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Items: 1 to 50 of 100

1.

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.

Gersch M, Wagstaff JL, Toms AV, Graves B, Freund SMV, Komander D.

Mol Cell. 2019 May 2;74(3):436-451.e7. doi: 10.1016/j.molcel.2019.02.030. Epub 2019 Mar 26.

2.

Evaluating enzyme activities and structures of DUBs.

Pruneda JN, Komander D.

Methods Enzymol. 2019;618:321-341. doi: 10.1016/bs.mie.2019.01.001. Epub 2019 Feb 22.

PMID:
30850058
3.

OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death.

Damgaard RB, Elliott PR, Swatek KN, Maher ER, Stepensky P, Elpeleg O, Komander D, Berkun Y.

EMBO Mol Med. 2019 Mar;11(3). pii: e9324. doi: 10.15252/emmm.201809324.

4.

Publisher Correction: Breaking the chains: deubiquitylating enzyme specificity begets function.

Clague MJ, Urbé S, Komander D.

Nat Rev Mol Cell Biol. 2019 May;20(5):321. doi: 10.1038/s41580-019-0112-8.

PMID:
30783221
5.

Breaking the chains: deubiquitylating enzyme specificity begets function.

Clague MJ, Urbé S, Komander D.

Nat Rev Mol Cell Biol. 2019 Jun;20(6):338-352. doi: 10.1038/s41580-019-0099-1. Review. Erratum in: Nat Rev Mol Cell Biol. 2019 May;20(5):321.

PMID:
30733604
6.

A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.

Pruneda JN, Bastidas RJ, Bertsoulaki E, Swatek KN, Santhanam B, Clague MJ, Valdivia RH, Urbé S, Komander D.

Nat Microbiol. 2018 Dec;3(12):1377-1384. doi: 10.1038/s41564-018-0271-y. Epub 2018 Nov 5.

7.

Enzymatic Assembly of Ubiquitin Chains.

Michel MA, Komander D, Elliott PR.

Methods Mol Biol. 2018;1844:73-84. doi: 10.1007/978-1-4939-8706-1_6.

PMID:
30242704
8.

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitin-binding proteins.

Morrow ME, Morgan MT, Clerici M, Growkova K, Yan M, Komander D, Sixma TK, Simicek M, Wolberger C.

EMBO Rep. 2018 Oct;19(10). pii: e45680. doi: 10.15252/embr.201745680. Epub 2018 Aug 27.

9.

Mechanism of parkin activation by PINK1.

Gladkova C, Maslen SL, Skehel JM, Komander D.

Nature. 2018 Jul;559(7714):410-414. doi: 10.1038/s41586-018-0224-x. Epub 2018 Jun 6.

10.

Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential.

Feltham R, Jamal K, Tenev T, Liccardi G, Jaco I, Domingues CM, Morris O, John SW, Annibaldi A, Widya M, Kearney CJ, Clancy D, Elliott PR, Glatter T, Qiao Q, Thompson AJ, Nesvizhskii A, Schmidt A, Komander D, Wu H, Martin S, Meier P.

Cell Rep. 2018 Apr 10;23(2):470-484. doi: 10.1016/j.celrep.2018.03.054.

11.

Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies.

Swatek KN, Aumayr M, Pruneda JN, Visser LJ, Berryman S, Kueck AF, Geurink PP, Ovaa H, van Kuppeveld FJM, Tuthill TJ, Skern T, Komander D.

Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2371-2376. doi: 10.1073/pnas.1710617115. Epub 2018 Feb 20.

12.

Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2.

Annibaldi A, Wicky John S, Vanden Berghe T, Swatek KN, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, Meier P.

Mol Cell. 2018 Feb 15;69(4):566-580.e5. doi: 10.1016/j.molcel.2018.01.027.

13.

Synthesis of Poly-Ubiquitin Chains Using a Bifunctional Ubiquitin Monomer.

van der Heden van Noort GJ, Kooij R, Elliott PR, Komander D, Ovaa H.

Org Lett. 2017 Dec 15;19(24):6490-6493. doi: 10.1021/acs.orglett.7b03085. Epub 2017 Nov 27.

14.

Structure of PINK1 in complex with its substrate ubiquitin.

Schubert AF, Gladkova C, Pardon E, Wagstaff JL, Freund SMV, Steyaert J, Maslen SL, Komander D.

Nature. 2017 Dec 7;552(7683):51-56. doi: 10.1038/nature24645. Epub 2017 Oct 30.

15.

An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1.

Gladkova C, Schubert AF, Wagstaff JL, Pruneda JN, Freund SM, Komander D.

EMBO J. 2017 Dec 15;36(24):3555-3572. doi: 10.15252/embj.201797876. Epub 2017 Nov 13.

16.

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D.

Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18.

17.

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

Gersch M, Gladkova C, Schubert AF, Michel MA, Maslen S, Komander D.

Nat Struct Mol Biol. 2017 Nov;24(11):920-930. doi: 10.1038/nsmb.3475. Epub 2017 Sep 25.

18.

Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling.

Michel MA, Swatek KN, Hospenthal MK, Komander D.

