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Murine myeloproliferative disorder as a consequence of impaired collaboration between dendritic cells and CD4 T cells.

Humblet-Baron S, Barber JS, Roca C, Lenaerts A, Koni PA, Liston A.

Blood. 2018 Oct 17. pii: blood-2018-05-850321. doi: 10.1182/blood-2018-05-850321. [Epub ahead of print]


Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.

Swafford D, Shanmugam A, Ranganathan P, Hussein MS, Koni PA, Prasad PD, Thangaraju M, Manicassamy S.

J Immunol. 2018 May 1;200(9):3259-3268. doi: 10.4049/jimmunol.1701086. Epub 2018 Mar 30.


GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis.

Ranganathan P, Shanmugam A, Swafford D, Suryawanshi A, Bhattacharjee P, Hussein MS, Koni PA, Prasad PD, Kurago ZB, Thangaraju M, Ganapathy V, Manicassamy S.

J Immunol. 2018 Mar 1;200(5):1781-1789. doi: 10.4049/jimmunol.1700604. Epub 2018 Jan 31.


Homeostatic PPARα Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine.

Manoharan I, Suryawanshi A, Hong Y, Ranganathan P, Shanmugam A, Ahmad S, Swafford D, Manicassamy B, Ramesh G, Koni PA, Thangaraju M, Manicassamy S.

J Immunol. 2016 Jun 1;196(11):4739-49. doi: 10.4049/jimmunol.1501489. Epub 2016 Apr 25.


B Cell-Specific MHC Class II Deletion Reveals Multiple Nonredundant Roles for B Cell Antigen Presentation in Murine Lupus.

Giles JR, Kashgarian M, Koni PA, Shlomchik MJ.

J Immunol. 2015 Sep 15;195(6):2571-9. doi: 10.4049/jimmunol.1500792. Epub 2015 Aug 12.


Health Facility Graduation from Donor-Supported Intensive Technical Assistance and Associated Factors in Zambia.

Koni P, Chishinga N, Nyirenda L, Kasonde P, Nsakanya R, Welsh M.

PLoS One. 2015 Jun 22;10(6):e0131084. doi: 10.1371/journal.pone.0131084. eCollection 2015.


B cell antigen presentation is sufficient to drive neuroinflammation in an animal model of multiple sclerosis.

Parker Harp CR, Archambault AS, Sim J, Ferris ST, Mikesell RJ, Koni PA, Shimoda M, Linington C, Russell JH, Wu GF.

J Immunol. 2015 Jun 1;194(11):5077-84. doi: 10.4049/jimmunol.1402236. Epub 2015 Apr 20.


Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.

Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, Mellor AL, Munn DH, Manicassamy S.

J Immunol. 2015 Apr 1;194(7):3295-304. doi: 10.4049/jimmunol.1402691. Epub 2015 Feb 20.


β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.

Hong Y, Manoharan I, Suryawanshi A, Majumdar T, Angus-Hill ML, Koni PA, Manicassamy B, Mellor AL, Munn DH, Manicassamy S.

Cancer Res. 2015 Feb 15;75(4):656-665. doi: 10.1158/0008-5472.CAN-14-2377. Epub 2015 Jan 7.


Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes.

Geem D, Medina-Contreras O, McBride M, Newberry RD, Koni PA, Denning TL.

J Immunol. 2014 Jul 1;193(1):431-8. doi: 10.4049/jimmunol.1303167. Epub 2014 Jun 4.


Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria.

Hepworth MR, Monticelli LA, Fung TC, Ziegler CG, Grunberg S, Sinha R, Mantegazza AR, Ma HL, Crawford A, Angelosanto JM, Wherry EJ, Koni PA, Bushman FD, Elson CO, Eberl G, Artis D, Sonnenberg GF.

Nature. 2013 Jun 6;498(7452):113-7. doi: 10.1038/nature12240. Epub 2013 May 22.


Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.

Koni PA, Bolduc A, Takezaki M, Ametani Y, Huang L, Lee JR, Nutt SL, Kamanaka M, Flavell RA, Mellor AL, Tsubata T, Shimoda M.

J Immunol. 2013 Apr 1;190(7):3189-96. doi: 10.4049/jimmunol.1203364. Epub 2013 Feb 25.


Reprogrammed foxp3(+) regulatory T cells provide essential help to support cross-presentation and CD8(+) T cell priming in naive mice.

Sharma MD, Hou DY, Baban B, Koni PA, He Y, Chandler PR, Blazar BR, Mellor AL, Munn DH.

Immunity. 2010 Dec 14;33(6):942-54. doi: 10.1016/j.immuni.2010.11.022. Epub 2010 Dec 9.


Constitutive CD40L expression on B cells prematurely terminates germinal center response and leads to augmented plasma cell production in T cell areas.

