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Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways.

Cheung-Flynn J, Alvis BD, Hocking KM, Guth CM, Luo W, McCallister R, Chadalavada K, Polcz M, Komalavilas P, Brophy CM.

PLoS One. 2019 Aug 14;14(8):e0220893. doi: 10.1371/journal.pone.0220893. eCollection 2019.


Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue.

Hocking KM, Evans BC, Komalavilas P, Cheung-Flynn J, Duvall CL, Brophy CM.

Tissue Eng Part A. 2019 Mar;25(5-6):416-426. doi: 10.1089/ten.TEA.2018.0169. Epub 2018 Oct 26.


Vascular surgical stretch injury leads to activation of P2X7 receptors and impaired endothelial function.

Komalavilas P, Luo W, Guth CM, Jolayemi O, Bartelson RI, Cheung-Flynn J, Brophy CM.

PLoS One. 2017 Nov 14;12(11):e0188069. doi: 10.1371/journal.pone.0188069. eCollection 2017.


Adenosine triphosphate as a molecular mediator of the vascular response to injury.

Guth CM, Luo W, Jolayemi O, Chadalavada KS, Komalavilas P, Cheung-Flynn J, Brophy CM.

J Surg Res. 2017 Aug;216:80-86. doi: 10.1016/j.jss.2017.03.025. Epub 2017 Mar 31.


Calcification of Human Saphenous Vein Associated with Endothelial Dysfunction: A Pilot Histopathophysiological and Demographical Study.

Pedigo SL, Guth CM, Hocking KM, Banathy A, Li FD, Cheung-Flynn J, Brophy CM, Guzman RJ, Komalavilas P.

Front Surg. 2017 Feb 9;4:6. doi: 10.3389/fsurg.2017.00006. eCollection 2017.


Use of Brilliant Blue FCF during vein graft preparation inhibits intimal hyperplasia.

Osgood MJ, Sexton K, Voskresensky I, Hocking K, Song J, Komalavilas P, Brophy C, Cheung-Flynn J.

J Vasc Surg. 2016 Aug;64(2):471-478. doi: 10.1016/j.jvs.2015.02.028.


Traditional graft preparation decreases physiologic responses, diminishes viscoelasticity, and reduces cellular viability of the conduit: A porcine saphenous vein model.

Wise ES, Hocking KM, Luo W, Feldman DL, Song J, Komalavilas P, Cheung-Flynn J, Brophy CM.

Vasc Med. 2016 Oct;21(5):413-421. Epub 2016 May 23.


Papaverine Prevents Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein.

Hocking KM, Putumbaka G, Wise ES, Cheung-Flynn J, Brophy CM, Komalavilas P.

PLoS One. 2016 May 2;11(5):e0154460. doi: 10.1371/journal.pone.0154460. eCollection 2016.


Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of β2-Adrenergic Receptor.

Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS Jr, Komalavilas P.

Am J Respir Cell Mol Biol. 2016 Aug;55(2):225-33. doi: 10.1165/rcmb.2015-0139OC.


An Optimized Preparation Technique for Saphenous Vein Graft.

Wise ES, Hocking KM, Feldman D, Komalavilas P, Cheung-Flynn J, Brophy CM.

Am Surg. 2015 Jul;81(7):E274-6. No abstract available.


Preservation solution impacts physiologic function and cellular viability of human saphenous vein graft.

Wise ES, Hocking KM, Eagle S, Absi T, Komalavilas P, Cheung-Flynn J, Brophy CM.

Surgery. 2015 Aug;158(2):537-46. doi: 10.1016/j.surg.2015.03.036. Epub 2015 May 21.


Brilliant blue FCF is a nontoxic dye for saphenous vein graft marking that abrogates response to injury.

Hocking KM, Luo W, Li FD, Komalavilas P, Brophy C, Cheung-Flynn J.

J Vasc Surg. 2016 Jul;64(1):210-8. doi: 10.1016/j.jvs.2014.12.059. Epub 2015 Feb 19.