Mol Cell. 2017 Oct 5;68(1):233-246.e5. doi: 10.1016/j.molcel.2017.08.020. Epub 2017 Sep 21.

19.

A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.

Weber A, Elliott PR, Pinto-Fernandez A, Bonham S, Kessler BM, Komander D, El Oualid F, Krappmann D.

Cell Chem Biol. 2017 Oct 19;24(10):1299-1313.e7. doi: 10.1016/j.chembiol.2017.08.006. Epub 2017 Sep 14.

20.

Mechanisms of Deubiquitinase Specificity and Regulation.

Mevissen TET, Komander D.

Annu Rev Biochem. 2017 Jun 20;86:159-192. doi: 10.1146/annurev-biochem-061516-044916. Epub 2017 May 12. Review.

PMID:
28498721
21.

LUBAC-synthesized linear ubiquitin chains restrict cytosol-invading bacteria by activating autophagy and NF-κB.

Noad J, von der Malsburg A, Pathe C, Michel MA, Komander D, Randow F.

Nat Microbiol. 2017 May 8;2:17063. doi: 10.1038/nmicrobiol.2017.63.

22.

Strange New World: Bacteria Catalyze Ubiquitylation via ADP Ribosylation.

Komander D, Randow F.

Cell Host Microbe. 2017 Feb 8;21(2):127-129. doi: 10.1016/j.chom.2017.01.014.

23.

The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.

Grabe GJ, Zhang Y, Przydacz M, Rolhion N, Yang Y, Pruneda JN, Komander D, Holden DW, Hare SA.

J Biol Chem. 2016 Dec 9;291(50):25853-25863. Epub 2016 Oct 27.

24.

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.

Mevissen TET, Kulathu Y, Mulder MPC, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BDM, Akutsu M, Oualid FE, Kawasaki M, Freund SMV, Ovaa H, Komander D.

Nature. 2016 Oct 20;538(7625):402-405. doi: 10.1038/nature19836. Epub 2016 Oct 12.

25.

SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling.

Elliott PR, Leske D, Hrdinka M, Bagola K, Fiil BK, McLaughlin SH, Wagstaff J, Volkmar N, Christianson JC, Kessler BM, Freund SM, Komander D, Gyrd-Hansen M.

Mol Cell. 2016 Sep 15;63(6):990-1005. doi: 10.1016/j.molcel.2016.08.001. Epub 2016 Aug 30.

26.

The tumour suppressor CYLD regulates the p53 DNA damage response.

Fernández-Majada V, Welz PS, Ermolaeva MA, Schell M, Adam A, Dietlein F, Komander D, Büttner R, Thomas RK, Schumacher B, Pasparakis M.

Nat Commun. 2016 Aug 26;7:12508. doi: 10.1038/ncomms12508.

27.

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.

Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ, Komander D.

Cell. 2016 Aug 25;166(5):1215-1230.e20. doi: 10.1016/j.cell.2016.07.019. Epub 2016 Aug 11.

28.

Gsk3β and Tomm20 are substrates of the SCFFbxo7/PARK15 ubiquitin ligase associated with Parkinson's disease.

Teixeira FR, Randle SJ, Patel SP, Mevissen TE, Zenkeviciute G, Koide T, Komander D, Laman H.

Biochem J. 2016 Oct 15;473(20):3563-3580. Epub 2016 Aug 8.

29.

The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.

Pruneda JN, Durkin CH, Geurink PP, Ovaa H, Santhanam B, Holden DW, Komander D.

Mol Cell. 2016 Jul 21;63(2):261-276. doi: 10.1016/j.molcel.2016.06.015. Epub 2016 Jul 14.

30.

Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.

Thurston TL, Boyle KB, Allen M, Ravenhill BJ, Karpiyevich M, Bloor S, Kaul A, Noad J, Foeglein A, Matthews SA, Komander D, Bycroft M, Randow F.

EMBO J. 2016 Aug 15;35(16):1779-92. doi: 10.15252/embj.201694491. Epub 2016 Jul 1.

31.

A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes.

Mulder MP, Witting K, Berlin I, Pruneda JN, Wu KP, Chang JG, Merkx R, Bialas J, Groettrup M, Vertegaal AC, Schulman BA, Komander D, Neefjes J, El Oualid F, Ovaa H.

Nat Chem Biol. 2016 Jul;12(7):523-30. doi: 10.1038/nchembio.2084. Epub 2016 May 16.

32.

Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets.

Flierman D, van der Heden van Noort GJ, Ekkebus R, Geurink PP, Mevissen TE, Hospenthal MK, Komander D, Ovaa H.

Cell Chem Biol. 2016 Apr 21;23(4):472-82. doi: 10.1016/j.chembiol.2016.03.009. Epub 2016 Apr 7.

33.

Ubiquitin modifications.

Swatek KN, Komander D.

Cell Res. 2016 Apr;26(4):399-422. doi: 10.1038/cr.2016.39. Epub 2016 Mar 25. Review.

34.

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling.

Hrdinka M, Fiil BK, Zucca M, Leske D, Bagola K, Yabal M, Elliott PR, Damgaard RB, Komander D, Jost PJ, Gyrd-Hansen M.

