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Items: 48

1.

Total Methionine Restriction Treatment of Cancer.

Hoffman RM, Kokkinakis DM, Frenkel EP.

Methods Mol Biol. 2019;1866:163-171. doi: 10.1007/978-1-4939-8796-2_13.

PMID:
30725415
2.

Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress.

Kokkinakis DM, Brickner AG, Kirkwood JM, Liu X, Goldwasser JE, Kastrama A, Sander C, Bocangel D, Chada S.

Mol Cancer Res. 2006 Aug;4(8):575-89.

3.

Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma.

Zeng G, Germinaro M, Micsenyi A, Monga NK, Bell A, Sood A, Malhotra V, Sood N, Midda V, Monga DK, Kokkinakis DM, Monga SP.

Neoplasia. 2006 Apr;8(4):279-89.

4.

Methionine-stress: a pleiotropic approach in enhancing the efficacy of chemotherapy.

Kokkinakis DM.

Cancer Lett. 2006 Feb 28;233(2):195-207. Review.

PMID:
16520149
6.

Physiology and gene expression characteristics of carcinogen-initiated and tumor-transformed glial progenitor cells derived from the CNS of methylnitrosourea (MNU)-treated Sprague-Dawley rats.

Kokkinakis DM, Rushing EJ, Shareef MM, Ahmed MM, Yang S, Singha UK, Luo J.

J Neuropathol Exp Neurol. 2004 Nov;63(11):1182-99.

PMID:
15581186
7.

Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress.

Kokkinakis DM, Liu X, Chada S, Ahmed MM, Shareef MM, Singha UK, Yang S, Luo J.

Cancer Res. 2004 Oct 15;64(20):7513-25.

8.

Potential use of MDA-7 as a biological adjuvant for radiation therapy.

Shareef MM, Kokkinakis DM, Ahmed MM.

Cancer Biol Ther. 2004 Aug;3(8):752-4. Epub 2004 Aug 15. No abstract available.

PMID:
15326389
9.

O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas.

Schold SC Jr, Kokkinakis DM, Chang SM, Berger MS, Hess KR, Schiff D, Robins HI, Mehta MP, Fink KL, Davis RL, Prados MD.

Neuro Oncol. 2004 Jan;6(1):28-32.

11.

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.

Srivastava SK, Xiao D, Lew KL, Hershberger P, Kokkinakis DM, Johnson CS, Trump DL, Singh SV.

Carcinogenesis. 2003 Oct;24(10):1665-70. Epub 2003 Aug 1.

PMID:
12896904
12.
13.

Multifaceted resistance of gliomas to temozolomide.

Bocangel DB, Finkelstein S, Schold SC, Bhakat KK, Mitra S, Kokkinakis DM.

Clin Cancer Res. 2002 Aug;8(8):2725-34.

14.

Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice.

Kokkinakis DM, Hoffman RM, Frenkel EP, Wick JB, Han Q, Xu M, Tan Y, Schold SC.

Cancer Res. 2001 May 15;61(10):4017-23.

15.

Characterization of initiated cells in N-methylnitrosourea-induced carcinogenesis of the CNS in the adult rat.

Kokkinakis DM, Watson ML, Honig LS, Rushing EJ, Mickey BE, Schold SC Jr.

Neuro Oncol. 2001 Apr;3(2):99-112. doi: 10.1093/neuonc/3.2.99.

17.

Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.

Kokkinakis DM, Moschel RC, Pegg AE, Schold SC.

Cancer Chemother Pharmacol. 2000;45(1):69-77.

PMID:
10647505
18.
19.

Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.

Wu MH, Lohrbach KE, Olopade OI, Kokkinakis DM, Friedman HS, Dolan ME.

Clin Cancer Res. 1999 Jan;5(1):209-13.

20.

Glial tumors in the MNU rat model: induction of pure and mixed gliomas that do not require typical missense mutations of p53.

Rushing EJ, Watson ML, Schold SC, Land KJ, Kokkinakis DM.

