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Items: 12


Knockout of the transcription factor Nrf2: Effects on testosterone production by aging mouse Leydig cells.

Chen H, Jin S, Guo J, Kombairaju P, Biswal S, Zirkin BR.

Mol Cell Endocrinol. 2015 Jul 5;409:113-20. doi: 10.1016/j.mce.2015.03.013. Epub 2015 Mar 25.


Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle.

Kombairaju P, Kerr JP, Roche JA, Pratt SJP, Lovering RM, Sussan TE, Kim JH, Shi G, Biswal S, Ward CW.

Front Physiol. 2014 Feb 19;5:57. doi: 10.3389/fphys.2014.00057. eCollection 2014.


NRF2-mediated Notch pathway activation enhances hematopoietic reconstitution following myelosuppressive radiation.

Kim JH, Thimmulappa RK, Kumar V, Cui W, Kumar S, Kombairaju P, Zhang H, Margolick J, Matsui W, Macvittie T, Malhotra SV, Biswal S.

J Clin Invest. 2014 Feb;124(2):730-41. doi: 10.1172/JCI70812. Epub 2014 Jan 27.


Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.

Kombairaju P, Ma J, Thimmulappa RK, Yan SG, Gabrielson E, Singh A, Biswal S.

J Carcinog. 2012;11:8. doi: 10.4103/1477-3163.98459. Epub 2012 Jul 13.


Tamoxifen-resistant, ER-positive MAC 51 cell line with a high metastatic potential developed from a spontaneous breast cancer mouse model.

Kumar JM, Kombairaju P, Nagarajan P, Subramanian T, Jose J, Ganapathy HS, Ohsugi T.

Cell Tissue Res. 2012 Nov;350(2):347-60. doi: 10.1007/s00441-012-1466-9. Epub 2012 Aug 7.


Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.

Malhotra D, Thimmulappa RK, Mercado N, Ito K, Kombairaju P, Kumar S, Ma J, Feller-Kopman D, Wise R, Barnes P, Biswal S.

J Clin Invest. 2011 Nov;121(11):4289-302. doi: 10.1172/JCI45144. Epub 2011 Oct 17. Retraction in: J Clin Invest. 2014 Dec;124(12):5521.


Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis.

Kong X, Thimmulappa R, Craciun F, Harvey C, Singh A, Kombairaju P, Reddy SP, Remick D, Biswal S.

Am J Respir Crit Care Med. 2011 Oct 15;184(8):928-38. doi: 10.1164/rccm.201102-0271OC. Epub 2011 Jul 28.


Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury.

Wei Y, Gong J, Yoshida T, Eberhart CG, Xu Z, Kombairaju P, Sporn MB, Handa JT, Duh EJ.

Free Radic Biol Med. 2011 Jul 1;51(1):216-24. doi: 10.1016/j.freeradbiomed.2011.04.026. Epub 2011 Apr 19.


NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.

Kong X, Thimmulappa R, Kombairaju P, Biswal S.

J Immunol. 2010 Jul 1;185(1):569-77. doi: 10.4049/jimmunol.0902315. Epub 2010 May 28.


Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

Zhang P, Singh A, Yegnasubramanian S, Esopi D, Kombairaju P, Bodas M, Wu H, Bova SG, Biswal S.

Mol Cancer Ther. 2010 Feb;9(2):336-46. doi: 10.1158/1535-7163.MCT-09-0589. Epub 2010 Feb 2.


Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S.

Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. doi: 10.1165/rcmb.2009-0054OC. Epub 2009 Jun 11.


Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, Biswal S.

Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5. doi: 10.1073/pnas.0804333106. Epub 2008 Dec 22.

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