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DNA Methylome and Transcriptome Alterations in High Glucose-Induced Diabetic Nephropathy Cellular Model and Identification of Novel Targets for Treatment by Tanshinone IIA.

Li W, Sargsyan D, Wu R, Li S, Wang L, Cheng D, Kong AN.

Chem Res Toxicol. 2019 Sep 17. doi: 10.1021/acs.chemrestox.9b00117. [Epub ahead of print]


Anthocyanin Delphinidin Prevents Neoplastic Transformation of Mouse Skin JB6 P+ Cells: Epigenetic Re-activation of Nrf2-ARE Pathway.

Kuo HD, Wu R, Li S, Yang AY, Kong AN.

AAPS J. 2019 Jun 28;21(5):83. doi: 10.1208/s12248-019-0355-5.


DNA methylome and transcriptome alterations and cancer prevention by triterpenoid ursolic acid in UVB-induced skin tumor in mice.

Yang Y, Yin R, Wu R, Ramirez CN, Sargsyan D, Li S, Wang L, Cheng D, Wang C, Hudlikar R, Kuo HC, Lu Y, Kong AN.

Mol Carcinog. 2019 Oct;58(10):1738-1753. doi: 10.1002/mc.23046. Epub 2019 Jun 25.


Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation.

Li S, Li W, Wang C, Wu R, Yin R, Kuo HC, Wang L, Kong AN.

Chem Biol Interact. 2019 Aug 25;309:108701. doi: 10.1016/j.cbi.2019.06.014. Epub 2019 Jun 7.


Quality of life of children with tuberous sclerosis complex.

Fong CY, Ng K, Kong AN, Ong LC, Rithauddin MA, Thong MK, Ganesan V, Heng HS, Teh CM, Yahya N.

Arch Dis Child. 2019 Oct;104(10):972-978. doi: 10.1136/archdischild-2018-316394. Epub 2019 May 23.


CpG methyl-seq and RNA-seq epigenomic and transcriptomic studies on the preventive effects of Moringa isothiocyanate in mouse epidermal JB6 cells induced by the tumor promoter TPA.

Wang C, Wu R, Sargsyan D, Zheng M, Li S, Yin R, Su S, Raskin I, Kong AN.

J Nutr Biochem. 2019 Jun;68:69-78. doi: 10.1016/j.jnutbio.2019.03.011. Epub 2019 Mar 28.


Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers.

Cheng D, Li W, Wang L, Lin T, Poiani G, Wassef A, Hudlikar R, Ondar P, Brunetti L, Kong AN.

Mol Pharm. 2019 May 6;16(5):1881-1889. doi: 10.1021/acs.molpharmaceut.8b01246. Epub 2019 Mar 28.


Epigenetic modifications but not genetic polymorphisms regulate KEAP1 expression in colorectal cancer.

Gao L, Yuan F, Che G, Xiao X, Nie X, Wang Y, Jia J, Kong AN, Zhang L.

J Cell Biochem. 2019 Aug;120(8):12311-12320. doi: 10.1002/jcb.28495. Epub 2019 Mar 1.


Moringa Isothiocyanate Activates Nrf2: Potential Role in Diabetic Nephropathy.

Cheng D, Gao L, Su S, Sargsyan D, Wu R, Raskin I, Kong AN.

AAPS J. 2019 Feb 19;21(2):31. doi: 10.1208/s12248-019-0301-6.


UVB drives different stages of epigenome alterations during progression of skin cancer.

Yang Y, Wu R, Sargsyan D, Yin R, Kuo HC, Yang I, Wang L, Cheng D, Wang C, Li S, Hudlikar R, Lu Y, Kong AN.

Cancer Lett. 2019 May 1;449:20-30. doi: 10.1016/j.canlet.2019.02.010. Epub 2019 Feb 13.


Paris Saponin II inhibits colorectal carcinogenesis by regulating mitochondrial fission and NF-κB pathway.

Chen M, Ye K, Zhang B, Xin Q, Li P, Kong AN, Wen X, Yang J.

Pharmacol Res. 2019 Jan;139:273-285. doi: 10.1016/j.phrs.2018.11.029. Epub 2018 Nov 22.


Transcriptomic Analysis of Histone Methyltransferase Setd7 Knockdown and Phenethyl Isothiocyanate in Human Prostate Cancer Cells.

Wang C, Sargsyan D, Zhang C, Wu R, Yang Y, Kong AN.

Anticancer Res. 2018 Nov;38(11):6069-6083. doi: 10.21873/anticanres.12957.


