Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 179

1.

Logarithmic expansion of LGR5+ cells in human colorectal cancer.

Martin ML, Zeng Z, Adileh M, Jacobo A, Li C, Vakiani E, Hua G, Zhang L, Haimovitz-Friedman A, Fuks Z, Kolesnick R, Paty PB.

Cell Signal. 2018 Jan;42:97-105. doi: 10.1016/j.cellsig.2017.09.018. Epub 2017 Sep 25.

PMID:
28958617
2.

Sphingolipid abnormalities in cancer multidrug resistance: Chicken or egg?

Lee WK, Kolesnick RN.

Cell Signal. 2017 Oct;38:134-145. doi: 10.1016/j.cellsig.2017.06.017. Epub 2017 Jul 4. Review.

PMID:
28687494
3.

Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation.

van Hell AJ, Haimovitz-Friedman A, Fuks Z, Tap WD, Kolesnick R.

Cell Signal. 2017 Jun;34:86-91. doi: 10.1016/j.cellsig.2017.02.021. Epub 2017 Feb 24.

4.

Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells.

Hua G, Wang C, Pan Y, Zeng Z, Lee SG, Martin ML, Haimovitz-Friedman A, Fuks Z, Paty PB, Kolesnick R.

Cancer Res. 2017 Apr 15;77(8):2124-2133. doi: 10.1158/0008-5472.CAN-15-2870. Epub 2017 Feb 15.

5.

Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.

Jacobi J, García-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Feldman R, Manova K, Bielawska A, Bielawska J, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

Cell Signal. 2017 Jan;29:52-61. doi: 10.1016/j.cellsig.2016.09.010. Epub 2016 Oct 1.

6.

Establishing estrogen-responsive mouse mammary organoids from single Lgr5+ cells.

Zhang L, Adileh M, Martin ML, Klingler S, White J, Ma X, Howe LR, Brown AM, Kolesnick R.

Cell Signal. 2017 Jan;29:41-51. doi: 10.1016/j.cellsig.2016.08.001. Epub 2016 Aug 7.

7.

Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart.

Klevstig M, Ståhlman M, Lundqvist A, Scharin Täng M, Fogelstrand P, Adiels M, Andersson L, Kolesnick R, Jeppsson A, Borén J, Levin MC.

J Mol Cell Cardiol. 2016 Apr;93:69-72. doi: 10.1016/j.yjmcc.2016.02.019. Epub 2016 Feb 28.

8.

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Albert Hubbard EJ, Kolesnick R.

PLoS One. 2016 Jan 22;11(1):e0141673. doi: 10.1371/journal.pone.0141673. eCollection 2016. No abstract available.

9.

Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

PLoS One. 2015 Dec 30;10(12):e0146210. doi: 10.1371/journal.pone.0146210. eCollection 2015. No abstract available.

10.

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.

Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow L, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MRM, Hanash AM.

Nature. 2015 Dec 24;528(7583):560-564. doi: 10.1038/nature16460. Epub 2015 Dec 9.

11.

Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis.

Wang SW, Hojabrpour P, Zhang P, Kolesnick RN, Steinbrecher UP, Gómez-Muñoz A, Duronio V.

Biochim Biophys Acta. 2015 Nov;1851(11):1482-9. doi: 10.1016/j.bbalip.2015.08.002. Epub 2015 Aug 4.

12.

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.

Deng X, Michaelson D, Tchieu J, Cheng J, Rothenstein D, Feldman R, Lee SG, Fuller J, Haimovitz-Friedman A, Studer L, Powell S, Fuks Z, Hubbard EJ, Kolesnick R.

PLoS One. 2015 Jun 29;10(6):e0127862. doi: 10.1371/journal.pone.0127862. eCollection 2015. Erratum in: PLoS One. 2016;11(1):e0141673.

13.

Caenorhabditis elegans as a model to study sphingolipid signaling.

Deng X, Kolesnick R.

Biol Chem. 2015 Jun;396(6-7):767-73. doi: 10.1515/hsz-2014-0298. Review.

PMID:
25720116
14.

The life and work of Dr. Robert Bittman (1942-2014).

Pyne NJ, Kolesnick RN.

Biol Chem. 2015 Jun;396(6-7):827-30. doi: 10.1515/hsz-2014-0275. No abstract available.

PMID:
25473803
15.

C16:0-ceramide signals insulin resistance.

Hla T, Kolesnick R.

Cell Metab. 2014 Nov 4;20(5):703-705. doi: 10.1016/j.cmet.2014.10.017. Epub 2014 Nov 4.

16.

Axitinib sensitization of high Single Dose Radiotherapy.

Rao SS, Thompson C, Cheng J, Haimovitz-Friedman A, Powell SN, Fuks Z, Kolesnick RN.

Radiother Oncol. 2014 Apr;111(1):88-93. doi: 10.1016/j.radonc.2014.02.010. Epub 2014 Apr 29.

