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Items: 1 to 50 of 69

1.

Elevated Circulating Activin A Levels in Patients With Malignant Pleural Mesothelioma Are Related to Cancer Cachexia and Reduced Response to Platinum-based Chemotherapy.

Paajanen J, Ilonen I, Lauri H, Järvinen T, Sutinen E, Ollila H, Rouvinen E, Lemström K, Räsänen J, Ritvos O, Koli K, Myllärniemi M.

Clin Lung Cancer. 2019 Oct 25. pii: S1525-7304(19)30287-6. doi: 10.1016/j.cllc.2019.10.013. [Epub ahead of print]

2.

Demographics and survival of patients with idiopathic pulmonary fibrosis in the FinnishIPF registry.

Kaunisto J, Salomaa ER, Hodgson U, Kaarteenaho R, Kankaanranta H, Koli K, Vahlberg T, Myllärniemi M.

ERJ Open Res. 2019 Jul 8;5(3). pii: 00170-2018. doi: 10.1183/23120541.00170-2018. eCollection 2019 Jul.

3.

Survey of dentin sialophosphoprotein and its cognate matrix metalloproteinase-20 in human cancers.

Aseervatham J, Geetu S, Anunobi CC, Koli K, Ogbureke KUE.

Cancer Med. 2019 May;8(5):2167-2178. doi: 10.1002/cam4.2117. Epub 2019 Apr 1.

4.

Malignant pleural mesothelioma in Finland: regional and gender variation.

Laaksonen S, Ilonen I, Kuosma E, Sutinen E, Wolff H, Vehmas T, Husgafvel-Pursiainen K, Salo JA, Koli K, Räsänen J, Myllärniemi M.

Acta Oncol. 2019 Jan;58(1):38-44. doi: 10.1080/0284186X.2018.1532599. Epub 2018 Oct 30.

PMID:
30375909
5.

Pirfenidone decreases mesothelioma cell proliferation and migration via inhibition of ERK and AKT and regulates mesothelioma tumor microenvironment in vivo.

Li C, Rezov V, Joensuu E, Vartiainen V, Rönty M, Yin M, Myllärniemi M, Koli K.

Sci Rep. 2018 Jul 3;8(1):10070. doi: 10.1038/s41598-018-28297-x.

6.

Pulmonary administration of a dry powder formulation of the antifibrotic drug tilorone reduces silica-induced lung fibrosis in mice.

Vartiainen V, Raula J, Bimbo LM, Viinamäki J, Backman JT, Ugur N, Kauppinen E, Sutinen E, Joensuu E, Koli K, Myllärniemi M.

Int J Pharm. 2018 Jun 10;544(1):121-128. doi: 10.1016/j.ijpharm.2018.04.019. Epub 2018 Apr 12.

PMID:
29655797
7.

Gremlin-1 is a key regulator of the invasive cell phenotype in mesothelioma.

Yin M, Tissari M, Tamminen J, Ylivinkka I, Rönty M, von Nandelstadh P, Lehti K, Hyytiäinen M, Myllärniemi M, Koli K.

Oncotarget. 2017 Oct 6;8(58):98280-98297. doi: 10.18632/oncotarget.21550. eCollection 2017 Nov 17.

8.

Matrix Metalloproteinase 20 Co-expression With Dentin Sialophosphoprotein in Human and Monkey Kidneys.

Ogbureke KU, Koli K, Saxena G.

J Histochem Cytochem. 2016 Oct;64(10):623-36. doi: 10.1369/0022155416665098.

9.

Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.

Tomasovic A, Kurrle N, Wempe F, De-Zolt S, Scheibe S, Koli K, Serchinger M, Schnütgen F, Sürün D, Sterner-Kock A, Weissmann N, von Melchner H.

Matrix Biol. 2017 May;59:109-120. doi: 10.1016/j.matbio.2016.09.006. Epub 2016 Sep 17.

10.

Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment - A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine.

Koli K, Sutinen E, Rönty M, Rantakari P, Fortino V, Pulkkinen V, Greco D, Sipilä P, Myllärniemi M.

PLoS One. 2016 Jul 18;11(7):e0159010. doi: 10.1371/journal.pone.0159010. eCollection 2016.

11.

Expression of the SIBLINGs and their MMP partners in human benign and malignant prostate neoplasms.

Anunobi CC, Koli K, Saxena G, Banjo AA, Ogbureke KU.

