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A Mutation in the Borcs7 Subunit of the Lysosome Regulatory BORC Complex Results in Motor Deficits and Dystrophic Axonopathy in Mice.

Snouwaert JN, Church RJ, Jania L, Nguyen M, Wheeler ML, Saintsing A, Mieczkowski P, Manuel de Villena FP, Armao D, Moy SS, Lorenzo DN, Koller BH.

Cell Rep. 2018 Jul 31;24(5):1254-1265. doi: 10.1016/j.celrep.2018.06.118.


Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid.

Lin L, Hwang BJ, Culton DA, Li N, Burette S, Koller BH, Messingham KA, Fairley JA, Lee JJ, Hall RP, An L, Diaz LA, Liu Z.

J Invest Dermatol. 2018 May;138(5):1032-1043. doi: 10.1016/j.jid.2017.11.031. Epub 2017 Dec 12.


Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.

Hagar JA, Edin ML, Lih FB, Thurlow LR, Koller BH, Cairns BA, Zeldin DC, Miao EA.

J Immunol. 2017 Nov 15;199(10):3634-3643. doi: 10.4049/jimmunol.1700820. Epub 2017 Oct 16.


An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice.

Snouwaert JN, Nguyen M, Repenning PW, Dye R, Livingston EW, Kovarova M, Moy SS, Brigman BE, Bateman TA, Ting JP, Koller BH.

Cell Rep. 2016 Dec 13;17(11):3077-3088. doi: 10.1016/j.celrep.2016.11.052.


Reversal of social deficits by subchronic oxytocin in two autism mouse models.

Teng BL, Nikolova VD, Riddick NV, Agster KL, Crowley JJ, Baker LK, Koller BH, Pedersen CA, Jarstfer MB, Moy SS.

Neuropharmacology. 2016 Jun;105:61-71. doi: 10.1016/j.neuropharm.2015.12.025. Epub 2015 Dec 31.


Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.

Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S, Mangano TJ, Deshpande DA, Jiang A, Penn RB, Jin J, Koller BH, Kenakin T, Shoichet BK, Roth BL.

Nature. 2015 Nov 26;527(7579):477-83. doi: 10.1038/nature15699. Epub 2015 Nov 9.


Xenobiotic Metabolism in Mice Lacking the UDP-Glucuronosyltransferase 2 Family.

Fay MJ, Nguyen MT, Snouwaert JN, Dye R, Grant DJ, Bodnar WM, Koller BH.

Drug Metab Dispos. 2015 Dec;43(12):1838-46. doi: 10.1124/dmd.115.065482. Epub 2015 Sep 9.


Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.

Kaushal V, Dye R, Pakavathkumar P, Foveau B, Flores J, Hyman B, Ghetti B, Koller BH, LeBlanc AC.

Cell Death Differ. 2015 Oct;22(10):1676-86. doi: 10.1038/cdd.2015.16. Epub 2015 Mar 6.


PGE₂ promotes apoptosis induced by cytokine deprivation through EP3 receptor and induces Bim in mouse mast cells.

Kovarova M, Koller BH.

PLoS One. 2014 Jul 23;9(7):e102948. doi: 10.1371/journal.pone.0102948. eCollection 2014.


Mice lacking three Loci encoding 14 glutathione transferase genes: a novel tool for assigning function to the GSTP, GSTM, and GSTT families.

Xiang Z, Snouwaert JN, Kovarova M, Nguyen M, Repenning PW, Latour AM, Cyphert JM, Koller BH.

Drug Metab Dispos. 2014 Jun;42(6):1074-83. doi: 10.1124/dmd.113.056481. Epub 2014 Mar 21.


Dual role for inflammasome sensors NLRP1 and NLRP3 in murine resistance to Toxoplasma gondii.

Gorfu G, Cirelli KM, Melo MB, Mayer-Barber K, Crown D, Koller BH, Masters S, Sher A, Leppla SH, Moayeri M, Saeij JP, Grigg ME.

MBio. 2014 Feb 18;5(1). pii: e01117-13. doi: 10.1128/mBio.01117-13.


Cyclic-di-GMP and cyclic-di-AMP activate the NLRP3 inflammasome.

Abdul-Sater AA, Tattoli I, Jin L, Grajkowski A, Levi A, Koller BH, Allen IC, Beaucage SL, Fitzgerald KA, Ting JP, Cambier JC, Girardin SE, Schindler C.

EMBO Rep. 2013 Oct;14(10):900-6. doi: 10.1038/embor.2013.132. Epub 2013 Sep 6.


Genetic loss of murine pyrin, the Familial Mediterranean Fever protein, increases interleukin-1β levels.

Hesker PR, Nguyen M, Kovarova M, Ting JP, Koller BH.

PLoS One. 2012;7(11):e51105. doi: 10.1371/journal.pone.0051105. Epub 2012 Nov 30.


Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death.

Sparks MA, Makhanova NA, Griffiths RC, Snouwaert JN, Koller BH, Coffman TM.

Hypertension. 2013 Jan;61(1):166-73. doi: 10.1161/HYPERTENSIONAHA.112.193250. Epub 2012 Nov 12.


