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An Optimised Protocol Harnessing Laser Capture Microdissection for Transcriptomic Analysis on Matched Primary and Metastatic Colorectal Tumours.

Ong CJ, Tan QX, Lim HJ, Shannon NB, Lim WK, Hendrikson J, Ng WH, Tan JWS, Koh KKN, Wasudevan SD, Ng CCY, Rajasegaran V, Lim TKH, Ong CK, Kon OL, Teh BT, Tan GHC, Chia CS, Soo KC, Teo MCC.

Sci Rep. 2020 Jan 20;10(1):682. doi: 10.1038/s41598-019-55146-2.


ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer.

Gupta N, Park JE, Tse W, Low JK, Kon OL, McCarthy N, Sze SK.

Oncotarget. 2019 Oct 15;10(57):5970-5982. doi: 10.18632/oncotarget.27235. eCollection 2019 Oct 15.


Roles and Regulation of Long Noncoding RNAs in Hepatocellular Carcinoma.

Lim LJ, Wong SYS, Huang F, Lim S, Chong SS, Ooi LL, Kon OL, Lee CG.

Cancer Res. 2019 Oct 15;79(20):5131-5139. doi: 10.1158/0008-5472.CAN-19-0255. Epub 2019 Jul 23. Review.


A set of molecular markers predicts chemosensitivity to Mitomycin-C following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastasis.

Shannon NB, Tan JW, Tan HL, Wang W, Chen Y, Lim HJ, Tan QX, Hendrikson J, Ng WH, Loo LY, Skanthakumar T, Wasudevan SD, Kon OL, Lim TKH, Tan GHC, Chia CS, Soo KC, Ong CJ, Teo MCC.

Sci Rep. 2019 Jul 22;9(1):10572. doi: 10.1038/s41598-019-46819-z.


Enabling Mitochondrial Uptake of Lipophilic Dications Using Methylated Triphenylphosphonium Moieties.

Ong HC, Hu Z, Coimbra JTS, Ramos MJ, Kon OL, Xing B, Yeow EKL, Fernandes PA, García F.

Inorg Chem. 2019 Jul 1;58(13):8293-8299. doi: 10.1021/acs.inorgchem.8b03380. Epub 2019 Jun 11.


Pulsed SILAC-based proteomic analysis unveils hypoxia- and serum starvation-induced de novo protein synthesis with PHD finger protein 14 (PHF14) as a hypoxia sensitive epigenetic regulator in cell cycle progression.

Park JE, Tse SW, Xue G, Assisi C, Maqueda AS, Ramon GPX, Low JK, Kon OL, Tay CY, Tam JP, Sze SK.

Oncotarget. 2019 Mar 15;10(22):2136-2150. doi: 10.18632/oncotarget.26669. eCollection 2019 Mar 15.


Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift.

Park JE, Dutta B, Tse SW, Gupta N, Tan CF, Low JK, Yeoh KW, Kon OL, Tam JP, Sze SK.

Oncogene. 2019 Jun;38(26):5158-5173. doi: 10.1038/s41388-019-0782-x. Epub 2019 Mar 12.


Development of a liver-specific Tet-off AAV8 vector for improved safety of insulin gene therapy for diabetes.

Gan SU, Fu Z, Sia KC, Kon OL, Calne R, Lee KO.

J Gene Med. 2019 Jan;21(1):e3067. doi: 10.1002/jgm.3067. Epub 2019 Jan 20.


Integrated Multimodal Evaluation of Genotoxicity in ZFN-Modified Primary Human Cells.

Sivalingam J, Kenanov D, Ng WH, Lee SS, Phan TT, Maurer-Stroh S, Kon OL.

Methods Mol Biol. 2018;1867:141-164. doi: 10.1007/978-1-4939-8799-3_11.


Soy-Derived Phytochemical Genistein Modifies Chromatome Topology to Restrict Cancer Cell Proliferation.

Dutta B, Park JE, Qing ITY, Kon OL, Sze SK.

Proteomics. 2018 Aug;18(16):e1700474. doi: 10.1002/pmic.201700474. Epub 2018 Aug 6.


Durable engraftment of genetically modified FVIII-secreting autologous bone marrow stromal cells in the intramedullary microenvironment.

Lee SS, Sivalingam J, Nirmal AJ, Ng WH, Kee I, Song IC, Kiong CY, Gales KA, Chua F, Pena EM, Ogden BE, Kon OL.

