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ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice.

Wang F, Hou W, Chitsike L, Xu Y, Bettler C, Perera A, Bank T, Cotler SJ, Dhanarajan A, Denning MF, Ding X, Breslin P, Qiang W, Li J, Koleske AJ, Qiu W.

Gastroenterology. 2020 Mar 11. pii: S0016-5085(20)30334-6. doi: 10.1053/j.gastro.2020.03.013. [Epub ahead of print]


Functional interactions of ion channels with the actin cytoskeleton: does coupling to dynamic actin regulate NMDA receptors?

Shaw JE, Koleske AJ.

J Physiol. 2020 Feb 7. doi: 10.1113/JP278702. [Epub ahead of print]


Regulation of MT dynamics via direct binding of an Abl family kinase.

Hu Y, Lyu W, Lowery LA, Koleske AJ.

J Cell Biol. 2019 Dec 2;218(12):3986-3997. doi: 10.1083/jcb.201812144. Epub 2019 Nov 7.


Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis.

Yun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA.

J Clin Invest. 2019 Aug 13;130:4863-4874. doi: 10.1172/JCI127692.


Trio Haploinsufficiency Causes Neurodevelopmental Disease-Associated Deficits.

Katrancha SM, Shaw JE, Zhao AY, Myers SA, Cocco AR, Jeng AT, Zhu M, Pittenger C, Greer CA, Carr SA, Xiao X, Koleske AJ.

Cell Rep. 2019 Mar 5;26(10):2805-2817.e9. doi: 10.1016/j.celrep.2019.02.022.


Abl2 is recruited to ventral actin waves through cytoskeletal interactions to promote lamellipodium extension.

Zhang K, Lyu W, Yu J, Koleske AJ.

Mol Biol Cell. 2018 Nov 15;29(23):2863-2873. doi: 10.1091/mbc.E18-01-0044. Epub 2018 Sep 26.


Noonan Syndrome-Associated SHP2 Dephosphorylates GluN2B to Regulate NMDA Receptor Function.

Levy AD, Xiao X, Shaw JE, Sudarsana Devi SP, Katrancha SM, Bennett AM, Greer CA, Howe JR, Machida K, Koleske AJ.

Cell Rep. 2018 Aug 7;24(6):1523-1535. doi: 10.1016/j.celrep.2018.07.006.


Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.

Kim SY, Nair DM, Romero M, Serna VA, Koleske AJ, Woodruff TK, Kurita T.

Cell Death Differ. 2019 Mar;26(3):502-515. doi: 10.1038/s41418-018-0151-2. Epub 2018 Jul 9.


Cortactin stabilization of actin requires actin-binding repeats and linker, is disrupted by specific substitutions, and is independent of nucleotide state.

Scherer AN, Anand NS, Koleske AJ.

J Biol Chem. 2018 Aug 24;293(34):13022-13032. doi: 10.1074/jbc.RA118.004068. Epub 2018 Jun 21.


A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation.

Jacobsen FA, Scherer AN, Mouritsen J, Bragadóttir H, Thomas Bäckström B, Sardar S, Holmberg D, Koleske AJ, Andersson Å.

J Neuroimmune Pharmacol. 2018 Jun;13(2):265-276. doi: 10.1007/s11481-018-9783-8. Epub 2018 Mar 17.


Analysis of Cellular Tyrosine Phosphorylation via Chemical Rescue of Conditionally Active Abl Kinase.

Wang Z, Kim MS, Martinez-Ferrando I, Koleske AJ, Pandey A, Cole PA.

Biochemistry. 2018 Feb 27;57(8):1390-1398. doi: 10.1021/acs.biochem.7b01158. Epub 2018 Feb 6.


The repeat region of cortactin is intrinsically disordered in solution.

Li X, Tao Y, Murphy JW, Scherer AN, Lam TT, Marshall AG, Koleske AJ, Boggon TJ.

