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Items: 36


Distal Consequences of Oral Inflammation.

Konkel JE, O'Boyle C, Krishnan S.

Front Immunol. 2019 Jun 25;10:1403. doi: 10.3389/fimmu.2019.01403. eCollection 2019. Review.


Ligature-induced periodontitis induces systemic inflammation but does not alter acute outcome after stroke in mice.

O'Boyle C, Haley MJ, Lemarchand E, Smith CJ, Allan SM, Konkel JE, Lawrence CB.

Int J Stroke. 2019 Feb 22:1747493019834191. doi: 10.1177/1747493019834191. [Epub ahead of print]


Amphiregulin-producing γδ T cells are vital for safeguarding oral barrier immune homeostasis.

Krishnan S, Prise IE, Wemyss K, Schenck LP, Bridgeman HM, McClure FA, Zangerle-Murray T, O'Boyle C, Barbera TA, Mahmood F, Bowdish DME, Zaiss DMW, Grainger JR, Konkel JE.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10738-10743. doi: 10.1073/pnas.1802320115. Epub 2018 Oct 2.


Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression.

Shaw TN, Houston SA, Wemyss K, Bridgeman HM, Barbera TA, Zangerle-Murray T, Strangward P, Ridley AJL, Wang P, Tamoutounour S, Allen JE, Konkel JE, Grainger JR.

J Exp Med. 2018 Jun 4;215(6):1507-1518. doi: 10.1084/jem.20180019. Epub 2018 May 22.


Oral Microbiome Characterization in Murine Models.

Abusleme L, Hong BY, Hoare A, Konkel JE, Diaz PI, Moutsopoulos NM.

Bio Protoc. 2017 Dec 20;7(24). pii: e2655. doi: 10.21769/BioProtoc.2655.


Unique Tailoring of Th17 at the Gingival Oral Mucosal Barrier.

Konkel JE, Moutsopoulos NM.

J Dent Res. 2018 Feb;97(2):128-131. doi: 10.1177/0022034517736030. Epub 2017 Oct 13.


Tissue-Specific Immunity at the Oral Mucosal Barrier.

Moutsopoulos NM, Konkel JE.

Trends Immunol. 2018 Apr;39(4):276-287. doi: 10.1016/ Epub 2017 Sep 8. Review.


D-mannose induces regulatory T cells and suppresses immunopathology.

Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, Chen Q, Sun L, Chen ZJ, Chen W.

Nat Med. 2017 Sep;23(9):1036-1045. doi: 10.1038/nm.4375. Epub 2017 Jul 24.


MLL4 prepares the enhancer landscape for Foxp3 induction via chromatin looping.

Placek K, Hu G, Cui K, Zhang D, Ding Y, Lee JE, Jang Y, Wang C, Konkel JE, Song J, Liu C, Ge K, Chen W, Zhao K.

Nat Immunol. 2017 Sep;18(9):1035-1045. doi: 10.1038/ni.3812. Epub 2017 Jul 31.


Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses.

Konkel JE, Zhang D, Zanvit P, Chia C, Zangarle-Murray T, Jin W, Wang S, Chen W.

Immunity. 2017 Apr 18;46(4):660-674. doi: 10.1016/j.immuni.2017.03.015.


Macrophages in gastrointestinal homeostasis and inflammation.

Grainger JR, Konkel JE, Zangerle-Murray T, Shaw TN.

Pflugers Arch. 2017 Apr;469(3-4):527-539. doi: 10.1007/s00424-017-1958-2. Epub 2017 Mar 10. Review.


On-going Mechanical Damage from Mastication Drives Homeostatic Th17 Cell Responses at the Oral Barrier.

Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Zangerle-Murray T, Fife ME, Bouladoux N, Linley H, Brenchley L, Wemyss K, Calderon G, Hong BY, Break TJ, Bowdish DME, Lionakis MS, Jones SA, Trinchieri G, Diaz PI, Belkaid Y, Konkel JE, Moutsopoulos NM.

