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Proteomic characterization of high-density lipoprotein particles in patients with non-alcoholic fatty liver disease.

Rao PK, Merath K, Drigalenko E, Jadhav AYL, Komorowski RA, Goldblatt MI, Rohatgi A, Sarzynski MA, Gawrieh S, Olivier M.

Clin Proteomics. 2018 Mar 6;15:10. doi: 10.1186/s12014-018-9186-0. eCollection 2018.


Long-acting MIC-1/GDF15 molecules to treat obesity: Evidence from mice to monkeys.

Xiong Y, Walker K, Min X, Hale C, Tran T, Komorowski R, Yang J, Davda J, Nuanmanee N, Kemp D, Wang X, Liu H, Miller S, Lee KJ, Wang Z, Véniant MM.

Sci Transl Med. 2017 Oct 18;9(412). pii: eaan8732. doi: 10.1126/scitranslmed.aan8732.


Scalable, Lightweight, Integrated and Quick-to-Assemble (SLIQ) Hyperdrives for Functional Circuit Dissection.

Liang L, Oline SN, Kirk JC, Schmitt LI, Komorowski RW, Remondes M, Halassa MM.

Front Neural Circuits. 2017 Feb 13;11:8. doi: 10.3389/fncir.2017.00008. eCollection 2017.


Radiation-induced changes in intestinal and tissue-nonspecific alkaline phosphatase: implications for recovery after radiation therapy.

Rentea RM, Lam V, Biesterveld B, Fredrich KM, Callison J, Fish BL, Baker JE, Komorowski R, Gourlay DM, Otterson MF.

Am J Surg. 2016 Oct;212(4):602-608. doi: 10.1016/j.amjsurg.2016.06.005. Epub 2016 Jul 18.


A colitogenic memory CD4+ T cell population mediates gastrointestinal graft-versus-host disease.

Zhou V, Agle K, Chen X, Beres A, Komorowski R, Belle L, Taylor C, Zhu F, Haribhai D, Williams CB, Verbsky J, Blumenschein W, Sadekova S, Bowman E, Ballantyne C, Weaver C, Serody DA, Vincent B, Serody J, Cua DJ, Drobyski WR.

J Clin Invest. 2016 Sep 1;126(9):3541-55. doi: 10.1172/JCI80874. Epub 2016 Aug 8.


Blockade of interleukin-27 signaling reduces GVHD in mice by augmenting Treg reconstitution and stabilizing Foxp3 expression.

Belle L, Agle K, Zhou V, Yin-Yuan C, Komorowski R, Eastwood D, Logan B, Sun J, Ghilardi N, Cua D, Williams CB, Gaignage M, Marillier R, van Snick J, Drobyski WR.

Blood. 2016 Oct 20;128(16):2068-2082. doi: 10.1182/blood-2016-02-698241. Epub 2016 Aug 3.


Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394.

Dransfield PJ, Pattaropong V, Lai S, Fu Z, Kohn TJ, Du X, Cheng A, Xiong Y, Komorowski R, Jin L, Conn M, Tien E, DeWolf WE Jr, Hinklin RJ, Aicher TD, Kraser CF, Boyd SA, Voegtli WC, Condroski KR, Veniant-Ellison M, Medina JC, Houze J, Coward P.

ACS Med Chem Lett. 2016 May 23;7(7):714-8. doi: 10.1021/acsmedchemlett.6b00140. eCollection 2016 Jul 14.


5-Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties.

Kohn TJ, Du X, Lai S, Xiong Y, Komorowski R, Veniant M, Fu Z, Jiao X, Pattaropong V, Chow D, Cardozo M, Jin L, Conn M, DeWolf WE Jr, Kraser CF, Hinklin RJ, Boys ML, Medina JC, Houze J, Dransfield P, Coward P.

ACS Med Chem Lett. 2016 Jun 1;7(7):666-70. doi: 10.1021/acsmedchemlett.6b00145. eCollection 2016 Jul 14.


Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity.

