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Items: 48

1.

Reply to Bogaard et al.: Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension.

Kojonazarov B, Hadzic S, Ghofrani HA, Grimminger F, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Dec 1;200(11):1450-1452. doi: 10.1164/rccm.201907-1367LE. No abstract available.

2.

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension.

Weiss A, Neubauer MC, Yerabolu D, Kojonazarov B, Schlueter BC, Neubert L, Jonigk D, Baal N, Ruppert C, Dorfmuller P, Pullamsetti SS, Weissmann N, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT.

Nat Commun. 2019 May 17;10(1):2204. doi: 10.1038/s41467-019-10135-x.

3.

Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension.

Kojonazarov B, Hadzic S, Ghofrani HA, Grimminger F, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Aug 15;200(4):515-518. doi: 10.1164/rccm.201902-0390LE. No abstract available.

PMID:
31034778
4.

Riociguat for treatment of pulmonary hypertension in COPD: a translational study.

Pichl A, Sommer N, Bednorz M, Seimetz M, Hadzic S, Kuhnert S, Kraut S, Roxlau ET, Kojonazarov B, Wilhelm J, Gredic M, Gall H, Tello K, Richter MJ, Pak O, Petrovic A, Hecker M, Schermuly RT, Grimminger F, Seeger W, Ghofrani HA, Weissmann N.

Eur Respir J. 2019 Jun 27;53(6). pii: 1802445. doi: 10.1183/13993003.02445-2018. Print 2019 Jun.

PMID:
30956210
5.

Protection against pressure overload-induced right heart failure by uncoupling protein 2 silencing.

Esfandiary A, Kutsche HS, Schreckenberg R, Weber M, Pak O, Kojonazarov B, Sydykov A, Hirschhäuser C, Wolf A, Haag D, Hecker M, Fink L, Seeger W, Ghofrani HA, Schermuly RT, Weißmann N, Schulz R, Rohrbach S, Li L, Sommer N, Schlüter KD.

Cardiovasc Res. 2019 Jun 1;115(7):1217-1227. doi: 10.1093/cvr/cvz049.

6.

Response to: Comment on "Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding".

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Dec 16;2018:7491284. doi: 10.1155/2018/7491284. eCollection 2018. No abstract available.

7.

Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension.

Novoyatleva T, Kojonazarov B, Owczarek A, Veeroju S, Rai N, Henneke I, Böhm M, Grimminger F, Ghofrani HA, Seeger W, Weissmann N, Schermuly RT.

Am J Respir Crit Care Med. 2019 Jun 1;199(11):1407-1420. doi: 10.1164/rccm.201806-1170OC.

PMID:
30557519
8.

Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography.

Kojonazarov B, Belenkov A, Shinomiya S, Wilchelm J, Kampschulte M, Mizuno S, Ghofrani HA, Grimminger F, Weissmann N, Seeger W, Schermuly RT.

Circ Cardiovasc Imaging. 2018 Dec;11(12):e007653. doi: 10.1161/CIRCIMAGING.118.007653.

PMID:
30525986
9.

Nitric Oxide Synthase 2 Induction Promotes Right Ventricular Fibrosis.

Boehm M, Novoyatleva T, Kojonazarov B, Veit F, Weissmann N, Ghofrani HA, Seeger W, Schermuly RT.

Am J Respir Cell Mol Biol. 2019 Mar;60(3):346-356. doi: 10.1165/rcmb.2018-0069OC.

PMID:
30277804
10.

Cystathionine γ Lyase Sulfhydrates the RNA Binding Protein Human Antigen R to Preserve Endothelial Cell Function and Delay Atherogenesis.

Bibli SI, Hu J, Sigala F, Wittig I, Heidler J, Zukunft S, Tsilimigras DI, Randriamboavonjy V, Wittig J, Kojonazarov B, Schürmann C, Siragusa M, Siuda D, Luck B, Abdel Malik R, Filis KA, Zografos G, Chen C, Wang DW, Pfeilschifter J, Brandes RP, Szabo C, Papapetropoulos A, Fleming I.

