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Psychiatric illness and regression in individuals with Phelan-McDermid syndrome.

Kohlenberg TM, Trelles MP, McLarney B, Betancur C, Thurm A, Kolevzon A.

J Neurodev Disord. 2020 Feb 12;12(1):7. doi: 10.1186/s11689-020-9309-6.


Neuropsychiatric decompensation in adolescents and adults with Phelan-McDermid syndrome: a systematic review of the literature.

Kolevzon A, Delaby E, Berry-Kravis E, Buxbaum JD, Betancur C.

Mol Autism. 2019 Dec 24;10:50. doi: 10.1186/s13229-019-0291-3. eCollection 2019. Review.


The Immersive Theater Experience for Individuals with Autism Spectrum Disorder.

Giserman-Kiss I, Gorenstein M, Feldman E, Rowe M, Grosman H, Weissman J, Rouhandeh A, Wilkinson E, Meyering K, Durkin A, Isenstein E, Kolevzon A, Buxbaum JD, Siper PM.

J Autism Dev Disord. 2020 Mar;50(3):1073-1080. doi: 10.1007/s10803-019-04284-7.


Child and Adolescent Psychiatry Perceptions and Career Preference: Participation in a National Medical Student Conference Improves Outcomes.

Kishore A, Sun K, Guth S, Kolevzon A, Martin A.

J Am Acad Child Adolesc Psychiatry. 2020 Jan;59(1):3-7. doi: 10.1016/j.jaac.2019.07.949. Epub 2019 Oct 1.


The SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder.

Herscu P, Handen BL, Arnold LE, Snape MF, Bregman JD, Ginsberg L, Hendren R, Kolevzon A, Melmed R, Mintz M, Minshew N, Sikich L, Attalla A, King B, Owley T, Childress A, Chugani H, Frazier J, Cartwright C, Murphy T; Autism Speaks Autism Clinical Trials Network.

J Autism Dev Disord. 2019 Jul 2. doi: 10.1007/s10803-019-04120-y. [Epub ahead of print]


Volumetric Analysis of the Basal Ganglia and Cerebellar Structures in Patients with Phelan-McDermid Syndrome.

Srivastava S, Scherrer B, Prohl AK, Filip-Dhima R, Kapur K, Kolevzon A, Buxbaum JD, Berry-Kravis E, Soorya L, Thurm A, Powell CM, Bernstein JA, Warfield SK, Sahin M; Developmental Synaptopathies Consortium.

Pediatr Neurol. 2019 Jan;90:37-43. doi: 10.1016/j.pediatrneurol.2018.09.008. Epub 2018 Sep 21.


Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder.

Curtin P, Austin C, Curtin A, Gennings C, Arora M; (for the Emergent Dynamical Systems Group), Tammimies K, Willfors C, Berggren S, Siper P, Rai D, Meyering K, Kolevzon A, Mollon J, David AS, Lewis G, Zammit S, Heilbrun L, Palmer RF, Wright RO, Bölte S, Reichenberg A.

Sci Adv. 2018 May 30;4(5):eaat1293. doi: 10.1126/sciadv.aat1293. eCollection 2018 May.


Delineation of the genetic and clinical spectrum of Phelan-McDermid syndrome caused by SHANK3 point mutations.

De Rubeis S, Siper PM, Durkin A, Weissman J, Muratet F, Halpern D, Trelles MDP, Frank Y, Lozano R, Wang AT, Holder JL Jr, Betancur C, Buxbaum JD, Kolevzon A.

Mol Autism. 2018 Apr 27;9:31. doi: 10.1186/s13229-018-0205-9. eCollection 2018.


Prospective investigation of FOXP1 syndrome.

Siper PM, De Rubeis S, Trelles MDP, Durkin A, Di Marino D, Muratet F, Frank Y, Lozano R, Eichler EE, Kelly M, Beighley J, Gerdts J, Wallace AS, Mefford HC, Bernier RA, Kolevzon A, Buxbaum JD.

Mol Autism. 2017 Oct 24;8:57. doi: 10.1186/s13229-017-0172-6. eCollection 2017.


Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder.