17.

It takes a CAD to kill a tumor cell with a LMP.

Gulbins E, Kolesnick RN.

Cancer Cell. 2013 Sep 9;24(3):279-81. doi: 10.1016/j.ccr.2013.08.025.

18.

Adenoviral transduction of human acid sphingomyelinase into neo-angiogenic endothelium radiosensitizes tumor cure.

Stancevic B, Varda-Bloom N, Cheng J, Fuller JD, Rotolo JA, García-Barros M, Feldman R, Rao S, Weichselbaum RR, Harats D, Haimovitz-Friedman A, Fuks Z, Sadelain M, Kolesnick R.

PLoS One. 2013 Aug 2;8(8):e69025. doi: 10.1371/journal.pone.0069025. Print 2013.

19.

Acid sphingomyelinase.

Henry B, Ziobro R, Becker KA, Kolesnick R, Gulbins E.

Handb Exp Pharmacol. 2013;(215):77-88. doi: 10.1007/978-3-7091-1368-4_4. Review.

PMID:
23579450
20.

Using ASMase knockout mice to model human diseases.

Hua G, Kolesnick R.

Handb Exp Pharmacol. 2013;(216):29-54. doi: 10.1007/978-3-7091-1511-4_2. Review.

PMID:
23563650
21.

Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease.

Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR.

Immunity. 2012 Aug 24;37(2):339-50. doi: 10.1016/j.immuni.2012.05.028.

22.

Crypt base columnar stem cells in small intestines of mice are radioresistant.

Hua G, Thin TH, Feldman R, Haimovitz-Friedman A, Clevers H, Fuks Z, Kolesnick R.

Gastroenterology. 2012 Nov;143(5):1266-1276. doi: 10.1053/j.gastro.2012.07.106. Epub 2012 Jul 27.

23.

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.

Rotolo J, Stancevic B, Zhang J, Hua G, Fuller J, Yin X, Haimovitz-Friedman A, Kim K, Qian M, Cardó-Vila M, Fuks Z, Pasqualini R, Arap W, Kolesnick R.

J Clin Invest. 2012 May;122(5):1786-90. doi: 10.1172/JCI59920. Epub 2012 Apr 2.

24.

Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation.

Chakravarty D, Santos E, Ryder M, Knauf JA, Liao XH, West BL, Bollag G, Kolesnick R, Thin TH, Rosen N, Zanzonico P, Larson SM, Refetoff S, Ghossein R, Fagin JA.

J Clin Invest. 2011 Dec;121(12):4700-11. doi: 10.1172/JCI46382. Epub 2011 Nov 21.

25.

Accelerated hematopoietic toxicity by high energy (56)Fe radiation.

Datta K, Suman S, Trani D, Doiron K, Rotolo JA, Kallakury BV, Kolesnick R, Cole MF, Fornace AJ Jr.

Int J Radiat Biol. 2012 Mar;88(3):213-22. doi: 10.3109/09553002.2012.639434. Epub 2011 Dec 12.

26.

The unconventional role of acid sphingomyelinase in regulation of retinal microangiopathy in diabetic human and animal models.

Opreanu M, Tikhonenko M, Bozack S, Lydic TA, Reid GE, McSorley KM, Sochacki A, Perez GI, Esselman WJ, Kern T, Kolesnick R, Grant MB, Busik JV.

Diabetes. 2011 Sep;60(9):2370-8. doi: 10.2337/db10-0550. Epub 2011 Jul 19.

27.

Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

PLoS One. 2011;6(6):e19783. doi: 10.1371/journal.pone.0019783. Epub 2011 Jun 13. Erratum in: PLoS One. 2015;10(12):e0146210.

28.

Alpha particles induce apoptosis through the sphingomyelin pathway.

Seideman JH, Stancevic B, Rotolo JA, McDevitt MR, Howell RW, Kolesnick RN, Scheinberg DA.

Radiat Res. 2011 Oct;176(4):434-46. Epub 2011 Jun 1.

29.

Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis.

Bonnaud S, Niaudet C, Legoux F, Corre I, Delpon G, Saulquin X, Fuks Z, Gaugler MH, Kolesnick R, Paris F.

Cancer Res. 2010 Dec 1;70(23):9905-15. doi: 10.1158/0008-5472.CAN-10-2043. Epub 2010 Nov 30.

30.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Sep 30;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

31.

Impact of stromal sensitivity on radiation response of tumors implanted in SCID hosts revisited.

García-Barros M, Thin TH, Maj J, Cordon-Cardo C, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cancer Res. 2010 Oct 15;70(20):8179-86. doi: 10.1158/0008-5472.CAN-10-1871. Epub 2010 Oct 5.

32.

Endothelial membrane remodeling is obligate for anti-angiogenic radiosensitization during tumor radiosurgery.

