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3D genomic architecture reveals that neocentromeres associate with heterochromatin regions.

Nishimura K, Komiya M, Hori T, Itoh T, Fukagawa T.

J Cell Biol. 2018 Nov 5. pii: jcb.201805003. doi: 10.1083/jcb.201805003. [Epub ahead of print]


O 074 - Effect of trunk motion restriction on the muscle activities of shoulder external rotators during throwing.

Anami K, Urabe Y, Sasadai J, Komiya M, Hashimoto R, Meada N.

Gait Posture. 2018 Sep;65 Suppl 1:152-153. doi: 10.1016/j.gaitpost.2018.06.100. Epub 2018 Jul 26. No abstract available.


P 178 - Effect of a 8 week Whole-Body-Vibration Training on muscle strength and dynamic balance in healthy men.

Maeda N, Urabe Y, Sasadai J, Komiya M.

Gait Posture. 2018 Sep;65 Suppl 1:535-536. doi: 10.1016/j.gaitpost.2018.07.098. Epub 2018 Jul 26. No abstract available.


Stimulation of accumbal GABAB receptors inhibits delta1- and delta2-opioid receptor-mediated dopamine efflux in the nucleus accumbens of freely moving rats.

Watanabe Y, Aono Y, Komiya M, Waddington JL, Saigusa T.

Eur J Pharmacol. 2018 Oct 15;837:88-95. doi: 10.1016/j.ejphar.2018.08.003. Epub 2018 Aug 5.


A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules.

Li Q, Yoshimura H, Komiya M, Tajiri K, Uesugi M, Hata Y, Ozawa T.

Analyst. 2018 Jul 9;143(14):3472-3480. doi: 10.1039/c8an00285a.


Quantitative analyses of the metaphase-to-anaphase transition reveal differential kinetic regulation for securin and cyclin B1.

Konishi M, Shindo N, Komiya M, Tanaka K, Itoh T, Hirota T.

Biomed Res. 2018;39(2):75-85. doi: 10.2220/biomedres.39.75.


A genetic screen to discover SUMOylated proteins in living mammalian cells.

Komiya M, Ito A, Endo M, Hiruma D, Hattori M, Saitoh H, Yoshida M, Ozawa T.

Sci Rep. 2017 Dec 12;7(1):17443. doi: 10.1038/s41598-017-17450-7.


Fish protein hydrolysate exhibits anti-obesity activity and reduces hypothalamic neuropeptide Y and agouti-related protein mRNA expressions in rats.

Mizushige T, Komiya M, Onda M, Uchida K, Hayamizu K, Kabuyama Y.

Biomed Res. 2017;38(6):351-357. doi: 10.2220/biomedres.38.351.


Chemopreventive effects of a low-side-effect antibiotic drug, erythromycin, on mouse intestinal tumors.

Hamoya T, Miyamoto S, Tomono S, Fujii G, Nakanishi R, Komiya M, Tamura S, Fujimoto K, Toshima J, Wakabayashi K, Mutoh M.

J Clin Biochem Nutr. 2017 May;60(3):199-207. doi: 10.3164/jcbn.16-107. Epub 2017 Apr 14.


Osteopontin Deficiency Suppresses Intestinal Tumor Development in Apc-Deficient Min Mice.

Ishigamori R, Komiya M, Takasu S, Mutoh M, Imai T, Takahashi M.

Int J Mol Sci. 2017 May 14;18(5). pii: E1058. doi: 10.3390/ijms18051058.


Impact of Acetazolamide, a Carbonic Anhydrase Inhibitor, on the Development of Intestinal Polyps in Min Mice.

Noma N, Fujii G, Miyamoto S, Komiya M, Nakanishi R, Shimura M, Tanuma SI, Mutoh M.

Int J Mol Sci. 2017 Apr 17;18(4). pii: E851. doi: 10.3390/ijms18040851.


Preventive Effects of Heat-Killed Enterococcus faecalis Strain EC-12 on Mouse Intestinal Tumor Development.

Miyamoto S, Komiya M, Fujii G, Hamoya T, Nakanishi R, Fujimoto K, Tamura S, Kurokawa Y, Takahashi M, Ijichi T, Mutoh M.

Int J Mol Sci. 2017 Apr 13;18(4). pii: E826. doi: 10.3390/ijms18040826.


Early Therapeutic Intervention for Crush Syndrome: Characterization of Intramuscular Administration of Dexamethasone by Pharmacokinetic and Biochemical Parameters in Rats.

