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Antibacterial activity of disodium succinoyl glycyrrhetinate, a derivative of glycyrrhetinic acid against Streptococcus mutans.

Yamashita T, Kawada-Matsuo M, Katsumata T, Watanabe A, Oogai Y, Nishitani Y, Miyawaki S, Komatsuzawa H.

Microbiol Immunol. 2019 Jul;63(7):251-260. doi: 10.1111/1348-0421.12717. Epub 2019 Jun 29.


Heparin-LL37 complexes are less cytotoxic for human dental pulp cells and have undiminished antimicrobial and LPS-neutralizing abilities.

Yoshida K, Suzuki S, Kawada-Matsuo M, Nakanishi J, Hirata-Tsuchiya S, Komatsuzawa H, Yamada S, Shiba H.

Int Endod J. 2019 Sep;52(9):1327-1343. doi: 10.1111/iej.13130. Epub 2019 May 11.


Single mutations in BraRS confer high resistance against nisin A in Staphylococcus aureus.

Arii K, Kawada-Matsuo M, Oogai Y, Noguchi K, Komatsuzawa H.

Microbiologyopen. 2019 Nov;8(11):e791. doi: 10.1002/mbo3.791. Epub 2019 Jan 17.


Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans.

Oogai Y, Gotoh Y, Ogura Y, Kawada-Matsuo M, Hayashi T, Komatsuzawa H.

DNA Res. 2018 Apr 1;25(2):207-215. doi: 10.1093/dnares/dsx050.


Impact of a 7-Day Field Training on Oral Health Condition in Japan Ground Self-Defense Force Personnel.

Yamashita K, Nishiyama T, Nagata E, Ramadhani A, Kawada-Matsuo M, Komatsuzawa H, Oho T.

Mil Med. 2017 Jul;182(7):e1869-e1877. doi: 10.7205/MILMED-D-16-00383.


Role of Streptococcus mutans two-component systems in antimicrobial peptide resistance in the oral cavity.

Kawada-Matsuo M, Komatsuzawa H.

Jpn Dent Sci Rev. 2017 Aug;53(3):86-94. doi: 10.1016/j.jdsr.2016.12.002. Epub 2017 Jan 13. Review.


Recombinant Sox Enzymes from Paracoccus pantotrophus Degrade Hydrogen Sulfide, a Major Component of Oral Malodor.

Ramadhani A, Kawada-Matsuo M, Komatsuzawa H, Oho T.

Microbes Environ. 2017 Mar 31;32(1):54-60. doi: 10.1264/jsme2.ME16140. Epub 2017 Mar 3.


Sugar Allocation to Metabolic Pathways is Tightly Regulated and Affects the Virulence of Streptococcus mutans.

Kawada-Matsuo M, Oogai Y, Komatsuzawa H.

Genes (Basel). 2016 Dec 28;8(1). pii: E11. doi: 10.3390/genes8010011. Review.


Antibacterial Effects of Glycyrrhetinic Acid and Its Derivatives on Staphylococcus aureus.

Oyama K, Kawada-Matsuo M, Oogai Y, Hayashi T, Nakamura N, Komatsuzawa H.

PLoS One. 2016 Nov 7;11(11):e0165831. doi: 10.1371/journal.pone.0165831. eCollection 2016.


Lysine and Threonine Biosynthesis from Aspartate Contributes to Staphylococcus aureus Growth in Calf Serum.

Oogai Y, Yamaguchi M, Kawada-Matsuo M, Sumitomo T, Kawabata S, Komatsuzawa H.

Appl Environ Microbiol. 2016 Sep 30;82(20):6150-6157. Print 2016 Oct 15.


Two-Component Systems Involved in Susceptibility to Nisin A in Streptococcus pyogenes.

Kawada-Matsuo M, Tatsuno I, Arii K, Zendo T, Oogai Y, Noguchi K, Hasegawa T, Sonomoto K, Komatsuzawa H.

Appl Environ Microbiol. 2016 Sep 16;82(19):5930-9. doi: 10.1128/AEM.01897-16. Print 2016 Oct 1.


Staphylococcus aureus SrrAB Affects Susceptibility to Hydrogen Peroxide and Co-Existence with Streptococcus sanguinis.

Oogai Y, Kawada-Matsuo M, Komatsuzawa H.

PLoS One. 2016 Jul 21;11(7):e0159768. doi: 10.1371/journal.pone.0159768. eCollection 2016.


Aggregatibacter actinomycetemcomitans outer membrane protein 29 (Omp29) induces TGF-╬▓-regulated apoptosis signal in human gingival epithelial cells via fibronectin/integrin╬▓1/FAK cascade.

Yoshimoto T, Fujita T, Kajiya M, Ouhara K, Matsuda S, Komatsuzawa H, Shiba H, Kurihara H.