J Cell Mol Med. 2018 Jul;22(7):3698-3702. doi: 10.1111/jcmm.13648. Epub 2018 Apr 23.


Unique Triphenylphosphonium Derivatives for Enhanced Mitochondrial Uptake and Photodynamic Therapy.

Hu Z, Sim Y, Kon OL, Ng WH, Ribeiro AJ, Ramos MJ, Fernandes PA, Ganguly R, Xing B, García F, Yeow EK.

Bioconjug Chem. 2017 Feb 15;28(2):590-599. doi: 10.1021/acs.bioconjchem.6b00682. Epub 2017 Jan 18.


Irradiation of Epithelial Carcinoma Cells Upregulates Calcium-Binding Proteins That Promote Survival under Hypoxic Conditions.

Ren Y, Yeoh KW, Hao P, Kon OL, Sze SK.

J Proteome Res. 2016 Dec 2;15(12):4258-4264. Epub 2016 Nov 10.


Mitochondrial-Targeting MET Kinase Inhibitor Kills Erlotinib-Resistant Lung Cancer Cells.

Yang T, Ng WH, Chen H, Chomchopbun K, Huynh TH, Go ML, Kon OL.

ACS Med Chem Lett. 2016 Jun 23;7(8):807-12. doi: 10.1021/acsmedchemlett.6b00223. eCollection 2016 Aug 11.


Multidimensional Genome-wide Analyses Show Accurate FVIII Integration by ZFN in Primary Human Cells.

Sivalingam J, Kenanov D, Han H, Nirmal AJ, Ng WH, Lee SS, Masilamani J, Phan TT, Maurer-Stroh S, Kon OL.

Mol Ther. 2016 Mar;24(3):607-19. doi: 10.1038/mt.2015.223. Epub 2015 Dec 22.


ST3GAL1-Associated Transcriptomic Program in Glioblastoma Tumor Growth, Invasion, and Prognosis.

Chong YK, Sandanaraj E, Koh LW, Thangaveloo M, Tan MS, Koh GR, Toh TB, Lim GG, Holbrook JD, Kon OL, Nadarajah M, Ng I, Ng WH, Tan NS, Lim KL, Tang C, Ang BT.

J Natl Cancer Inst. 2015 Nov 7;108(2). pii: djv326. doi: 10.1093/jnci/djv326. Print 2016 Feb.


Extracellular vesicles are rapidly purified from human plasma by PRotein Organic Solvent PRecipitation (PROSPR).

Gallart-Palau X, Serra A, Wong AS, Sandin S, Lai MK, Chen CP, Kon OL, Sze SK.

Sci Rep. 2015 Sep 30;5:14664. doi: 10.1038/srep14664.


Characterization of Insulin-Secreting Porcine Bone Marrow Stromal Cells Ex Vivo and Autologous Cell Therapy In Vivo.

Do HV, Loke WT, Kee I, Liang V, David SJ, Gan SU, Lee SS, Ng WH, Koong HN, Ong HS, Lee KO, Calne RY, Kon OL.

Cell Transplant. 2015;24(7):1205-20. doi: 10.3727/096368914X679363. Epub 2014 Mar 24.


Intragenic integration in DLC1 sustains factor VIII expression in primary human cells without insertional oncogenicity.

Sivalingam J, Phan TT, Kon OL.

Gene Ther. 2014 Apr;21(4):402-12. doi: 10.1038/gt.2014.11. Epub 2014 Feb 20.


A distinct reactive oxygen species profile confers chemoresistance in glioma-propagating cells and associates with patient survival outcome.

Koh LW, Koh GR, Ng FS, Toh TB, Sandanaraj E, Chong YK, Phong M, Tucker-Kellogg G, Kon OL, Ng WH, Ng IH, Clement MV, Pervaiz S, Ang BT, Tang CS.

Antioxid Redox Signal. 2013 Dec 20;19(18):2261-79. doi: 10.1089/ars.2012.4999. Epub 2013 Apr 12.


Negative regulatory responses to metabolically triggered inflammation impair renal epithelial immunity in diabetes mellitus.

Chen NK, Chong TW, Loh HL, Lim KH, Gan VH, Wang M, Kon OL.

J Mol Med (Berl). 2013 May;91(5):587-98. doi: 10.1007/s00109-012-0969-x. Epub 2012 Nov 14.


Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors.

Ng FS, Toh TB, Ting EH, Koh GR, Sandanaraj E, Phong M, Wong SS, Leong SH, Kon OL, Tucker-Kellogg G, Ng WH, Ng I, Tang C, Ang BT.

Clin Cancer Res. 2012 Aug 1;18(15):4122-35. Epub 2012 Jun 6.


Multidimensional identification of tissue biomarkers of gastric cancer.

Guo T, Fan L, Ng WH, Zhu Y, Ho M, Wan WK, Lim KH, Ong WS, Lee SS, Huang S, Kon OL, Sze SK.

J Proteome Res. 2012 Jun 1;11(6):3405-13. doi: 10.1021/pr300212g. Epub 2012 May 7.


Characterization of the human gastric fluid proteome reveals distinct pH-dependent protein profiles: implications for biomarker studies.

Kam SY, Hennessy T, Chua SC, Gan CS, Philp R, Hon KK, Lai L, Chan WH, Ong HS, Wong WK, Lim KH, Ling KL, Tan HS, Tan MM, Ho M, Kon OL.

J Proteome Res. 2011 Oct 7;10(10):4535-46. doi: 10.1021/pr200349z. Epub 2011 Sep 22.


CD44-SLC1A2 gene fusions in gastric cancer.

Tao J, Deng NT, Ramnarayanan K, Huang B, Oh HK, Leong SH, Lim SS, Tan IB, Ooi CH, Wu J, Lee M, Zhang S, Rha SY, Chung HC, Smoot DT, Ashktorab H, Kon OL, Cacheux V, Yap C, Palanisamy N, Tan P.

Sci Transl Med. 2011 Apr 6;3(77):77ra30. doi: 10.1126/scitranslmed.3001423.


Global molecular dysfunctions in gastric cancer revealed by an integrated analysis of the phosphoproteome and transcriptome.

Guo T, Lee SS, Ng WH, Zhu Y, Gan CS, Zhu J, Wang H, Huang S, Sze SK, Kon OL.

Cell Mol Life Sci. 2011 Jun;68(11):1983-2002. doi: 10.1007/s00018-010-0545-x. Epub 2010 Oct 16.


Quantitative proteomics discloses MET expression in mitochondria as a direct target of MET kinase inhibitor in cancer cells.

Guo T, Zhu Y, Gan CS, Lee SS, Zhu J, Wang H, Li X, Christensen J, Huang S, Kon OL, Sze SK.

Mol Cell Proteomics. 2010 Dec;9(12):2629-41. doi: 10.1074/mcp.M110.001776. Epub 2010 Aug 16.


Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells.

Sivalingam J, Krishnan S, Ng WH, Lee SS, Phan TT, Kon OL.

Mol Ther. 2010 Jul;18(7):1346-56. doi: 10.1038/mt.2010.61. Epub 2010 Apr 27.


Insulin expressed from endogenously active glucose-responsive EGR1 promoter in bone marrow mesenchymal stromal cells as diabetes therapy.

Chen NK, Tan SY, Udolph G, Kon OL.

Gene Ther. 2010 May;17(5):592-605. doi: 10.1038/gt.2010.12. Epub 2010 Feb 25.


Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line.

Li G, Luo R, Zhang J, Yeo KS, Lian Q, Xie F, Tan EK, Caille D, Kon OL, Salto-Tellez M, Meda P, Lim SK.

Stem Cell Res. 2009 Jan;2(1):41-55. doi: 10.1016/j.scr.2008.07.006. Epub 2008 Aug 8.


Derivation of functional insulin-producing cell lines from primary mouse embryo culture.

Li G, Luo R, Zhang J, Yeo KS, Xie F, Way Tan EK, Caille D, Que J, Kon OL, Salto-Tellez M, Meda P, Lim SK.

Stem Cell Res. 2009 Jan;2(1):29-40. doi: 10.1016/j.scr.2008.07.004. Epub 2008 Jul 31.


One-step procedure for peptide extraction from in-gel digestion sample for mass spectrometric analysis.

Meng W, Zhang H, Guo T, Pandey C, Zhu Y, Kon OL, Sze SK.

Anal Chem. 2008 Dec 15;80(24):9797-805. doi: 10.1021/ac801344z.


The distinctive gastric fluid proteome in gastric cancer reveals a multi-biomarker diagnostic profile.