Kaplan ES, Cooke SF, Komorowski RW, Chubykin AA, Thomazeau A, Khibnik LA, Gavornik JP, Bear MF.

Elife. 2016 Mar 4;5. pii: e11450. doi: 10.7554/eLife.11450.


Representation of memories in the cortical-hippocampal system: Results from the application of population similarity analyses.

McKenzie S, Keene CS, Farovik A, Bladon J, Place R, Komorowski R, Eichenbaum H.

Neurobiol Learn Mem. 2016 Oct;134 Pt A:178-191. doi: 10.1016/j.nlm.2015.12.008. Epub 2015 Dec 31. Review.


Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation.

Lenarczyk M, Su J, Haworth ST, Komorowski R, Fish BL, Migrino RQ, Harmann L, Hopewell JW, Kronenberg A, Patel S, Moulder JE, Baker JE.

Pharmacol Res Perspect. 2015 Jun;3(3):e00145. doi: 10.1002/prp2.145. Epub 2015 Jun 1.


Erratum: Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.

Cooke SF, Komorowski RW, Kaplan ES, Gavornik JP, Bear MF.

Nat Neurosci. 2015 Jun;18(6):926. doi: 10.1038/nn0615-926d. No abstract available.


Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.

Véniant MM, Sivits G, Helmering J, Komorowski R, Lee J, Fan W, Moyer C, Lloyd DJ.

Cell Metab. 2015 May 5;21(5):731-8. doi: 10.1016/j.cmet.2015.04.019.


Automatic quantification of lobular inflammation and hepatocyte ballooning in nonalcoholic fatty liver disease liver biopsies.

Vanderbeck S, Bockhorst J, Kleiner D, Komorowski R, Chalasani N, Gawrieh S.

Hum Pathol. 2015 May;46(5):767-75. doi: 10.1016/j.humpath.2015.01.019. Epub 2015 Feb 19.


Visual recognition memory, manifested as long-term habituation, requires synaptic plasticity in V1.

Cooke SF, Komorowski RW, Kaplan ES, Gavornik JP, Bear MF.

Nat Neurosci. 2015 Feb;18(2):262-71. doi: 10.1038/nn.3920. Epub 2015 Jan 19. Erratum in: Nat Neurosci. 2015 Jun;18(6):926.


Automatic classification of white regions in liver biopsies by supervised machine learning.

Vanderbeck S, Bockhorst J, Komorowski R, Kleiner DE, Gawrieh S.

Hum Pathol. 2014 Apr;45(4):785-92. doi: 10.1016/j.humpath.2013.11.011. Epub 2013 Nov 26.


A case study: refractory recurrent autoimmune hepatitis following liver transplantation in two male patients.

Tencate V, Komorowski R, Cronin D, Hong J, Gawrieh S.

Transplant Proc. 2014 Jan-Feb;46(1):298-300. doi: 10.1016/j.transproceed.2013.09.028.


Piperazine oxadiazole inhibitors of acetyl-CoA carboxylase.

Bourbeau MP, Siegmund A, Allen JG, Shu H, Fotsch C, Bartberger MD, Kim KW, Komorowski R, Graham M, Busby J, Wang M, Meyer J, Xu Y, Salyers K, Fielden M, Véniant MM, Gu W.

J Med Chem. 2013 Dec 27;56(24):10132-41. doi: 10.1021/jm401601s. Epub 2013 Dec 11.


PTTG1 overexpression in adrenocortical cancer is associated with poor survival and represents a potential therapeutic target.

Demeure MJ, Coan KE, Grant CS, Komorowski RA, Stephan E, Sinari S, Mount D, Bussey KJ.

Surgery. 2013 Dec;154(6):1405-16; discussion 1416. doi: 10.1016/j.surg.2013.06.058.


Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.

