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Items: 27


Effector CD8 T cells dedifferentiate into long-lived memory cells.

Youngblood B, Hale JS, Kissick HT, Ahn E, Xu X, Wieland A, Araki K, West EE, Ghoneim HE, Fan Y, Dogra P, Davis CW, Konieczny BT, Antia R, Cheng X, Ahmed R.

Nature. 2017 Dec 21;552(7685):404-409. doi: 10.1038/nature25144. Epub 2017 Dec 13.


Translation is actively regulated during the differentiation of CD8+ effector T cells.

Araki K, Morita M, Bederman AG, Konieczny BT, Kissick HT, Sonenberg N, Ahmed R.

Nat Immunol. 2017 Sep;18(9):1046-1057. doi: 10.1038/ni.3795. Epub 2017 Jul 17.


Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent.

Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai RN, Ramalingam SS, Araki K, Ahmed R.

Science. 2017 Mar 31;355(6332):1423-1427. doi: 10.1126/science.aaf0683. Epub 2017 Mar 9.


Adenovirus Serotype 5 Vaccination Results in Suboptimal CD4 T Helper 1 Responses in Mice.

Lee J, Hashimoto M, Im SJ, Araki K, Jin HT, Davis CW, Konieczny BT, Spies GA, McElrath MJ, Ahmed R.

J Virol. 2017 Feb 14;91(5). pii: e01132-16. doi: 10.1128/JVI.01132-16. Print 2017 Mar 1.


Autophagy is essential for effector CD8(+) T cell survival and memory formation.

Xu X, Araki K, Li S, Han JH, Ye L, Tan WG, Konieczny BT, Bruinsma MW, Martinez J, Pearce EL, Green DR, Jones DP, Virgin HW, Ahmed R.

Nat Immunol. 2014 Dec;15(12):1152-61. doi: 10.1038/ni.3025. Epub 2014 Nov 2.


Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection.

Penaloza-MacMaster P, Kamphorst AO, Wieland A, Araki K, Iyer SS, West EE, O'Mara L, Yang S, Konieczny BT, Sharpe AH, Freeman GJ, Rudensky AY, Ahmed R.

J Exp Med. 2014 Aug 25;211(9):1905-18. doi: 10.1084/jem.20132577. Epub 2014 Aug 11.


Interleukin-21 is a critical cytokine for the generation of virus-specific long-lived plasma cells.

Rasheed MA, Latner DR, Aubert RD, Gourley T, Spolski R, Davis CW, Langley WA, Ha SJ, Ye L, Sarkar S, Kalia V, Konieczny BT, Leonard WJ, Ahmed R.

J Virol. 2013 Jul;87(13):7737-46. doi: 10.1128/JVI.00063-13. Epub 2013 May 1.


Utilizing a retroviral RNAi system to investigate in vivo mTOR functions in T cells.

Araki K, Konieczny BT.

Methods Mol Biol. 2012;821:305-16. doi: 10.1007/978-1-61779-430-8_19.


Tight regulation of memory CD8(+) T cells limits their effectiveness during sustained high viral load.

West EE, Youngblood B, Tan WG, Jin HT, Araki K, Alexe G, Konieczny BT, Calpe S, Freeman GJ, Terhorst C, Haining WN, Ahmed R.

Immunity. 2011 Aug 26;35(2):285-98. doi: 10.1016/j.immuni.2011.05.017.


Functional and genomic profiling of effector CD8 T cell subsets with distinct memory fates.

Sarkar S, Kalia V, Haining WN, Konieczny BT, Subramaniam S, Ahmed R.

J Exp Med. 2008 Mar 17;205(3):625-40. doi: 10.1084/jem.20071641. Epub 2008 Mar 3.


Regulation of homeostatic chemokine expression and cell trafficking during immune responses.

Mueller SN, Hosiawa-Meagher KA, Konieczny BT, Sullivan BM, Bachmann MF, Locksley RM, Ahmed R, Matloubian M.

