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Items: 1 to 50 of 62

1.

Daily light and darkness onset and circadian rhythms metabolically synchronize hematopoietic stem cell differentiation and maintenance: The role of bone marrow norepinephrine, tumor necrosis factor, and melatonin cycles.

Golan K, Kollet O, Markus RP, Lapidot T.

Exp Hematol. 2019 Sep 5. pii: S0301-472X(19)30994-4. doi: 10.1016/j.exphem.2019.08.008. [Epub ahead of print] Review.

PMID:
31494174
2.

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance.

Golan K, Kumari A, Kollet O, Khatib-Massalha E, Subramaniam MD, Ferreira ZS, Avemaria F, Rzeszotek S, García-García A, Xie S, Flores-Figueroa E, Gur-Cohen S, Itkin T, Ludin-Tal A, Massalha H, Bernshtein B, Ciechanowicz AK, Brandis A, Mehlman T, Bhattacharya S, Bertagna M, Cheng H, Petrovich-Kopitman E, Janus T, Kaushansky N, Cheng T, Sagi I, Ratajczak MZ, Méndez-Ferrer S, Dick JE, Markus RP, Lapidot T.

Cell Stem Cell. 2018 Oct 4;23(4):572-585.e7. doi: 10.1016/j.stem.2018.08.002. Epub 2018 Aug 30.

3.

MicroRNA-155 promotes G-CSF-induced mobilization of murine hematopoietic stem and progenitor cells via propagation of CXCL12 signaling.

Itkin T, Kumari A, Schneider E, Gur-Cohen S, Ludwig C, Brooks R, Kollet O, Golan K, Khatib-Massalha E, Russo CM, Chisholm JD, Rouhi A, Geiger H, Hornstein E, Kerr WG, Kuchenbauer F, Lapidot T.

Leukemia. 2017 May;31(5):1247-1250. doi: 10.1038/leu.2017.50. Epub 2017 Feb 8. No abstract available.

PMID:
28174416
4.

Corrigendum: Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Golan K, Khatib E, Kumari A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T.

Nature. 2016 Oct 13;538(7624):274. doi: 10.1038/nature19088. Epub 2016 Jul 20. No abstract available.

PMID:
27437586
5.

Distinct bone marrow blood vessels differentially regulate haematopoiesis.

Itkin T, Gur-Cohen S, Spencer JA, Schajnovitz A, Ramasamy SK, Kusumbe AP, Ledergor G, Jung Y, Milo I, Poulos MG, Kalinkovich A, Ludin A, Kollet O, Shakhar G, Butler JM, Rafii S, Adams RH, Scadden DT, Lin CP, Lapidot T.

Nature. 2016 Apr 21;532(7599):323-8. doi: 10.1038/nature17624. Epub 2016 Apr 13.

6.

Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T.

Nat Med. 2016 Apr;22(4):446. doi: 10.1038/nm0416-446b. No abstract available.

PMID:
27050594
7.

Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling.

Gur-Cohen S, Kollet O, Graf C, Esmon CT, Ruf W, Lapidot T.

Ann N Y Acad Sci. 2016 Apr;1370(1):65-81. doi: 10.1111/nyas.13013. Epub 2016 Mar 1. Review.

8.

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells.

Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T.

Nat Med. 2015 Nov;21(11):1307-17. doi: 10.1038/nm.3960. Epub 2015 Oct 12. Erratum in: Nat Med. 2016 Apr;22(4):446.

9.

Reactive oxygen species regulate hematopoietic stem cell self-renewal, migration and development, as well as their bone marrow microenvironment.

Ludin A, Gur-Cohen S, Golan K, Kaufmann KB, Itkin T, Medaglia C, Lu XJ, Ledergor G, Kollet O, Lapidot T.

Antioxid Redox Signal. 2014 Oct 10;21(11):1605-19. doi: 10.1089/ars.2014.5941. Epub 2014 Jun 26. Review.

10.

Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling.

Golan K, Kollet O, Lapidot T.

Pharmaceuticals (Basel). 2013 Sep 23;6(9):1145-69. doi: 10.3390/ph6091145.

11.

Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors.

Kollet O, Vagima Y, D'Uva G, Golan K, Canaani J, Itkin T, Gur-Cohen S, Kalinkovich A, Caglio G, Medaglia C, Ludin A, Lapid K, Shezen E, Neufeld-Cohen A, Varol D, Chen A, Lapidot T.