Oncotarget. 2016 Jul 26;7(30):48038-48049. doi: 10.18632/oncotarget.10110.

12.

Absence of TGF-β Receptor Activation by Highly Purified hCG Preparations.

Koistinen H, Hautala L, Koli K, Stenman UH.

Mol Endocrinol. 2015 Dec;29(12):1787-91. doi: 10.1210/me.2015-1187. Epub 2015 Oct 23.

13.

Expression of Matrix Metalloproteinase (MMP)-20 and Potential Interaction with Dentin Sialophosphoprotein (DSPP) in Human Major Salivary Glands.

Koli K, Saxena G, Ogbureke KU.

J Histochem Cytochem. 2015 Jul;63(7):524-33. doi: 10.1369/0022155415580817. Epub 2015 Mar 24.

PMID:
25805840
14.

Modeling autosomal recessive cutis laxa type 1C in mice reveals distinct functions for Ltbp-4 isoforms.

Bultmann-Mellin I, Conradi A, Maul AC, Dinger K, Wempe F, Wohl AP, Imhof T, Wunderlich FT, Bunck AC, Nakamura T, Koli K, Bloch W, Ghanem A, Heinz A, von Melchner H, Sengle G, Sterner-Kock A.

Dis Model Mech. 2015 Apr;8(4):403-15. doi: 10.1242/dmm.018960. Epub 2015 Feb 20.

15.

Matrix metalloproteinase 20-dentin sialophosphoprotein interaction in oral cancer.

Saxena G, Koli K, de la Garza J, Ogbureke KU.

J Dent Res. 2015 Apr;94(4):584-93. doi: 10.1177/0022034515570156. Epub 2015 Feb 9.

PMID:
25666817
16.

Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.

Tamminen JA, Yin M, Rönty M, Sutinen E, Pasternack A, Ritvos O, Myllärniemi M, Koli K.

Exp Cell Res. 2015 Mar 1;332(1):102-15. doi: 10.1016/j.yexcr.2014.12.010. Epub 2014 Dec 31.

17.

Upregulation of alveolar levels of activin B, but not activin A, in lungs of west highland white terriers with idiopathic pulmonary fibrosis and diffuse alveolar damage.

Lilja-Maula L, Syrjä P, Laurila HP, Sutinen E, Palviainen M, Ritvos O, Koli K, Rajamäki MM, Myllärniemi M.

J Comp Pathol. 2015 Feb-Apr;152(2-3):192-200. doi: 10.1016/j.jcpa.2014.11.006. Epub 2014 Dec 30.

PMID:
25555634
18.

Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models.

Myllärniemi M, Tikkanen J, Hulmi JJ, Pasternack A, Sutinen E, Rönty M, Leppäranta O, Ma H, Ritvos O, Koli K.

BMC Pulm Med. 2014 Nov 1;14:170. doi: 10.1186/1471-2466-14-170.

19.

Expression of p8 in Human Oral Squamous Cell Carcinoma.

Bingham C, Dickinson D, Cray J, Koli K, Ogbureke KU.

Head Neck Pathol. 2015 Jun;9(2):214-22. doi: 10.1007/s12105-014-0565-1. Epub 2014 Aug 26.

20.

Comparative study of transforming growth factor-β signalling and regulatory molecules in human and canine idiopathic pulmonary fibrosis.

Lilja-Maula L, Syrjä P, Laurila HP, Sutinen E, Rönty M, Koli K, Rajamäki MM, Myllärniemi M.

J Comp Pathol. 2014 May;150(4):399-407. doi: 10.1016/j.jcpa.2013.12.001. Epub 2013 Dec 10.

PMID:
24529509
21.

Increased intravitreal angiopoietin-2 levels associated with rhegmatogenous retinal detachment.

Loukovaara S, Lehti K, Robciuc A, Pessi T, Holopainen JM, Koli K, Immonen I, Keski-Oja J.

Graefes Arch Clin Exp Ophthalmol. 2014 Jun;252(6):881-8. doi: 10.1007/s00417-013-2508-z. Epub 2013 Nov 12.

PMID:
24218041
22.

Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug.

Tamminen JA, Parviainen V, Rönty M, Wohl AP, Murray L, Joenväärä S, Varjosalo M, Leppäranta O, Ritvos O, Sengle G, Renkonen R, Myllärniemi M, Koli K.

Oncogenesis. 2013 Aug 26;2:e66. doi: 10.1038/oncsis.2013.29.

