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Items: 13

1.

Multi-strain Tn-Seq reveals common daptomycin resistance determinants in Staphylococcus aureus.

Coe KA, Lee W, Stone MC, Komazin-Meredith G, Meredith TC, Grad YH, Walker S.

PLoS Pathog. 2019 Nov 18;15(11):e1007862. doi: 10.1371/journal.ppat.1007862. [Epub ahead of print]

2.

Activation of 6-Alkoxy-Substituted Methylenecyclopropane Nucleoside Analogs Requires Enzymatic Modification by Adenosine Deaminase-Like Protein 1.

Vollmer KJ, Burns AC, Sauer HE, Williams JD, Komazin-Meredith G, Cardinale S, Butler M, Aron Z, Hussein I, Busch MG, Bowlin TL, Gentry BG.

Antimicrob Agents Chemother. 2019 Sep 23;63(10). pii: e01301-19. doi: 10.1128/AAC.01301-19. Print 2019 Oct.

PMID:
31332074
3.

Molecular Mechanism Underlying the Action of Influenza A Virus Fusion Inhibitor MBX2546.

Basu A, Komazin-Meredith G, McCarthy C, Antanasijevic A, Cardinale SC, Mishra RK, Barnard DL, Caffrey M, Rong L, Bowlin TL.

ACS Infect Dis. 2017 May 12;3(5):330-335. doi: 10.1021/acsinfecdis.6b00194. Epub 2017 Apr 3.

4.

A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.

Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM.

ACS Infect Dis. 2017 Feb 10;3(2):112-118. doi: 10.1021/acsinfecdis.6b00079. Epub 2016 Dec 6.

5.

TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate.

Komazin-Meredith G, Cardinale SC, Comeau K, Magalhaes KJ, Hartline CB, Williams JD, Opperman TJ, Prichard MN, Bowlin TL.

Antiviral Res. 2015 Jul;119:23-7. doi: 10.1016/j.antiviral.2015.04.001. Epub 2015 Apr 7.

6.

Cytomegalovirus mutants resistant to ganciclovir and cidofovir differ in susceptibilities to synguanol and its 6-ether and 6-thioether derivatives.

Chou S, Komazin-Meredith G, Williams JD, Bowlin TL.

Antimicrob Agents Chemother. 2014;58(3):1809-12. doi: 10.1128/AAC.02544-13. Epub 2013 Dec 30.

7.

Human cytomegalovirus UL97 kinase is involved in the mechanism of action of methylenecyclopropane analogs with 6-ether and -thioether substitutions.

Komazin-Meredith G, Chou S, Prichard MN, Hartline CB, Cardinale SC, Comeau K, Williams JD, Khan AR, Peet NP, Bowlin TL.

Antimicrob Agents Chemother. 2014;58(1):274-8. doi: 10.1128/AAC.01726-13. Epub 2013 Oct 21.

8.

Human herpesvirus 6 U69 kinase phosphorylates the methylenecyclopropane nucleosides cyclopropavir, MBX 2168, and MBX 1616 to their monophosphates.

Komazin-Meredith G, Cardinale SC, Williams JD, Peet NP, Prichard MN, Bowlin TL.

Antimicrob Agents Chemother. 2013 Nov;57(11):5760-2. doi: 10.1128/AAC.00978-13. Epub 2013 Aug 26.

9.

Synthesis and antiviral activities of methylenecyclopropane analogs with 6-alkoxy and 6-alkylthio substitutions that exhibit broad-spectrum antiviral activity against human herpesviruses.

Prichard MN, Williams JD, Komazin-Meredith G, Khan AR, Price NB, Jefferson GM, Harden EA, Hartline CB, Peet NP, Bowlin TL.

Antimicrob Agents Chemother. 2013 Aug;57(8):3518-27. doi: 10.1128/AAC.00429-13. Epub 2013 May 13.

10.

Mutations that increase DNA binding by the processivity factor of herpes simplex virus affect virus production and DNA replication fidelity.

Jiang C, Komazin-Meredith G, Tian W, Coen DM, Hwang CB.

J Virol. 2009 Aug;83(15):7573-80. doi: 10.1128/JVI.00193-09. Epub 2009 May 27.

11.

The human cytomegalovirus UL44 C clamp wraps around DNA.

Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM.

Structure. 2008 Aug 6;16(8):1214-25. doi: 10.1016/j.str.2008.05.008.

12.

Hopping of a processivity factor on DNA revealed by single-molecule assays of diffusion.

Komazin-Meredith G, Mirchev R, Golan DE, van Oijen AM, Coen DM.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10721-6. doi: 10.1073/pnas.0802676105. Epub 2008 Jul 25.

13.

The positively charged surface of herpes simplex virus UL42 mediates DNA binding.

Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM.

J Biol Chem. 2008 Mar 7;283(10):6154-61. doi: 10.1074/jbc.M708691200. Epub 2008 Jan 4.

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