Sci Rep. 2017 Dec 1;7(1):16696. doi: 10.1038/s41598-017-16959-1.


The vascular endothelial specific IL-4 receptor alpha-ABL1 kinase signaling axis regulates the severity of IgE-mediated anaphylactic reactions.

Yamani A, Wu D, Waggoner L, Noah T, Koleske AJ, Finkelman F, Hogan SP.

J Allergy Clin Immunol. 2018 Oct;142(4):1159-1172.e5. doi: 10.1016/j.jaci.2017.08.046. Epub 2017 Nov 17.


Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase.

Shapiro LP, Omar MH, Koleske AJ, Gourley SL.

Mol Cell Neurosci. 2017 Dec;85:226-234. doi: 10.1016/j.mcn.2017.10.007. Epub 2017 Oct 26.


CNS Neurons Deposit Laminin α5 to Stabilize Synapses.

Omar MH, Kerrisk Campbell M, Xiao X, Zhong Q, Brunken WJ, Miner JH, Greer CA, Koleske AJ.

Cell Rep. 2017 Oct 31;21(5):1281-1292. doi: 10.1016/j.celrep.2017.10.028.


Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity.

Katrancha SM, Wu Y, Zhu M, Eipper BA, Koleske AJ, Mains RE.

Hum Mol Genet. 2017 Dec 1;26(23):4728-4740. doi: 10.1093/hmg/ddx355.


Long-Term Live-Cell STED Nanoscopy of Primary and Cultured Cells with the Plasma Membrane HIDE Probe DiI-SiR.

Thompson AD, Omar MH, Rivera-Molina F, Xi Z, Koleske AJ, Toomre DK, Schepartz A.

Angew Chem Int Ed Engl. 2017 Aug 21;56(35):10408-10412. doi: 10.1002/anie.201704783. Epub 2017 Jul 24.


The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.

Ganesan S, Luu TT, Chambers BJ, Meinke S, Brodin P, Vivier E, Wetzel DM, Koleske AJ, Kadri N, Höglund P.

Scand J Immunol. 2017 Sep;86(3):135-142. doi: 10.1111/sji.12574.


Brain Region and Isoform-Specific Phosphorylation Alters Kalirin SH2 Domain Interaction Sites and Calpain Sensitivity.

Miller MB, Yan Y, Machida K, Kiraly DD, Levy AD, Wu YI, Lam TT, Abbott T, Koleske AJ, Eipper BA, Mains RE.

ACS Chem Neurosci. 2017 Jul 19;8(7):1554-1569. doi: 10.1021/acschemneuro.7b00076. Epub 2017 Apr 25.


Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.

Rosenberg BJ, Gil-Henn H, Mader CC, Halo T, Yin T, Condeelis J, Machida K, Wu YI, Koleske AJ.

Mol Biol Cell. 2017 May 15;28(10):1347-1360. doi: 10.1091/mbc.E16-12-0885. Epub 2017 Mar 29.


Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

Matsumoto Y, La Rose J, Kent OA, Wagner MJ, Narimatsu M, Levy AD, Omar MH, Tong J, Krieger JR, Riggs E, Storozhuk Y, Pasquale J, Ventura M, Yeganeh B, Post M, Moran MF, Grynpas MD, Wrana JL, Superti-Furga G, Koleske AJ, Pendergast AM, Rottapel R.

J Clin Invest. 2016 Dec 1;126(12):4482-4496. doi: 10.1172/JCI87802. Epub 2016 Oct 31.


Differential expression of cytoskeletal regulatory factors in the adolescent prefrontal cortex: Implications for cortical development.

Shapiro LP, Parsons RG, Koleske AJ, Gourley SL.

J Neurosci Res. 2017 May;95(5):1123-1143. doi: 10.1002/jnr.23960. Epub 2016 Oct 13. Review.


The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.

Wetzel DM, Rhodes EL, Li S, McMahon-Pratt D, Koleske AJ.