Sophora flavescens Containing-QYJD Formula Activates Nrf2 Anti-Oxidant Response, Blocks Cellular Transformation and Protects Against DSS-Induced Colitis in Mouse Model.

Fang R, Wu R, Zuo Q, Yin R, Zhang C, Wang C, Guo Y, Yang AY, Li W, Lin L, Kong AN.

Am J Chin Med. 2018 Oct 4:1-15. doi: 10.1142/S0192415X18500829. [Epub ahead of print]


Nrf2 deletion results in impaired performance in memory tasks and hyperactivity in mature and aged mice.

Gergues MM, Moiseyenko A, Saad SZ, Kong AN, Wagner GC.

Brain Res. 2018 Dec 15;1701:103-111. doi: 10.1016/j.brainres.2018.08.033. Epub 2018 Sep 5.


The dietary flavone luteolin epigenetically activates the Nrf2 pathway and blocks cell transformation in human colorectal cancer HCT116 cells.

Zuo Q, Wu R, Xiao X, Yang C, Yang Y, Wang C, Lin L, Kong AN.

J Cell Biochem. 2018 Nov;119(11):9573-9582. doi: 10.1002/jcb.27275. Epub 2018 Aug 20.


Pharmacokinetics and Pharmacodynamics of Curcumin in regulating anti-inflammatory and epigenetic gene expression.

Boyanapalli SSS, Huang Y, Su Z, Cheng D, Zhang C, Guo Y, Rao R, Androulakis IP, Kong AN.

Biopharm Drug Dispos. 2018 Jun;39(6):289-297. doi: 10.1002/bdd.2136.


A Novel Triple Stage Ion Trap MS method validated for curcumin pharmacokinetics application: A comparison summary of the latest validated curcumin LC/MS methods.

Li W, Yang H, Buckley B, Wang L, Kong AN.

J Pharm Biomed Anal. 2018 Jul 15;156:116-124. doi: 10.1016/j.jpba.2018.04.022. Epub 2018 Apr 17.


Fucoxanthin Elicits Epigenetic Modifications, Nrf2 Activation and Blocking Transformation in Mouse Skin JB6 P+ Cells.

Yang Y, Yang I, Cao M, Su ZY, Wu R, Guo Y, Fang M, Kong AN.

AAPS J. 2018 Feb 20;20(2):32. doi: 10.1208/s12248-018-0197-6.


DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice.

Guo Y, Wu R, Gaspar JM, Sargsyan D, Su ZY, Zhang C, Gao L, Cheng D, Li W, Wang C, Yin R, Fang M, Verzi MP, Hart RP, Kong AN.

Carcinogenesis. 2018 May 3;39(5):669-680. doi: 10.1093/carcin/bgy043.


Sulforaphane epigenetically demethylates the CpG sites of the miR-9-3 promoter and reactivates miR-9-3 expression in human lung cancer A549 cells.

Gao L, Cheng D, Yang J, Wu R, Li W, Kong AN.

J Nutr Biochem. 2018 Jun;56:109-115. doi: 10.1016/j.jnutbio.2018.01.015. Epub 2018 Feb 9.


Quality of life in Malaysian children with epilepsy.

Fong CY, Chang WM, Kong AN, Rithauddin AM, Khoo TB, Ong LC.

Epilepsy Behav. 2018 Mar;80:15-20. doi: 10.1016/j.yebeh.2017.12.032. Epub 2018 Jan 20.


Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells.

Wang C, Shu L, Zhang C, Li W, Wu R, Guo Y, Yang Y, Kong AN.

Mol Nutr Food Res. 2018 Sep;62(18):e1700840. doi: 10.1002/mnfr.201700840. Epub 2018 Mar 6.


Epigenetic alterations in TRAMP mice: epigenome DNA methylation profiling using MeDIP-seq.

Li W, Huang Y, Sargsyan D, Khor TO, Guo Y, Shu L, Yang AY, Zhang C, Paredes-Gonzalez X, Verzi M, Hart RP, Kong AN.

Cell Biosci. 2018 Jan 12;8:3. doi: 10.1186/s13578-018-0201-y. eCollection 2018.


Red Ginseng Oil Inhibits TPA-Induced Transformation of Skin Epidermal JB6 Cells.

Truong VL, Kong AN, Jeong WS.

J Med Food. 2018 Apr;21(4):380-389. doi: 10.1089/jmf.2017.4082. Epub 2017 Dec 22.


In Vitro-In Vivo Dose Response of Ursolic Acid, Sulforaphane, PEITC, and Curcumin in Cancer Prevention.

Ramirez CN, Li W, Zhang C, Wu R, Su S, Wang C, Gao L, Yin R, Kong AN.