Lim ET, Uddin M, De Rubeis S, Chan Y, Kamumbu AS, Zhang X, D'Gama AM, Kim SN, Hill RS, Goldberg AP, Poultney C, Minshew NJ, Kushima I, Aleksic B, Ozaki N, Parellada M, Arango C, Penzol MJ, Carracedo A, Kolevzon A, Hultman CM, Weiss LA, Fromer M, Chiocchetti AG, Freitag CM; Autism Sequencing Consortium, Church GM, Scherer SW, Buxbaum JD, Walsh CA.

Nat Neurosci. 2017 Sep;20(9):1217-1224. doi: 10.1038/nn.4598. Epub 2017 Jul 17.


Association of Antidepressant Medication Use During Pregnancy With Intellectual Disability in Offspring.

Viktorin A, Uher R, Kolevzon A, Reichenberg A, Levine SZ, Sandin S.

JAMA Psychiatry. 2017 Oct 1;74(10):1031-1038. doi: 10.1001/jamapsychiatry.2017.1727.


Heightened brain response to pain anticipation in high-functioning adults with autism spectrum disorder.

Gu X, Zhou TJ, Anagnostou E, Soorya L, Kolevzon A, Hof PR, Fan J.

Eur J Neurosci. 2018 Mar;47(6):592-601. doi: 10.1111/ejn.13598. Epub 2017 May 25.


A clinician-administered observation and corresponding caregiver interview capturing DSM-5 sensory reactivity symptoms in children with ASD.

Siper PM, Kolevzon A, Wang AT, Buxbaum JD, Tavassoli T.

Autism Res. 2017 Jun;10(6):1133-1140. doi: 10.1002/aur.1750. Epub 2017 Mar 11.


Language ENvironment Analysis (LENA) in Phelan-McDermid Syndrome: Validity and Suggestions for Use in Minimally Verbal Children with Autism Spectrum Disorder.

Rankine J, Li E, Lurie S, Rieger H, Fourie E, Siper PM, Wang AT, Buxbaum JD, Kolevzon A.

J Autism Dev Disord. 2017 Jun;47(6):1605-1617. doi: 10.1007/s10803-017-3082-8.


Examining the Efficacy of a Family Peer Advocate Model for Black and Hispanic Caregivers of Children with Autism Spectrum Disorder.

Jamison JM, Fourie E, Siper PM, Trelles MP, George-Jones J, Buxbaum Grice A, Krata J, Holl E, Shaoul J, Hernandez B, Mitchell L, McKay MM, Buxbaum JD, Kolevzon A.

J Autism Dev Disord. 2017 May;47(5):1314-1322. doi: 10.1007/s10803-017-3045-0.


The neurobiology of the Prader-Willi phenotype of fragile X syndrome.

Muzar Z, Lozano R, Kolevzon A, Hagerman RJ.

Intractable Rare Dis Res. 2016 Nov;5(4):255-261. Review.


Rapid and Objective Assessment of Neural Function in Autism Spectrum Disorder Using Transient Visual Evoked Potentials.

Siper PM, Zemon V, Gordon J, George-Jones J, Lurie S, Zweifach J, Tavassoli T, Wang AT, Jamison J, Buxbaum JD, Kolevzon A.

PLoS One. 2016 Oct 7;11(10):e0164422. doi: 10.1371/journal.pone.0164422. eCollection 2016.


Characterization of the Statistical Signatures of Micro-Movements Underlying Natural Gait Patterns in Children with Phelan McDermid Syndrome: Towards Precision-Phenotyping of Behavior in ASD.

Torres EB, Nguyen J, Mistry S, Whyatt C, Kalampratsidou V, Kolevzon A.

Front Integr Neurosci. 2016 Jun 27;10:22. doi: 10.3389/fnint.2016.00022. eCollection 2016.


Detecting Autism Spectrum Disorder in Children With ADHD and Social Disability.

Øien RA, Siper P, Kolevzon A, Grodberg D.

J Atten Disord. 2016 Apr 13. pii: 1087054716642518. [Epub ahead of print]


Justice in Selecting Participants for a Study in Phelan-McDermid Syndrome.

Rhodes R, Kolevzon A.