J Cell Sci. 2016 Aug 15;129(16):3130-43. doi: 10.1242/jcs.185595. Epub 2016 Jun 29.


Disruption of Coordinated Presynaptic and Postsynaptic Maturation Underlies the Defects in Hippocampal Synapse Stability and Plasticity in Abl2/Arg-Deficient Mice.

Xiao X, Levy AD, Rosenberg BJ, Higley MJ, Koleske AJ.

J Neurosci. 2016 Jun 22;36(25):6778-91. doi: 10.1523/JNEUROSCI.4092-15.2016.


SNARE Complex Dysfunction: A Unifying Hypothesis for Schizophrenia.

Katrancha SM, Koleske AJ.

Biol Psychiatry. 2015 Sep 15;78(6):356-8. doi: 10.1016/j.biopsych.2015.07.013. No abstract available.


A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

Nygaard HB, Wagner AF, Bowen GS, Good SP, MacAvoy MG, Strittmatter KA, Kaufman AC, Rosenberg BJ, Sekine-Konno T, Varma P, Chen K, Koleske AJ, Reiman EM, Strittmatter SM, van Dyck CH.

Alzheimers Res Ther. 2015 Apr 14;7(1):35. doi: 10.1186/s13195-015-0119-0. eCollection 2015.


Structure of the ABL2/ARG kinase in complex with dasatinib.

Ha BH, Simpson MA, Koleske AJ, Boggon TJ.

Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):443-8. doi: 10.1107/S2053230X15004793. Epub 2015 Mar 20.


Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.

Simpson MA, Bradley WD, Harburger D, Parsons M, Calderwood DA, Koleske AJ.

J Biol Chem. 2015 Mar 27;290(13):8360-72. doi: 10.1074/jbc.M115.638874. Epub 2015 Feb 18.


Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin.

Courtemanche N, Gifford SM, Simpson MA, Pollard TD, Koleske AJ.

J Biol Chem. 2015 Feb 13;290(7):4038-46. doi: 10.1074/jbc.M114.608117. Epub 2014 Dec 24.


Adolescent cocaine exposure simplifies orbitofrontal cortical dendritic arbors.

DePoy LM, Perszyk RE, Zimmermann KS, Koleske AJ, Gourley SL.

Front Pharmacol. 2014 Oct 27;5:228. doi: 10.3389/fphar.2014.00228. eCollection 2014.


ECM receptors in neuronal structure, synaptic plasticity, and behavior.

Kerrisk ME, Cingolani LA, Koleske AJ.

Prog Brain Res. 2014;214:101-31. doi: 10.1016/B978-0-444-63486-3.00005-0. Review.


Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood.

Levy AD, Omar MH, Koleske AJ.

Front Neuroanat. 2014 Oct 20;8:116. doi: 10.3389/fnana.2014.00116. eCollection 2014. Review.


Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin.

Gifford SM, Liu W, Mader CC, Halo TL, Machida K, Boggon TJ, Koleske AJ.

J Biol Chem. 2014 Jul 11;289(28):19704-13. doi: 10.1074/jbc.M114.556480. Epub 2014 Jun 2.


Ablation of ErbB4 from excitatory neurons leads to reduced dendritic spine density in mouse prefrontal cortex.

Cooper MA, Koleske AJ.

J Comp Neurol. 2014 Oct 1;522(14):3351-62. doi: 10.1002/cne.23615. Epub 2014 Apr 29.


Abelson phosphorylation of CLASP2 modulates its association with microtubules and actin.

Engel U, Zhan Y, Long JB, Boyle SN, Ballif BA, Dorey K, Gygi SP, Koleske AJ, Vanvactor D.

Cytoskeleton (Hoboken). 2014 Mar;71(3):195-209. doi: 10.1002/cm.21164. Epub 2014 Mar 12.


Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.

Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM.

Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036. Erratum in: Neuron. 2013 Oct 16;80(2):531.


Arg kinase signaling in dendrite and synapse stabilization pathways: memory, cocaine sensitivity, and stress.