AAPS J. 2017 Dec 20;20(1):19. doi: 10.1208/s12248-017-0177-2. Erratum in: AAPS J. 2018 Feb 6;20(2):27.


The triterpenoid corosolic acid blocks transformation and epigenetically reactivates Nrf2 in TRAMP-C1 prostate cells.

Yang J, Wu R, Li W, Gao L, Yang Y, Li P, Kong AN.

Mol Carcinog. 2018 Apr;57(4):512-521. doi: 10.1002/mc.22776. Epub 2018 Jan 11.


Curcumin Derivative Epigenetically Reactivates Nrf2 Antioxidative Stress Signaling in Mouse Prostate Cancer TRAMP C1 Cells.

Li W, Su ZY, Guo Y, Zhang C, Wu R, Gao L, Zheng X, Du ZY, Zhang K, Kong AN.

Chem Res Toxicol. 2018 Feb 19;31(2):88-96. doi: 10.1021/acs.chemrestox.7b00248. Epub 2018 Jan 8.


DACT2 Epigenetic Stimulator Exerts Dual Efficacy for Colorectal Cancer Prevention and Treatment.

Lu L, Wang Y, Ou R, Feng Q, Ji L, Zheng H, Guo Y, Qi X, Kong AN, Liu Z.

Pharmacol Res. 2018 Mar;129:318-328. doi: 10.1016/j.phrs.2017.11.032. Epub 2017 Dec 1.


Determinants of low bone mineral density in children with epilepsy.

Fong CY, Kong AN, Noordin M, Poh BK, Ong LC, Ng CC.

Eur J Paediatr Neurol. 2018 Jan;22(1):155-163. doi: 10.1016/j.ejpn.2017.10.007. Epub 2017 Oct 24.


Regulation of Keap1-Nrf2 signaling: The role of epigenetics.

Cheng D, Wu R, Guo Y, Kong AN.

Curr Opin Toxicol. 2016 Dec;1:134-138. doi: 10.1016/j.cotox.2016.10.008. Epub 2016 Nov 5.


Pharmacokinetics and Pharmacodynamics of the Triterpenoid Ursolic Acid in Regulating the Antioxidant, Anti-inflammatory, and Epigenetic Gene Responses in Rat Leukocytes.

Zhang C, Wang C, Li W, Wu R, Guo Y, Cheng D, Yang Y, Androulakis IP, Kong AN.

Mol Pharm. 2017 Nov 6;14(11):3709-3717. doi: 10.1021/acs.molpharmaceut.7b00469. Epub 2017 Oct 25.


Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling.

Cao M, Wang H, Guo L, Yang S, Liu C, Khor TO, Yu S, Kong AN.

AAPS J. 2017 Nov;19(6):1703-1714. doi: 10.1208/s12248-017-0133-1. Epub 2017 Aug 21.


Provision of sudden unexpected death in epilepsy (SUDEP) information among Malaysian parents of children with epilepsy.

Fong CY, Lim WK, Kong AN, Lua PL, Ong LC.

Epilepsy Behav. 2017 Oct;75:6-12. doi: 10.1016/j.yebeh.2017.06.037. Epub 2017 Aug 12.


Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications.

Kuang H, Tang Z, Zhang C, Wang Z, Li W, Yang C, Wang Q, Yang B, Kong AN.

Int J Mol Sci. 2017 Jul 17;18(7). pii: E1546. doi: 10.3390/ijms18071546.


Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq.

Guo Y, Su ZY, Zhang C, Gaspar JM, Wang R, Hart RP, Verzi MP, Kong AN.

Biochem Pharmacol. 2017 Jul 1;135:22-34. doi: 10.1016/j.bcp.2017.02.021. Epub 2017 Mar 4.


Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics.

Li W, Guo Y, Zhang C, Wu R, Yang AY, Gaspar J, Kong AN.

Chem Res Toxicol. 2016 Dec 19;29(12):2071-2095. Epub 2016 Dec 5.


Epigenetic CpG Methylation of the Promoter and Reactivation of the Expression of GSTP1 by Astaxanthin in Human Prostate LNCaP Cells.

Yang Y, Fuentes F, Shu L, Wang C, Pung D, Li W, Zhang C, Guo Y, Kong AN.

AAPS J. 2017 Mar;19(2):421-430. doi: 10.1208/s12248-016-0016-x. Epub 2016 Dec 2.


A naturally occurring mixture of tocotrienols inhibits the growth of human prostate tumor, associated with epigenetic modifications of cyclin-dependent kinase inhibitors p21 and p27.

