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Items: 1 to 50 of 98

1.

Mesenchymal WNT-5A/5B Signaling Represses Lung Alveolar Epithelial Progenitors.

Wu X, van Dijk EM, Ng-Blichfeldt JP, Bos IST, Ciminieri C, Königshoff M, Kistemaker LEM, Gosens R.

Cells. 2019 Sep 25;8(10). pii: E1147. doi: 10.3390/cells8101147.

2.

Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended ex vivo Culture.

Bailey KE, Pino C, Lennon ML, Lyons A, Jacot JG, Lammers SR, Königshoff M, Magin CM.

Am J Respir Cell Mol Biol. 2019 Sep 12. doi: 10.1165/rcmb.2019-0232MA. [Epub ahead of print]

PMID:
31513744
3.

Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles.

Parimon T, Yao C, Habiel DM, Ge L, Bora SA, Brauer R, Evans CM, Xie T, Alonso-Valenteen F, Medina-Kauwe LK, Jiang D, Noble PW, Hogaboam CM, Deng N, Burgy O, Antes TJ, Königshoff M, Stripp BR, Gharib SA, Chen P.

JCI Insight. 2019 Aug 8;5. pii: 129359. doi: 10.1172/jci.insight.129359.

4.

The oncogene ECT2 contributes to a hyperplastic, proliferative lung epithelial cell phenotype in IPF.

Ulke HM, Mutze K, Lehmann M, Wagner DE, Heinzelmann K, Günther A, Eickelberg O, Königshoff M.

Am J Respir Cell Mol Biol. 2019 May 30. doi: 10.1165/rcmb.2019-0047OC. [Epub ahead of print]

PMID:
31145635
5.

TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.

Ng-Blichfeldt JP, de Jong T, Kortekaas RK, Wu X, Lindner M, Guryev V, Hiemstra PS, Stolk J, Königshoff M, Gosens R.

Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L14-L28. doi: 10.1152/ajplung.00400.2018. Epub 2019 Apr 10.

PMID:
30969812
6.

Generation of Human 3D Lung Tissue Cultures (3D-LTCs) for Disease Modeling.

Gerckens M, Alsafadi HN, Wagner DE, Lindner M, Burgstaller G, Königshoff M.

J Vis Exp. 2019 Feb 12;(144). doi: 10.3791/58437.

PMID:
30829341
7.

New players in chronic lung disease identified at the European Respiratory Society International Congress in Paris 2018: from microRNAs to extracellular vesicles.

Burgy O, Fernandez Fernandez E, Rolandsson Enes S, Königshoff M, Greene CM, Bartel S.

J Thorac Dis. 2018 Sep;10(Suppl 25):S2983-S2987. doi: 10.21037/jtd.2018.08.20. No abstract available.

8.

Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation.

Ng-Blichfeldt JP, Schrik A, Kortekaas RK, Noordhoek JA, Heijink IH, Hiemstra PS, Stolk J, Königshoff M, Gosens R.

EBioMedicine. 2018 Oct;36:461-474. doi: 10.1016/j.ebiom.2018.09.002. Epub 2018 Sep 17.

9.

Differential effects of Nintedanib and Pirfenidone on lung alveolar epithelial cell function in ex vivo murine and human lung tissue cultures of pulmonary fibrosis.

Lehmann M, Buhl L, Alsafadi HN, Klee S, Hermann S, Mutze K, Ota C, Lindner M, Behr J, Hilgendorff A, Wagner DE, Königshoff M.

Respir Res. 2018 Sep 15;19(1):175. doi: 10.1186/s12931-018-0876-y.

10.

Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis.

Ota C, Ng-Blichfeldt JP, Korfei M, Alsafadi HN, Lehmann M, Skronska-Wasek W, M De Santis M, Guenther A, Wagner DE, Königshoff M.

Sci Rep. 2018 Aug 28;8(1):12983. doi: 10.1038/s41598-018-31214-x.

11.

Increased Extracellular Vesicles Mediate WNT-5A Signaling in Idiopathic Pulmonary Fibrosis.

Martin-Medina A, Lehmann M, Burgy O, Hermann S, Baarsma HA, Wagner DE, De Santis MM, Ciolek F, Hofer TP, Frankenberger M, Aichler M, Lindner M, Gesierich W, Guenther A, Walch A, Coughlan C, Wolters P, Lee JS, Behr J, Königshoff M.

Am J Respir Crit Care Med. 2018 Jul 25. doi: 10.1164/rccm.201708-1580OC. [Epub ahead of print]

PMID:
30044642
12.

Cell-surface phenotyping identifies CD36 and CD97 as novel markers of fibroblast quiescence in lung fibrosis.