23.

Events of wound healing/regeneration in the canine supraalveolar periodontal defect model.

Dickinson DP, Coleman BG, Batrice N, Lee J, Koli K, Pennington C, Susin C, Wikesjö UM.

J Clin Periodontol. 2013 May;40(5):527-41. doi: 10.1111/jcpe.12055. Epub 2013 Mar 5.

PMID:
23461721
24.

Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.

Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2852-7. doi: 10.1073/pnas.1215779110. Epub 2013 Feb 4.

25.

Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo.

Leppäranta O, Tikkanen JM, Bespalov MM, Koli K, Myllärniemi M.

Am J Respir Cell Mol Biol. 2013 Apr;48(4):448-55. doi: 10.1165/rcmb.2012-0201OC.

PMID:
23258233
26.

Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy.

Loukovaara S, Robciuc A, Holopainen JM, Lehti K, Pessi T, Liinamaa J, Kukkonen KT, Jauhiainen M, Koli K, Keski-Oja J, Immonen I.

Acta Ophthalmol. 2013 Sep;91(6):531-9. doi: 10.1111/j.1755-3768.2012.02473.x. Epub 2012 Oct 26.

27.

Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling.

Tamminen JA, Myllärniemi M, Hyytiäinen M, Keski-Oja J, Koli K.

J Cell Biochem. 2012 Jul;113(7):2234-47. doi: 10.1002/jcb.24094.

PMID:
22573546
28.

Regulation of TGF-β storage and activation in the human idiopathic pulmonary fibrosis lung.

Leppäranta O, Sens C, Salmenkivi K, Kinnula VL, Keski-Oja J, Myllärniemi M, Koli K.

Cell Tissue Res. 2012 Jun;348(3):491-503. doi: 10.1007/s00441-012-1385-9. Epub 2012 Mar 22.

PMID:
22434388
29.

A covalently dimerized recombinant human bone morphogenetic protein-15 variant identifies bone morphogenetic protein receptor type 1B as a key cell surface receptor on ovarian granulosa cells.

Pulkki MM, Mottershead DG, Pasternack AH, Muggalla P, Ludlow H, van Dinther M, Myllymaa S, Koli K, ten Dijke P, Laitinen M, Ritvos O.

Endocrinology. 2012 Mar;153(3):1509-18. doi: 10.1210/en.2010-1390. Epub 2012 Jan 31.

PMID:
22294741
30.

Cysteine-rich protein 1 is regulated by transforming growth factor-β1 and expressed in lung fibrosis.

Järvinen PM, Myllärniemi M, Liu H, Moore HM, Leppäranta O, Salmenkivi K, Koli K, Latonen L, Band AM, Laiho M.

J Cell Physiol. 2012 Jun;227(6):2605-12. doi: 10.1002/jcp.23000.

PMID:
21882188
31.

Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection.

Tuuminen R, Syrjälä S, Krebs R, Keränen MA, Koli K, Abo-Ramadan U, Neuvonen PJ, Tikkanen JM, Nykänen AI, Lemström KB.

Circulation. 2011 Sep 6;124(10):1138-50. doi: 10.1161/CIRCULATIONAHA.110.005249. Epub 2011 Aug 15.

PMID:
21844074
32.

Latent TGF-β binding proteins (LTBPs) 1 and 3 differentially regulate transforming growth factor-β activity in malignant mesothelioma.

Vehviläinen P, Koli K, Myllärniemi M, Lindholm P, Soini Y, Salmenkivi K, Kinnula VL, Keski-Oja J.

Hum Pathol. 2011 Feb;42(2):269-78. doi: 10.1016/j.humpath.2010.07.005. Epub 2010 Nov 24.

PMID:
21106222
33.

Independent regulation of short and long forms of latent TGF-beta binding protein (LTBP)-4 in cultured fibroblasts and human tissues.

Kantola AK, Ryynänen MJ, Lhota F, Keski-Oja J, Koli K.

J Cell Physiol. 2010 Jun;223(3):727-36. doi: 10.1002/jcp.22082.

PMID:
20175115
34.

Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.

Wempe F, De-Zolt S, Koli K, Bangsow T, Parajuli N, Dumitrascu R, Sterner-Kock A, Weissmann N, Keski-Oja J, von Melchner H.

Dis Model Mech. 2010 Mar-Apr;3(3-4):246-53. doi: 10.1242/dmm.004234. Epub 2010 Jan 27.