Am J Bioeth. 2016;16(4):74-6. doi: 10.1080/15265161.2016.1145303. No abstract available.


Erratum to: Neural selectivity for communicative auditory signals in Phelan-McDermid syndrome.

Wang AT, Lim T, Jamison J, Bush L, Soorya LV, Tavassoli T, Siper PM, Buxbaum JD, Kolevzon A.

J Neurodev Disord. 2016 Mar 15;8:8. doi: 10.1186/s11689-016-9143-z. eCollection 2016.


Brief Report: Sensory Reactivity in Children with Phelan-McDermid Syndrome.

Mieses AM, Tavassoli T, Li E, Soorya L, Lurie S, Wang AT, Siper PM, Kolevzon A.

J Autism Dev Disord. 2016 Jul;46(7):2508-13. doi: 10.1007/s10803-016-2754-0.


Neural selectivity for communicative auditory signals in Phelan-McDermid syndrome.

Wang AT, Lim T, Jamison J, Bush L, Soorya LV, Tavassoli T, Siper PM, Buxbaum JD, Kolevzon A.

J Neurodev Disord. 2016 Feb 23;8:5. doi: 10.1186/s11689-016-9138-9. eCollection 2016. Erratum in: J Neurodev Disord. 2016;8:8.


Initial severity and efficacy of risperidone in autism: Results from the RUPP trial.

Levine SZ, Kodesh A, Goldberg Y, Reichenberg A, Furukawa TA, Kolevzon A, Leucht S.

Eur Psychiatry. 2016 Feb;32:16-20. doi: 10.1016/j.eurpsy.2015.11.004. Epub 2016 Jan 21.


The therapeutic potential of insulin-like growth factor-1 in central nervous system disorders.

Costales J, Kolevzon A.

Neurosci Biobehav Rev. 2016 Apr;63:207-22. doi: 10.1016/j.neubiorev.2016.01.001. Epub 2016 Jan 15. Review.


Altered tactile processing in children with autism spectrum disorder.

Tavassoli T, Bellesheim K, Tommerdahl M, Holden JM, Kolevzon A, Buxbaum JD.

Autism Res. 2016 Jun;9(6):616-20. doi: 10.1002/aur.1563. Epub 2015 Nov 16.


Phelan McDermid Syndrome: From Genetic Discoveries to Animal Models and Treatment.

Harony-Nicolas H, De Rubeis S, Kolevzon A, Buxbaum JD.

J Child Neurol. 2015 Dec;30(14):1861-70. doi: 10.1177/0883073815600872. Epub 2015 Sep 8. Review.


Measuring Sensory Reactivity in Autism Spectrum Disorder: Application and Simplification of a Clinician-Administered Sensory Observation Scale.

Tavassoli T, Bellesheim K, Siper PM, Wang AT, Halpern D, Gorenstein M, Grodberg D, Kolevzon A, Buxbaum JD.

J Autism Dev Disord. 2016 Jan;46(1):287-293. doi: 10.1007/s10803-015-2578-3.


A Simplified Diagnostic Observational Assessment of Autism Spectrum Disorder in Early Childhood.

Grodberg D, Siper P, Jamison J, Buxbaum JD, Kolevzon A.

Autism Res. 2016 Apr;9(4):443-9. doi: 10.1002/aur.1539. Epub 2015 Aug 25.


Differential Effects of Oxytocin on Agency and Communion for Anxiously and Avoidantly Attached Individuals.

Bartz JA, Lydon JE, Kolevzon A, Zaki J, Hollander E, Ludwig N, Bolger N.

Psychol Sci. 2015 Aug;26(8):1177-86. doi: 10.1177/0956797615580279. Epub 2015 Jun 29.


Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID.

Cochoy DM, Kolevzon A, Kajiwara Y, Schoen M, Pascual-Lucas M, Lurie S, Buxbaum JD, Boeckers TM, Schmeisser MJ.

Mol Autism. 2015 Apr 29;6:23. doi: 10.1186/s13229-015-0020-5. eCollection 2015.


Erratum: A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome.

Kolevzon A, Bush L, Wang AT, Halpern D, Frank Y, Grodberg D, Rapaport R, Tavassoli T, Chaplin W, Soorya L, Buxbaum JD.