Bolduc A, Long E, Stapler D, Cascalho M, Tsubata T, Koni PA, Shimoda M.

J Immunol. 2010 Jul 1;185(1):220-30. doi: 10.4049/jimmunol.0901689. Epub 2010 May 26. Erratum in: J Immunol. 2010 Aug 15;185(4):2631.


B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase.

Johnson BA 3rd, Kahler DJ, Baban B, Chandler PR, Kang B, Shimoda M, Koni PA, Pihkala J, Vilagos B, Busslinger M, Munn DH, Mellor AL.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10644-8. doi: 10.1073/pnas.0914347107. Epub 2010 May 24.


Langerhans cells suppress contact hypersensitivity responses via cognate CD4 interaction and langerhans cell-derived IL-10.

Igyarto BZ, Jenison MC, Dudda JC, Roers A, Müller W, Koni PA, Campbell DJ, Shlomchik MJ, Kaplan DH.

J Immunol. 2009 Oct 15;183(8):5085-93. doi: 10.4049/jimmunol.0901884.


IDO activates regulatory T cells and blocks their conversion into Th17-like T cells.

Baban B, Chandler PR, Sharma MD, Pihkala J, Koni PA, Munn DH, Mellor AL.

J Immunol. 2009 Aug 15;183(4):2475-83. doi: 10.4049/jimmunol.0900986. Epub 2009 Jul 27.


The CXCL12 (SDF-1)/CXCR4 axis is essential for the development of renal vasculature.

Takabatake Y, Sugiyama T, Kohara H, Matsusaka T, Kurihara H, Koni PA, Nagasawa Y, Hamano T, Matsui I, Kawada N, Imai E, Nagasawa T, Rakugi H, Isaka Y.

J Am Soc Nephrol. 2009 Aug;20(8):1714-23. doi: 10.1681/ASN.2008060640. Epub 2009 May 14.


Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes.

Sharma MD, Hou DY, Liu Y, Koni PA, Metz R, Chandler P, Mellor AL, He Y, Munn DH.

Blood. 2009 Jun 11;113(24):6102-11. doi: 10.1182/blood-2008-12-195354. Epub 2009 Apr 14.


Differentiation of regulatory Foxp3+ T cells in the thymic cortex.

Liston A, Nutsch KM, Farr AG, Lund JM, Rasmussen JP, Koni PA, Rudensky AY.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11903-8. doi: 10.1073/pnas.0801506105. Epub 2008 Aug 11.


Generation of C57BL/6 knockout mice using C3H x BALB/c blastocysts.

Pacholczyk G, Suhag R, Mazurek M, Dederscheck SM, Koni PA.

Biotechniques. 2008 Mar;44(3):413-6. doi: 10.2144/000112706.


Regulation of immune response and inflammatory reactions against viral infection by VCAM-1.

Ou R, Zhang M, Huang L, Flavell RA, Koni PA, Moskophidis D.

J Virol. 2008 Mar;82(6):2952-65. doi: 10.1128/JVI.02191-07. Epub 2008 Jan 23.


MHC-restricted B-cell antigen presentation in memory B-cell maintenance and differentiation.

Shimoda M, Koni PA.

Crit Rev Immunol. 2007;27(1):47-60. Review.


Conditional ablation of MHC-II suggests an indirect role for MHC-II in regulatory CD4 T cell maintenance.

Shimoda M, Mmanywa F, Joshi SK, Li T, Miyake K, Pihkala J, Abbas JA, Koni PA.

J Immunol. 2006 Jun 1;176(11):6503-11.


Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung.

Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF.

Blood. 2006 Sep 1;108(5):1588-94. Epub 2006 May 2.


Role of MHC class II on memory B cells in post-germinal center B cell homeostasis and memory response.

Shimoda M, Li T, Pihkala JP, Koni PA.

J Immunol. 2006 Feb 15;176(4):2122-33.


Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells.

Cavanagh LL, Bonasio R, Mazo IB, Halin C, Cheng G, van der Velden AW, Cariappa A, Chase C, Russell P, Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH.

Nat Immunol. 2005 Oct;6(10):1029-37. Epub 2005 Sep 11.


The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.

Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A.

Genes Dev. 2005 Sep 1;19(17):2054-65. Epub 2005 Aug 17.


Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis.

Shen TL, Park AY, Alcaraz A, Peng X, Jang I, Koni P, Flavell RA, Gu H, Guan JL.

J Cell Biol. 2005 Jun 20;169(6):941-52.


VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin.

Ulyanova T, Scott LM, Priestley GV, Jiang Y, Nakamoto B, Koni PA, Papayannopoulou T.

Blood. 2005 Jul 1;106(1):86-94. Epub 2005 Mar 15.