J Neuropathol Exp Neurol. 1998 Nov;57(11):1053-60.

PMID:
9825942
21.

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma.

Friedman HS, Kokkinakis DM, Pluda J, Friedman AH, Cokgor I, Haglund MM, Ashley DM, Rich J, Dolan ME, Pegg AE, Moschel RC, McLendon RE, Kerby T, Herndon JE, Bigner DD, Schold SC Jr.

J Clin Oncol. 1998 Nov;16(11):3570-5.

PMID:
9817277
22.

Role of O6-methylguanine-DNA methyltransferase in the resistance of pancreatic tumors to DNA alkylating agents.

Kokkinakis DM, Ahmed MM, Delgado R, Fruitwala MM, Mohiuddin M, Albores-Saavedra J.

Cancer Res. 1997 Dec 1;57(23):5360-8.

23.
24.

Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells.

Kokkinakis DM, von Wronski MA, Vuong TH, Brent TP, Schold SC Jr.

Br J Cancer. 1997;75(6):779-88.

25.

Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2'-deoxyguanosine. Role of metabolism.

Kokkinakis DM, Moschel RC, Vuong TH, Reddy MV, Schold SC, Pegg AE.

In Vivo. 1996 May-Jun;10(3):297-306.

PMID:
8797031
26.

Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.

Schold SC Jr, Kokkinakis DM, Rudy JL, Moschel RC, Pegg AE.

Cancer Res. 1996 May 1;56(9):2076-81.

28.

Metabolism and disposition of O6-benzyl-2'-deoxyguanosine in Sprague-Dawley rats.

Kokkinakis DM, Moschel RC, Pegg AE, Dolan ME, Schold SC Jr.

Chem Res Toxicol. 1994 Nov-Dec;7(6):762-9.

PMID:
7696530
30.

Metabolism and activation of pancreas specific nitrosamines by pancreatic ductal cells in culture.

Kokkinakis DM, Reddy MK, Norgle JR, Baskaran K.

Carcinogenesis. 1993 Aug;14(8):1705-9.

PMID:
8353856
32.

Alkylation of rodent tissue DNA induced by N-nitrosobis(2-hydroxypropyl)amine.

Kokkinakis DM.

Carcinogenesis. 1992 May;13(5):759-65.

PMID:
1586988
33.
36.
38.

DNA alkylation in the hamster induced by two pancreatic carcinogens.

Kokkinakis DM, Scarpelli DG.

Cancer Res. 1989 Jun 15;49(12):3184-9.

40.

Species differences in the metabolism of N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine.

Kokkinakis DM, Scarpelli DG, Subbarao V, Hollenberg PF.

Carcinogenesis. 1987 Feb;8(2):295-303.

PMID:
3802415
41.

Structural relationships of pancreatic nitrosamine carcinogens.

Kokkinakis DM, Wieboldt R, Hollenberg PF, Scarpelli DG.

Carcinogenesis. 1987 Jan;8(1):81-90.

PMID:
3802397
42.
43.

Major urinary metabolites in hamsters and rats treated with N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine.

Kokkinakis DM, Hollenberg PF, Scarpelli DG.

Cancer Res. 1985 Aug;45(8):3586-92.

44.

Metabolism of N-nitroso-2,6-dimethylmorpholine by isozymes of rabbit liver microsomal cytochrome P-450.

Kokkinakis DM, Koop DR, Scarpelli DG, Coon MJ, Hollenberg PF.

Cancer Res. 1985 Feb;45(2):619-24.

45.
46.

Metabolism of the pancreatic carcinogen N-nitroso-2,6-dimethylmorpholine by hamster liver and component cells of pancreas.

Scarpelli DG, Kokkinakis DM, Rao MS, Subbarao V, Luetteke N, Hollenberg PF.

Cancer Res. 1982 Dec;42(12):5089-95. No abstract available.

47.
48.

Tomato peroxidase: purification, characterization, and catalytic properties.

Kokkinakis DM, Brooks JL.

Plant Physiol. 1979 Jan;63(1):93-9.

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