Science. 2007 Aug 3;317(5838):670-4.


The allograft defines the type of rejection (acute versus chronic) in the face of an established effector immune response.

Chalasani G, Li Q, Konieczny BT, Smith-Diggs L, Wrobel B, Dai Z, Perkins DL, Baddoura FK, Lakkis FG.

J Immunol. 2004 Jun 15;172(12):7813-20.


Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

Kaech SM, Tan JT, Wherry EJ, Konieczny BT, Surh CD, Ahmed R.

Nat Immunol. 2003 Dec;4(12):1191-8. Epub 2003 Nov 16.


Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.

Chalasani G, Dai Z, Konieczny BT, Baddoura FK, Lakkis FG.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6175-80.


Failure to induce neonatal tolerance in mice that lack both IL-4 and IL-13 but not in those that lack IL-4 alone.

Inoue Y, Konieczny BT, Wagener ME, McKenzie AN, Lakkis FG.

J Immunol. 2001 Jul 15;167(2):1125-8.


The dual role of IL-2 in the generation and maintenance of CD8+ memory T cells.

Dai Z, Konieczny BT, Lakkis FG.

J Immunol. 2000 Sep 15;165(6):3031-6.


Alloantigen-driven T cell death mediated by Fas ligand and tumor necrosis factor-alpha is not essential for the induction of allograft acceptance.

Wagener ME, Konieczny BT, Dai Z, Ring GH, Lakkis FG.

Transplantation. 2000 Jun 15;69(11):2428-32.


Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue.

Lakkis FG, Arakelov A, Konieczny BT, Inoue Y.

Nat Med. 2000 Jun;6(6):686-8.


The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death.

Dai Z, Arakelov A, Wagener M, Konieczny BT, Lakkis FG.

J Immunol. 1999 Sep 15;163(6):3131-7.


Regulation of alloantigen-mediated T-cell proliferation by endogenous interferon-gamma: implications for long-term allograft acceptance.

Hassan AT, Dai Z, Konieczny BT, Ring GH, Baddoura FK, Abou-Dahab LH, El-Sayed AA, Lakkis FG.

Transplantation. 1999 Jul 15;68(1):124-9.


Interferon-gamma is necessary for initiating the acute rejection of major histocompatibility complex class II-disparate skin allografts.

Ring GH, Saleem S, Dai Z, Hassan AT, Konieczny BT, Baddoura FK, Lakkis FG.

Transplantation. 1999 May 27;67(10):1362-5.


IL-4 is an endogenous inhibitor of neutrophil influx and subsequent pathology in acute antibody-mediated inflammation.

Saleem S, Dai Z, Coelho SN, Konieczny BT, Assmann KJ, Baddoura FK, Lakkis FG.

J Immunol. 1998 Jan 15;160(2):979-84.


IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

Konieczny BT, Dai Z, Elwood ET, Saleem S, Linsley PS, Baddoura FK, Larsen CP, Pearson TC, Lakkis FG.

J Immunol. 1998 Mar 1;160(5):2059-64.


Immunologic determinants of susceptibility to experimental glomerulonephritis: role of cellular immunity.

Coelho SN, Saleem S, Konieczny BT, Parekh KR, Baddoura FK, Lakkis FG.

Kidney Int. 1997 Mar;51(3):646-52.


Blocking the CD28-B7 T cell costimulation pathway induces long term cardiac allograft acceptance in the absence of IL-4.

Lakkis FG, Konieczny BT, Saleem S, Baddoura FK, Linsley PS, Alexander DZ, Lowry RP, Pearson TC, Larsen CP.

J Immunol. 1997 Mar 1;158(5):2443-8.


Acute rejection of vascularized heart allografts in the absence of IFNgamma.

Saleem S, Konieczny BT, Lowry RP, Baddoura FK, Lakkis FG.

Transplantation. 1996 Dec 27;62(12):1908-11.


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