Huang Y, Wu R, Su ZY, Guo Y, Zheng X, Yang CS, Kong AN.

J Nutr Biochem. 2017 Feb;40:155-163. doi: 10.1016/j.jnutbio.2016.10.019. Epub 2016 Nov 4.


Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells.

Boyanapalli SS, Li W, Fuentes F, Guo Y, Ramirez CN, Gonzalez XP, Pung D, Kong AN.

Pharmacol Res. 2016 Dec;114:175-184. doi: 10.1016/j.phrs.2016.10.021. Epub 2016 Nov 3.


Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1.

Zhang C, Su ZY, Wang L, Shu L, Yang Y, Guo Y, Pung D, Bountra C, Kong AN.

Biochem Pharmacol. 2016 Oct 1;117:35-45. doi: 10.1016/j.bcp.2016.08.009. Epub 2016 Aug 9.


Corynoline Isolated from Corydalis bungeana Turcz. Exhibits Anti-Inflammatory Effects via Modulation of Nfr2 and MAPKs.

Yang C, Zhang C, Wang Z, Tang Z, Kuang H, Kong AN.

Molecules. 2016 Jul 27;21(8). pii: E975. doi: 10.3390/molecules21080975.


Vitamin D deficiency and its risk factors in Malaysian children with epilepsy.

Fong CY, Kong AN, Poh BK, Mohamed AR, Khoo TB, Ng RL, Noordin M, Nadarajaw T, Ong LC.

Epilepsia. 2016 Aug;57(8):1271-9. doi: 10.1111/epi.13443. Epub 2016 Jul 5.


Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells.

Kim H, Ramirez CN, Su ZY, Kong AN.

J Nutr Biochem. 2016 Jul;33:54-62. doi: 10.1016/j.jnutbio.2015.09.014. Epub 2015 Sep 28.


The epigenetic effects of aspirin: the modification of histone H3 lysine 27 acetylation in the prevention of colon carcinogenesis in azoxymethane- and dextran sulfate sodium-treated CF-1 mice.

Guo Y, Liu Y, Zhang C, Su ZY, Li W, Huang MT, Kong AN.

Carcinogenesis. 2016 Jun;37(6):616-624. doi: 10.1093/carcin/bgw042. Epub 2016 Apr 9.


Epigenetics Reactivation of Nrf2 in Prostate TRAMP C1 Cells by Curcumin Analogue FN1.

Li W, Pung D, Su ZY, Guo Y, Zhang C, Yang AY, Zheng X, Du ZY, Zhang K, Kong AN.

Chem Res Toxicol. 2016 Apr 18;29(4):694-703. doi: 10.1021/acs.chemrestox.6b00016. Epub 2016 Mar 29.


Reserpine Inhibit the JB6 P+ Cell Transformation Through Epigenetic Reactivation of Nrf2-Mediated Anti-oxidative Stress Pathway.

Hong B, Su Z, Zhang C, Yang Y, Guo Y, Li W, Kong AN.

AAPS J. 2016 May;18(3):659-69. doi: 10.1208/s12248-016-9901-6. Epub 2016 Mar 17.


Protein arginine methyltransferase 1 may be involved in pregnane x receptor-activated overexpression of multidrug resistance 1 gene during acquired multidrug resistant.

Li T, Kong AN, Ma Z, Liu H, Liu P, Xiao Y, Jiang X, Wang L.

Oncotarget. 2016 Apr 12;7(15):20236-48. doi: 10.18632/oncotarget.7752.


Phenethyl isothiocyanate (PEITC) suppresses prostate cancer cell invasion epigenetically through regulating microRNA-194.

Zhang C, Shu L, Kim H, Khor TO, Wu R, Li W, Kong AN.

Mol Nutr Food Res. 2016 Jun;60(6):1427-36. doi: 10.1002/mnfr.201500918. Epub 2016 May 17.


Rh2E2, a novel metabolic suppressor, specifically inhibits energy-based metabolism of tumor cells.

Wong VK, Dong H, Liang X, Bai LP, Jiang ZH, Guo Y, Kong AN, Wang R, Kam RK, Law BY, Hsiao WW, Chan KM, Wang J, Chan RW, Guo J, Zhang W, Yen FG, Zhou H, Leung EL, Yu Z, Liu L.

Oncotarget. 2016 Mar 1;7(9):9907-24. doi: 10.18632/oncotarget.6934.


MicroRNAs: New players in cancer prevention targeting Nrf2, oxidative stress and inflammatory pathways.

Zhang C, Shu L, Kong AN.

Curr Pharmacol Rep. 2015 Feb;1(1):21-30. Epub 2015 Jan 11.

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