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Items: 37

1.

Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.

Pichkur EB, Paleskava A, Tereshchenkov AG, Kasatsky P, Komarova E, Shiriaev D, Bogdanov A, Dontsova OA, Osterman I, Sergiev PV, Polikanov YS, Myasnikov AG, Konevega AL.

RNA. 2020 Mar 6. pii: rna.073817.119. doi: 10.1261/rna.073817.119. [Epub ahead of print]

PMID:
32144191
2.

How the initiating ribosome copes with ppGpp to translate mRNAs.

Vinogradova DS, Zegarra V, Maksimova E, Nakamoto JA, Kasatsky P, Paleskava A, Konevega AL, Milón P.

PLoS Biol. 2020 Jan 29;18(1):e3000593. doi: 10.1371/journal.pbio.3000593. eCollection 2020 Jan.

3.

Erratum for Khabibullina et al., "Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides".

Khabibullina NF, Tereshchenkov AG, Komarova ES, Syroegin EA, Shiriaev DI, Paleskava A, Kartsev VG, Bogdanov AA, Konevega AL, Dontsova OA, Sergiev PV, Osterman IA, Polikanov YS.

Antimicrob Agents Chemother. 2020 Jan 27;64(2). pii: e02360-19. doi: 10.1128/AAC.02360-19. Print 2020 Jan 27. No abstract available.

4.

Structure of Dirithromycin Bound to the Bacterial Ribosome Suggests New Ways for Rational Improvement of Macrolides.

Khabibullina NF, Tereshchenkov AG, Komarova ES, Syroegin EA, Shiriaev DI, Paleskava A, Kartsev VG, Bogdanov AA, Konevega AL, Dontsova OA, Sergiev PV, Osterman IA, Polikanov YS.

Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e02266-18. doi: 10.1128/AAC.02266-18. Print 2019 Jun. Erratum in: Antimicrob Agents Chemother. 2020 Jan 27;64(2):.

5.

[Isolation of extracellular micro-vesicles from cell culture medium: comparative evaluation of methods].

Shtam TA, Samsonov RA, Volnitskiy AV, Kamyshinsky RA, Verlov NA, Kniazeva MS, Korobkina EA, Orehov AS, Vasiliev AL, Konevega AL, Malek AV.

Biomed Khim. 2018 Jan;64(1):23-30. doi: 10.18097/PBMC20186401023. Russian.

PMID:
29460831
6.

Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.

Tereshchenkov AG, Dobosz-Bartoszek M, Osterman IA, Marks J, Sergeeva VA, Kasatsky P, Komarova ES, Stavrianidi AN, Rodin IA, Konevega AL, Sergiev PV, Sumbatyan NV, Mankin AS, Bogdanov AA, Polikanov YS.

J Mol Biol. 2018 Mar 16;430(6):842-852. doi: 10.1016/j.jmb.2018.01.016. Epub 2018 Feb 2.

7.

The ribosomal A-site finger is crucial for binding and activation of the stringent factor RelA.

Kudrin P, Dzhygyr I, Ishiguro K, Beljantseva J, Maksimova E, Oliveira SRA, Varik V, Payoe R, Konevega AL, Tenson T, Suzuki T, Hauryliuk V.

Nucleic Acids Res. 2018 Feb 28;46(4):1973-1983. doi: 10.1093/nar/gky023.

8.

Biodiversity, drug discovery, and the future of global health: Introducing the biodiversity to biomedicine consortium, a call to action.

Neergheen-Bhujun V, Awan AT, Baran Y, Bunnefeld N, Chan K, Dela Cruz TE, Egamberdieva D, Elsässer S, Johnson MV, Komai S, Konevega AL, Malone JH, Mason P, Nguon R, Piper R, Shrestha UB, Pešić M, Kagansky A.

J Glob Health. 2017 Dec;7(2):020304. doi: 10.7189/jogh.07.020304. Review. No abstract available.

9.

Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.

Metelev M, Osterman IA, Ghilarov D, Khabibullina NF, Yakimov A, Shabalin K, Utkina I, Travin DY, Komarova ES, Serebryakova M, Artamonova T, Khodorkovskii M, Konevega AL, Sergiev PV, Severinov K, Polikanov YS.

Nat Chem Biol. 2017 Oct;13(10):1129-1136. doi: 10.1038/nchembio.2462. Epub 2017 Aug 28.

10.

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.

Osterman IA, Khabibullina NF, Komarova ES, Kasatsky P, Kartsev VG, Bogdanov AA, Dontsova OA, Konevega AL, Sergiev PV, Polikanov YS.

