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Items: 25

1.

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment.

Chodorge M, Celeste AJ, Grimsby J, Konkar A, Davidsson P, Fairman D, Jenkinson L, Naylor J, White N, Seaman JC, Dickson K, Kemp B, Spooner J, Rossy E, Hornigold DC, Trevaskis JL, Bond NJ, London TB, Buchanan A, Vaughan T, Rondinone CM, Osbourn JK.

Sci Rep. 2018 Dec 3;8(1):17545. doi: 10.1038/s41598-018-35869-4.

2.

Acute and Repeated Treatment with 5-PAHSA or 9-PAHSA Isomers Does Not Improve Glucose Control in Mice.

Pflimlin E, Bielohuby M, Korn M, Breitschopf K, Löhn M, Wohlfart P, Konkar A, Podeschwa M, Bärenz F, Pfenninger A, Schwahn U, Opatz T, Reimann M, Petry S, Tennagels N.

Cell Metab. 2018 Aug 7;28(2):217-227.e13. doi: 10.1016/j.cmet.2018.05.028. Epub 2018 Jun 21.

3.

Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.

Evers A, Bossart M, Pfeiffer-Marek S, Elvert R, Schreuder H, Kurz M, Stengelin S, Lorenz M, Herling A, Konkar A, Lukasczyk U, Pfenninger A, Lorenz K, Haack T, Kadereit D, Wagner M.

J Med Chem. 2018 Jul 12;61(13):5580-5593. doi: 10.1021/acs.jmedchem.8b00292. Epub 2018 Jun 25.

PMID:
29879354
4.

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.

Ge X, Yang H, Bednarek MA, Galon-Tilleman H, Chen P, Chen M, Lichtman JS, Wang Y, Dalmas O, Yin Y, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD.

Cell Metab. 2018 Feb 6;27(2):461-469.e6. doi: 10.1016/j.cmet.2017.10.016. Epub 2017 Dec 7.

5.

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.

Galon-Tilleman H, Yang H, Bednarek MA, Spurlock SM, Paavola KJ, Ko B, To C, Luo J, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD.

J Biol Chem. 2017 Feb 3;292(5):1925-1933. doi: 10.1074/jbc.M116.748103. Epub 2016 Dec 19.

6.

A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice.

Valdecantos MP, Pardo V, Ruiz L, Castro-Sánchez L, Lanzón B, Fernández-Millán E, García-Monzón C, Arroba AI, González-Rodríguez Á, Escrivá F, Álvarez C, Rupérez FJ, Barbas C, Konkar A, Naylor J, Hornigold D, Santos AD, Bednarek M, Grimsby J, Rondinone CM, Valverde ÁM.

Hepatology. 2017 Mar;65(3):950-968. doi: 10.1002/hep.28962. Epub 2017 Jan 30.

PMID:
27880981
7.

Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates.

Henderson SJ, Konkar A, Hornigold DC, Trevaskis JL, Jackson R, Fritsch Fredin M, Jansson-Löfmark R, Naylor J, Rossi A, Bednarek MA, Bhagroo N, Salari H, Will S, Oldham S, Hansen G, Feigh M, Klein T, Grimsby J, Maguire S, Jermutus L, Rondinone CM, Coghlan MP.

Diabetes Obes Metab. 2016 Dec;18(12):1176-1190. doi: 10.1111/dom.12735. Epub 2016 Aug 15.

8.

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH.

Nat Med. 2015 Jan;21(1):27-36. doi: 10.1038/nm.3761. Epub 2014 Dec 8.

PMID:
25485909
9.

Cellular origins of cold-induced brown adipocytes in adult mice.

Lee YH, Petkova AP, Konkar AA, Granneman JG.

FASEB J. 2015 Jan;29(1):286-99. doi: 10.1096/fj.14-263038. Epub 2014 Nov 12.

10.

Preparation and characterization of albumin conjugates of a truncated peptide YY analogue for half-life extension.

Ehrlich GK, Michel H, Truitt T, Riboulet W, Pop-Damkov P, Goelzer P, Hainzl D, Qureshi F, Lueckel B, Danho W, Conde-Knape K, Konkar A.

Bioconjug Chem. 2013 Dec 18;24(12):2015-24. doi: 10.1021/bc400340z. Epub 2013 Nov 27.

PMID:
24251972
11.

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, DiMarchi RD, Tschöp MH.