Lloyd DJ, St Jean DJ Jr, Kurzeja RJ, Wahl RC, Michelsen K, Cupples R, Chen M, Wu J, Sivits G, Helmering J, Komorowski R, Ashton KS, Pennington LD, Fotsch C, Vazir M, Chen K, Chmait S, Zhang J, Liu L, Norman MH, Andrews KL, Bartberger MD, Van G, Galbreath EJ, Vonderfecht SL, Wang M, Jordan SR, Véniant MM, Hale C.

Nature. 2013 Dec 19;504(7480):437-40. doi: 10.1038/nature12724. Epub 2013 Nov 13.


Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs.

Lenarczyk M, Lam V, Jensen E, Fish BL, Su J, Koprowski S, Komorowski RA, Harmann L, Migrino RQ, Li XA, Hopewell JW, Moulder JE, Baker JE.

Radiat Res. 2013 Sep;180(3):247-58. doi: 10.1667/RR3292.1. Epub 2013 Aug 6.


Divergent effects of novel immunomodulatory agents and cyclophosphamide on the risk of engraftment syndrome after autologous peripheral blood stem cell transplantation for multiple myeloma.

Cornell RF, Hari P, Zhang MJ, Zhong X, Thompson J, Fenske TS, Horowitz MM, Komorowski R, Palmer J, Pasquini MC, Rizzo JD, Saber W, Thomas M, Drobyski WR.

Biol Blood Marrow Transplant. 2013 Sep;19(9):1368-73. doi: 10.1016/j.bbmt.2013.06.017. Epub 2013 Jun 24.


Ventral hippocampal neurons are shaped by experience to represent behaviorally relevant contexts.

Komorowski RW, Garcia CG, Wilson A, Hattori S, Howard MW, Eichenbaum H.

J Neurosci. 2013 May 1;33(18):8079-87. doi: 10.1523/JNEUROSCI.5458-12.2013.


FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.

Smith R, Duguay A, Bakker A, Li P, Weiszmann J, Thomas MR, Alba BM, Wu X, Gupte J, Yang L, Stevens J, Hamburger A, Smith S, Chen J, Komorowski R, Moore KW, Véniant MM, Li Y.

PLoS One. 2013 Apr 22;8(4):e61432. doi: 10.1371/journal.pone.0061432. Print 2013.


A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease.

Chen X, Dodge J, Komorowski R, Drobyski WR.

Blood. 2013 May 9;121(19):3970-80. doi: 10.1182/blood-2012-08-445130. Epub 2013 Mar 25.


Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.

Foltz IN, Hu S, King C, Wu X, Yang C, Wang W, Weiszmann J, Stevens J, Chen JS, Nuanmanee N, Gupte J, Komorowski R, Sekirov L, Hager T, Arora T, Ge H, Baribault H, Wang F, Sheng J, Karow M, Wang M, Luo Y, McKeehan W, Wang Z, Véniant MM, Li Y.

Sci Transl Med. 2012 Nov 28;4(162):162ra153. doi: 10.1126/scitranslmed.3004690.


Invasion in follicular thyroid cancer cell lines is mediated by EphA2 and pAkt.

O'Malley Y, Lal G, Howe JR, Weigel RJ, Komorowski RA, Shilyansky J, Sugg SL.

Surgery. 2012 Dec;152(6):1218-24. doi: 10.1016/j.surg.2012.08.041.


Neosquamous epithelium after ablation of Barrett's epithelium: cause for concern?

Dua KS, Merrill J, Komorowski R.

Gastrointest Endosc. 2012 Nov;76(5):1082-3. doi: 10.1016/j.gie.2012.07.008. No abstract available.


Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys.

Véniant MM, Komorowski R, Chen P, Stanislaus S, Winters K, Hager T, Zhou L, Wada R, Hecht R, Xu J.

Endocrinology. 2012 Sep;153(9):4192-203. doi: 10.1210/en.2012-1211. Epub 2012 Jul 13.


Extracolonic gastrointestinal tract morphologic findings in a case of pseudomembranous collagenous colitis.

Fons ME, Stein DJ, Patel A, Ferrer MS, Ammon H, Mackinnon AC, Komorowski RA, Yan BC.