Nucleic Acids Res. 2017 Jul 7;45(12):7507-7514. doi: 10.1093/nar/gkx413.

11.

New Fluorescent Macrolide Derivatives for Studying Interactions of Antibiotics and Their Analogs with the Ribosomal Exit Tunnel.

Tereshchenkov AG, Shishkina AV, Karpenko VV, Chertkov VA, Konevega AL, Kasatsky PS, Bogdanov AA, Sumbatyan NV.

Biochemistry (Mosc). 2016 Oct;81(10):1163-1172.

12.

The pathway to GTPase activation of elongation factor SelB on the ribosome.

Fischer N, Neumann P, Bock LV, Maracci C, Wang Z, Paleskava A, Konevega AL, Schröder GF, Grubmüller H, Ficner R, Rodnina MV, Stark H.

Nature. 2016 Dec 1;540(7631):80-85. doi: 10.1038/nature20560. Epub 2016 Nov 14.

PMID:
27842381
13.

Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases.

Byrne RT, Jenkins HT, Peters DT, Whelan F, Stowell J, Aziz N, Kasatsky P, Rodnina MV, Koonin EV, Konevega AL, Antson AA.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6033-7. doi: 10.1073/pnas.1500161112. Epub 2015 Apr 22.

14.

Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM.

Fischer N, Neumann P, Konevega AL, Bock LV, Ficner R, Rodnina MV, Stark H.

Nature. 2015 Apr 23;520(7548):567-70. doi: 10.1038/nature14275. Epub 2015 Feb 23.

PMID:
25707802
15.

Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.

Polikanov YS, Osterman IA, Szal T, Tashlitsky VN, Serebryakova MV, Kusochek P, Bulkley D, Malanicheva IA, Efimenko TA, Efremenkova OV, Konevega AL, Shaw KJ, Bogdanov AA, Rodnina MV, Dontsova OA, Mankin AS, Steitz TA, Sergiev PV.

Mol Cell. 2014 Nov 20;56(4):531-40. doi: 10.1016/j.molcel.2014.09.020. Epub 2014 Oct 9.

16.

High-efficiency translational bypassing of non-coding nucleotides specified by mRNA structure and nascent peptide.

Samatova E, Konevega AL, Wills NM, Atkins JF, Rodnina MV.

Nat Commun. 2014 Jul 21;5:4459. doi: 10.1038/ncomms5459.

PMID:
25041899
17.

GTP hydrolysis by EF-G synchronizes tRNA movement on small and large ribosomal subunits.

Holtkamp W, Cunha CE, Peske F, Konevega AL, Wintermeyer W, Rodnina MV.

EMBO J. 2014 May 2;33(9):1073-85. doi: 10.1002/embj.201387465. Epub 2014 Mar 10.

18.

A kinetic safety gate controlling the delivery of unnatural amino acids to the ribosome.

Mittelstaet J, Konevega AL, Rodnina MV.

J Am Chem Soc. 2013 Nov 13;135(45):17031-8. doi: 10.1021/ja407511q. Epub 2013 Oct 29.

PMID:
24079513
19.

tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding.

Rezgui VA, Tyagi K, Ranjan N, Konevega AL, Mittelstaet J, Rodnina MV, Peter M, Pedrioli PG.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12289-94. doi: 10.1073/pnas.1300781110. Epub 2013 Jul 8.

20.

Thermodynamics of the GTP-GDP-operated conformational switch of selenocysteine-specific translation factor SelB.

Paleskava A, Konevega AL, Rodnina MV.

J Biol Chem. 2012 Aug 10;287(33):27906-12. doi: 10.1074/jbc.M112.366120. Epub 2012 Jun 27.

21.

Evolutionary optimization of speed and accuracy of decoding on the ribosome.

Wohlgemuth I, Pohl C, Mittelstaet J, Konevega AL, Rodnina MV.

Philos Trans R Soc Lond B Biol Sci. 2011 Oct 27;366(1580):2979-86. doi: 10.1098/rstb.2011.0138. Review.

22.

The structure of helix 89 of 23S rRNA is important for peptidyl transferase function of Escherichia coli ribosome.

Burakovsky DE, Sergiev PV, Steblyanko MA, Konevega AL, Bogdanov AA, Dontsova OA.

FEBS Lett. 2011 Oct 3;585(19):3073-8. doi: 10.1016/j.febslet.2011.08.030. Epub 2011 Aug 27.

23.

Distortion of tRNA upon near-cognate codon recognition on the ribosome.