Leukemia. 2013 Oct;27(10):2006-15. doi: 10.1038/leu.2013.154. Epub 2013 May 17.

PMID:
23680895
12.

Egress and Mobilization of Hematopoietic Stem and Progenitor Cells: A Dynamic Multi-facet Process.

Lapid K, Glait-Santar C, Gur-Cohen S, Canaani J, Kollet O, Lapidot T.

StemBook [Internet]. Cambridge (MA): Harvard Stem Cell Institute; 2008-.
2012 Dec 10.

13.

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.

Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S, Lapidot T.

Nat Immunol. 2012 Nov;13(11):1072-82. doi: 10.1038/ni.2408. Epub 2012 Sep 16.

PMID:
22983360
14.

FGF-2 expands murine hematopoietic stem and progenitor cells via proliferation of stromal cells, c-Kit activation, and CXCL12 down-regulation.

Itkin T, Ludin A, Gradus B, Gur-Cohen S, Kalinkovich A, Schajnovitz A, Ovadya Y, Kollet O, Canaani J, Shezen E, Coffin DJ, Enikolopov GN, Berg T, Piacibello W, Hornstein E, Lapidot T.

Blood. 2012 Aug 30;120(9):1843-55. doi: 10.1182/blood-2011-11-394692. Epub 2012 May 29.

PMID:
22645180
15.

Regulatory cross talks of bone cells, hematopoietic stem cells and the nervous system maintain hematopoiesis.

Kollet O, Canaani J, Kalinkovich A, Lapidot T.

Inflamm Allergy Drug Targets. 2012 Jun;11(3):170-80. Review.

PMID:
22280241
16.

S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release.

Golan K, Vagima Y, Ludin A, Itkin T, Cohen-Gur S, Kalinkovich A, Kollet O, Kim C, Schajnovitz A, Ovadya Y, Lapid K, Shivtiel S, Morris AJ, Ratajczak MZ, Lapidot T.

Blood. 2012 Mar 15;119(11):2478-88. doi: 10.1182/blood-2011-06-358614. Epub 2012 Jan 25.

17.

CD45 regulates homing and engraftment of immature normal and leukemic human cells in transplanted immunodeficient mice.

Shivtiel S, Lapid K, Kalchenko V, Avigdor A, Goichberg P, Kalinkovich A, Nagler A, Kollet O, Lapidot T.

Exp Hematol. 2011 Dec;39(12):1161-1170.e1. doi: 10.1016/j.exphem.2011.08.012. Epub 2011 Sep 10.

PMID:
21911094
18.

Neural regulation of bone, marrow, and the microenvironment.

Canaani J, Kollet O, Lapidot T.

Front Biosci (Schol Ed). 2011 Jun 1;3:1021-31. Review.

PMID:
21622251
19.

Pathways implicated in stem cell migration: the SDF-1/CXCR4 axis.

Vagima Y, Lapid K, Kollet O, Goichberg P, Alon R, Lapidot T.

Methods Mol Biol. 2011;750:277-89. doi: 10.1007/978-1-61779-145-1_19.

PMID:
21618098
20.

Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferation.

Orlovsky K, Kalinkovich A, Rozovskaia T, Shezen E, Itkin T, Alder H, Ozer HG, Carramusa L, Avigdor A, Volinia S, Buchberg A, Mazo A, Kollet O, Largman C, Croce CM, Nakamura T, Lapidot T, Canaani E.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7956-61. doi: 10.1073/pnas.1103154108. Epub 2011 Apr 25.

21.

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells.

Dar A, Schajnovitz A, Lapid K, Kalinkovich A, Itkin T, Ludin A, Kao WM, Battista M, Tesio M, Kollet O, Cohen NN, Margalit R, Buss EC, Baleux F, Oishi S, Fujii N, Larochelle A, Dunbar CE, Broxmeyer HE, Frenette PS, Lapidot T.

Leukemia. 2011 Aug;25(8):1286-1296. doi: 10.1038/leu.2011.62. Epub 2011 Apr 15. Erratum in: Leukemia. 2011 Aug;25(8):1378.

22.

CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.

Schajnovitz A, Itkin T, D'Uva G, Kalinkovich A, Golan K, Ludin A, Cohen D, Shulman Z, Avigdor A, Nagler A, Kollet O, Seger R, Lapidot T.

Nat Immunol. 2011 May;12(5):391-8. doi: 10.1038/ni.2017. Epub 2011 Mar 27.