Immunity. 2017 Jan 17;46(1):133-147. doi: 10.1016/j.immuni.2016.12.010. Epub 2017 Jan 10.


Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network.

Dutzan N, Abusleme L, Konkel JE, Moutsopoulos NM.

J Vis Exp. 2016 Feb 16;(108):53736. doi: 10.3791/53736.


Characterization of the human immune cell network at the gingival barrier.

Dutzan N, Konkel JE, Greenwell-Wild T, Moutsopoulos NM.

Mucosal Immunol. 2016 Sep;9(5):1163-1172. doi: 10.1038/mi.2015.136. Epub 2016 Jan 6.


Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Zanvit P, Konkel JE, Jiao X, Kasagi S, Zhang D, Wu R, Chia C, Ajami NJ, Smith DP, Petrosino JF, Abbatiello B, Nakatsukasa H, Chen Q, Belkaid Y, Chen ZJ, Chen W.

Nat Commun. 2015 Sep 29;6:8424. doi: 10.1038/ncomms9424.


Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis.

Yang R, Qu C, Zhou Y, Konkel JE, Shi S, Liu Y, Chen C, Liu S, Liu D, Chen Y, Zandi E, Chen W, Zhou Y, Shi S.

Immunity. 2015 Aug 18;43(2):251-63. doi: 10.1016/j.immuni.2015.07.017. Epub 2015 Aug 11.


Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection.

Askenase MH, Han SJ, Byrd AL, Morais da Fonseca D, Bouladoux N, Wilhelm C, Konkel JE, Hand TW, Lacerda-Queiroz N, Su XZ, Trinchieri G, Grainger JR, Belkaid Y.

Immunity. 2015 Jun 16;42(6):1130-42. doi: 10.1016/j.immuni.2015.05.011. Epub 2015 Jun 9.


Development of thymic Foxp3(+) regulatory T cells: TGF-β matters.

Chen W, Konkel JE.

Eur J Immunol. 2015 Apr;45(4):958-65. doi: 10.1002/eji.201444999. Epub 2015 Mar 18. Review.


Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy.

McPherson RC, Konkel JE, Prendergast CT, Thomson JP, Ottaviano R, Leech MD, Kay O, Zandee SE, Sweenie CH, Wraith DC, Meehan RR, Drake AJ, Anderton SM.

Elife. 2014 Dec 29;3. doi: 10.7554/eLife.03416.


In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response.

Kasagi S, Zhang P, Che L, Abbatiello B, Maruyama T, Nakatsukasa H, Zanvit P, Jin W, Konkel JE, Chen W.

Sci Transl Med. 2014 Jun 18;6(241):241ra78. doi: 10.1126/scitranslmed.3008895.


A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.

Wang D, Feng X, Lu L, Konkel JE, Zhang H, Chen Z, Li X, Gao X, Lu L, Shi S, Chen W, Sun L.

Arthritis Rheumatol. 2014 Aug;66(8):2234-45. doi: 10.1002/art.38674.


Thymocyte apoptosis drives the intrathymic generation of regulatory T cells.

Konkel JE, Jin W, Abbatiello B, Grainger JR, Chen W.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):E465-73. doi: 10.1073/pnas.1320319111. Epub 2014 Jan 13.


Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis.

Sales KU, Friis S, Konkel JE, Godiksen S, Hatakeyama M, Hansen KK, Rogatto SR, Szabo R, Vogel LK, Chen W, Gutkind JS, Bugge TH.

Oncogene. 2015 Jan 15;34(3):346-56. doi: 10.1038/onc.2013.563. Epub 2014 Jan 27.


Transforming growth factor-β3 (TGF-β3) knock-in ameliorates inflammation due to TGF-β1 deficiency while promoting glucose tolerance.

Hall BE, Wankhade UD, Konkel JE, Cherukuri K, Nagineni CN, Flanders KC, Arany PR, Chen W, Rane SG, Kulkarni AB.