Kerrisk ME, Koleske AJ.

Int J Biochem Cell Biol. 2013 Nov;45(11):2496-500. doi: 10.1016/j.biocel.2013.07.018. Epub 2013 Aug 2. Review.


Molecular mechanisms of dendrite stability.

Koleske AJ.

Nat Rev Neurosci. 2013 Aug;14(8):536-50. doi: 10.1038/nrn3486. Epub 2013 Jul 10. Review.


WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl.

Bryce NS, Reynolds AB, Koleske AJ, Weaver AM.

PLoS One. 2013 May 15;8(5):e64533. doi: 10.1371/journal.pone.0064533. Print 2013.


Integrin α3 is required for late postnatal stability of dendrite arbors, dendritic spines and synapses, and mouse behavior.

Kerrisk ME, Greer CA, Koleske AJ.

J Neurosci. 2013 Apr 17;33(16):6742-52. doi: 10.1523/JNEUROSCI.0528-13.2013.


β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation.

Beaty BT, Sharma VP, Bravo-Cordero JJ, Simpson MA, Eddy RJ, Koleske AJ, Condeelis J.

Mol Biol Cell. 2013 Jun;24(11):1661-75, S1-11. doi: 10.1091/mbc.E12-12-0908. Epub 2013 Apr 3.


Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience.

Gourley SL, Swanson AM, Koleske AJ.

J Neurosci. 2013 Feb 13;33(7):3107-12. doi: 10.1523/JNEUROSCI.2138-12.2013.


Abl2/Arg controls dendritic spine and dendrite arbor stability via distinct cytoskeletal control pathways.

Lin YC, Yeckel MF, Koleske AJ.

J Neurosci. 2013 Jan 30;33(5):1846-57. doi: 10.1523/JNEUROSCI.4284-12.2013.


Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding.

Gourley SL, Swanson AM, Jacobs AM, Howell JL, Mo M, Dileone RJ, Koleske AJ, Taylor JR.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20714-9. doi: 10.1073/pnas.1208342109. Epub 2012 Nov 26.


A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase.

Deng Y, Couch BA, Koleske AJ, Turk BE.

Chembiochem. 2012 Nov 26;13(17):2510-2. doi: 10.1002/cbic.201200560. Epub 2012 Oct 18. No abstract available.


Delayed amyloid plaque deposition and behavioral deficits in outcrossed AβPP/PS1 mice.

Couch BA, Kerrisk ME, Kaufman AC, Nygaard HB, Strittmatter SM, Koleske AJ.

J Comp Neurol. 2013 Apr 15;521(6):1395-408. doi: 10.1002/cne.23239.


Met acts through Abl to regulate p53 transcriptional outcomes and cell survival in the developing liver.

Furlan A, Lamballe F, Stagni V, Hussain A, Richelme S, Prodosmo A, Moumen A, Brun C, Del Barco Barrantes I, Arthur JS, Koleske AJ, Nebreda AR, Barilà D, Maina F.

J Hepatol. 2012 Dec;57(6):1292-8. doi: 10.1016/j.jhep.2012.07.044. Epub 2012 Aug 10.


Arg/Abl2 modulates the affinity and stoichiometry of binding of cortactin to F-actin.

MacGrath SM, Koleske AJ.

Biochemistry. 2012 Aug 21;51(33):6644-53. doi: 10.1021/bi300722t. Epub 2012 Aug 10.


Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo.

Gil-Henn H, Patsialou A, Wang Y, Warren MS, Condeelis JS, Koleske AJ.

Oncogene. 2013 May 23;32(21):2622-30. doi: 10.1038/onc.2012.284. Epub 2012 Jul 9.


The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.

Wetzel DM, McMahon-Pratt D, Koleske AJ.

Mol Cell Biol. 2012 Aug;32(15):3176-86. doi: 10.1128/MCB.00086-12. Epub 2012 Jun 4.

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