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A Novel Angiotensin-(1-7)-glycosylated Mas Receptor Agonist for Treating Vascular Cognitive Impairment and Inflammation Related Memory Dysfunction.

Hay M, Polt R, Heien ML, Vanderah TW, Largen-Milnes TM, Rodgers KE, Falk T, Bartlett MJ, Doyle K, Konhilas J.

J Pharmacol Exp Ther. 2019 Feb 1. pii: jpet.118.254854. doi: 10.1124/jpet.118.254854. [Epub ahead of print]


Liquefaction of the Brain following Stroke Shares a Similar Molecular and Morphological Profile with Atherosclerosis and Mediates Secondary Neurodegeneration in an Osteopontin-Dependent Mechanism.

Chung AG, Frye JB, Zbesko JC, Constantopoulos E, Hayes M, Figueroa AG, Becktel DA, Antony Day W, Konhilas JP, McKay BS, Nguyen TV, Doyle KP.

eNeuro. 2018 Nov 8;5(5). pii: ENEURO.0076-18.2018. doi: 10.1523/ENEURO.0076-18.2018. eCollection 2018 Sep-Oct.


Cardiac-specific knockout of Lmod2 results in a severe reduction in myofilament force production and rapid cardiac failure.

Pappas CT, Farman GP, Mayfield RM, Konhilas JP, Gregorio CC.

J Mol Cell Cardiol. 2018 Sep;122:88-97. doi: 10.1016/j.yjmcc.2018.08.009. Epub 2018 Aug 11.


Remodeling Failing Human Myocardium With Hybrid Cell/Matrix and Transmyocardial Revascularization.

Avery RJ, Yu SK, Cherukuri G, Runyan RB, Konhilas J, Khalpey ZI.

ASAIO J. 2018 Sep/Oct;64(5):e130-e133. doi: 10.1097/MAT.0000000000000727.


Cyclin D2 is a critical mediator of exercise-induced cardiac hypertrophy.

Luckey SW, Haines CD, Konhilas JP, Luczak ED, Messmer-Kratzsch A, Leinwand LA.

Exp Biol Med (Maywood). 2017 Dec;242(18):1820-1830. doi: 10.1177/1535370217731503. Epub 2017 Sep 13.


A dual therapy of off-pump temporary left ventricular extracorporeal device and amniotic stem cell for cardiogenic shock.

Kazui T, Tran PL, Pilikian TR, Marsh KM, Runyan R, Konhilas J, Smith R, Khalpey ZI.

J Cardiothorac Surg. 2017 Sep 7;12(1):80. doi: 10.1186/s13019-017-0648-7.


Improved metabolism and redox state with a novel preservation solution: implications for donor lungs after cardiac death (DCD).

Schipper DA, Louis AV, Dicken DS, Johnson K, Smolenski RT, Black SM, Runyan R, Konhilas J, Garcia JGN, Khalpey Z.

Pulm Circ. 2017 Apr-Jun;7(2):494-504. doi: 10.1177/2045893217706065. Epub 2017 May 24.


Molecular Mechanisms Underlying Cardiac Adaptation to Exercise.

Vega RB, Konhilas JP, Kelly DP, Leinwand LA.

Cell Metab. 2017 May 2;25(5):1012-1026. doi: 10.1016/j.cmet.2017.04.025. Review.


Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse.

Danilo CA, Constantopoulos E, McKee LA, Chen H, Regan JA, Lipovka Y, Lahtinen S, Stenman LK, Nguyen TV, Doyle KP, Slepian MJ, Khalpey ZI, Konhilas JP.

Benef Microbes. 2017 Apr 26;8(2):257-269. doi: 10.3920/BM2016.0119. Epub 2017 Apr 14.


Cognitive impairment in heart failure: A protective role for angiotensin-(1-7).

Hay M, Vanderah TW, Samareh-Jahani F, Constantopoulos E, Uprety AR, Barnes CA, Konhilas J.

Behav Neurosci. 2017 Feb;131(1):99-114. doi: 10.1037/bne0000182. Epub 2017 Jan 5.


Sex dimorphisms of crossbridge cycling kinetics in transgenic hypertrophic cardiomyopathy mice.

Birch CL, Behunin SM, Lopez-Pier MA, Danilo C, Lipovka Y, Saripalli C, Granzier H, Konhilas JP.

Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H125-36. doi: 10.1152/ajpheart.00592.2015. Epub 2016 May 6.


The complex nature of oestrogen signalling in breast cancer: enemy or ally?

Lipovka Y, Konhilas JP.

Biosci Rep. 2016 Jun 30;36(3). pii: e00352. doi: 10.1042/BSR20160017. Print 2016 Jul. Review.


The impact of post-exercise hydration with deep-ocean mineral water on rehydration and exercise performance.

Keen DA, Constantopoulos E, Konhilas JP.

J Int Soc Sports Nutr. 2016 Apr 16;13:17. doi: 10.1186/s12970-016-0129-8. eCollection 2016.


Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes.

Behunin SM, Lopez-Pier MA, Mayfield RM, Danilo CA, Lipovka Y, Birch C, Lehman S, Tardiff JC, Gregorio CC, Konhilas JP.