PMID:
21441933
23.

The brain-bone-blood triad: traffic lights for stem-cell homing and mobilization.

Lapidot T, Kollet O.

Hematology Am Soc Hematol Educ Program. 2010;2010:1-6. doi: 10.1182/asheducation-2010.1.1. Review.

PMID:
21239763
24.

Enhanced c-Met activity promotes G-CSF-induced mobilization of hematopoietic progenitor cells via ROS signaling.

Tesio M, Golan K, Corso S, Giordano S, Schajnovitz A, Vagima Y, Shivtiel S, Kalinkovich A, Caione L, Gammaitoni L, Laurenti E, Buss EC, Shezen E, Itkin T, Kollet O, Petit I, Trumpp A, Christensen J, Aglietta M, Piacibello W, Lapidot T.

Blood. 2011 Jan 13;117(2):419-28. doi: 10.1182/blood-2009-06-230359. Epub 2010 Jun 28.

25.

Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system.

Kalinkovich A, Spiegel A, Shivtiel S, Kollet O, Jordaney N, Piacibello W, Lapidot T.

Brain Behav Immun. 2009 Nov;23(8):1059-65. doi: 10.1016/j.bbi.2009.03.008. Epub 2009 Mar 31. Review.

PMID:
19341792
26.

MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.

Vagima Y, Avigdor A, Goichberg P, Shivtiel S, Tesio M, Kalinkovich A, Golan K, Dar A, Kollet O, Petit I, Perl O, Rosenthal E, Resnick I, Hardan I, Gellman YN, Naor D, Nagler A, Lapidot T.

J Clin Invest. 2009 Mar;119(3):492-503. doi: 10.1172/JCI36541. Epub 2009 Feb 9.

27.

Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment.

Spiegel A, Kalinkovich A, Shivtiel S, Kollet O, Lapidot T.

Cell Stem Cell. 2008 Nov 6;3(5):484-92. doi: 10.1016/j.stem.2008.10.006. Review.

28.

The endosteum region keeps human leukemic stem cells alive.

Lapidot T, Goichberg P, Lapid K, Avigdor A, Kollet O.

Cell Stem Cell. 2007 Nov;1(5):483-4. No abstract available.

29.

CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules.

Shivtiel S, Kollet O, Lapid K, Schajnovitz A, Goichberg P, Kalinkovich A, Shezen E, Tesio M, Netzer N, Petit I, Sharir A, Lapidot T.

J Exp Med. 2008 Sep 29;205(10):2381-95. doi: 10.1084/jem.20080072. Epub 2008 Sep 8.

30.

The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche.

Aicher A, Kollet O, Heeschen C, Liebner S, Urbich C, Ihling C, Orlandi A, Lapidot T, Zeiher AM, Dimmeler S.

Circ Res. 2008 Oct 10;103(8):796-803. doi: 10.1161/CIRCRESAHA.107.172718. Epub 2008 Sep 5.

PMID:
18776043
31.

NeoR6 inhibits HIV-1-CXCR4 interaction without affecting CXCL12 chemotaxis activity.

Lapidot A, Peled A, Berchanski A, Pal B, Kollet O, Lapidot T, Borkow G.

Biochim Biophys Acta. 2008 Jun;1780(6):914-20. doi: 10.1016/j.bbagen.2008.03.011. Epub 2008 Mar 21.

PMID:
18410746
32.

Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment.

Spiegel A, Zcharia E, Vagima Y, Itkin T, Kalinkovich A, Dar A, Kollet O, Netzer N, Golan K, Shafat I, Ilan N, Nagler A, Vlodavsky I, Lapidot T.

Blood. 2008 May 15;111(10):4934-43. doi: 10.1182/blood-2007-10-116145. Epub 2008 Mar 11.

33.

The multiple roles of osteoclasts in host defense: bone remodeling and hematopoietic stem cell mobilization.

Kollet O, Dar A, Lapidot T.

Annu Rev Immunol. 2007;25:51-69. Review.

PMID:
17042735
35.

Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells.

Kollet O, Dar A, Shivtiel S, Kalinkovich A, Lapid K, Sztainberg Y, Tesio M, Samstein RM, Goichberg P, Spiegel A, Elson A, Lapidot T.

Nat Med. 2006 Jun;12(6):657-64. Epub 2006 May 21.

PMID:
16715089
36.

Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells.