The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB.

Schneider M, Zimmermann AG, Roberts RA, Zhang L, Swanson KV, Wen H, Davis BK, Allen IC, Holl EK, Ye Z, Rahman AH, Conti BJ, Eitas TK, Koller BH, Ting JP.

Nat Immunol. 2012 Sep;13(9):823-31. doi: 10.1038/ni.2378. Epub 2012 Aug 5.


NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice.

Kovarova M, Hesker PR, Jania L, Nguyen M, Snouwaert JN, Xiang Z, Lommatzsch SE, Huang MT, Ting JP, Koller BH.

J Immunol. 2012 Aug 15;189(4):2006-16. doi: 10.4049/jimmunol.1201065. Epub 2012 Jun 29.


Preweaning sensorimotor deficits and adolescent hypersociability in Grin1 knockdown mice.

Moy SS, Nikolova VD, Riddick NV, Baker LK, Koller BH.

Dev Neurosci. 2012;34(2-3):159-73. Epub 2012 May 8.


Prostaglandin E(2) produced by the lung augments the effector phase of allergic inflammation.

Church RJ, Jania LA, Koller BH.

J Immunol. 2012 Apr 15;188(8):4093-102. doi: 10.4049/jimmunol.1101873. Epub 2012 Mar 12.


PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth.

Gruzdev A, Nguyen M, Kovarova M, Koller BH.

Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):109-19. doi: 10.1016/j.prostaglandins.2012.02.001. Epub 2012 Feb 11.


Analysis of NLRP3 in the development of allergic airway disease in mice.

Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JP.

J Immunol. 2012 Mar 15;188(6):2884-93. doi: 10.4049/jimmunol.1102488. Epub 2012 Feb 8.


Effects of the selective kainate receptor antagonist ACET on altered sensorimotor gating in a genetic model of reduced NMDA receptor function.

Duncan GE, Koller BH, Moy SS.

Brain Res. 2012 Mar 14;1443:98-105. doi: 10.1016/j.brainres.2012.01.009. Epub 2012 Jan 20.


ONZIN deficiency attenuates contact hypersensitivity responses in mice.

Ledford JG, Kovarova M, Jania LA, Nguyen M, Koller BH.

Immunol Cell Biol. 2012 Aug;90(7):733-42. doi: 10.1038/icb.2011.107. Epub 2012 Jan 17.


Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse.

Cyphert JM, Allen IC, Church RJ, Latour AM, Snouwaert JN, Coffman TM, Koller BH.

Am J Physiol Lung Cell Mol Physiol. 2012 Jan 1;302(1):L140-51. doi: 10.1152/ajplung.00152.2011. Epub 2011 Oct 7.


A major role for the EP4 receptor in regulation of renin.

Facemire CS, Nguyen M, Jania L, Beierwaltes WH, Kim HS, Koller BH, Coffman TM.

Am J Physiol Renal Physiol. 2011 Nov;301(5):F1035-41. doi: 10.1152/ajprenal.00054.2011. Epub 2011 Aug 10.


AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure.

Gurley SB, Riquier-Brison ADM, Schnermann J, Sparks MA, Allen AM, Haase VH, Snouwaert JN, Le TH, McDonough AA, Koller BH, Coffman TM.

Cell Metab. 2011 Apr 6;13(4):469-475. doi: 10.1016/j.cmet.2011.03.001.


Role of TNFR-related 2 mediated immune responses in dextran sulfate sodium-induced inflammatory bowel disease.

Kim WK, Park JS, Sul OJ, Seo JH, Choi BK, Park HY, Latour AM, Koller BH, Kwon BS, Jeong CS.

Mol Cells. 2011 Feb;31(2):99-104. doi: 10.1007/s10059-011-0013-y. Epub 2011 Jan 6.


Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells.

Kim WK, Sul OJ, Kwak JS, Hur HY, Latour AM, Koller BH, Kwon BS, Jeong CS.

Exp Mol Med. 2010 Dec 31;42(12):805-10.


Cutting edge: NLRP12 controls dendritic and myeloid cell migration to affect contact hypersensitivity.

Arthur JC, Lich JD, Ye Z, Allen IC, Gris D, Wilson JE, Schneider M, Roney KE, O'Connor BP, Moore CB, Morrison A, Sutterwala FS, Bertin J, Koller BH, Liu Z, Ting JP.

J Immunol. 2010 Oct 15;185(8):4515-9. doi: 10.4049/jimmunol.1002227. Epub 2010 Sep 22.


Unique populations of lung mast cells are required for antigen-mediated bronchoconstriction.

Cyphert JM, Kovarova M, Koller BH.

Clin Exp Allergy. 2011 Feb;41(2):260-9. doi: 10.1111/j.1365-2222.2010.03583.x. Epub 2010 Aug 16.


Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990.

Koller BH, Marrack P, Kappler JW, Smithies O.

J Immunol. 2010 May 1;184(9):4592-5. No abstract available.


Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases.

Kovarova M, Latour AM, Chason KD, Tilley SL, Koller BH.