Heinzelmann K, Lehmann M, Gerckens M, Noskovičová N, Frankenberger M, Lindner M, Hatz R, Behr J, Hilgendorff A, Königshoff M, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L682-L696. doi: 10.1152/ajplung.00439.2017. Epub 2018 Jun 28.

PMID:
29952218
13.

S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis.

Zhang W, Ohno S, Steer B, Klee S, Staab-Weijnitz CA, Wagner D, Lehmann M, Stoeger T, Königshoff M, Adler H.

Front Immunol. 2018 Jun 1;9:1216. doi: 10.3389/fimmu.2018.01216. eCollection 2018.

14.

The WNT signaling pathways in wound healing and fibrosis.

Burgy O, Königshoff M.

Matrix Biol. 2018 Aug;68-69:67-80. doi: 10.1016/j.matbio.2018.03.017. Epub 2018 Mar 20. Review.

PMID:
29572156
15.

WNT receptor signalling in lung physiology and pathology.

Skronska-Wasek W, Gosens R, Königshoff M, Baarsma HA.

Pharmacol Ther. 2018 Jul;187:150-166. doi: 10.1016/j.pharmthera.2018.02.009. Epub 2018 Feb 17. Review.

PMID:
29458107
16.

Distinct niches within the extracellular matrix dictate fibroblast function in (cell free) 3D lung tissue cultures.

Burgstaller G, Sengupta A, Vierkotten S, Preissler G, Lindner M, Behr J, Königshoff M, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L708-L723. doi: 10.1152/ajplung.00408.2017. Epub 2018 Jan 18.

17.

Breaking the In Vitro Barrier in Respiratory Medicine. Engineered Microphysiological Systems for Chronic Obstructive Pulmonary Disease and Beyond.

Benam KH, Königshoff M, Eickelberg O.

Am J Respir Crit Care Med. 2018 Apr 1;197(7):869-875. doi: 10.1164/rccm.201709-1795PP. Review. No abstract available.

PMID:
29262260
18.

Towards a global initiative for fibrosis treatment (GIFT).

Molina-Molina M, Agusti A, Crestani B, Schwartz DA, Königshoff M, Chambers RC, Maher TM, Faner R, Mora AL, Rojas M, Antoniou KM, Sellares J.

ERJ Open Res. 2017 Dec 1;3(4). pii: 00106-2017. doi: 10.1183/23120541.00106-2017. eCollection 2017 Oct.

19.

Lung ageing and COPD: is there a role for ageing in abnormal tissue repair?

Brandsma CA, de Vries M, Costa R, Woldhuis RR, Königshoff M, Timens W.

Eur Respir Rev. 2017 Dec 6;26(146). pii: 170073. doi: 10.1183/16000617.0073-2017. Print 2017 Dec 31. Review.

20.

Cancer cells induce interleukin-22 production from memory CD4+ T cells via interleukin-1 to promote tumor growth.

Voigt C, May P, Gottschlich A, Markota A, Wenk D, Gerlach I, Voigt S, Stathopoulos GT, Arendt KAM, Heise C, Rataj F, Janssen KP, Königshoff M, Winter H, Himsl I, Thasler WE, Schnurr M, Rothenfußer S, Endres S, Kobold S.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12994-12999. doi: 10.1073/pnas.1705165114. Epub 2017 Nov 17.

21.

Cell-specific expression of runt-related transcription factor 2 contributes to pulmonary fibrosis.

Mümmler C, Burgy O, Hermann S, Mutze K, Günther A, Königshoff M.

FASEB J. 2018 Feb;32(2):703-716. doi: 10.1096/fj.201700482R. Epub 2018 Jan 4.

PMID:
28986417
22.

Pulmonary CCR2+CD4+ T cells are immune regulatory and attenuate lung fibrosis development.

Milger K, Yu Y, Brudy E, Irmler M, Skapenko A, Mayinger M, Lehmann M, Beckers J, Reichenberger F, Behr J, Eickelberg O, Königshoff M, Krauss-Etschmann S.

Thorax. 2017 Nov;72(11):1007-1020. doi: 10.1136/thoraxjnl-2016-208423. Epub 2017 Aug 5.

PMID:
28780502
23.

Senolytic drugs target alveolar epithelial cell function and attenuate experimental lung fibrosis ex vivo.

Lehmann M, Korfei M, Mutze K, Klee S, Skronska-Wasek W, Alsafadi HN, Ota C, Costa R, Schiller HB, Lindner M, Wagner DE, Günther A, Königshoff M.

Eur Respir J. 2017 Aug 3;50(2). pii: 1602367. doi: 10.1183/13993003.02367-2016. Print 2017 Aug.

24.

An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES; ATS Assembly on Respiratory Cell and Molecular Biology.

Am J Respir Cell Mol Biol. 2017 May;56(5):667-679. doi: 10.1165/rcmb.2017-0096ST.