Cell Microbiol. 2016 Dec;18(12):1723-1738. doi: 10.1111/cmi.12607. Epub 2016 Jun 10.


C55 bacteriocin produced by ETB-plasmid positive Staphylococcus aureus strains is a key factor for competition with S. aureus strains.

Kawada-Matsuo M, Shammi F, Oogai Y, Nakamura N, Sugai M, Komatsuzawa H.

Microbiol Immunol. 2016 Mar;60(3):139-47. doi: 10.1111/1348-0421.12360.


Significant increase of oral bacteria in the early pregnancy period in Japanese women.

Fujiwara N, Tsuruda K, Iwamoto Y, Kato F, Odaki T, Yamane N, Hori Y, Harashima Y, Sakoda A, Tagaya A, Komatsuzawa H, Sugai M, Noguchi M.

J Investig Clin Dent. 2017 Feb;8(1). doi: 10.1111/jicd.12189. Epub 2015 Sep 8.


LL37 induces VEGF expression in dental pulp cells through ERK signalling.

Khung R, Shiba H, Kajiya M, Kittaka M, Ouhara K, Takeda K, Mizuno N, Fujita T, Komatsuzawa H, Kurihara H.

Int Endod J. 2015 Jul;48(7):673-9. doi: 10.1111/iej.12365. Epub 2014 Sep 12.


Three distinct two-component systems are involved in resistance to the class I bacteriocins, Nukacin ISK-1 and nisin A, in Staphylococcus aureus.

Kawada-Matsuo M, Yoshida Y, Zendo T, Nagao J, Oogai Y, Nakamura Y, Sonomoto K, Nakamura N, Komatsuzawa H.

PLoS One. 2013 Jul 22;8(7):e69455. doi: 10.1371/journal.pone.0069455. Print 2013.


The antimicrobial peptide LL37 promotes bone regeneration in a rat calvarial bone defect.

Kittaka M, Shiba H, Kajiya M, Fujita T, Iwata T, Rathvisal K, Ouhara K, Takeda K, Fujita T, Komatsuzawa H, Kurihara H.

Peptides. 2013 Aug;46:136-42. doi: 10.1016/j.peptides.2013.06.001. Epub 2013 Jun 12.


Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans.

Kawada-Matsuo M, Oogai Y, Zendo T, Nagao J, Shibata Y, Yamashita Y, Ogura Y, Hayashi T, Sonomoto K, Komatsuzawa H.

Appl Environ Microbiol. 2013 Aug;79(15):4751-5. doi: 10.1128/AEM.00780-13. Epub 2013 May 24.


Staphylococcus aureus SasA is responsible for binding to the salivary agglutinin gp340, derived from human saliva.

Kukita K, Kawada-Matsuo M, Oho T, Nagatomo M, Oogai Y, Hashimoto M, Suda Y, Tanaka T, Komatsuzawa H.

Infect Immun. 2013 Jun;81(6):1870-9. doi: 10.1128/IAI.00011-13. Epub 2013 Feb 25.


The surface layer of Tannerella forsythia contributes to serum resistance and oral bacterial coaggregation.

Shimotahira N, Oogai Y, Kawada-Matsuo M, Yamada S, Fukutsuji K, Nagano K, Yoshimura F, Noguchi K, Komatsuzawa H.

Infect Immun. 2013 Apr;81(4):1198-206. doi: 10.1128/IAI.00983-12. Epub 2013 Jan 28.


dpr and sod in Streptococcus mutans are involved in coexistence with S. sanguinis, and PerR is associated with resistance to H2O2.

Fujishima K, Kawada-Matsuo M, Oogai Y, Tokuda M, Torii M, Komatsuzawa H.

Appl Environ Microbiol. 2013 Mar;79(5):1436-43. doi: 10.1128/AEM.03306-12. Epub 2012 Dec 21.


Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells.

Kittaka M, Shiba H, Kajiya M, Ouhara K, Takeda K, Kanbara K, Fujita T, Kawaguchi H, Komatsuzawa H, Kurihara H.

J Periodontal Res. 2013 Apr;48(2):228-34. doi: 10.1111/j.1600-0765.2012.01524.x. Epub 2012 Sep 3.


GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence.

Kawada-Matsuo M, Mazda Y, Oogai Y, Kajiya M, Kawai T, Yamada S, Miyawaki S, Oho T, Komatsuzawa H.

PLoS One. 2012;7(3):e33382. doi: 10.1371/journal.pone.0033382. Epub 2012 Mar 16.


Association of CiaRH with resistance of Streptococcus mutans to antimicrobial peptides in biofilms.

Mazda Y, Kawada-Matsuo M, Kanbara K, Oogai Y, Shibata Y, Yamashita Y, Miyawaki S, Komatsuzawa H.