35.

Reduced phosphorylation of the TGF-Beta signal transducer Smad2 in emphysematous human lung.

Leppäranta O, Myllärniemi M, Salmenkivi K, Kinnula VL, Keski-Oja J, Koli K.

COPD. 2009 Aug;6(4):234-41.

PMID:
19811381
36.

Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis.

Leppäranta O, Pulkkinen V, Koli K, Vähätalo R, Salmenkivi K, Kinnula VL, Heikinheimo M, Myllärniemi M.

Am J Respir Cell Mol Biol. 2010 May;42(5):626-32. doi: 10.1165/rcmb.2009-0021OC. Epub 2009 Jul 13.

PMID:
19597127
37.

Latent transforming growth factor-beta-binding protein-4 regulates transforming growth factor-beta1 bioavailability for activation by fibrogenic lung fibroblasts in response to bleomycin.

Zhou Y, Koli K, Hagood JS, Miao M, Mavalli M, Rifkin DB, Murphy-Ullrich JE.

Am J Pathol. 2009 Jan;174(1):21-33. doi: 10.2353/ajpath.2009.080620. Epub 2008 Dec 4.

38.

Latent TGF-beta binding proteins (LTBPs)-1 and -3 coordinate proliferation and osteogenic differentiation of human mesenchymal stem cells.

Koli K, Ryynänen MJ, Keski-Oja J.

Bone. 2008 Oct;43(4):679-88. doi: 10.1016/j.bone.2008.06.016. Epub 2008 Jul 11.

PMID:
18672106
39.

Fibronectin and heparin binding domains of latent TGF-beta binding protein (LTBP)-4 mediate matrix targeting and cell adhesion.

Kantola AK, Keski-Oja J, Koli K.

Exp Cell Res. 2008 Aug 1;314(13):2488-500. doi: 10.1016/j.yexcr.2008.05.010. Epub 2008 May 29.

PMID:
18585707
40.

Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype.

Myllärniemi M, Vuorinen K, Pulkkinen V, Kankaanranta H, Aine T, Salmenkivi K, Keski-Oja J, Koli K, Kinnula V.

J Pathol. 2008 Mar;214(4):456-63.

PMID:
18072275
41.

Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis.

Myllärniemi M, Lindholm P, Ryynänen MJ, Kliment CR, Salmenkivi K, Keski-Oja J, Kinnula VL, Oury TD, Koli K.

Am J Respir Crit Care Med. 2008 Feb 1;177(3):321-9. Epub 2007 Nov 1.

42.

Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species.

Koli K, Myllärniemi M, Keski-Oja J, Kinnula VL.

Antioxid Redox Signal. 2008 Feb;10(2):333-42. Review.

PMID:
17961070
43.

Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis.

Koli K, Myllärniemi M, Vuorinen K, Salmenkivi K, Ryynänen MJ, Kinnula VL, Keski-Oja J.

Am J Pathol. 2006 Jul;169(1):61-71.

44.

Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.

Leivonen SK, Ala-Aho R, Koli K, Grénman R, Peltonen J, Kähäri VM.

Oncogene. 2006 Apr 27;25(18):2588-600.

PMID:
16407850
45.

Induction of human LTBP-3 promoter activity by TGF-beta1 is mediated by Smad3/4 and AP-1 binding elements.

Kantola AK, Keski-Oja J, Koli K.

Gene. 2005 Dec 19;363:142-50. Epub 2005 Oct 11.

PMID:
16223572
46.

Sequential deposition of latent TGF-beta binding proteins (LTBPs) during formation of the extracellular matrix in human lung fibroblasts.

Koli K, Hyytiäinen M, Ryynänen MJ, Keski-Oja J.

Exp Cell Res. 2005 Nov 1;310(2):370-82. Epub 2005 Sep 12.

PMID:
16157329
47.

TGF-beta activation by traction?

Keski-Oja J, Koli K, von Melchner H.

Trends Cell Biol. 2004 Dec;14(12):657-9. Review.

PMID:
15564041
48.

Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung.

Koli K, Wempe F, Sterner-Kock A, Kantola A, Komor M, Hofmann WK, von Melchner H, Keski-Oja J.

J Cell Biol. 2004 Oct 11;167(1):123-33. Epub 2004 Oct 4.

49.
50.

Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer.

Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H.

Genes Dev. 2002 Sep 1;16(17):2264-73.

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