Cell Rep. 2016 Mar 29;14(12):2846-58. doi: 10.1016/j.celrep.2016.02.062. Epub 2016 Mar 17.

35.

Development of Diubiquitin-Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes.

Geurink PP, van Tol BD, van Dalen D, Brundel PJ, Mevissen TE, Pruneda JN, Elliott PR, van Tilburg GB, Komander D, Ovaa H.

Chembiochem. 2016 May 3;17(9):816-20. doi: 10.1002/cbic.201600017. Epub 2016 Mar 21.

36.

Regulation of Met1-linked polyubiquitin signalling by the deubiquitinase OTULIN.

Elliott PR, Komander D.

FEBS J. 2016 Jan;283(1):39-53. doi: 10.1111/febs.13547. Epub 2015 Nov 2. Review.

37.

Efficient APC/C substrate degradation in cells undergoing mitotic exit depends on K11 ubiquitin linkages.

Min M, Mevissen TE, De Luca M, Komander D, Lindon C.

Mol Biol Cell. 2015 Dec 1;26(24):4325-32. doi: 10.1091/mbc.E15-02-0102. Epub 2015 Oct 7.

38.

Erratum: Mechanism of phospho-ubiquitin-induced PARKIN activation.

Wauer T, Simicek M, Schubert A, Komander D.

Nature. 2015 Oct 29;526(7575):728. doi: 10.1038/nature15531. Epub 2015 Sep 23. No abstract available.

PMID:
26416742
39.

Mechanism of phospho-ubiquitin-induced PARKIN activation.

Wauer T, Simicek M, Schubert A, Komander D.

Nature. 2015 Aug 20;524(7565):370-4. doi: 10.1038/nature14879. Epub 2015 Jul 10. Erratum in: Nature. 2015 Oct 29;526(7575):728.

40.

Cezanne regulates E2F1-dependent HIF2α expression.

Moniz S, Bandarra D, Biddlestone J, Campbell KJ, Komander D, Bremm A, Rocha S.

J Cell Sci. 2015 Aug 15;128(16):3082-93. doi: 10.1242/jcs.168864. Epub 2015 Jul 6.

41.

Biochemistry. Details of destruction, one molecule at a time.

Komander D.

Science. 2015 Apr 10;348(6231):183-4. doi: 10.1126/science.aab0931. No abstract available.

PMID:
25859031
42.

Assembly and specific recognition of k29- and k33-linked polyubiquitin.

Michel MA, Elliott PR, Swatek KN, Simicek M, Pruneda JN, Wagstaff JL, Freund SM, Komander D.

Mol Cell. 2015 Apr 2;58(1):95-109. doi: 10.1016/j.molcel.2015.01.042. Epub 2015 Mar 5.

43.

Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest).

Hospenthal MK, Mevissen TET, Komander D.

Nat Protoc. 2015 Feb;10(2):349-361. doi: 10.1038/nprot.2015.018. Epub 2015 Jan 29.

44.

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

Wauer T, Swatek KN, Wagstaff JL, Gladkova C, Pruneda JN, Michel MA, Gersch M, Johnson CM, Freund SM, Komander D.

EMBO J. 2015 Feb 3;34(3):307-25. doi: 10.15252/embj.201489847. Epub 2014 Dec 19.

45.

Cezanne (OTUD7B) regulates HIF-1α homeostasis in a proteasome-independent manner.

Bremm A, Moniz S, Mader J, Rocha S, Komander D.

EMBO Rep. 2014 Dec;15(12):1268-77. doi: 10.15252/embr.201438850. Epub 2014 Oct 29.

46.

Molecular basis and regulation of OTULIN-LUBAC interaction.

Elliott PR, Nielsen SV, Marco-Casanova P, Fiil BK, Keusekotten K, Mailand N, Freund SM, Gyrd-Hansen M, Komander D.

Mol Cell. 2014 May 8;54(3):335-48. doi: 10.1016/j.molcel.2014.03.018. Epub 2014 Apr 10.

47.

The JAMM in the proteasome.

Wauer T, Komander D.

Nat Struct Mol Biol. 2014 Apr;21(4):346-8. doi: 10.1038/nsmb.2800. No abstract available.

PMID:
24699083
48.

Lysine 27 ubiquitination of the mitochondrial transport protein Miro is dependent on serine 65 of the Parkin ubiquitin ligase.

Birsa N, Norkett R, Wauer T, Mevissen TE, Wu HC, Foltynie T, Bhatia K, Hirst WD, Komander D, Plun-Favreau H, Kittler JT.

J Biol Chem. 2014 May 23;289(21):14569-82. doi: 10.1074/jbc.M114.563031. Epub 2014 Mar 26.

49.

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains.

Emmerich CH, Ordureau A, Strickson S, Arthur JS, Pedrioli PG, Komander D, Cohen P.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15247-52. doi: 10.1073/pnas.1314715110. Epub 2013 Aug 28.

50.

OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.

Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D.

Cell. 2013 Jul 3;154(1):169-84. doi: 10.1016/j.cell.2013.05.046.

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