Ann Diagn Pathol. 2013 Jun;17(3):291-4. doi: 10.1016/j.anndiagpath.2012.04.003. Epub 2012 Jun 1.


Emergence of T cells that recognize nonpolymorphic antigens during graft-versus- host disease.

Rangarajan H, Yassai M, Subramanian H, Komorowski R, Whitaker M, Gorski J, Drobyski WR.

Blood. 2012 Jun 28;119(26):6354-64. doi: 10.1182/blood-2012-01-401596. Epub 2012 Apr 10.


Surgical resection as definitive treatment for refractory GVHD of the colon.

Cornell RF, Palmer J, Komorowski R, Drobyski WR.

Bone Marrow Transplant. 2012 Oct;47(10):1366-7. doi: 10.1038/bmt.2012.15. Epub 2012 Feb 13. No abstract available.


An apoA-I mimetic peptibody generates HDL-like particles and increases alpha-1 HDL subfraction in mice.

Lu SC, Atangan L, Won Kim K, Chen MM, Komorowski R, Chu C, Han J, Hu S, Gu W, Véniant M, Wang M.

J Lipid Res. 2012 Apr;53(4):643-52. doi: 10.1194/jlr.M020438. Epub 2012 Jan 27.


Genetic variation in the peroxisome proliferator activated receptor-gamma gene is associated with histologically advanced NAFLD.

Gawrieh S, Marion MC, Komorowski R, Wallace J, Charlton M, Kissebah A, Langefeld CD, Olivier M.

Dig Dis Sci. 2012 Apr;57(4):952-7. doi: 10.1007/s10620-011-1994-2. Epub 2011 Dec 9.


Preclinical investigation of nanoparticle albumin-bound paclitaxel as a potential treatment for adrenocortical cancer.

Demeure MJ, Stephan E, Sinari S, Mount D, Gately S, Gonzales P, Hostetter G, Komorowski R, Kiefer J, Grant CS, Han H, Von Hoff DD, Bussey KJ.

Ann Surg. 2012 Jan;255(1):140-6. doi: 10.1097/SLA.0b013e3182402d21.


Synthesis and Evaluation of the Metabolites of AMG 221, a Clinical Candidate for the Treatment of Type 2 Diabetes.

Li A, Yuan CC, Chow D, Chen M, Emery MG, Hale C, Zhang X, Subramanian R, St Jean DJ Jr, Komorowski R, Véniant M, Wang M, Fotsch C.

ACS Med Chem Lett. 2011 Sep 13;2(11):824-7. doi: 10.1021/ml2001467. eCollection 2011 Nov 10.


A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where.

Tort AB, Komorowski R, Kopell N, Eichenbaum H.

Learn Mem. 2011 Oct 21;18(11):718-27. doi: 10.1101/lm.2307711. Print 2011.


Towards a functional organization of episodic memory in the medial temporal lobe.

Eichenbaum H, Sauvage M, Fortin N, Komorowski R, Lipton P.

Neurosci Biobehav Rev. 2012 Aug;36(7):1597-608. doi: 10.1016/j.neubiorev.2011.07.006. Epub 2011 Jul 23. Review.


Detection of amyloid in abdominal fat pad aspirates in early amyloidosis: Role of electron microscopy and Congo red stained cell block sections.

Devata S, Hari P, Markelova N, Li R, Komorowski R, Shidham VB.

Cytojournal. 2011;8:11. doi: 10.4103/1742-6413.82278. Epub 2011 Jun 20.


Instability of Foxp3 expression limits the ability of induced regulatory T cells to mitigate graft versus host disease.

Beres A, Komorowski R, Mihara M, Drobyski WR.

Clin Cancer Res. 2011 Jun 15;17(12):3969-83. doi: 10.1158/1078-0432.CCR-10-3347. Epub 2011 May 10.


Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice.

Gu W, Lloyd DJ, Chinookswong N, Komorowski R, Sivits G Jr, Graham M, Winters KA, Yan H, Boros LG, Lindberg RA, Véniant MM.