Arch Biochem Biophys. 2016 Jul 1;601:32-41. doi: 10.1016/ Epub 2016 Mar 10.


AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy.

Lipovka Y, Konhilas JP.

Cardiovasc Pharm Open Access. 2015 Aug;4(3). pii: 154. Epub 2015 Aug 31.


ANG II-induced hypertension in the VCD mouse model of menopause is prevented by estrogen replacement during perimenopause.

Pollow DP Jr, Romero-Aleshire MJ, Sanchez JN, Konhilas JP, Brooks HL.

Am J Physiol Regul Integr Comp Physiol. 2015 Dec 15;309(12):R1546-52. doi: 10.1152/ajpregu.00170.2015. Epub 2015 Oct 21.


Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase.

Lipovka Y, Chen H, Vagner J, Price TJ, Tsao TS, Konhilas JP.

Biosci Rep. 2015 Sep 15;35(5). pii: e00264. doi: 10.1042/BSR20150074.


Nebulin deficiency in adult muscle causes sarcomere defects and muscle-type-dependent changes in trophicity: novel insights in nemaline myopathy.

Li F, Buck D, De Winter J, Kolb J, Meng H, Birch C, Slater R, Escobar YN, Smith JE 3rd, Yang L, Konhilas J, Lawlor MW, Ottenheijm C, Granzier HL.

Hum Mol Genet. 2015 Sep 15;24(18):5219-33. doi: 10.1093/hmg/ddv243. Epub 2015 Jun 29.


LKB1/Mo25/STRAD uniquely impacts sarcomeric contractile function and posttranslational modification.

Behunin SM, Lopez-Pier MA, Birch CL, McKee LAK, Danilo C, Khalpey Z, Konhilas JP.

Biophys J. 2015 Mar 24;108(6):1484-1494. doi: 10.1016/j.bpj.2015.02.012.


Diet and sex modify exercise and cardiac adaptation in the mouse.

Konhilas JP, Chen H, Luczak E, McKee LA, Regan J, Watson PA, Stauffer BL, Khalpey ZI, Mckinsey TA, Horn T, LaFleur B, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2015 Jan 15;308(2):H135-45. doi: 10.1152/ajpheart.00532.2014. Epub 2014 Nov 14.


Rapid porcine lung decellularization using a novel organ regenerative control acquisition bioreactor.

Khalpey Z, Qu N, Hemphill C, Louis AV, Ferng AS, Son TG, Stavoe K, Penick K, Tran PL, Konhilas J, Lagrand DS, Garcia JG.

ASAIO J. 2015 Jan-Feb;61(1):71-7. doi: 10.1097/MAT.0000000000000159.


First in man: adipose-derived stromal vascular fraction cells may promote restorative cardiac function.

Khalpey Z, Janardhanan R, Konhilas J, Hemphill C.

Am J Med. 2014 May;127(5):e11-2. doi: 10.1016/j.amjmed.2013.12.024. No abstract available.


A method to study the impact of chemically-induced ovarian failure on exercise capacity and cardiac adaptation in mice.

Chen H, Perez JN, Constantopoulos E, McKee L, Regan J, Hoyer PB, Brooks HL, Konhilas J.

J Vis Exp. 2014 Apr 7;(86). doi: 10.3791/51083.


Temporal and morphological impact of pressure overload in transgenic FHC mice.

Chen H, Hwang H, McKee LA, Perez JN, Regan JA, Constantopoulos E, Lafleur B, Konhilas JP.

Front Physiol. 2013 Aug 27;4:205. doi: 10.3389/fphys.2013.00205. eCollection 2013.


Effects of chemically induced ovarian failure on voluntary wheel-running exercise and cardiac adaptation in mice.

Perez JN, Chen H, Regan JA, Emert A, Constantopoulos E, Lynn M, Konhilas JP.

Comp Med. 2013 Jun;63(3):233-43.


Sexually dimorphic myofilament function and cardiac troponin I phosphospecies distribution in hypertrophic cardiomyopathy mice.

McKee LA, Chen H, Regan JA, Behunin SM, Walker JW, Walker JS, Konhilas JP.

Arch Biochem Biophys. 2013 Jul 1;535(1):39-48. doi: 10.1016/ Epub 2013 Jan 23.


Keeping the beat. Focus on "enrichment of neonatal rat cardiomyocytes in primary culture facilitates long-term maintenance of contractility in vitro".

Konhilas JP, Behunin SM, Lynch RM.

Am J Physiol Cell Physiol. 2012 Dec 15;303(12):C1218-9. doi: 10.1152/ajpcell.00310.2012. Epub 2012 Sep 26. No abstract available.


Micro-RNA-195 and -451 regulate the LKB1/AMPK signaling axis by targeting MO25.

Chen H, Untiveros GM, McKee LA, Perez J, Li J, Antin PB, Konhilas JP.

PLoS One. 2012;7(7):e41574. doi: 10.1371/journal.pone.0041574. Epub 2012 Jul 23.


Estrogenic compounds are not always cardioprotective and can be lethal in males with genetic heart disease.