Mittelstaet J, Konevega AL, Rodnina MV.

J Biol Chem. 2011 Mar 11;286(10):8158-64. doi: 10.1074/jbc.M110.210021. Epub 2011 Jan 6.

24.

Mutations at the accommodation gate of the ribosome impair RF2-dependent translation termination.

Burakovsky DE, Sergiev PV, Steblyanko MA, Kubarenko AV, Konevega AL, Bogdanov AA, Rodnina MV, Dontsova OA.

RNA. 2010 Sep;16(9):1848-53. doi: 10.1261/rna.2185710. Epub 2010 Jul 28.

25.

Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopy.

Fischer N, Konevega AL, Wintermeyer W, Rodnina MV, Stark H.

Nature. 2010 Jul 15;466(7304):329-33. doi: 10.1038/nature09206.

PMID:
20631791
26.

The ribosome-bound initiation factor 2 recruits initiator tRNA to the 30S initiation complex.

Milon P, Carotti M, Konevega AL, Wintermeyer W, Rodnina MV, Gualerzi CO.

EMBO Rep. 2010 Apr;11(4):312-6. doi: 10.1038/embor.2010.12. Epub 2010 Mar 12.

27.

The crystal structure of unmodified tRNAPhe from Escherichia coli.

Byrne RT, Konevega AL, Rodnina MV, Antson AA.

Nucleic Acids Res. 2010 Jul;38(12):4154-62. doi: 10.1093/nar/gkq133. Epub 2010 Mar 4.

28.

Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB.

Paleskava A, Konevega AL, Rodnina MV.

J Biol Chem. 2010 Jan 29;285(5):3014-20. doi: 10.1074/jbc.M109.081380. Epub 2009 Nov 23.

29.

Structure of ratcheted ribosomes with tRNAs in hybrid states.

Julián P, Konevega AL, Scheres SH, Lázaro M, Gil D, Wintermeyer W, Rodnina MV, Valle M.

Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16924-7. doi: 10.1073/pnas.0809587105. Epub 2008 Oct 29.

30.

Kinetic checkpoint at a late step in translation initiation.

Milon P, Konevega AL, Gualerzi CO, Rodnina MV.

Mol Cell. 2008 Jun 20;30(6):712-20. doi: 10.1016/j.molcel.2008.04.014.

31.

Towards understanding selenocysteine incorporation into bacterial proteins.

Fischer N, Paleskava A, Gromadski KB, Konevega AL, Wahl MC, Stark H, Rodnina MV.

Biol Chem. 2007 Oct;388(10):1061-7.

PMID:
17937620
32.

Transient kinetics, fluorescence, and FRET in studies of initiation of translation in bacteria.

Milon P, Konevega AL, Peske F, Fabbretti A, Gualerzi CO, Rodnina MV.

Methods Enzymol. 2007;430:1-30.

PMID:
17913632
33.

Spontaneous reverse movement of mRNA-bound tRNA through the ribosome.

Konevega AL, Fischer N, Semenkov YP, Stark H, Wintermeyer W, Rodnina MV.

Nat Struct Mol Biol. 2007 Apr;14(4):318-24. Epub 2007 Mar 18.

PMID:
17369838
34.

[The effect of modification of tRNA nucleotide-37 on the tRNA interaction with the P- and A-site of the 70S ribosome Escherichia coli].

Konevega AL, Soboleva NG, Makhno VI, Peshekhonov AV, Katunin VI.

Mol Biol (Mosk). 2006 Jul-Aug;40(4):669-83. Review. Russian.

PMID:
16913226
35.

Single-step purification of specific tRNAs by hydrophobic tagging.

Kothe U, Paleskava A, Konevega AL, Rodnina MV.

Anal Biochem. 2006 Sep 1;356(1):148-50. Epub 2006 May 11. No abstract available.

PMID:
16750812
36.

Purine bases at position 37 of tRNA stabilize codon-anticodon interaction in the ribosomal A site by stacking and Mg2+-dependent interactions.

Konevega AL, Soboleva NG, Makhno VI, Semenkov YP, Wintermeyer W, Rodnina MV, Katunin VI.

RNA. 2004 Jan;10(1):90-101.

37.

[The effect of modification of nucleotide-37 on the interaction of aminoacyl-tRNA with the A-site of the 70S ribosome].

Soboleva NG, Makhno VI, Konevega AL, Semenkov IuP, Katunin VI.

Mol Biol (Mosk). 2003 Jan-Feb;37(1):121-7. Russian.

PMID:
12624954

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