Mol Oral Microbiol. 2012 Apr;27(2):124-35. doi: 10.1111/j.2041-1014.2012.00637.x. Epub 2012 Jan 30.


Lipopolysaccharides mediate leukotoxin secretion in Aggregatibacter actinomycetemcomitans.

Tang G, Kawai T, Komatsuzawa H, Mintz KP.

Mol Oral Microbiol. 2012 Apr;27(2):70-82. doi: 10.1111/j.2041-1014.2011.00632.x. Epub 2011 Dec 7.


Detection of Fusobacterium nucleatum in chorionic tissues of high-risk pregnant women.

Tateishi F, Hasegawa-Nakamura K, Nakamura T, Oogai Y, Komatsuzawa H, Kawamata K, Douchi T, Hatae M, Noguchi K.

J Clin Periodontol. 2012 May;39(5):417-24. doi: 10.1111/j.1600-051X.2012.01855.x. Epub 2012 Feb 6.


Expression of virulence factors by Staphylococcus aureus grown in serum.

Oogai Y, Matsuo M, Hashimoto M, Kato F, Sugai M, Komatsuzawa H.

Appl Environ Microbiol. 2011 Nov;77(22):8097-105. doi: 10.1128/AEM.05316-11. Epub 2011 Sep 16.


Role of two-component systems in the resistance of Staphylococcus aureus to antibacterial agents.

Kawada-Matsuo M, Yoshida Y, Nakamura N, Komatsuzawa H.

Virulence. 2011 Sep-Oct;2(5):427-30. doi: 10.4161/viru.2.5.17711. Epub 2011 Sep 1. Review.


MK615: a new therapeutic approach for the treatment of oral disease.

Morimoto-Yamashita Y, Matsuo M, Komatsuzawa H, Kawahara K, Kikuchi K, Torii M, Tokuda M.

Med Hypotheses. 2011 Aug;77(2):258-60. doi: 10.1016/j.mehy.2011.04.027. Epub 2011 May 11.


Aggregatibacter actinomycetemcomitans Omp29 is associated with bacterial entry to gingival epithelial cells by F-actin rearrangement.

Kajiya M, Komatsuzawa H, Papantonakis A, Seki M, Makihira S, Ouhara K, Kusumoto Y, Murakami S, Taubman MA, Kawai T.

PLoS One. 2011 Apr 29;6(4):e18287. doi: 10.1371/journal.pone.0018287.


Bacitracin sensing and resistance in Staphylococcus aureus.

Yoshida Y, Matsuo M, Oogai Y, Kato F, Nakamura N, Sugai M, Komatsuzawa H.

FEMS Microbiol Lett. 2011 Jul;320(1):33-9. doi: 10.1111/j.1574-6968.2011.02291.x. Epub 2011 May 9.


Growth-phase dependence of susceptibility to antimicrobial peptides in Staphylococcus aureus.

Matsuo M, Oogai Y, Kato F, Sugai M, Komatsuzawa H.

Microbiology. 2011 Jun;157(Pt 6):1786-1797. doi: 10.1099/mic.0.044727-0. Epub 2011 Mar 10.


Regulatory mechanism for exfoliative toxin production in Staphylococcus aureus.

Kato F, Kadomoto N, Iwamoto Y, Bunai K, Komatsuzawa H, Sugai M.

Infect Immun. 2011 Apr;79(4):1660-70. doi: 10.1128/IAI.00872-10. Epub 2011 Jan 31.


Additive effects of orexin B and vasoactive intestinal polypeptide on LL-37-mediated antimicrobial activities.

Ohta K, Kajiya M, Zhu T, Nishi H, Mawardi H, Shin J, Elbadawi L, Kamata N, Komatsuzawa H, Kawai T.

J Neuroimmunol. 2011 Apr;233(1-2):37-45. doi: 10.1016/j.jneuroim.2010.11.009. Epub 2010 Dec 21.


The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.

Kajiya M, Shiba H, Komatsuzawa H, Ouhara K, Fujita T, Takeda K, Uchida Y, Mizuno N, Kawaguchi H, Kurihara H.

J Endod. 2010 Jun;36(6):1009-13. doi: 10.1016/j.joen.2010.02.028. Epub 2010 Apr 14.


Distinct two-component systems in methicillin-resistant Staphylococcus aureus can change the susceptibility to antimicrobial agents.

Matsuo M, Kato F, Oogai Y, Kawai T, Sugai M, Komatsuzawa H.

J Antimicrob Chemother. 2010 Jul;65(7):1536-7. doi: 10.1093/jac/dkq141. Epub 2010 Apr 29. No abstract available.


Automutanolysin disrupts clinical isolates of cariogenic streptococci in biofilms and planktonic cells.