Circulation. 2019 Jan 2;139(1):101-114. doi: 10.1161/CIRCULATIONAHA.118.034757.

PMID:
29970364
11.

JDP2 overexpression provokes cardiac dysfunction in mice.

Heger J, Bornbaum J, Würfel A, Hill C, Brockmann N, Gáspár R, Pálóczi J, Varga ZV, Sárközy M, Bencsik P, Csont T, Török S, Kojonazarov B, Schermuly RT, Böngler K, Parahuleva M, Ferdinandy P, Schulz R, Euler G.

Sci Rep. 2018 May 16;8(1):7647. doi: 10.1038/s41598-018-26052-w.

12.

Nintedanib in Severe Pulmonary Arterial Hypertension.

Richter MJ, Ewert J, Grimminger F, Ghofrani HA, Kojonazarov B, Petrovic A, Seeger W, Schermuly RT, Tello K, Gall H.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):808-810. doi: 10.1164/rccm.201801-0195LE. No abstract available.

PMID:
29763335
13.

Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding.

Rai N, Veeroju S, Schymura Y, Janssen W, Wietelmann A, Kojonazarov B, Weissmann N, Stasch JP, Ghofrani HA, Seeger W, Schermuly RT, Novoyatleva T.

Biomed Res Int. 2018 Jan 3;2018:3293584. doi: 10.1155/2018/3293584. eCollection 2018.

14.

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension.

Boehm M, Arnold N, Braithwaite A, Pickworth J, Lu C, Novoyatleva T, Kiely DG, Grimminger F, Ghofrani HA, Weissmann N, Seeger W, Lawrie A, Schermuly RT, Kojonazarov B.

BMC Pulm Med. 2018 Mar 2;18(1):41. doi: 10.1186/s12890-018-0604-x.

15.

Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk.

Pullamsetti SS, Kojonazarov B, Storn S, Gall H, Salazar Y, Wolf J, Weigert A, El-Nikhely N, Ghofrani HA, Krombach GA, Fink L, Gattenlöhner S, Rapp UR, Schermuly RT, Grimminger F, Seeger W, Savai R.

Sci Transl Med. 2017 Nov 15;9(416). pii: eaai9048. doi: 10.1126/scitranslmed.aai9048.

PMID:
29141888
16.

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension.

Budas GR, Boehm M, Kojonazarov B, Viswanathan G, Tian X, Veeroju S, Novoyatleva T, Grimminger F, Hinojosa-Kirschenbaum F, Ghofrani HA, Weissmann N, Seeger W, Liles JT, Schermuly RT.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):373-385. doi: 10.1164/rccm.201703-0502OC.

PMID:
28910144
17.

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

Lu S, Liu S, Wietelmann A, Kojonazarov B, Atzberger A, Tang C, Schermuly RT, Gröne HJ, Offermanns S.

PLoS One. 2017 Aug 14;12(8):e0183166. doi: 10.1371/journal.pone.0183166. eCollection 2017.

18.

p38 MAPK Inhibition Improves Heart Function in Pressure-Loaded Right Ventricular Hypertrophy.

Kojonazarov B, Novoyatleva T, Boehm M, Happe C, Sibinska Z, Tian X, Sajjad A, Luitel H, Kriechling P, Posern G, Evans SM, Grimminger F, Ghofrani HA, Weissmann N, Bogaard HJ, Seeger W, Schermuly RT.

Am J Respir Cell Mol Biol. 2017 Nov;57(5):603-614. doi: 10.1165/rcmb.2016-0374OC.

PMID:
28657795
19.

Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension.

Amirjanians M, Egemnazarov B, Sydykov A, Kojonazarov B, Brandes R, Luitel H, Pradhan K, Stasch JP, Redlich G, Weissmann N, Grimminger F, Seeger W, Ghofrani H, Schermuly R.