J Biol Chem. 2013 Nov 1;288(44):32074-92. doi: 10.1074/jbc.M113.480764. Epub 2013 Sep 20.


PARP-1 controls immunosuppressive function of regulatory T cells by destabilizing Foxp3.

Zhang P, Maruyama T, Konkel JE, Abbatiello B, Zamarron B, Wang ZQ, Chen W.

PLoS One. 2013 Aug 19;8(8):e71590. doi: 10.1371/journal.pone.0071590. eCollection 2013.


PARP-1 regulates expression of TGF-β receptors in T cells.

Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel JE, Maruyama T, Wei G, Abbatiello B, Wang ZQ, Zhao K, Chen W.

Blood. 2013 Sep 26;122(13):2224-32. doi: 10.1182/blood-2013-05-503250. Epub 2013 Aug 12.


GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.

Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R, Paul WE, Bosselut R, Wei G, Zhao K, Oukka M, Zhu J, Belkaid Y.

J Clin Invest. 2011 Nov;121(11):4503-15. doi: 10.1172/JCI57456. Epub 2011 Oct 3.


Balancing acts: the role of TGF-β in the mucosal immune system.

Konkel JE, Chen W.

Trends Mol Med. 2011 Nov;17(11):668-76. doi: 10.1016/j.molmed.2011.07.002. Epub 2011 Sep 2. Review.


The molecular mechanisms of Foxp3 gene regulation.

Maruyama T, Konkel JE, Zamarron BF, Chen W.

Semin Immunol. 2011 Dec;23(6):418-23. doi: 10.1016/j.smim.2011.06.005. Epub 2011 Jul 12. Review.


Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.

Konkel JE, Maruyama T, Carpenter AC, Xiong Y, Zamarron BF, Hall BE, Kulkarni AB, Zhang P, Bosselut R, Chen W.

Nat Immunol. 2011 Apr;12(4):312-9. doi: 10.1038/ni.1997. Epub 2011 Feb 6.


Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.

Maruyama T, Li J, Vaque JP, Konkel JE, Wang W, Zhang B, Zhang P, Zamarron BF, Yu D, Wu Y, Zhuang Y, Gutkind JS, Chen W.

Nat Immunol. 2011 Jan;12(1):86-95. doi: 10.1038/ni.1965. Epub 2010 Dec 5.


Generation of pathogenic T(H)17 cells in the absence of TGF-β signalling.

Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, Grainger JR, Chen Q, Kanno Y, Watford WT, Sun HW, Eberl G, Shevach EM, Belkaid Y, Cua DJ, Chen W, O'Shea JJ.

Nature. 2010 Oct 21;467(7318):967-71. doi: 10.1038/nature09447.


Mutation of inhibitory helix-loop-helix protein Id3 causes γδ T-cell lymphoma in mice.

Li J, Maruyama T, Zhang P, Konkel JE, Hoffman V, Zamarron B, Chen W.

Blood. 2010 Dec 16;116(25):5615-21. doi: 10.1182/blood-2010-03-274506. Epub 2010 Sep 17.


PD-1 signalling in CD4(+) T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide-induced tolerance.

Konkel JE, Frommer F, Leech MD, Yagita H, Waisman A, Anderton SM.

Immunology. 2010 May;130(1):92-102. doi: 10.1111/j.1365-2567.2009.03216.x. Epub 2010 Jan 27.


TGF-beta and 'adaptive' Foxp3(+) regulatory T cells.

Chen W, Konkel JE.

J Mol Cell Biol. 2010 Feb;2(1):30-6. doi: 10.1093/jmcb/mjp004. Epub 2009 Jul 31.


PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport.

Palmer KJ, Konkel JE, Stephens DJ.

J Cell Sci. 2005 Sep 1;118(Pt 17):3839-47. Epub 2005 Aug 9. Erratum in: J Cell Sci. 2005 Nov 1;118(Pt 21):5155.

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