Truman JP, García-Barros M, Kaag M, Hambardzumyan D, Stancevic B, Chan M, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

PLoS One. 2010 Aug 19;5(8):e12310. doi: 10.1371/journal.pone.0012310. Corrected and republished in: PLoS One. 2010;5(9). doi: 10.1371/annotation/6e222ad5-b175-4a00-9d04-4d120568a897.

33.

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.

Mesicek J, Lee H, Feldman T, Jiang X, Skobeleva A, Berdyshev EV, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Signal. 2010 Sep;22(9):1300-7. doi: 10.1016/j.cellsig.2010.04.006. Epub 2010 Apr 18.

34.

Ceramide-rich platforms in transmembrane signaling.

Stancevic B, Kolesnick R.

FEBS Lett. 2010 May 3;584(9):1728-40. doi: 10.1016/j.febslet.2010.02.026. Epub 2010 Feb 20. Review.

35.

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.

Rotolo JA, Mesicek J, Maj J, Truman JP, Haimovitz-Friedman A, Kolesnick R, Fuks Z.

Cancer Res. 2010 Feb 1;70(3):957-67. doi: 10.1158/0008-5472.CAN-09-1562. Epub 2010 Jan 19.

36.

Response: Sample size and statistical comparisons of GVHD rates in pediatric Niemann-Pick disease patients.

Kolesnick R, van den Brink M, Heller G, Rotolo JA.

Blood. 2010 Jan 14;115(2):436. doi: 10.1182/blood-2009-10-246561. No abstract available.

37.

Kinase suppressor of Ras transphosphorylates c-Raf-1.

Zafrullah M, Yin X, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Biochem Biophys Res Commun. 2009 Dec 18;390(3):434-40. doi: 10.1016/j.bbrc.2009.09.048. Epub 2009 Sep 17.

38.

A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation.

Yin X, Zafrullah M, Lee H, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

Cell Physiol Biochem. 2009;24(3-4):219-30. doi: 10.1159/000233248. Epub 2009 Aug 3.

39.

Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease.

Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R.

Blood. 2009 Oct 22;114(17):3693-706. doi: 10.1182/blood-2008-11-191148. Epub 2009 Aug 7.

40.

RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance.

Lee AJ, Kolesnick R, Swanton C.

Expert Rev Mol Med. 2009 May 21;11:e15. doi: 10.1017/S1462399409001070. Review.

PMID:
19467173
41.

Timing of lethality from gastrointestinal syndrome in mice revisited.

Rotolo JA, Kolesnick R, Fuks Z.

Int J Radiat Oncol Biol Phys. 2009 Jan 1;73(1):6-8. doi: 10.1016/j.ijrobp.2008.09.009. No abstract available.

PMID:
19100919
42.

PKCalpha activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo.

Truman JP, Rotenberg SA, Kang JH, Lerman G, Fuks Z, Kolesnick R, Marquez VE, Haimovitz-Friedman A.

Cancer Biol Ther. 2009 Jan;8(1):54-63. Epub 2009 Jan 4.

43.

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans.

Deng X, Yin X, Allan R, Lu DD, Maurer CW, Haimovitz-Friedman A, Fuks Z, Shaham S, Kolesnick R.

Science. 2008 Oct 3;322(5898):110-5. doi: 10.1126/science.1158111.

44.

Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake.

Zhang J, Zafrullah M, Yang X, Yin X, Zhang Z, Fuks Z, Kolesnick R.

Cancer Biol Ther. 2008 Sep;7(9):1490-5. Epub 2008 Sep 15.

45.

Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo.

Henkes LE, Sullivan BT, Lynch MP, Kolesnick R, Arsenault D, Puder M, Davis JS, Rueda BR.

Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7670-5. doi: 10.1073/pnas.0712260105. Epub 2008 May 27.

46.

Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa.

Rotolo JA, Maj JG, Feldman R, Ren D, Haimovitz-Friedman A, Cordon-Cardo C, Cheng EH, Kolesnick R, Fuks Z.

Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):804-15. doi: 10.1016/j.ijrobp.2007.11.043. Epub 2008 Jan 11.

PMID:
18191336
47.

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.

Lahiri S, Lee H, Mesicek J, Fuks Z, Haimovitz-Friedman A, Kolesnick RN, Futerman AH.

FEBS Lett. 2007 Nov 13;581(27):5289-94. Epub 2007 Oct 23.

48.

A CERTain role for ceramide in taxane-induced cell death.

Kolesnick R, Altieri D, Fuks Z.

Cancer Cell. 2007 Jun;11(6):473-5.

49.

Sphingolipids and cell death.

Morales A, Lee H, Goñi FM, Kolesnick R, Fernandez-Checa JC.

Apoptosis. 2007 May;12(5):923-39. Review.

PMID:
17294080
50.

Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations.

Siskind LJ, Kolesnick RN, Colombini M.

Mitochondrion. 2006 Jun;6(3):118-25. Epub 2006 Mar 29.

Supplemental Content

Loading ...
Support Center