Oncotarget. 2017 May 2;8(18):29613-29624. doi: 10.18632/oncotarget.16769.

20.

Amplified canonical transforming growth factor-β signalling via heat shock protein 90 in pulmonary fibrosis.

Sibinska Z, Tian X, Korfei M, Kojonazarov B, Kolb JS, Klepetko W, Kosanovic D, Wygrecka M, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Guenther A, Schermuly RT.

Eur Respir J. 2017 Feb 23;49(2). pii: 1501941. doi: 10.1183/13993003.01941-2015. Print 2017 Feb.

21.

Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice.

Boehm M, Lawrie A, Wilhelm J, Ghofrani HA, Grimminger F, Weissmann N, Seeger W, Schermuly RT, Kojonazarov B.

Exp Physiol. 2017 Feb 1;102(2):180-189. doi: 10.1113/EP085963.

22.

Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension.

Dabral S, Tian X, Kojonazarov B, Savai R, Ghofrani HA, Weissmann N, Florio M, Sun J, Jonigk D, Maegel L, Grimminger F, Seeger W, Savai Pullamsetti S, Schermuly RT.

Eur Respir J. 2016 Oct;48(4):1137-1149. doi: 10.1183/13993003.00773-2015. Epub 2016 Jul 28.

23.

miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach.

Shi L, Kojonazarov B, Elgheznawy A, Popp R, Dahal BK, Böhm M, Pullamsetti SS, Ghofrani HA, Gödecke A, Jungmann A, Katus HA, Müller OJ, Schermuly RT, Fisslthaler B, Seeger W, Fleming I.

Cardiovasc Res. 2016 Aug 1;111(3):184-93. doi: 10.1093/cvr/cvw065. Epub 2016 Mar 24.

PMID:
27013635
24.

Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice.

Werner F, Kojonazarov B, Gaßner B, Abeßer M, Schuh K, Völker K, Baba HA, Dahal BK, Schermuly RT, Kuhn M.

Basic Res Cardiol. 2016 Mar;111(2):22. doi: 10.1007/s00395-016-0541-x. Epub 2016 Feb 24.

25.

Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks.

Mizuno S, Ishizaki T, Toga H, Sakai A, Isakova J, Taalaibekova E, Baiserkeev Z, Kojonazarov B, Aldashev A.

Biomed Res Int. 2015;2015:196904. doi: 10.1155/2015/196904. Epub 2015 Aug 26.

26.

The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function.

Kovacevic I, Müller M, Kojonazarov B, Ehrke A, Randriamboavonjy V, Kohlstedt K, Hindemith T, Schermuly RT, Fleming I, Hoffmeister M, Oess S.

Circ Res. 2015 Aug 14;117(5):460-9. doi: 10.1161/CIRCRESAHA.115.306187. Epub 2015 Jul 13.

PMID:
26169369
27.

5-HT2B receptor antagonists inhibit fibrosis and protect from RV heart failure.

Janssen W, Schymura Y, Novoyatleva T, Kojonazarov B, Boehm M, Wietelmann A, Luitel H, Murmann K, Krompiec DR, Tretyn A, Pullamsetti SS, Weissmann N, Seeger W, Ghofrani HA, Schermuly RT.

Biomed Res Int. 2015;2015:438403. doi: 10.1155/2015/438403. Epub 2015 Feb 1.

28.

Blunted activation of Rho-kinase in yak pulmonary circulation.

Ishizaki T, Mizuno S, Sakai A, Matsukawa S, Kojonazarov B, Zamirbek B, Umeda Y, Morikawa M, Anzai M, Ishizuka T, Aldashev A.

Biomed Res Int. 2015;2015:720250. doi: 10.1155/2015/720250. Epub 2015 Jan 14.

29.

α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.

Wilkins MR, Aldashev AA, Wharton J, Rhodes CJ, Vandrovcova J, Kasperaviciute D, Bhosle SG, Mueller M, Geschka S, Rison S, Kojonazarov B, Morrell NW, Neidhardt I, Surmeli NB, Aitman TJ, Stasch JP, Behrends S, Marletta MA.