Murata I, Goto M, Komiya M, Motohashi R, Hirata M, Inoue Y, Kanamoto I.

Biol Pharm Bull. 2016;39(9):1424-31. doi: 10.1248/bpb.b15-01034.


MYU, a Target lncRNA for Wnt/c-Myc Signaling, Mediates Induction of CDK6 to Promote Cell Cycle Progression.

Kawasaki Y, Komiya M, Matsumura K, Negishi L, Suda S, Okuno M, Yokota N, Osada T, Nagashima T, Hiyoshi M, Okada-Hatakeyama M, Kitayama J, Shirahige K, Akiyama T.

Cell Rep. 2016 Sep 6;16(10):2554-2564. doi: 10.1016/j.celrep.2016.08.015. Epub 2016 Aug 25.


Possible pharmacotherapy for nifedipine-induced gingival overgrowth: 18α-glycyrrhetinic acid inhibits human gingival fibroblast growth.

Takeuchi R, Hiratsuka K, Arikawa K, Ono M, Komiya M, Akimoto Y, Fujii A, Matsumoto H.

Br J Pharmacol. 2016 Mar;173(5):913-24. doi: 10.1111/bph.13410. Epub 2016 Feb 3.


Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK-A(y) and Apc mutant Min mice.

Komiya M, Fujii G, Miyamoto S, Takahashi M, Ishigamori R, Onuma W, Ishino K, Totsuka Y, Fujimoto K, Mutoh M.

Cancer Sci. 2015 Nov;106(11):1499-505. doi: 10.1111/cas.12801. Epub 2015 Oct 16.


Establishment of a syngeneic orthotopic model of prostate cancer in immunocompetent rats.

Suzuki S, Naiki-Ito A, Kuno T, Punfa W, Long N, Kato H, Inaguma S, Komiya M, Shirai T, Takahashi S.

J Toxicol Pathol. 2015 Jan;28(1):21-6. doi: 10.1293/tox.2014-0050. Epub 2014 Dec 18. Erratum in: J Toxicol Pathol. 2016 Jan;29(1):74.


Establishment of an invasive prostate cancer model in transgenic rats by intermittent testosterone administration.

Sato S, Suzuki S, Naiki-Ito A, Komiya M, Ne L, Kato H, Sagawa H, Yamashita Y, Shirai T, Takahashi S.

J Toxicol Pathol. 2014 Apr;27(1):43-9. doi: 10.1293/tox.2013-0052. Epub 2014 Apr 30. Erratum in: J Toxicol Pathol. 2016 Jan;29(1):74.


Sesamol suppresses cyclooxygenase-2 transcriptional activity in colon cancer cells and modifies intestinal polyp development in Apc (Min/+) mice.

Shimizu S, Fujii G, Takahashi M, Nakanishi R, Komiya M, Shimura M, Noma N, Onuma W, Terasaki M, Yano T, Mutoh M.

J Clin Biochem Nutr. 2014 Mar;54(2):95-101. doi: 10.3164/jcbn.13-91. Epub 2014 Feb 19.


Bi-directional regulation between adiponectin and plasminogen activator-inhibitor-1 in 3T3-L1 cells.

Komiya M, Fujii G, Takahashi M, Shimura M, Noma N, Shimizu S, Onuma W, Mutoh M.

In Vivo. 2014 Jan-Feb;28(1):13-9.


Synthesis of novel benzo-fused heteroaryl derivatives as Ca²⁺/calmodulin-dependent protein kinase II inhibitors.

Komiya M, Asano S, Koike N, Koga E, Igarashi J, Nakatani S, Isobe Y.

Chem Pharm Bull (Tokyo). 2013;61(10):1094-7.


Prevention and intervention trials for colorectal cancer.

Komiya M, Fujii G, Takahashi M, Iigo M, Mutoh M.

Jpn J Clin Oncol. 2013 Jul;43(7):685-94. doi: 10.1093/jjco/hyt053. Epub 2013 Apr 23. Review.


Study of sustained blood pressure-lowering effect of azelnidipine guided by self-measured morning and evening home blood pressure: subgroup analysis of the At-HOME study.

Kario K, Uehara Y, Shirayama M, Takahashi M, Shiosakai K, Hiramatsu K, Komiya M, Shimada K.

Drugs R D. 2013 Mar;13(1):75-85. doi: 10.1007/s40268-013-0007-7.


Inhibitory effects of azelnidipine tablets on morning hypertension.

Kario K, Sato Y, Shirayama M, Takahashi M, Shiosakai K, Hiramatsu K, Komiya M, Shimada K.