J Pharmacol Exp Ther. 2011 Jul;338(1):70-81. doi: 10.1124/jpet.111.179986. Epub 2011 Apr 6.


Neosquamous epithelium after Barrett's ablation: cause for concern?

Dua KS, Merrill JT, Komorowski R.

Gastrointest Endosc. 2011 Dec;74(6):1424-5. doi: 10.1016/j.gie.2010.12.023. Epub 2011 Mar 22. No abstract available.


Effects of interventions on intra- and interobserver agreement on interpretation of nonalcoholic fatty liver disease histology.

Gawrieh S, Knoedler DM, Saeian K, Wallace JR, Komorowski RA.

Ann Diagn Pathol. 2011 Feb;15(1):19-24. doi: 10.1016/j.anndiagpath.2010.08.001. Epub 2010 Nov 24.


Gastrointestinal pathology of autologous graft-versus-host disease following hematopoietic stem cell transplantation: a clinicopathological study of 17 cases.

Cogbill CH, Drobyski WR, Komorowski RA.

Mod Pathol. 2011 Jan;24(1):117-25. doi: 10.1038/modpathol.2010.163. Epub 2010 Oct 15.


Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.

Gu W, Winters KA, Motani AS, Komorowski R, Zhang Y, Liu Q, Wu X, Rulifson IC, Sivits G Jr, Graham M, Yan H, Wang P, Moore S, Meng T, Lindberg RA, Véniant MM.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E624-32. doi: 10.1152/ajpendo.00102.2010. Epub 2010 Jul 20.


Hepatic gene networks in morbidly obese patients with nonalcoholic fatty liver disease.

Gawrieh S, Baye TM, Carless M, Wallace J, Komorowski R, Kleiner DE, Andris D, Makladi B, Cole R, Charlton M, Curran J, Dyer TD, Charlesworth J, Wilke R, Blangero J, Kissebah AH, Olivier M.

Obes Surg. 2010 Dec;20(12):1698-709. doi: 10.1007/s11695-010-0171-6.


Discovery of a potent, orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor for clinical study: identification of (S)-2-((1S,2S,4R)-bicyclo[2.2.1]heptan-2-ylamino)-5-isopropyl-5-methylthiazol-4(5H)-one (AMG 221).

Véniant MM, Hale C, Hungate RW, Gahm K, Emery MG, Jona J, Joseph S, Adams J, Hague A, Moniz G, Zhang J, Bartberger MD, Li V, Syed R, Jordan S, Komorowski R, Chen MM, Cupples R, Kim KW, St Jean DJ Jr, Johansson L, Henriksson MA, Williams M, Vallgårda J, Fotsch C, Wang M.

J Med Chem. 2010 Jun 10;53(11):4481-7. doi: 10.1021/jm100242d.


Measuring phase-amplitude coupling between neuronal oscillations of different frequencies.

Tort AB, Komorowski R, Eichenbaum H, Kopell N.

J Neurophysiol. 2010 Aug;104(2):1195-210. doi: 10.1152/jn.00106.2010. Epub 2010 May 12. Erratum in: J Neurophysiol. 2010 Oct;104(4):2302.


Blockade of interleukin-23 signaling results in targeted protection of the colon and allows for separation of graft-versus-host and graft-versus-leukemia responses.

Das R, Komorowski R, Hessner MJ, Subramanian H, Huettner CS, Cua D, Drobyski WR.

Blood. 2010 Jun 24;115(25):5249-58. doi: 10.1182/blood-2009-11-255422. Epub 2010 Apr 9.


A noninvasive clinical scoring model predicts risk of nonalcoholic steatohepatitis in morbidly obese patients.

Ulitsky A, Ananthakrishnan AN, Komorowski R, Wallace J, Surapaneni SN, Franco J, Saeian K, Gawrieh S.

Obes Surg. 2010 Jun;20(6):685-91. doi: 10.1007/s11695-010-0118-y.


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