Brilliant blue FCF as an alternative dye for saphenous vein graft marking: effect on conduit function.

Voskresensky IV, Wise ES, Hocking KM, Li FD, Osgood MJ, Komalavilas P, Brophy C, Cheung-Flynn J.

JAMA Surg. 2014 Nov;149(11):1176-81. doi: 10.1001/jamasurg.2014.2029.


Pressure control during preparation of saphenous veins.

Li FD, Eagle S, Brophy C, Hocking KM, Osgood M, Komalavilas P, Cheung-Flynn J.

JAMA Surg. 2014 Jul;149(7):655-62. doi: 10.1001/jamasurg.2013.5067.


Surgical vein graft preparation promotes cellular dysfunction, oxidative stress, and intimal hyperplasia in human saphenous vein.

Osgood MJ, Hocking KM, Voskresensky IV, Li FD, Komalavilas P, Cheung-Flynn J, Brophy CM.

J Vasc Surg. 2014 Jul;60(1):202-11. doi: 10.1016/j.jvs.2013.06.004. Epub 2013 Jul 30.


Role of cyclic nucleotide-dependent actin cytoskeletal dynamics:Ca(2+)](i) and force suppression in forskolin-pretreated porcine coronary arteries.

Hocking KM, Baudenbacher FJ, Putumbaka G, Venkatraman S, Cheung-Flynn J, Brophy CM, Komalavilas P.

PLoS One. 2013 Apr 12;8(4):e60986. doi: 10.1371/journal.pone.0060986. Print 2013.


Cell-permeant peptide inhibitors of vasospasm and intimal hyperplasia.

Osgood MJ, Flynn CR, Komalavilas P, Brophy C.

Vascular. 2013 Feb;21(1):46-53. doi: 10.1258/vasc.2011.201203. Epub 2012 Oct 26. Review.


Intimal thickness associated with endothelial dysfunction in human vein grafts.

Li FD, Sexton KW, Hocking KM, Osgood MJ, Eagle S, Cheung-Flynn J, Brophy CM, Komalavilas P.

J Surg Res. 2013 Mar;180(1):e55-62. doi: 10.1016/j.jss.2012.06.017. Epub 2012 Jun 23.


Role of the renin-angiotensin system in the pathogenesis of intimal hyperplasia: therapeutic potential for prevention of vein graft failure?

Osgood MJ, Harrison DG, Sexton KW, Hocking KM, Voskresensky IV, Komalavilas P, Cheung-Flynn J, Guzman RJ, Brophy CM.

Ann Vasc Surg. 2012 Nov;26(8):1130-44. doi: 10.1016/j.avsg.2011.12.001. Epub 2012 Mar 22. Review.


Women in academic surgery: the pipeline is busted.

Sexton KW, Hocking KM, Wise E, Osgood MJ, Cheung-Flynn J, Komalavilas P, Campbell KE, Dattilo JB, Brophy CM.

J Surg Educ. 2012 Jan-Feb;69(1):84-90. doi: 10.1016/j.jsurg.2011.07.008. Epub 2011 Sep 3.


Inhibition of Mitogen Activated Protein Kinase Activated Protein Kinase II with MMI-0100 reduces intimal hyperplasia ex vivo and in vivo.

Muto A, Panitch A, Kim N, Park K, Komalavilas P, Brophy CM, Dardik A.

Vascul Pharmacol. 2012 Jan-Feb;56(1-2):47-55. doi: 10.1016/j.vph.2011.07.008. Epub 2011 Oct 17.


Surgical skin markers impair human saphenous vein graft smooth muscle and endothelial function.

Eagle S, Brophy CM, Komalavilas P, Hocking K, Putumbaka G, Osgood M, Sexton K, Leacche M, Cheung-Flynn J.

Am Surg. 2011 Jul;77(7):922-8.


Detrimental effects of mechanical stretch on smooth muscle function in saphenous veins.