25.

Linking Wnt Signaling to Mucosal Inflammation.

Costa R, Königshoff M.

Am J Respir Cell Mol Biol. 2017 May;56(5):551-552. doi: 10.1165/rcmb.2017-0054ED. No abstract available.

PMID:
28459386
26.

'WNT-er is coming': WNT signalling in chronic lung diseases.

Baarsma HA, Königshoff M.

Thorax. 2017 Aug;72(8):746-759. doi: 10.1136/thoraxjnl-2016-209753. Epub 2017 Apr 17. Review.

27.

Lung volumes predict survival in patients with chronic lung allograft dysfunction.

Kneidinger N, Milger K, Janitza S, Ceelen F, Leuschner G, Dinkel J, Königshoff M, Weig T, Schramm R, Winter H, Behr J, Neurohr C.

Eur Respir J. 2017 Apr 12;49(4). pii: 1601315. doi: 10.1183/13993003.01315-2016. Print 2017 Apr.

28.

An ex vivo model to induce early fibrosis-like changes in human precision-cut lung slices.

Alsafadi HN, Staab-Weijnitz CA, Lehmann M, Lindner M, Peschel B, Königshoff M, Wagner DE.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L896-L902. doi: 10.1152/ajplung.00084.2017. Epub 2017 Mar 17.

29.

Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease.

Skronska-Wasek W, Mutze K, Baarsma HA, Bracke KR, Alsafadi HN, Lehmann M, Costa R, Stornaiuolo M, Novellino E, Brusselle GG, Wagner DE, Yildirim AÖ, Königshoff M.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):172-185. doi: 10.1164/rccm.201605-0904OC.

PMID:
28245136
30.

Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair.

Poobalasingam T, Yates LL, Walker SA, Pereira M, Gross NY, Ali A, Kolatsi-Joannou M, Jarvelin MR, Pekkanen J, Papakrivopoulou E, Long DA, Griffiths M, Wagner D, Königshoff M, Hind M, Minelli C, Lloyd CM, Dean CH.

Dis Model Mech. 2017 Apr 1;10(4):409-423. doi: 10.1242/dmm.028175. Epub 2017 Feb 24.

31.

Correction: Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Feb;214(2):565. doi: 10.1084/jem.2016067501052017c. Epub 2017 Jan 9. No abstract available.

32.

WNT Signaling in Lung Aging and Disease.

Lehmann M, Baarsma HA, Königshoff M.

Ann Am Thorac Soc. 2016 Dec;13 Suppl 5:S411-S416. doi: 10.1513/AnnalsATS.201608-586AW. Review.

PMID:
28005418
33.

Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD.

Baarsma HA, Skronska-Wasek W, Mutze K, Ciolek F, Wagner DE, John-Schuster G, Heinzelmann K, Günther A, Bracke KR, Dagouassat M, Boczkowski J, Brusselle GG, Smits R, Eickelberg O, Yildirim AÖ, Königshoff M.

J Exp Med. 2017 Jan;214(1):143-163. doi: 10.1084/jem.20160675. Epub 2016 Dec 15. Erratum in: J Exp Med. 2017 Feb;214(2):565.

34.

miR-323a-3p regulates lung fibrosis by targeting multiple profibrotic pathways.

Ge L, Habiel DM, Hansbro PM, Kim RY, Gharib SA, Edelman JD, Königshoff M, Parimon T, Brauer R, Huang Y, Allen J, Jiang D, Kurkciyan AA, Mizuno T, Stripp BR, Noble PW, Hogaboam CM, Chen P.

JCI Insight. 2016 Dec 8;1(20):e90301. doi: 10.1172/jci.insight.90301.

35.

Classical transient receptor potential 6 (TRPC6) channels support myofibroblast differentiation and development of experimental pulmonary fibrosis.

Hofmann K, Fiedler S, Vierkotten S, Weber J, Klee S, Jia J, Zwickenpflug W, Flockerzi V, Storch U, Yildirim AÖ, Gudermann T, Königshoff M, Dietrich A.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):560-568. doi: 10.1016/j.bbadis.2016.12.002. Epub 2016 Dec 6.

36.

Cigarette smoke alters the secretome of lung epithelial cells.

Mossina A, Lukas C, Merl-Pham J, Uhl FE, Mutze K, Schamberger A, Staab-Weijnitz C, Jia J, Yildirim AÖ, Königshoff M, Hauck SM, Eickelberg O, Meiners S.

Proteomics. 2017 Jan;17(1-2). doi: 10.1002/pmic.201600243.

PMID:
27891773
37.

Systematic Identification of Pharmacological Targets from Small-Molecule Phenotypic Screens.