Bone marrow is a major reservoir and site of recruitment for central memory CD8+ T cells.

Mazo IB, Honczarenko M, Leung H, Cavanagh LL, Bonasio R, Weninger W, Engelke K, Xia L, McEver RP, Koni PA, Silberstein LE, von Andrian UH.

Immunity. 2005 Feb;22(2):259-70.


Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2.

Abonia JP, Austen KF, Rollins BJ, Joshi SK, Flavell RA, Kuziel WA, Koni PA, Gurish MF.

Blood. 2005 Jun 1;105(11):4308-13. Epub 2005 Feb 10.


The role of CXCL12 in the organ-specific process of artery formation.

Ara T, Tokoyoda K, Okamoto R, Koni PA, Nagasawa T.

Blood. 2005 Apr 15;105(8):3155-61. Epub 2004 Dec 30.


Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes.

Munn DH, Sharma MD, Hou D, Baban B, Lee JR, Antonia SJ, Messina JL, Chandler P, Koni PA, Mellor AL.

J Clin Invest. 2004 Jul;114(2):280-90. Erratum in: J Clin Invest. 2004 Aug;114(4):599.


The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity.

Xu J, Wang P, Li Y, Li G, Kaczmarek LK, Wu Y, Koni PA, Flavell RA, Desir GV.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3112-7. Epub 2004 Feb 23.


Kv1.3 channel gene-targeted deletion produces "Super-Smeller Mice" with altered glomeruli, interacting scaffolding proteins, and biophysics.

Fadool DA, Tucker K, Perkins R, Fasciani G, Thompson RN, Parsons AD, Overton JM, Koni PA, Flavell RA, Kaczmarek LK.

Neuron. 2004 Feb 5;41(3):389-404.


Cutting edge: induced indoleamine 2,3 dioxygenase expression in dendritic cell subsets suppresses T cell clonal expansion.

Mellor AL, Baban B, Chandler P, Marshall B, Jhaver K, Hansen A, Koni PA, Iwashima M, Munn DH.

J Immunol. 2003 Aug 15;171(4):1652-5.


Compensatory anion currents in Kv1.3 channel-deficient thymocytes.

Koni PA, Khanna R, Chang MC, Tang MD, Kaczmarek LK, Schlichter LC, Flavella RA.

J Biol Chem. 2003 Oct 10;278(41):39443-51. Epub 2003 Jul 22.


Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination.

Suzuki A, Kaisho T, Ohishi M, Tsukio-Yamaguchi M, Tsubata T, Koni PA, Sasaki T, Mak TW, Nakano T.

J Exp Med. 2003 Mar 3;197(5):657-67.


The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight.

Xu J, Koni PA, Wang P, Li G, Kaczmarek L, Wu Y, Li Y, Flavell RA, Desir GV.

Hum Mol Genet. 2003 Mar 1;12(5):551-9.


STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity.

Welte T, Zhang SS, Wang T, Zhang Z, Hesslein DG, Yin Z, Kano A, Iwamoto Y, Li E, Craft JE, Bothwell AL, Fikrig E, Koni PA, Flavell RA, Fu XY.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1879-84. Epub 2003 Feb 5.


Induced DNA recombination by Cre recombinase protein transduction.

Joshi SK, Hashimoto K, Koni PA.

Genesis. 2002 May;33(1):48-54.


Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion.

Oldstone MB, Race R, Thomas D, Lewicki H, Homann D, Smelt S, Holz A, Koni P, Lo D, Chesebro B, Flavell R.

J Virol. 2002 May;76(9):4357-63.


A conditional null allele of the major histocompatibility IA-beta chain gene.

Hashimoto K, Joshi SK, Koni PA.

Genesis. 2002 Feb;32(2):152-3. No abstract available.


Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches.

Spahn TW, Fontana A, Faria AM, Slavin AJ, Eugster HP, Zhang X, Koni PA, Ruddle NH, Flavell RA, Rennert PD, Weiner HL.

Eur J Immunol. 2001 Apr;31(4):1278-87.


Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow.

Koni PA, Joshi SK, Temann UA, Olson D, Burkly L, Flavell RA.

J Exp Med. 2001 Mar 19;193(6):741-54.


Follicular dendritic cells and dissemination of Creutzfeldt-Jakob disease.

Manuelidis L, Zaitsev I, Koni P, Lu ZY, Flavell RA, Fritch W.

J Virol. 2000 Sep;74(18):8614-22.


Lymphotoxin-beta-deficient mice show defective antiviral immunity.

Berger DP, Naniche D, Crowley MT, Koni PA, Flavell RA, Oldstone MB.

Virology. 1999 Jul 20;260(1):136-47.


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