Hocking KM, Brophy C, Rizvi SZ, Komalavilas P, Eagle S, Leacche M, Balaguer JM, Cheung-Flynn J.

J Vasc Surg. 2011 Feb;53(2):454-60. doi: 10.1016/j.jvs.2010.09.010. Epub 2010 Dec 13.


A novel cell permeant peptide inhibitor of MAPKAP kinase II inhibits intimal hyperplasia in a human saphenous vein organ culture model.

Lopes LB, Brophy CM, Flynn CR, Yi Z, Bowen BP, Smoke C, Seal B, Panitch A, Komalavilas P.

J Vasc Surg. 2010 Dec;52(6):1596-607. doi: 10.1016/j.jvs.2010.06.168. Epub 2010 Sep 22.


The small heat shock protein, HSPB6, in muscle function and disease.

Dreiza CM, Komalavilas P, Furnish EJ, Flynn CR, Sheller MR, Smoke CC, Lopes LB, Brophy CM.

Cell Stress Chaperones. 2010 Jan;15(1):1-11. doi: 10.1007/s12192-009-0127-8. Epub 2009 Jul 1. Review.


Inhibition of HSP27 phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor.

Lopes LB, Flynn C, Komalavilas P, Panitch A, Brophy CM, Seal BL.

Biochem Biophys Res Commun. 2009 May 8;382(3):535-9. doi: 10.1016/j.bbrc.2009.03.056. Epub 2009 Mar 14.


Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts.

Lopes LB, Furnish EJ, Komalavilas P, Flynn CR, Ashby P, Hansen A, Ly DP, Yang GP, Longaker MT, Panitch A, Brophy CM.

J Invest Dermatol. 2009 Mar;129(3):590-8. doi: 10.1038/jid.2008.264. Epub 2008 Sep 11.


Enhanced skin penetration of P20 phosphopeptide using protein transduction domains.

Lopes LB, Furnish E, Komalavilas P, Seal BL, Panitch A, Bentley MV, Brophy CM.

Eur J Pharm Biopharm. 2008 Feb;68(2):441-5. Epub 2007 Oct 5.


The small heat shock-related protein, HSP20, is a cAMP-dependent protein kinase substrate that is involved in airway smooth muscle relaxation.

Komalavilas P, Penn RB, Flynn CR, Thresher J, Lopes LB, Furnish EJ, Guo M, Pallero MA, Murphy-Ullrich JE, Brophy CM.

Am J Physiol Lung Cell Mol Physiol. 2008 Jan;294(1):L69-78. Epub 2007 Nov 9.


Phosphorylation and activation of a transducible recombinant form of human HSP20 in Escherichia coli.

Flynn CR, Smoke CC, Furnish E, Komalavilas P, Thresher J, Yi Z, Mandarino LJ, Brophy CM.

Protein Expr Purif. 2007 Mar;52(1):50-8. Epub 2006 Sep 12.


Role of the small heat shock proteins in regulating vascular smooth muscle tone.

McLemore EC, Tessier DJ, Thresher J, Komalavilas P, Brophy CM.

J Am Coll Surg. 2005 Jul;201(1):30-6.


Comparative study of the skin penetration of protein transduction domains and a conjugated peptide.

Lopes LB, Brophy CM, Furnish E, Flynn CR, Sparks O, Komalavilas P, Joshi L, Panitch A, Bentley MV.

Pharm Res. 2005 May;22(5):750-7. Epub 2005 May 17.


Transduction of phosphorylated heat shock-related protein 20, HSP20, prevents vasospasm of human umbilical artery smooth muscle.

Flynn CR, Brophy CM, Furnish EJ, Komalavilas P, Tessier D, Thresher J, Joshi L.

J Appl Physiol (1985). 2005 May;98(5):1836-45.


Transducible heat shock protein 20 (HSP20) phosphopeptide alters cytoskeletal dynamics.

Dreiza CM, Brophy CM, Komalavilas P, Furnish EJ, Joshi L, Pallero MA, Murphy-Ullrich JE, von Rechenberg M, Ho YS, Richardson B, Xu N, Zhen Y, Peltier JM, Panitch A.