Drugs R D. 2013 Mar;13(1):63-73. doi: 10.1007/s40268-013-0006-8.


Non-invasive X-ray micro-computed tomographic evaluation of indomethacin on urethane-induced lung carcinogenesis in mice.

Ueno T, Imaida K, Yoshimoto M, Hayakawa T, Takahashi M, Imai T, Yanaka A, Tsuta K, Komiya M, Wakabayashi K, Mutoh M.

Anticancer Res. 2012 Nov;32(11):4773-80.


The context of transcription start site regions is crucial for transcription of a plant tRNA(Lys)(UUU) gene group both in vitro and in vivo.

Yukawa Y, Akama K, Noguchi K, Komiya M, Sugiura M.

Gene. 2013 Jan 10;512(2):286-93. doi: 10.1016/j.gene.2012.10.022. Epub 2012 Oct 26.


Suppressive effect of pioglitazone, a PPAR gamma ligand, on azoxymethane-induced colon aberrant crypt foci in KK-Ay mice.

Ueno T, Teraoka N, Takasu S, Nakano K, Takahashi M, Yamamoto M, Fujii G, Komiya M, Yanaka A, Wakabayashi K, Mutoh M.

Asian Pac J Cancer Prev. 2012;13(8):4067-73.


Synthesis and structure based optimization of 2-(4-phenoxybenzoyl)-5-hydroxyindole as a novel CaMKII inhibitor.

Komiya M, Asano S, Koike N, Koga E, Igarashi J, Nakatani S, Isobe Y.

Bioorg Med Chem. 2012 Dec 1;20(23):6840-7. doi: 10.1016/j.bmc.2012.09.048. Epub 2012 Oct 2.


Novel compound SK-1009 suppresses interleukin-6 expression through modulation of activation of nuclear factor-kappaB pathway.

Shimura M, Yamamoto M, Fujii G, Takahashi M, Komiya M, Noma N, Tanuma S, Yanaka A, Mutoh M.

Biol Pharm Bull. 2012;35(12):2186-91. Epub 2012 Sep 27.


An epidermal growth factor motif from Del1 protein increases the efficiency of in vivo gene transfer with a non-viral vector.

Mamiya A, Kitano H, Takao K, Kokubun S, Komiya M, Hidai C.

Mol Biotechnol. 2013 Jun;54(2):445-50. doi: 10.1007/s12033-012-9582-z.


Therapeutic targeting of angiotensin II receptor type 1 to regulate androgen receptor in prostate cancer.

Takahashi S, Uemura H, Seeni A, Tang M, Komiya M, Long N, Ishiguro H, Kubota Y, Shirai T.

Prostate. 2012 Oct 1;72(14):1559-72. doi: 10.1002/pros.22505. Epub 2012 Mar 16.


A rare case of sialolithiasis of the lower lip simulating a mucocele and review of the literature.

Okada H, Yokokawa M, Komiya M, Akimoto Y, Kaneda T, Yamamoto H.

Quintessence Int. 2011 Jul-Aug;42(7):589-94. Review.


Artist® tablets (carvedilol) for hypertensive patients in Japan: results of a long-term special survey.

Iizuka T, Nishikawa Y, Mori Y, Zenimura N, Matsumoto T, Hiramatsu K, Komiya M.

Drugs R D. 2011;11(2):191-205. doi: 10.2165/11592460-000000000-00000.


Artist® tablets (carvedilol) for hypertensive patients in Japan: results of a drug use survey.

Mori Y, Nishikawa Y, Iizuka T, Zenimura N, Matsumoto T, Hiramatsu K, Komiya M.

Drugs R D. 2011;11(2):171-90. doi: 10.2165/11592450-000000000-00000.


Deduction of the evaluation limit and termination timing of multi-round protein misfolding cyclic amplification from a titration curve.

Takeuchi A, Komiya M, Kitamoto T, Morita M.

Microbiol Immunol. 2011 Jul;55(7):502-9. doi: 10.1111/j.1348-0421.2011.00340.x.


Structure and activity relationship of 2-(substituted benzoyl)-hydroxyindoles as novel CaMKII inhibitors.

Komiya M, Asano S, Koike N, Koga E, Igarashi J, Nakatani S, Isobe Y.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1456-8. doi: 10.1016/j.bmcl.2011.01.012. Epub 2011 Jan 8.


5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors.

Asano S, Komiya M, Koike N, Koga E, Nakatani S, Isobe Y.

Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8. doi: 10.1016/j.bmcl.2010.09.005. Epub 2010 Sep 9.


Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice.

Mutoh M, Komiya M, Teraoka N, Ueno T, Takahashi M, Kitahashi T, Sugimura T, Wakabayashi K.

Int J Cancer. 2009 Dec 1;125(11):2505-10. doi: 10.1002/ijc.24667.


Evaluation of the effect of topical application of lavender oil on autonomic nerve activity in dogs.

Komiya M, Sugiyama A, Tanabe K, Uchino T, Takeuchi T.

Am J Vet Res. 2009 Jun;70(6):764-9. doi: 10.2460/ajvr.70.6.764.


Blood pressure-lowering effects of angiotensin receptor antagonist monotherapy and in combination with other anti-hypertensive drugs in primary care settings in Japan.

Kushiro T, Saito I, Hirata K, Ishikawa M, Yamashita T, Matsushita Y, Sagawa K, Hiramatsu K, Komiya M.

Clin Exp Hypertens. 2009 Apr;31(2):127-41. doi: 10.1080/10641960802621275.


Influence of guidelines on physicians' assessment of blood pressure lowering effects and achievement rate of blood pressure target during transitional period of guidelines.

Kushiro T, Saito I, Sato Y, Hirata K, Kobayashi F, Sagawa K, Hiramatsu K, Komiya M.

Clin Exp Hypertens. 2009 Apr;31(2):116-26. doi: 10.1080/10641960802627348.


Early antihypertensive efficacy of olmesartan medoxomil.

Saito I, Kushiro T, Ishikawa M, Matsushita Y, Sagawa K, Hiramatsu K, Komiya M.

J Clin Hypertens (Greenwich). 2008 Dec;10(12):930-5. doi: 10.1111/j.1751-7176.2008.00050.x.


Rare Lipomatous Tumors with Osseous and/or Chondroid Differentiation in the Oral Cavity Report of Two Cases and Review of the Literature.

Kuyama K, Fifita SF, Komiya M, Sun Y, Akimoto Y, Yamamoto H.

Int J Dent. 2009;2009:143460. doi: 10.1155/2009/143460. Epub 2009 Nov 4.


Increased expression of inducible nitric oxide synthase (iNOS) in N-nitrosobis(2-oxopropyl)amine-induced hamster pancreatic carcinogenesis and prevention of cancer development by ONO-1714, an iNOS inhibitor.

Takahashi M, Kitahashi T, Ishigamori R, Mutoh M, Komiya M, Sato H, Kamanaka Y, Naka M, Maruyama T, Sugimura T, Wakabayashi K.

Carcinogenesis. 2008 Aug;29(8):1608-13. doi: 10.1093/carcin/bgn152. Epub 2008 Jun 20.


The use of olmesartan medoxomil as monotherapy or in combination with other antihypertensive agents in elderly hypertensive patients in Japan.

Saito I, Kushiro T, Hirata K, Sato Y, Kobayashi F, Sagawa K, Hiramatsu K, Komiya M.

J Clin Hypertens (Greenwich). 2008 Apr;10(4):272-9.


Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice.

Mutoh M, Niho N, Komiya M, Takahashi M, Ohtsubo R, Nakatogawa K, Ueda K, Sugimura T, Wakabayashi K.

Carcinogenesis. 2008 Apr;29(4):824-9. doi: 10.1093/carcin/bgn028. Epub 2008 Feb 6.


Improvement of hyperlipidemia by indomethacin in Min mice.

Niho N, Mutoh M, Komiya M, Ohta T, Sugimura T, Wakabayashi K.

Int J Cancer. 2007 Oct 15;121(8):1665-9.


Enhanced thyroid carcinogenicity of N-nitrosobis(2-oxopropyl)amine in Otsuka Long-Evans Tokushima Fatty rats, a model of type II diabetes mellitus.

Sakano K, Takahashi M, Mutoh M, Niho N, Komiya M, Sato H, Tanaka T, Sugimura T, Wakabayashi K.

Carcinogenesis. 2007 Oct;28(10):2193-8. Epub 2007 May 16.


Post-marketing surveillance of the safety of levofloxacin in Japan.

Yamaguchi H, Kawai H, Matsumoto T, Yokoyama H, Nakayasu T, Komiya M, Shimada J.

Chemotherapy. 2007;53(2):85-103. Epub 2007 Jan 26.


Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice.

Komiya M, Takeuchi T, Harada E.

Behav Brain Res. 2006 Sep 25;172(2):240-9. Epub 2006 Jun 15.


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