Sci Transl Med. 2013 Oct 30;5(209):209ra151. doi: 10.1126/scitranslmed.3007218.

12.

PK modulation of haptenylated peptides via non-covalent antibody complexation.

Hoffmann E, Konkar A, Dziadek S, Josel HP, Conde-Knape K, Kropp H, Kling L, Stubenrauch K, Thorey I, Dengl S, Brinkmann U.

J Control Release. 2013 Oct 10;171(1):48-56. doi: 10.1016/j.jconrel.2013.06.021. Epub 2013 Jun 22.

13.

Fibroblast growth factor 21 mediates specific glucagon actions.

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH.

Diabetes. 2013 May;62(5):1453-63. doi: 10.2337/db12-1116. Epub 2013 Jan 10.

14.

Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.

Smith RA, Fathi Z, Achebe F, Akuche C, Brown SE, Choi S, Fan J, Jenkins S, Kluender HC, Konkar A, Lavoie R, Mays R, Natoli J, O'Connor SJ, Ortiz AA, Su N, Taing C, Tomlinson S, Tritto T, Wang G, Wirtz SN, Wong W, Yang XF, Ying S, Zhang Z.

Bioorg Med Chem Lett. 2007 May 15;17(10):2706-11. Epub 2007 Mar 12.

PMID:
17383180
15.

Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.

Smith RA, Fathi Z, Brown SE, Choi S, Fan J, Jenkins S, Kluender HC, Konkar A, Lavoie R, Mays R, Natoli J, O'Connor SJ, Ortiz AA, Podlogar B, Taing C, Tomlinson S, Tritto T, Zhang Z.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):673-8. Epub 2006 Nov 2.

PMID:
17107792
16.

Semiconductor nanocrystal quantum dots on single crystal semiconductor substrates: high resolution transmission electron microscopy.

Konkar A, Lu S, Madhukar A, Hughes SM, Alivisatos AP.

Nano Lett. 2005 May;5(5):969-73.

PMID:
15884904
17.

Integrated semiconductor nanocrystal and epitaxical nanostructure systems: structural and optical behavior.

Madhukar A, Lu S, Konkar A, Zhang Y, Ho M, Hughes SM, Alivisatos AP.

Nano Lett. 2005 Mar;5(3):479-82.

PMID:
15755098
18.

Biochemical activities of trimetoquinol analogs at human beta(1)- and beta(3)-adrenergic receptors.

Konkar AA, Nikulin VI, De Los Angeles J, Hong SS, Fertel RH, Miller DD, Feller DR.

Pharmacology. 2001 Jan;62(1):45-55.

PMID:
11150922
20.

beta1-adrenergic receptors mediate beta3-adrenergic-independent effects of CGP 12177 in brown adipose tissue.

Konkar AA, Zhai Y, Granneman JG.

Mol Pharmacol. 2000 Feb;57(2):252-8.

PMID:
10648634
21.

Beta-adrenoceptor subtype activities of trimetoquinol derivatives: biochemical studies on human beta-adrenoceptors expressed in chinese hamster ovary cells.

Konkar AA, Vansal SS, Shams G, Fraundorfer PF, Zheng WP, Nikulin VI, De Los Angeles J, Fertel RH, Miller DD, Feller DR.

J Pharmacol Exp Ther. 1999 Nov;291(2):875-83.

PMID:
10525112
22.

2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists.

Zheng W, Nikulin VI, Konkar AA, Vansal SS, Shams G, Feller DR, Miller DD.

J Med Chem. 1999 Jun 17;42(12):2287-94.

PMID:
10377236
23.

Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands.

De Los Angeles JE, Nikulin VI, Shams G, Konkar AA, Mehta R, Feller DR, Miller DD.

J Med Chem. 1996 Sep 13;39(19):3701-11.

PMID:
8809159
24.

Pharmacological study of atypical beta-adrenoceptors in rat esophageal smooth muscle.

Lezama EJ, Konkar AA, Salazar-Bookaman MM, Miller DD, Feller DR.

Eur J Pharmacol. 1996 Jul 11;308(1):69-80.

PMID:
8836634
25.

Pharmacological activities of trimetoquinol and 1-benzyl halogen-substituted analogues on rat beta-adrenoceptor subtypes.

Konkar AA, Fraundorfer PF, Fertel RH, Burkman AM, Miller DD, Feller DR.

Eur J Pharmacol. 1996 Jun 3;305(1-3):63-71.

PMID:
8813533

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