FASEB J. 2005 Feb;19(2):261-3. Epub 2004 Dec 14.


Transducible recombinant small heat shock-related protein, HSP20, inhibits vasospasm and platelet aggregation.

McLemore EC, Tessier DJ, Flynn CR, Furnish EJ, Komalavilas P, Thresher JS, Joshi L, Stone WM, Fowl RJ, Brophy CM.

Surgery. 2004 Sep;136(3):573-8.


Transduction of peptide analogs of the small heat shock-related protein HSP20 inhibits intimal hyperplasia.

Tessier DJ, Komalavilas P, Liu B, Kent CK, Thresher JS, Dreiza CM, Panitch A, Joshi L, Furnish E, Stone W, Fowl R, Brophy CM.

J Vasc Surg. 2004 Jul;40(1):106-14.


Heat shock-related protein 20 (HSP20) in cardiomyocytes.

Brophy CM, Komalavilas P.

Circ Res. 2004 May 28;94(10):e85. No abstract available.


Sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of the heat shock-related protein 20 (HSP20).

Tessier DJ, Komalavilas P, McLemore E, Thresher J, Brophy CM.

J Surg Res. 2004 May 1;118(1):21-5.


The small heat shock protein (HSP) 20 is dynamically associated with the actin cross-linking protein actinin.

Tessier DJ, Komalavilas P, Panitch A, Joshi L, Brophy CM.

J Surg Res. 2003 May 1;111(1):152-7.


Transduction of biologically active motifs of the small heat shock-related protein HSP20 leads to relaxation of vascular smooth muscle.

Flynn CR, Komalavilas P, Tessier D, Thresher J, Niederkofler EE, Dreiza CM, Nelson RW, Panitch A, Joshi L, Brophy CM.

FASEB J. 2003 Jul;17(10):1358-60. Epub 2003 May 8.


Phosphorylation of the heat shock-related protein, HSP20, mediates cyclic nucleotide-dependent relaxation.

Woodrum D, Pipkin W, Tessier D, Komalavilas P, Brophy CM.

J Vasc Surg. 2003 Apr;37(4):874-81.


Localization, macromolecular associations, and function of the small heat shock-related protein HSP20 in rat heart.

Pipkin W, Johnson JA, Creazzo TL, Burch J, Komalavilas P, Brophy C.

Circulation. 2003 Jan 28;107(3):469-76.


cGMP-dependent protein kinase expression restores contractile function in cultured vascular smooth muscle cells.

Brophy CM, Woodrum DA, Pollock J, Dickinson M, Komalavilas P, Cornwell TL, Lincoln TM.

J Vasc Res. 2002 Mar-Apr;39(2):95-103.


PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways.

Komalavilas P, Mehta S, Wingard CJ, Dransfield DT, Bhalla J, Woodrum JE, Molinaro JR, Brophy CM.

J Appl Physiol (1985). 2001 Oct;91(4):1819-27.


Analysis of expression of cGMP-dependent protein kinase in rabbit heart cells.

Kumar R, Joyner RW, Komalavilas P, Lincoln TM.

J Pharmacol Exp Ther. 1999 Dec;291(3):967-75.


Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.

Weisbrod RM, Griswold MC, Yaghoubi M, Komalavilas P, Lincoln TM, Cohen RA.

Br J Pharmacol. 1998 Dec;125(8):1695-707.


Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.

Fouty B, Komalavilas P, Muramatsu M, Cohen A, McMurtry IF, Lincoln TM, Rodman DM.

Am J Physiol. 1998 Feb;274(2):H672-8. doi: 10.1152/ajpheart.1998.274.2.H672.


Cyclic GMP-dependent protein kinase in nitric oxide signaling.

Lincoln TM, Cornwell TL, Komalavilas P, Boerth N.

Methods Enzymol. 1996;269:149-66. Review. No abstract available.


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