Mol Autism. 2015 Jun 2;6:31. doi: 10.1186/s13229-015-0025-0. eCollection 2015.


Autonomic and brain responses associated with empathy deficits in autism spectrum disorder.

Gu X, Eilam-Stock T, Zhou T, Anagnostou E, Kolevzon A, Soorya L, Hof PR, Friston KJ, Fan J.

Hum Brain Mapp. 2015 Sep;36(9):3323-38. doi: 10.1002/hbm.22840. Epub 2015 May 21.


Phelan-McDermid Syndrome and SHANK3: Implications for Treatment.

Costales JL, Kolevzon A.

Neurotherapeutics. 2015 Jul;12(3):620-30. doi: 10.1007/s13311-015-0352-z. Review.


Randomized comparative trial of a social cognitive skills group for children with autism spectrum disorder.

Soorya LV, Siper PM, Beck T, Soffes S, Halpern D, Gorenstein M, Kolevzon A, Buxbaum J, Wang AT.

J Am Acad Child Adolesc Psychiatry. 2015 Mar;54(3):208-216.e1. doi: 10.1016/j.jaac.2014.12.005. Epub 2014 Dec 20.


A pilot controlled trial of insulin-like growth factor-1 in children with Phelan-McDermid syndrome.

Kolevzon A, Bush L, Wang AT, Halpern D, Frank Y, Grodberg D, Rapaport R, Tavassoli T, Chaplin W, Soorya L, Buxbaum JD.

Mol Autism. 2014 Dec 12;5(1):54. doi: 10.1186/2040-2392-5-54. eCollection 2014. Erratum in: Mol Autism. 2015;6:31.


Self-injury in autism spectrum disorder: an effect of serotonin transporter gene promoter variants.

Kolevzon A, Lim T, Schmeidler J, Martello T, Cook EH Jr, Silverman JM.

Psychiatry Res. 2014 Dec 30;220(3):987-90.


Synaptic, transcriptional and chromatin genes disrupted in autism.

De Rubeis S, He X, Goldberg AP, Poultney CS, Samocha K, Cicek AE, Kou Y, Liu L, Fromer M, Walker S, Singh T, Klei L, Kosmicki J, Shih-Chen F, Aleksic B, Biscaldi M, Bolton PF, Brownfeld JM, Cai J, Campbell NG, Carracedo A, Chahrour MH, Chiocchetti AG, Coon H, Crawford EL, Curran SR, Dawson G, Duketis E, Fernandez BA, Gallagher L, Geller E, Guter SJ, Hill RS, Ionita-Laza J, Jimenz Gonzalez P, Kilpinen H, Klauck SM, Kolevzon A, Lee I, Lei I, Lei J, Lehtimäki T, Lin CF, Ma'ayan A, Marshall CR, McInnes AL, Neale B, Owen MJ, Ozaki N, Parellada M, Parr JR, Purcell S, Puura K, Rajagopalan D, Rehnström K, Reichenberg A, Sabo A, Sachse M, Sanders SJ, Schafer C, Schulte-Rüther M, Skuse D, Stevens C, Szatmari P, Tammimies K, Valladares O, Voran A, Li-San W, Weiss LA, Willsey AJ, Yu TW, Yuen RK; DDD Study; Homozygosity Mapping Collaborative for Autism; UK10K Consortium, Cook EH, Freitag CM, Gill M, Hultman CM, Lehner T, Palotie A, Schellenberg GD, Sklar P, State MW, Sutcliffe JS, Walsh CA, Scherer SW, Zwick ME, Barett JC, Cutler DJ, Roeder K, Devlin B, Daly MJ, Buxbaum JD.

Nature. 2014 Nov 13;515(7526):209-15. doi: 10.1038/nature13772. Epub 2014 Oct 29.


Convergence of genes and cellular pathways dysregulated in autism spectrum disorders.

Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L, Thiruvahindrapuram B, Xu X, Ziman R, Wang Z, Vorstman JA, Thompson A, Regan R, Pilorge M, Pellecchia G, Pagnamenta AT, Oliveira B, Marshall CR, Magalhaes TR, Lowe JK, Howe JL, Griswold AJ, Gilbert J, Duketis E, Dombroski BA, De Jonge MV, Cuccaro M, Crawford EL, Correia CT, Conroy J, Conceição IC, Chiocchetti AG, Casey JP, Cai G, Cabrol C, Bolshakova N, Bacchelli E, Anney R, Gallinger S, Cotterchio M, Casey G, Zwaigenbaum L, Wittemeyer K, Wing K, Wallace S, van Engeland H, Tryfon A, Thomson S, Soorya L, Rogé B, Roberts W, Poustka F, Mouga S, Minshew N, McInnes LA, McGrew SG, Lord C, Leboyer M, Le Couteur AS, Kolevzon A, Jiménez González P, Jacob S, Holt R, Guter S, Green J, Green A, Gillberg C, Fernandez BA, Duque F, Delorme R, Dawson G, Chaste P, Café C, Brennan S, Bourgeron T, Bolton PF, Bölte S, Bernier R, Baird G, Bailey AJ, Anagnostou E, Almeida J, Wijsman EM, Vieland VJ, Vicente AM, Schellenberg GD, Pericak-Vance M, Paterson AD, Parr JR, Oliveira G, Nurnberger JI, Monaco AP, Maestrini E, Klauck SM, Hakonarson H, Haines JL, Geschwind DH, Freitag CM, Folstein SE, Ennis S, Coon H, Battaglia A, Szatmari P, Sutcliffe JS, Hallmayer J, Gill M, Cook EH, Buxbaum JD, Devlin B, Gallagher L, Betancur C, Scherer SW.

Am J Hum Genet. 2014 May 1;94(5):677-94. doi: 10.1016/j.ajhg.2014.03.018. Epub 2014 Apr 24.


De novo SCN2A splice site mutation in a boy with Autism spectrum disorder.

Tavassoli T, Kolevzon A, Wang AT, Curchack-Lichtin J, Halpern D, Schwartz L, Soffes S, Bush L, Grodberg D, Cai G, Buxbaum JD.

BMC Med Genet. 2014 Mar 20;15:35. doi: 10.1186/1471-2350-15-35.


Abnormal autonomic and associated brain activities during rest in autism spectrum disorder.

Eilam-Stock T, Xu P, Cao M, Gu X, Van Dam NT, Anagnostou E, Kolevzon A, Soorya L, Park Y, Siller M, He Y, Hof PR, Fan J.

Brain. 2014 Jan;137(Pt 1):153-71. doi: 10.1093/brain/awt294.


Phelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoring.

Kolevzon A, Angarita B, Bush L, Wang AT, Frank Y, Yang A, Rapaport R, Saland J, Srivastava S, Farrell C, Edelmann LJ, Buxbaum JD.

J Neurodev Disord. 2014;6(1):39. doi: 10.1186/1866-1955-6-39. Epub 2014 Oct 8. Review.


A rare case of anti-N-methyl-D-aspartate receptor encephalitis in an adolescent.

Fields J, Lim T, Kolevzon A, Coffey BJ.

J Child Adolesc Psychopharmacol. 2013 Sep;23(7):502-6. doi: 10.1089/cap.2013.2372. No abstract available.


Does early mentorship in child and adolescent psychiatry make a difference? The Klingenstein Third-Generation Foundation Medical Student Fellowship Program.

Stein JA, Althoff R, Anders T, Davison Y, Edwards S, Frosch E, Horst R, Hudziak JJ, Hunt J, Joshi SV, Kitts RL, Larson J, Leckman J, O'Brien J, Lowenhaupt E, Pruitt D, Malloy E, Martin A, Partner A, Sarles R, Sikich L, Wells L, Kolevzon A.

Acad Psychiatry. 2013 Sep;37(5):321-4. doi: 10.1176/appi.ap.12070136.


The autism mental status exam: sensitivity and specificity using DSM-5 criteria for autism spectrum disorder in verbally fluent adults.

Grodberg D, Weinger PM, Halpern D, Parides M, Kolevzon A, Buxbaum JD.

J Autism Dev Disord. 2014 Mar;44(3):609-14. doi: 10.1007/s10803-013-1917-5.