Circ Cardiovasc Genet. 2014 Dec;7(6):920-9. doi: 10.1161/CIRCGENETICS.114.000763. Epub 2014 Nov 4. Erratum in: Circ Cardiovasc Genet. 2015 Feb;8(1):244. Surmeli, Nur Basek [corrected to Surmeli, Nur Basak]. Circ Cardiovasc Genet. 2015 Feb;8(1):244.

30.

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS.

Nat Med. 2014 Nov;20(11):1289-300. doi: 10.1038/nm.3695. Epub 2014 Oct 26.

PMID:
25344740
31.

The peroxisome proliferator-activated receptor β/δ agonist GW0742 has direct protective effects on right heart hypertrophy.

Kojonazarov B, Luitel H, Sydykov A, Dahal BK, Paul-Clark MJ, Bonvini S, Reed A, Schermuly RT, Mitchell JA.

Pulm Circ. 2013 Dec;3(4):926-35. doi: 10.1086/674755. Erratum in: Pulm Circ. 2014 Jun;4(2):352.

32.

Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling.

Weisel FC, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, Roth M, Ridge KM, Igarashi K, Nishimura K, Maison W, Wackendorff C, Klepetko W, Jaksch P, Ghofrani HA, Grimminger F, Seeger W, Schermuly RT, Weissmann N, Kwapiszewska G.

Circulation. 2014 Apr 8;129(14):1510-23. doi: 10.1161/CIRCULATIONAHA.113.006402. Epub 2014 Jan 27.

PMID:
24470481
33.

The role of cGMP in the physiological and molecular responses of the right ventricle to pressure overload.

Janssen W, Schermuly RT, Kojonazarov B.

Exp Physiol. 2013 Aug;98(8):1274-8. doi: 10.1113/expphysiol.2012.069138. Review.

34.

A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension.

Schwappacher R, Kilic A, Kojonazarov B, Lang M, Diep T, Zhuang S, Gawlowski T, Schermuly RT, Pfeifer A, Boss GR, Pilz RB.

J Biol Chem. 2013 Jun 7;288(23):16557-66. doi: 10.1074/jbc.M113.458729. Epub 2013 Apr 23.

35.

Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model.

Pak O, Sommer N, Hoeres T, Bakr A, Waisbrod S, Sydykov A, Haag D, Esfandiary A, Kojonazarov B, Veit F, Fuchs B, Weisel FC, Hecker M, Schermuly RT, Grimminger F, Ghofrani HA, Seeger W, Weissmann N.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):358-67. doi: 10.1165/rcmb.2012-0361OC.

PMID:
23590303
36.

Bosentan reduces pulmonary artery pressure in high altitude residents.

Kojonazarov B, Isakova J, Imanov B, Sovkhozova N, Sooronbaev T, Ishizaki T, Aldashev AA.

High Alt Med Biol. 2012 Sep;13(3):217-23.

PMID:
22994522
37.

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.

Lang M, Kojonazarov B, Tian X, Kalymbetov A, Weissmann N, Grimminger F, Kretschmer A, Stasch JP, Seeger W, Ghofrani HA, Schermuly RT.

PLoS One. 2012;7(8):e43433. doi: 10.1371/journal.pone.0043433. Epub 2012 Aug 17.

38.

Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling.

Kojonazarov B, Sydykov A, Pullamsetti SS, Luitel H, Dahal BK, Kosanovic D, Tian X, Majewski M, Baumann C, Evans S, Phillips P, Fairman D, Davie N, Wayman C, Kilty I, Weissmann N, Grimminger F, Seeger W, Ghofrani HA, Schermuly RT.

Int J Cardiol. 2013 Sep 10;167(6):2630-7. doi: 10.1016/j.ijcard.2012.06.129. Epub 2012 Jul 31.

PMID:
22854298
39.