Blood. 2010 May 6;115(18):3695-703. doi: 10.1182/blood-2009-08-237206. Epub 2010 Mar 3.


The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background.

Facemire CS, Griffiths R, Audoly LP, Koller BH, Coffman TM.

Hypertension. 2010 Feb;55(2):531-8. doi: 10.1161/HYPERTENSIONAHA.109.145631. Epub 2010 Jan 11.


Increased sensitivity to kainic acid in a genetic model of reduced NMDA receptor function.

Duncan GE, Inada K, Koller BH, Moy SS.

Brain Res. 2010 Jan 11;1307:166-76. doi: 10.1016/j.brainres.2009.10.023. Epub 2009 Oct 22.


Cooperation between mast cells and neurons is essential for antigen-mediated bronchoconstriction.

Cyphert JM, Kovarova M, Allen IC, Hartney JM, Murphy DL, Wess J, Koller BH.

J Immunol. 2009 Jun 15;182(12):7430-9. doi: 10.4049/jimmunol.0900039.


Neural activation deficits in a mouse genetic model of NMDA receptor hypofunction in tests of social aggression and swim stress.

Duncan GE, Inada K, Farrington JS, Koller BH, Moy SS.

Brain Res. 2009 Apr 10;1265:186-95. doi: 10.1016/j.brainres.2009.02.002. Epub 2009 Feb 13.


Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.

Németh K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, Robey PG, Leelahavanichkul K, Koller BH, Brown JM, Hu X, Jelinek I, Star RA, Mezey E.

Nat Med. 2009 Jan;15(1):42-9. doi: 10.1038/nm.1905. Epub 2008 Nov 21. Erratum in: Nat Med. 2009 Apr;15(4):462.


Microsomal prostaglandin E synthase-2 is not essential for in vivo prostaglandin E2 biosynthesis.

Jania LA, Chandrasekharan S, Backlund MG, Foley NA, Snouwaert J, Wang IM, Clark P, Audoly LP, Koller BH.

Prostaglandins Other Lipid Mediat. 2009 Apr;88(3-4):73-81. doi: 10.1016/j.prostaglandins.2008.10.003. Epub 2008 Nov 1.


Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction.

Duncan GE, Inada K, Farrington JS, Koller BH.

Brain Res. 2008 Jul 24;1221:41-8. doi: 10.1016/j.brainres.2008.05.001. Epub 2008 May 8.


The Hippocratic finger points the blame at PGE2.

Coggins KG, Coffman TM, Koller BH.

Nat Genet. 2008 Jun;40(6):691-2. doi: 10.1038/ng0608-691. No abstract available.


Regulation of the murine TR2/HVEM gene expression by IRF.

Sul OJ, Lee HW, Kim WK, Choi JH, Kwak JS, Choi YJ, Latour AM, Koller BH, Jeong CS, Kwon BS.

Biochem Biophys Res Commun. 2008 Mar 7;367(2):277-83. Epub 2007 Dec 26.


Development of a mouse test for repetitive, restricted behaviors: relevance to autism.

Moy SS, Nadler JJ, Poe MD, Nonneman RJ, Young NB, Koller BH, Crawley JN, Duncan GE, Bodfish JW.

Behav Brain Res. 2008 Mar 17;188(1):178-94. Epub 2007 Nov 4.


cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis.

Lovgren AK, Kovarova M, Koller BH.

Mol Cell Biol. 2007 Jun;27(12):4416-30. Epub 2007 Apr 16.


Impaired host defense in mice lacking ONZIN.

Ledford JG, Kovarova M, Koller BH.

J Immunol. 2007 Apr 15;178(8):5132-43.


Assessment of NMDA receptor activation in vivo by Fos induction after challenge with the direct NMDA agonist (tetrazol-5-yl)glycine: effects of clozapine and haloperidol.

Inada K, Farrington JS, Moy SS, Koller BH, Duncan GE.

J Neural Transm (Vienna). 2007 Jul;114(7):899-908. Epub 2007 Feb 22.


Retinoid-related orphan receptor gamma controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen.

Tilley SL, Jaradat M, Stapleton C, Dixon D, Hua X, Erikson CJ, McCaskill JG, Chason KD, Liao G, Jania L, Koller BH, Jetten AM.

J Immunol. 2007 Mar 1;178(5):3208-18.


Enhanced mast cell activation in mice deficient in the A2b adenosine receptor.

Hua X, Kovarova M, Chason KD, Nguyen M, Koller BH, Tilley SL.

J Exp Med. 2007 Jan 22;204(1):117-28. Epub 2007 Jan 2. Erratum in: J Exp Med. 2007 Apr 16;204(4):963.


Growth retardation, DNA repair defects, and lack of spermatogenesis in BRCA1-deficient mice.

Cressman VL, Backlund DC, Avrutskaya AV, Leadon SA, Godfrey V, Koller BH.

Mol Cell Biol. 2006 Dec;26(24):9571. No abstract available.


Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease.

Allen IC, Pace AJ, Jania LA, Ledford JG, Latour AM, Snouwaert JN, Bernier V, Stocco R, Therien AG, Koller BH.

Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L1005-17. Epub 2006 Jul 7.

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