Kon OL, Yip TT, Ho MF, Chan WH, Wong WK, Tan SY, Ng WH, Kam SY, Eng AKh, Ho P, Viner R, Ong HS, Kumarasinghe MP.

BMC Med Genomics. 2008 Oct 25;1:54. doi: 10.1186/1755-8794-1-54.


Cryopreservation of neurospheres derived from human glioblastoma multiforme.

Chong YK, Toh TB, Zaiden N, Poonepalli A, Leong SH, Ong CE, Yu Y, Tan PB, See SJ, Ng WH, Ng I, Hande MP, Kon OL, Ang BT, Tang C.

Stem Cells. 2009 Jan;27(1):29-39. doi: 10.1634/stemcells.2008-0009.


Hybridization of pulsed-Q dissociation and collision-activated dissociation in linear ion trap mass spectrometer for iTRAQ quantitation.

Guo T, Gan CS, Zhang H, Zhu Y, Kon OL, Sze SK.

J Proteome Res. 2008 Nov;7(11):4831-40. doi: 10.1021/pr800403z. Epub 2008 Oct 7.


Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.

Hou Q, Wu YH, Grabsch H, Zhu Y, Leong SH, Ganesan K, Cross D, Tan LK, Tao J, Gopalakrishnan V, Tang BL, Kon OL, Tan P.

Cancer Res. 2008 Jun 15;68(12):4623-30. doi: 10.1158/0008-5472.CAN-07-5870.


Nonvirally modified autologous primary hepatocytes correct diabetes and prevent target organ injury in a large preclinical model.

Chen NK, Wong JS, Kee IH, Lai SH, Thng CH, Ng WH, Ng RT, Tan SY, Lee SY, Tan ME, Sivalingam J, Chow PK, Kon OL.

PLoS One. 2008 Mar 5;3(3):e1734. doi: 10.1371/journal.pone.0001734.


Primer design for Whole Genome Amplification using genetic algorithms.

Png AE, Choo KW, Lee CI, Leong SH, Kon OL.

In Silico Biol. 2006;6(6):505-14.


Genetic engineering for haemophilia A.

Gan SU, Kon OL, Calne RY.

Expert Opin Biol Ther. 2006 Oct;6(10):1023-30. Review.


An isothermal method for whole genome amplification of fresh and degraded DNA for comparative genomic hybridization, genotyping and mutation detection.

Lee CI, Leong SH, Png AE, Choo KW, Syn C, Lim DT, Law HY, Kon OL.

DNA Res. 2006 Apr 30;13(2):77-88. Epub 2006 Mar 27.


In vivo liver electroporation: optimization and demonstration of therapeutic efficacy.

Jaichandran S, Yap ST, Khoo AB, Ho LP, Tien SL, Kon OL.

Hum Gene Ther. 2006 Mar;17(3):362-75.


FAT10 plays a role in the regulation of chromosomal stability.

Ren J, Kan A, Leong SH, Ooi LL, Jeang KT, Chong SS, Kon OL, Lee CG.

J Biol Chem. 2006 Apr 21;281(16):11413-21. Epub 2006 Feb 22.


FVIII gene delivery by muscle electroporation corrects murine hemophilia A.

Long YC, Jaichandran S, Ho LP, Tien SL, Tan SY, Kon OL.

J Gene Med. 2005 Apr;7(4):494-505.


Regarding clinical implications of chromosomal abnormalities in gastric adenocarcinomas.

Leong SH, Kon OL, Machin D, Li H.

Genes Chromosomes Cancer. 2003 Oct;38(2):201-3; author reply 204-6. No abstract available.


A combined comparative genomic hybridization and expression microarray analysis of gastric cancer reveals novel molecular subtypes.

Tay ST, Leong SH, Yu K, Aggarwal A, Tan SY, Lee CH, Wong K, Visvanathan J, Lim D, Wong WK, Soo KC, Kon OL, Tan P.

Cancer Res. 2003 Jun 15;63(12):3309-16.


Human liver-derived cells stably modified for regulated proinsulin secretion function as bioimplants in vivo.

Chen X, Patil JG, Lok SH, Kon OL.

J Gene Med. 2002 Jul-Aug;4(4):447-58.


Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus.

Kon OL, Sivakumar S, Teoh KL, Lok SH, Long YC.

J Gene Med. 1999 May-Jun;1(3):186-94.


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