Thanyasrisung P, Komatsuzawa H, Yoshimura G, Fujiwara T, Yamada S, Kozai K, Eto K, Izumi Y, Sugai M.

Oral Microbiol Immunol. 2009 Dec;24(6):451-5. doi: 10.1111/j.1399-302X.2009.00536.x.


[Strategy of Staphylococcus aureus infection to the host].

Matsuo M, Komatsuzawa H.

Tanpakushitsu Kakusan Koso. 2009 Jun;54(8 Suppl):975-81. Review. Japanese. No abstract available.


Cytolethal distending toxin induces caspase-dependent and -independent cell death in MOLT-4 cells.

Ohara M, Hayashi T, Kusunoki Y, Nakachi K, Fujiwara T, Komatsuzawa H, Sugai M.

Infect Immun. 2008 Oct;76(10):4783-91. doi: 10.1128/IAI.01612-07. Epub 2008 Jul 21.


Irsogladine maleate abolishes the increase in interleukin-8 levels caused by outer membrane protein 29 from Aggregatibacter (Actinobacillus) actinomycetemcomitans through the ERK pathway in human gingival epithelial cells.

Kishimoto A, Fujita T, Shiba H, Komatsuzawa H, Takeda K, Kajiya M, Hayashida K, Kawaguchi H, Kurihara H.

J Periodontal Res. 2008 Oct;43(5):508-13. doi: 10.1111/j.1600-0765.2007.01059.x. Epub 2008 Jun 28.


Increased resistance to cationic antimicrobial peptide LL-37 in methicillin-resistant strains of Staphylococcus aureus.

Ouhara K, Komatsuzawa H, Kawai T, Nishi H, Fujiwara T, Fujiue Y, Kuwabara M, Sayama K, Hashimoto K, Sugai M.

J Antimicrob Chemother. 2008 Jun;61(6):1266-9. doi: 10.1093/jac/dkn106. Epub 2008 Mar 26.


Susceptibility of periodontopathogenic and cariogenic bacteria to defensins and potential therapeutic use of defensins in oral diseases.

Komatsuzawa H, Ouhara K, Kawai T, Yamada S, Fujiwara T, Shiba H, Kurihara H, Taubman MA, Sugai M.

Curr Pharm Des. 2007;13(30):3084-95. Review.


CXCL16 is a novel mediator of the innate immunity of epidermal keratinocytes.

Tohyama M, Sayama K, Komatsuzawa H, Hanakawa Y, Shirakata Y, Dai X, Yang L, Tokumaru S, Nagai H, Hirakawa S, Sugai M, Hashimoto K.

Int Immunol. 2007 Sep;19(9):1095-102.


First isolation of blaIMP-7 in a Pseudomonas aeruginosa in Japan.

Kouda S, Kuwahara R, Ohara M, Shigeta M, Fujiwara T, Komatsuzawa H, Usui T, Sugai M.

J Infect Chemother. 2007 Aug;13(4):276-7. Epub 2007 Aug 27.


Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent periodontal bone resorption in a mouse model.

Kawai T, Paster BJ, Komatsuzawa H, Ernst CW, Goncalves RB, Sasaki H, Ouhara K, Stashenko PP, Sugai M, Taubman MA.

Oral Microbiol Immunol. 2007 Jun;22(3):208-15.


Molecular characterization of imipenem-resistant Pseudomonas aeruginosa in Hiroshima, Japan.

Ohara M, Kouda S, Onodera M, Fujiue Y, Sasaki M, Kohara T, Kashiyama S, Hayashida S, Kadono M, Komatsuzawa H, Gotoh N, Usui T, Itaha H, Kuwabara M, Yokoyama T, Sugai M.

Microbiol Immunol. 2007;51(3):271-7.


Innate immune peptide LL-37 displays distinct expression pattern from beta-defensins in inflamed gingival tissue.

Hosokawa I, Hosokawa Y, Komatsuzawa H, Goncalves RB, Karimbux N, Napimoga MH, Seki M, Ouhara K, Sugai M, Taubman MA, Kawai T.

Clin Exp Immunol. 2006 Nov;146(2):218-25.


[Analysis of the factors involved in cell wall biosynthesis in Staphylococcus aureus].

Komatsuzawa H.

Nihon Saikingaku Zasshi. 2006 Aug;61(3):305-15. Review. Japanese. No abstract available.


Identification and molecular characterization of an N-Acetylmuraminidase, Aml, involved in Streptococcus mutans cell separation.

Yoshimura G, Komatsuzawa H, Hayashi I, Fujiwara T, Yamada S, Nakano Y, Tomita Y, Kozai K, Sugai M.

Microbiol Immunol. 2006;50(9):729-42.

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