Liu X, Baarsma HA, Thiam CH, Montrone C, Brauner B, Fobo G, Heier JS, Duscha S, Königshoff M, Angeli V, Ruepp A, Campillos M.

Cell Chem Biol. 2016 Oct 20;23(10):1302-1313. doi: 10.1016/j.chembiol.2016.08.011. Epub 2016 Sep 22.

38.

Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling.

Ota C, Baarsma HA, Wagner DE, Hilgendorff A, Königshoff M.

Mol Cell Pediatr. 2016 Dec;3(1):34. Epub 2016 Oct 7. Review.

39.

Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways.

Dietz K, de Los Reyes Jiménez M, Gollwitzer ES, Chaker AM, Zissler UM, Rådmark OP, Baarsma HA, Königshoff M, Schmidt-Weber CB, Marsland BJ, Esser-von Bieren J.

J Allergy Clin Immunol. 2017 Apr;139(4):1343-1354.e6. doi: 10.1016/j.jaci.2016.07.014. Epub 2016 Aug 20.

PMID:
27554815
40.

No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice.

Chen S, Yin R, Mutze K, Yu Y, Takenaka S, Königshoff M, Stoeger T.

Part Fibre Toxicol. 2016 Jun 21;13(1):33. doi: 10.1186/s12989-016-0144-6.

41.

Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis.

Fernandez IE, Amarie OV, Mutze K, Königshoff M, Yildirim AÖ, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L919-27. doi: 10.1152/ajplung.00183.2015. Epub 2016 Mar 18.

42.

WISP1 mediates IL-6-dependent proliferation in primary human lung fibroblasts.

Klee S, Lehmann M, Wagner DE, Baarsma HA, Königshoff M.

Sci Rep. 2016 Feb 12;6:20547. doi: 10.1038/srep20547.

43.

TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8.

Spanjer AI, Baarsma HA, Oostenbrink LM, Jansen SR, Kuipers CC, Lindner M, Postma DS, Meurs H, Heijink IH, Gosens R, Königshoff M.

FASEB J. 2016 May;30(5):1823-35. doi: 10.1096/fj.201500129. Epub 2016 Feb 5.

PMID:
26849959
44.

Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease.

Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Königshoff M, Preissler G, Winter H, Lindner M, Hatz R, Behr J, Heinzelmann K, Yildirim AÖ, Noessner E, Eickelberg O, Meiners S.

Am J Respir Crit Care Med. 2016 Jun 1;193(11):1230-41. doi: 10.1164/rccm.201506-1122OC.

PMID:
26756824
45.

Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.

Bardou O, Menou A, François C, Duitman JW, von der Thüsen JH, Borie R, Sales KU, Mutze K, Castier Y, Sage E, Liu L, Bugge TH, Fairlie DP, Königshoff M, Crestani B, Borensztajn KS.

Am J Respir Crit Care Med. 2016 Apr 15;193(8):847-60. doi: 10.1164/rccm.201502-0299OC.

46.

BARD1 mediates TGF-β signaling in pulmonary fibrosis.

André PA, Prêle CM, Vierkotten S, Carnesecchi S, Donati Y, Chambers RC, Pache JC, Crestani B, Barazzone-Argiroffo C, Königshoff M, Laurent GJ, Irminger-Finger I.

Respir Res. 2015 Sep 29;16:118. doi: 10.1186/s12931-015-0278-3.

47.

Validation of the 2nd Generation Proteasome Inhibitor Oprozomib for Local Therapy of Pulmonary Fibrosis.

Semren N, Habel-Ungewitter NC, Fernandez IE, Königshoff M, Eickelberg O, Stöger T, Meiners S.

PLoS One. 2015 Sep 4;10(9):e0136188. doi: 10.1371/journal.pone.0136188. eCollection 2015.

48.

Multidimensional immunolabeling and 4D time-lapse imaging of vital ex vivo lung tissue.

Burgstaller G, Vierkotten S, Lindner M, Königshoff M, Eickelberg O.

Am J Physiol Lung Cell Mol Physiol. 2015 Aug 15;309(4):L323-32. doi: 10.1152/ajplung.00061.2015. Epub 2015 Jun 19.

49.

Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells.

Mutze K, Vierkotten S, Milosevic J, Eickelberg O, Königshoff M.

Dis Model Mech. 2015 Aug 1;8(8):877-90. doi: 10.1242/dmm.019117. Epub 2015 May 14.

50.

Preclinical validation and imaging of Wnt-induced repair in human 3D lung tissue cultures.

Uhl FE, Vierkotten S, Wagner DE, Burgstaller G, Costa R, Koch I, Lindner M, Meiners S, Eickelberg O, Königshoff M.

Eur Respir J. 2015 Oct;46(4):1150-66. doi: 10.1183/09031936.00183214. Epub 2015 Apr 30.

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