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Items: 13

1.

Saxagliptin, a potent, selective inhibitor of DPP-4, does not alter the pharmacokinetics of three oral antidiabetic drugs (metformin, glyburide or pioglitazone) in healthy subjects.

Patel CG, Kornhauser D, Vachharajani N, Komoroski B, Brenner E, Handschuh del Corral M, Li L, Boulton DW.

Diabetes Obes Metab. 2011 Jul;13(7):604-14. doi: 10.1111/j.1463-1326.2011.01381.x.

PMID:
21332626
2.

In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humans.

Obermeier M, Yao M, Khanna A, Koplowitz B, Zhu M, Li W, Komoroski B, Kasichayanula S, Discenza L, Washburn W, Meng W, Ellsworth BA, Whaley JM, Humphreys WG.

Drug Metab Dispos. 2010 Mar;38(3):405-14. doi: 10.1124/dmd.109.029165. Epub 2009 Dec 8.

PMID:
19996149
3.

Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus.

Komoroski B, Vachharajani N, Feng Y, Li L, Kornhauser D, Pfister M.

Clin Pharmacol Ther. 2009 May;85(5):513-9. doi: 10.1038/clpt.2008.250. Epub 2009 Jan 7. Erratum in: Clin Pharmacol Ther. 2009 May;85(5):558.

PMID:
19129749
4.

Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects.

Komoroski B, Vachharajani N, Boulton D, Kornhauser D, Geraldes M, Li L, Pfister M.

Clin Pharmacol Ther. 2009 May;85(5):520-6. doi: 10.1038/clpt.2008.251. Epub 2009 Jan 7.

PMID:
19129748
5.

Pharmacokinetics and tolerability of intramuscular, oral and intravenous aripiprazole in healthy subjects and in patients with schizophrenia.

Boulton DW, Kollia G, Mallikaarjun S, Komoroski B, Sharma A, Kovalick LJ, Reeves RA.

Clin Pharmacokinet. 2008;47(7):475-85.

PMID:
18563956
6.

Effects of green tea compounds on irinotecan metabolism.

Mirkov S, Komoroski BJ, Ramírez J, Graber AY, Ratain MJ, Strom SC, Innocenti F.

Drug Metab Dispos. 2007 Feb;35(2):228-33. Epub 2006 Nov 15.

PMID:
17108060
7.

In vitro and in vivo assessment of herb drug interactions.

Venkataramanan R, Komoroski B, Strom S.

Life Sci. 2006 Mar 27;78(18):2105-15. Epub 2006 Jan 19. Review.

PMID:
16427092
8.

Study of the genetic determinants of UGT1A1 inducibility by phenobarbital in cultured human hepatocytes.

Ramírez J, Komoroski BJ, Mirkov S, Graber AY, Fackenthal DL, Schuetz EG, Das S, Ratain MJ, Innocenti F, Strom SC.

Pharmacogenet Genomics. 2006 Feb;16(2):79-86.

PMID:
16424820
9.

Effect of the St. John's wort constituent hyperforin on docetaxel metabolism by human hepatocyte cultures.

Komoroski BJ, Parise RA, Egorin MJ, Strom SC, Venkataramanan R.

Clin Cancer Res. 2005 Oct 1;11(19 Pt 1):6972-9.

10.

Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures.

Komoroski BJ, Zhang S, Cai H, Hutzler JM, Frye R, Tracy TS, Strom SC, Lehmann T, Ang CY, Cui YY, Venkataramanan R.

Drug Metab Dispos. 2004 May;32(5):512-8.

PMID:
15100173
11.

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

Schuetz EG, Strom S, Yasuda K, Lecureur V, Assem M, Brimer C, Lamba J, Kim RB, Ramachandran V, Komoroski BJ, Venkataramanan R, Cai H, Sinal CJ, Gonzalez FJ, Schuetz JD.

J Biol Chem. 2001 Oct 19;276(42):39411-8. Epub 2001 Aug 16.

12.

Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures.

Venkataramanan R, Ramachandran V, Komoroski BJ, Zhang S, Schiff PL, Strom SC.

Drug Metab Dispos. 2000 Nov;28(11):1270-3.

PMID:
11038151
13.

Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes.

Ramachandran V, Kostrubsky VE, Komoroski BJ, Zhang S, Dorko K, Esplen JE, Strom SC, Venkataramanan R.

Drug Metab Dispos. 1999 Oct;27(10):1194-9.

PMID:
10497147

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