PAR-2 inhibition reverses experimental pulmonary hypertension.

Kwapiszewska G, Markart P, Dahal BK, Kojonazarov B, Marsh LM, Schermuly RT, Taube C, Meinhardt A, Ghofrani HA, Steinhoff M, Seeger W, Preissner KT, Olschewski A, Weissmann N, Wygrecka M.

Circ Res. 2012 Apr 27;110(9):1179-91. doi: 10.1161/CIRCRESAHA.111.257568. Epub 2012 Mar 29.

PMID:
22461388
40.

Effects of fasudil in patients with high-altitude pulmonary hypertension.

Kojonazarov B, Myrzaakhmatova A, Sooronbaev T, Ishizaki T, Aldashev A.

Eur Respir J. 2012 Feb;39(2):496-8. doi: 10.1183/09031936.00095211. No abstract available.

41.

Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension.

Pullamsetti SS, Doebele C, Fischer A, Savai R, Kojonazarov B, Dahal BK, Ghofrani HA, Weissmann N, Grimminger F, Bonauer A, Seeger W, Zeiher AM, Dimmeler S, Schermuly RT.

Am J Respir Crit Care Med. 2012 Feb 15;185(4):409-19. doi: 10.1164/rccm.201106-1093OC. Epub 2011 Dec 8.

PMID:
22161164
42.

Regression of cardiac hypertrophy by granulocyte colony-stimulating factor-stimulated interleukin-1β synthesis.

Szardien S, Nef HM, Voss S, Troidl C, Liebetrau C, Hoffmann J, Rauch M, Mayer K, Kimmich K, Rolf A, Rixe J, Troidl K, Kojonazarov B, Schermuly RT, Kostin S, Elsässer A, Hamm CW, Möllmann H.

Eur Heart J. 2012 Mar;33(5):595-605. doi: 10.1093/eurheartj/ehr434. Epub 2011 Nov 21.

PMID:
22106340
43.

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension.

Kosanovic D, Kojonazarov B, Luitel H, Dahal BK, Sydykov A, Cornitescu T, Janssen W, Brandes RP, Davie N, Ghofrani HA, Weissmann N, Grimminger F, Seeger W, Schermuly RT.

Respir Res. 2011 Jun 23;12:87. doi: 10.1186/1465-9921-12-87.

44.

Noninvasive and invasive evaluation of pulmonary arterial pressure in highlanders.

Kojonazarov BK, Imanov BZ, Amatov TA, Mirrakhimov MM, Naeije R, Wilkins MR, Aldashev AA.

Eur Respir J. 2007 Feb;29(2):352-6. Epub 2006 Nov 1.

45.

Phosphodiesterase type 5 and high altitude pulmonary hypertension.

Aldashev AA, Kojonazarov BK, Amatov TA, Sooronbaev TM, Mirrakhimov MM, Morrell NW, Wharton J, Wilkins MR.

Thorax. 2005 Aug;60(8):683-7.

46.

Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans.

Velez-Roa S, Kojonazarov B, Ciarka A, Godart P, Naeije R, Somers VK, van de Borne P.

Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1356-61. Epub 2003 May 15.

47.

Characterization of high-altitude pulmonary hypertension in the Kyrgyz: association with angiotensin-converting enzyme genotype.

Aldashev AA, Sarybaev AS, Sydykov AS, Kalmyrzaev BB, Kim EV, Mamanova LB, Maripov R, Kojonazarov BK, Mirrakhimov MM, Wilkins MR, Morrell NW.

Am J Respir Crit Care Med. 2002 Nov 15;166(10):1396-402. Epub 2002 Aug 28.

PMID:
12406857
48.

Sildenafil inhibits hypoxia-induced pulmonary hypertension.

Zhao L, Mason NA, Morrell NW, Kojonazarov B, Sadykov A, Maripov A, Mirrakhimov MM, Aldashev A, Wilkins MR.

Circulation. 2001 Jul 24;104(4):424-8.

PMID:
11468204

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