Haines CD, Harvey PA, Luczak ED, Barthel KK, Konhilas JP, Watson PA, Stauffer BL, Leinwand LA.

Endocrinology. 2012 Sep;153(9):4470-9. doi: 10.1210/en.2012-1391. Epub 2012 Jul 9.


Inhibition of ovarian KIT phosphorylation by the ovotoxicant 4-vinylcyclohexene diepoxide in rats.

Mark-Kappeler CJ, Sen N, Lukefahr A, McKee L, Sipes IG, Konhilas J, Hoyer PB.

Biol Reprod. 2011 Oct;85(4):755-62. doi: 10.1095/biolreprod.111.092742. Epub 2011 Jun 15.


Remodeling the cardiac transcriptional landscape with diet.

Luczak ED, Barthel KK, Stauffer BL, Konhilas JP, Cheung TH, Leinwand LA.

Physiol Genomics. 2011 Jun 28;43(12):772-80. doi: 10.1152/physiolgenomics.00237.2010. Epub 2011 Apr 12.


The role of MEKK1 in hypertrophic cardiomyopathy.

Konhilas JP, Boucek DM, Horn TR, Johnson GL, Leinwand LA.

Int Heart J. 2010 Jul;51(4):277-84.


What we know and do not know about sex and cardiac disease.

Konhilas JP.

J Biomed Biotechnol. 2010;2010:562051. doi: 10.1155/2010/562051. Epub 2010 Apr 22. Review.


Clinical Experience of a Diet Designed to Reduce Aging.

Rosedale R, Westman EC, Konhilas JP.

J Appl Res. 2009 Jan 1;9(4):159-165.


Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?

Jensen DR, Knaub LA, Konhilas JP, Leinwand LA, MacLean PS, Eckel RH.

J Lipid Res. 2008 Apr;49(4):870-9. doi: 10.1194/jlr.M700519-JLR200. Epub 2008 Jan 5.


What makes a dead cell attractive?

Konhilas JP.

J Appl Physiol (1985). 2008 Mar;104(3):573-4. doi: 10.1152/japplphysiol.01376.2007. Epub 2008 Jan 3. No abstract available.


The effects of biological sex and diet on the development of heart failure.

Konhilas JP, Leinwand LA.

Circulation. 2007 Dec 4;116(23):2747-59. Review. No abstract available.


Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise.

Watson PA, Reusch JE, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Sparagna GC, Long CS, Moore RL.

Am J Physiol Heart Circ Physiol. 2007 Jul;293(1):H246-59. Epub 2007 Mar 2.


Partnering up for cardiac hypertrophy.

Konhilas JP, Leinwand LA.

Circ Res. 2006 Apr 28;98(8):985-7. No abstract available.


Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy.

Konhilas JP, Watson PA, Maass A, Boucek DM, Horn T, Stauffer BL, Luckey SW, Rosenberg P, Leinwand LA.

Circ Res. 2006 Mar 3;98(4):540-8. Epub 2006 Jan 26.


Soy diet worsens heart disease in mice.

Stauffer BL, Konhilas JP, Luczak ED, Leinwand LA.

J Clin Invest. 2006 Jan;116(1):209-16.


Loaded wheel running and muscle adaptation in the mouse.

Konhilas JP, Widegren U, Allen DL, Paul AC, Cleary A, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H455-65. Epub 2005 Feb 25.


Sex modifies exercise and cardiac adaptation in mice.

Konhilas JP, Maass AH, Luckey SW, Stauffer BL, Olson EN, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2768-76. Epub 2004 Aug 19.


From sarcomeric mutations to heart disease: understanding familial hypertrophic cardiomyopathy.

Maass A, Konhilas JP, Stauffer BL, Leinwand LA.

Cold Spring Harb Symp Quant Biol. 2002;67:409-15. Review. No abstract available.


Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing.

Konhilas JP, Irving TC, Wolska BM, Jweied EE, Martin AF, Solaro RJ, de Tombe PP.

J Physiol. 2003 Mar 15;547(Pt 3):951-61. Epub 2003 Jan 24.


Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation.

Konhilas JP, Irving TC, de Tombe PP.

Pflugers Arch. 2002 Dec;445(3):305-10. Epub 2002 Nov 1. Review. No abstract available.


Length-dependent activation in three striated muscle types of the rat.

Konhilas JP, Irving TC, de Tombe PP.

J Physiol. 2002 Oct 1;544(Pt 1):225-36.


Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.

Pieples K, Arteaga G, Solaro RJ, Grupp I, Lorenz JN, Boivin GP, Jagatheesan G, Labitzke E, DeTombe PP, Konhilas JP, Irving TC, Wieczorek DF.

Am J Physiol Heart Circ Physiol. 2002 Oct;283(4):H1344-53. Epub 2002 Jun 13.


Cooperative activation in cardiac muscle: impact of sarcomere length.

Dobesh DP, Konhilas JP, de Tombe PP.

Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H1055-62.


Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing.

Konhilas JP, Irving TC, de Tombe PP.

Circ Res. 2002 Jan 11;90(1):59-65.


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