25. Review.


In vivo calcium recordings and channelrhodopsin-2 activation through an optical fiber.

Adelsberger H, Grienberger C, Stroh A, Konnerth A.

Cold Spring Harb Protoc. 2014 Oct 1;2014(10):pdb.prot084145. doi: 10.1101/pdb.prot084145.


An assay to image neuronal microtubule dynamics in mice.

Kleele T, Marinković P, Williams PR, Stern S, Weigand EE, Engerer P, Naumann R, Hartmann J, Karl RM, Bradke F, Bishop D, Herms J, Konnerth A, Kerschensteiner M, Godinho L, Misgeld T.

Nat Commun. 2014 Sep 12;5:4827. doi: 10.1038/ncomms5827.


Linear integration of spine Ca2+ signals in layer 4 cortical neurons in vivo.

Jia H, Varga Z, Sakmann B, Konnerth A.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9277-82. doi: 10.1073/pnas.1408525111. Epub 2014 Jun 9.


STIM1 controls neuronal Ca²⁺ signaling, mGluR1-dependent synaptic transmission, and cerebellar motor behavior.

Hartmann J, Karl RM, Alexander RP, Adelsberger H, Brill MS, Rühlmann C, Ansel A, Sakimura K, Baba Y, Kurosaki T, Misgeld T, Konnerth A.

Neuron. 2014 May 7;82(3):635-44. doi: 10.1016/j.neuron.2014.03.027.


NMDA receptor-dependent multidendrite Ca(2+) spikes required for hippocampal burst firing in vivo.

Grienberger C, Chen X, Konnerth A.

Neuron. 2014 Mar 19;81(6):1274-1281. doi: 10.1016/j.neuron.2014.01.014. Epub 2014 Feb 20.


Local domains of motor cortical activity revealed by fiber-optic calcium recordings in behaving nonhuman primates.

Adelsberger H, Zainos A, Alvarez M, Romo R, Konnerth A.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):463-8. doi: 10.1073/pnas.1321612111. Epub 2013 Dec 16.


Multibranch activity in basal and tuft dendrites during firing of layer 5 cortical neurons in vivo.

Hill DN, Varga Z, Jia H, Sakmann B, Konnerth A.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13618-23. doi: 10.1073/pnas.1312599110. Epub 2013 Jul 31.


Reactivation of the same synapses during spontaneous up states and sensory stimuli.

Chen X, Rochefort NL, Sakmann B, Konnerth A.

Cell Rep. 2013 Jul 11;4(1):31-9. doi: 10.1016/j.celrep.2013.05.042. Epub 2013 Jun 27.


Making waves: initiation and propagation of corticothalamic Ca2+ waves in vivo.

Stroh A, Adelsberger H, Groh A, Rühlmann C, Fischer S, Schierloh A, Deisseroth K, Konnerth A.

Neuron. 2013 Mar 20;77(6):1136-50. doi: 10.1016/j.neuron.2013.01.031.


In vivo functional properties of juxtaglomerular neurons in the mouse olfactory bulb.

Homma R, Kovalchuk Y, Konnerth A, Cohen LB, Garaschuk O.

Front Neural Circuits. 2013 Feb 21;7:23. doi: 10.3389/fncir.2013.00023. eCollection 2013.


LOTOS-based two-photon calcium imaging of dendritic spines in vivo.

Chen X, Leischner U, Varga Z, Jia H, Deca D, Rochefort NL, Konnerth A.

Nat Protoc. 2012 Oct;7(10):1818-29. doi: 10.1038/nprot.2012.106. Epub 2012 Sep 13.


Dendritic spines: from structure to in vivo function.

Rochefort NL, Konnerth A.

EMBO Rep. 2012 Aug;13(8):699-708. doi: 10.1038/embor.2012.102. Epub 2012 Jul 13. Review.


Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer's disease.

Busche MA, Chen X, Henning HA, Reichwald J, Staufenbiel M, Sakmann B, Konnerth A.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8740-5. doi: 10.1073/pnas.1206171109. Epub 2012 May 16.


Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease.

Grienberger C, Rochefort NL, Adelsberger H, Henning HA, Hill DN, Reichwald J, Staufenbiel M, Konnerth A.

Nat Commun. 2012 Apr 10;3:774. doi: 10.1038/ncomms1783.


Imaging calcium in neurons.

Grienberger C, Konnerth A.

Neuron. 2012 Mar 8;73(5):862-85. doi: 10.1016/j.neuron.2012.02.011. Review.


Kainate receptor-induced retrograde inhibition of glutamatergic transmission in vasopressin neurons.

Bonfardin VD, Theodosis DT, Konnerth A, Oliet SH.

J Neurosci. 2012 Jan 25;32(4):1301-10. doi: 10.1523/JNEUROSCI.3017-11.2012.


Sound-evoked network calcium transients in mouse auditory cortex in vivo.

Grienberger C, Adelsberger H, Stroh A, Milos RI, Garaschuk O, Schierloh A, Nelken I, Konnerth A.

J Physiol. 2012 Feb 15;590(4):899-918. doi: 10.1113/jphysiol.2011.222513. Epub 2011 Nov 21.


Dendritic coding of multiple sensory inputs in single cortical neurons in vivo.

Varga Z, Jia H, Sakmann B, Konnerth A.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15420-5. doi: 10.1073/pnas.1112355108. Epub 2011 Aug 29.


Development of direction selectivity in mouse cortical neurons.

Rochefort NL, Narushima M, Grienberger C, Marandi N, Hill DN, Konnerth A.

Neuron. 2011 Aug 11;71(3):425-32. doi: 10.1016/j.neuron.2011.06.013.


Functional mapping of single spines in cortical neurons in vivo.

Chen X, Leischner U, Rochefort NL, Nelken I, Konnerth A.

Nature. 2011 Jun 26;475(7357):501-5. doi: 10.1038/nature10193.


mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons.

Hartmann J, Henning HA, Konnerth A.

Cold Spring Harb Perspect Biol. 2011 Apr 1;3(4). pii: a006726. doi: 10.1101/cshperspect.a006726. Review.


Tracking stem cell differentiation in the setting of automated optogenetic stimulation.

Stroh A, Tsai HC, Wang LP, Zhang F, Kressel J, Aravanis A, Santhanam N, Deisseroth K, Konnerth A, Schneider MB.

Stem Cells. 2011 Jan;29(1):78-88. doi: 10.1002/stem.558.


In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons.

Jia H, Rochefort NL, Chen X, Konnerth A.

Nat Protoc. 2011 Jan;6(1):28-35. doi: 10.1038/nprot.2010.169. Epub 2010 Dec 9.


In vivo two-photon calcium imaging using multicell bolus loading.

Garaschuk O, Konnerth A.

Cold Spring Harb Protoc. 2010 Oct 1;2010(10):pdb.prot5482. doi: 10.1101/pdb.prot5482.


Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels.

Chen X, Kovalchuk Y, Adelsberger H, Henning HA, Sausbier M, Wietzorrek G, Ruth P, Yarom Y, Konnerth A.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12323-8. doi: 10.1073/pnas.1001745107. Epub 2010 Jun 21.

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