Dar A, Goichberg P, Shinder V, Kalinkovich A, Kollet O, Netzer N, Margalit R, Zsak M, Nagler A, Hardan I, Resnick I, Rot A, Lapidot T.

Nat Immunol. 2005 Oct;6(10):1038-46. Epub 2005 Sep 18.

PMID:
16170318
37.

How do stem cells find their way home?

Lapidot T, Dar A, Kollet O.

Blood. 2005 Sep 15;106(6):1901-10. Epub 2005 May 12. Review.

PMID:
15890683
38.

Cycling G1 CD34+/CD38+ cells potentiate the motility and engraftment of quiescent G0 CD34+/CD38-/low severe combined immunodeficiency repopulating cells.

Byk T, Kahn J, Kollet O, Petit I, Samira S, Shivtiel S, Ben-Hur H, Peled A, Piacibello W, Lapidot T.

Stem Cells. 2005 Apr;23(4):561-74.

39.

Correlation between CXCR4 and homing or engraftment of acute myelogenous leukemia.

Monaco G, Belmont JW, Konopleva M, Andreeff M, Tavor S, Petit I, Kollet O, Lapidot T.

Cancer Res. 2004 Sep 15;64(18):6832 author reply 6832-3. No abstract available.

40.

CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.

Avigdor A, Goichberg P, Shivtiel S, Dar A, Peled A, Samira S, Kollet O, Hershkoviz R, Alon R, Hardan I, Ben-Hur H, Naor D, Nagler A, Lapidot T.

Blood. 2004 Apr 15;103(8):2981-9. Epub 2004 Jan 15.

PMID:
15070674
41.

Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling.

Spiegel A, Kollet O, Peled A, Abel L, Nagler A, Bielorai B, Rechavi G, Vormoor J, Lapidot T.

Blood. 2004 Apr 15;103(8):2900-7. Epub 2003 Nov 20.

PMID:
15070661
42.

Stem cell mobilization.

Cottler-Fox MH, Lapidot T, Petit I, Kollet O, DiPersio JF, Link D, Devine S.

Hematology Am Soc Hematol Educ Program. 2003:419-37. Review.

PMID:
14633793
43.

HGF, SDF-1, and MMP-9 are involved in stress-induced human CD34+ stem cell recruitment to the liver.

Kollet O, Shivtiel S, Chen YQ, Suriawinata J, Thung SN, Dabeva MD, Kahn J, Spiegel A, Dar A, Samira S, Goichberg P, Kalinkovich A, Arenzana-Seisdedos F, Nagler A, Hardan I, Revel M, Shafritz DA, Lapidot T.

J Clin Invest. 2003 Jul;112(2):160-9.

44.

Ex vivo expansion of human adult stem cells capable of primary and secondary hemopoietic reconstitution.

Gammaitoni L, Bruno S, Sanavio F, Gunetti M, Kollet O, Cavalloni G, Falda M, Fagioli F, Lapidot T, Aglietta M, Piacibello W.

Exp Hematol. 2003 Mar;31(3):261-70.

PMID:
12644024
46.

Human CD34(+)CXCR4(-) sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation.

Kollet O, Petit I, Kahn J, Samira S, Dar A, Peled A, Deutsch V, Gunetti M, Piacibello W, Nagler A, Lapidot T.

Blood. 2002 Oct 15;100(8):2778-86.

PMID:
12351385
47.

Immature leukemic CD34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1.

Peled A, Hardan I, Trakhtenbrot L, Gur E, Magid M, Darash-Yahana M, Cohen N, Grabovsky V, Franitza S, Kollet O, Lider O, Alon R, Rechavi G, Lapidot T.

Stem Cells. 2002;20(3):259-66.

48.

TGF-beta1 enhances SDF-1alpha-induced chemotaxis and homing of naive T cells by up-regulating CXCR4 expression and downstream cytoskeletal effector molecules.

Franitza S, Kollet O, Brill A, Vaday GG, Petit I, Lapidot T, Alon R, Lider O.

Eur J Immunol. 2002 Jan;32(1):193-202.

49.

Rapid and efficient homing of human CD34(+)CD38(-/low)CXCR4(+) stem and progenitor cells to the bone marrow and spleen of NOD/SCID and NOD/SCID/B2m(null) mice.

Kollet O, Spiegel A, Peled A, Petit I, Byk T, Hershkoviz R, Guetta E, Barkai G, Nagler A, Lapidot T.

Blood. 2001 May 15;97(10):3283-91.

PMID:
11342460

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