Prospective investigation of autism and genotype-phenotype correlations in 22q13 deletion syndrome and SHANK3 deficiency.

Soorya L, Kolevzon A, Zweifach J, Lim T, Dobry Y, Schwartz L, Frank Y, Wang AT, Cai G, Parkhomenko E, Halpern D, Grodberg D, Angarita B, Willner JP, Yang A, Canitano R, Chaplin W, Betancur C, Buxbaum JD.

Mol Autism. 2013 Jun 11;4(1):18. doi: 10.1186/2040-2392-4-18.


Functional deficits of the attentional networks in autism.

Fan J, Bernardi S, Van Dam NT, Anagnostou E, Gu X, Martin L, Park Y, Liu X, Kolevzon A, Soorya L, Grodberg D, Hollander E, Hof PR.

Brain Behav. 2012 Sep;2(5):647-60. doi: 10.1002/brb3.90. Epub 2012 Aug 27.


Individual common variants exert weak effects on the risk for autism spectrum disorders.

Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, Corsello C, Crawford EL, de Jonge M, Delorme R, Duketis E, Duque F, Estes A, Farrar P, Fernandez BA, Folstein SE, Fombonne E, Gilbert J, Gillberg C, Glessner JT, Green A, Green J, Guter SJ, Heron EA, Holt R, Howe JL, Hughes G, Hus V, Igliozzi R, Jacob S, Kenny GP, Kim C, Kolevzon A, Kustanovich V, Lajonchere CM, Lamb JA, Law-Smith M, Leboyer M, Le Couteur A, Leventhal BL, Liu XQ, Lombard F, Lord C, Lotspeich L, Lund SC, Magalhaes TR, Mantoulan C, McDougle CJ, Melhem NM, Merikangas A, Minshew NJ, Mirza GK, Munson J, Noakes C, Nygren G, Papanikolaou K, Pagnamenta AT, Parrini B, Paton T, Pickles A, Posey DJ, Poustka F, Ragoussis J, Regan R, Roberts W, Roeder K, Roge B, Rutter ML, Schlitt S, Shah N, Sheffield VC, Soorya L, Sousa I, Stoppioni V, Sykes N, Tancredi R, Thompson AP, Thomson S, Tryfon A, Tsiantis J, Van Engeland H, Vincent JB, Volkmar F, Vorstman JA, Wallace S, Wing K, Wittemeyer K, Wood S, Zurawiecki D, Zwaigenbaum L, Bailey AJ, Battaglia A, Cantor RM, Coon H, Cuccaro ML, Dawson G, Ennis S, Freitag CM, Geschwind DH, Haines JL, Klauck SM, McMahon WM, Maestrini E, Miller J, Monaco AP, Nelson SF, Nurnberger JI Jr, Oliveira G, Parr JR, Pericak-Vance MA, Piven J, Schellenberg GD, Scherer SW, Vicente AM, Wassink TH, Wijsman EM, Betancur C, Buxbaum JD, Cook EH, Gallagher L, Gill M, Hallmayer J, Paterson AD, Sutcliffe JS, Szatmari P, Vieland VJ, Hakonarson H, Devlin B.

Hum Mol Genet. 2012 Nov 1;21(21):4781-92. doi: 10.1093/hmg/dds301. Epub 2012 Jul 26.


Advancing maternal age is associated with increasing risk for autism: a review and meta-analysis.

Sandin S, Hultman CM, Kolevzon A, Gross R, MacCabe JH, Reichenberg A.

J Am Acad Child Adolesc Psychiatry. 2012 May;51(5):477-486.e1. doi: 10.1016/j.jaac.2012.02.018. Epub 2012 Apr 5. Review. Erratum in: J Am Acad Child Adolesc Psychiatry. 2012 Jun;51(6):660.


Complex autism spectrum disorder in a patient with a 17q12 microduplication.

Brandt T, Desai K, Grodberg D, Mehta L, Cohen N, Tryfon A, Kolevzon A, Soorya L, Buxbaum JD, Edelmann L.

Am J Med Genet A. 2012 May;158A(5):1170-7. doi: 10.1002/ajmg.a.35267. Epub 2012 Apr 4.


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