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Items: 1 to 50 of 169

1.

Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism.

Määttä J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P.

Sci Rep. 2020 Mar 3;10(1):4260. doi: 10.1038/s41598-020-61220-x.

2.

Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.

Laitakari A, Huttunen R, Kuvaja P, Hannuksela P, Szabo Z, Heikkilä M, Kerkelä R, Myllyharju J, Dimova EY, Serpi R, Koivunen P.

FASEB J. 2020 Feb 25. doi: 10.1096/fj.201902331R. [Epub ahead of print]

PMID:
32100354
3.

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase.

D'Hulst G, Soro-Arnaiz I, Masschelein E, Veys K, Fitzgerald G, Smeuninx B, Kim S, Deldicque L, Blaauw B, Carmeliet P, Breen L, Koivunen P, Zhao SM, De Bock K.

Nat Commun. 2020 Jan 10;11(1):174. doi: 10.1038/s41467-019-13889-6.

4.

A descriptive study highlighting the differences in the treatment protocol for oral tongue cancer in Sweden and Finland.

Mäkitie A, Kamali A, Mroueh R, Lindford A, Koivunen P, Autio T, Lassus P, Halle M, Bäck L, Palmgren B, Hammarstedt-Nordenvall L.

Acta Otolaryngol. 2020 Feb;140(2):188-194. doi: 10.1080/00016489.2019.1699663. Epub 2019 Dec 18.

PMID:
31852347
5.

The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.

Kozlova N, Mennerich D, Samoylenko A, Dimova EY, Koivunen P, Biterova E, Richter K, Hassinen A, Kellokumpu S, Manninen A, Miinalainen I, Glumoff V, Ruddock L, Drobot LB, Kietzmann T.

Cancer Res. 2019 Aug 15;79(16):4042-4056. doi: 10.1158/0008-5472.CAN-18-3852. Epub 2019 May 29.

6.

Maternal hemoglobin associates with preterm delivery and small for gestational age in two Finnish birth cohorts.

Ronkainen J, Lowry E, Heiskala A, Uusitalo I, Koivunen P, Kajantie E, Vääräsmäki M, Järvelin MR, Sebert S.

Eur J Obstet Gynecol Reprod Biol. 2019 Jul;238:44-48. doi: 10.1016/j.ejogrb.2019.04.045. Epub 2019 May 4.

PMID:
31082743
7.

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice.

Leinonen H, Koivisto H, Lipponen HR, Matilainen A, Salo AM, Dimova EY, Hämäläinen E, Stavén S, Miettinen P, Myllyharju J, Koivunen P, Tanila H.

Neuropharmacology. 2019 Jul 15;153:63-72. doi: 10.1016/j.neuropharm.2019.04.023. Epub 2019 Apr 25.

PMID:
31029587
8.

Craniomaxillofacial osteosarcoma - The role of surgical margins.

Kontio R, Hagström J, Lindholm P, Böhling T, Sampo M, Mesimäki K, Saarilahti K, Koivunen P, Mäkitie AA.

J Craniomaxillofac Surg. 2019 Jun;47(6):922-925. doi: 10.1016/j.jcms.2019.03.020. Epub 2019 Mar 25.

PMID:
31005379
9.

Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome).

Rahikkala E, Myllykoski M, Hinttala R, Vieira P, Nayebzadeh N, Weiss S, Plomp AS, Bittner RE, Kurki MI, Kuismin O, Lewis AM, Väisänen ML, Kokkonen H, Westermann J, Bernert G, Tuominen H, Palotie A, Aaltonen L, Yang Y, Potocki L, Moilanen J, van Koningsbruggen S, Wang X, Schmidt WM, Koivunen P, Uusimaa J.

Genet Med. 2019 Oct;21(10):2355-2363. doi: 10.1038/s41436-019-0503-4. Epub 2019 Apr 3.

10.

The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α.

Dimova EY, Jakupovic M, Kubaichuk K, Mennerich D, Chi TF, Tamanini F, Oklejewicz M, Hänig J, Byts N, Mäkelä KA, Herzig KH, Koivunen P, Chaves I, van der Horst G, Kietzmann T.

iScience. 2019 Mar 29;13:284-304. doi: 10.1016/j.isci.2019.02.027. Epub 2019 Mar 1.

11.

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate.

Chakraborty AA, Laukka T, Myllykoski M, Ringel AE, Booker MA, Tolstorukov MY, Meng YJ, Meier SR, Jennings RB, Creech AL, Herbert ZT, McBrayer SK, Olenchock BA, Jaffe JD, Haigis MC, Beroukhim R, Signoretti S, Koivunen P, Kaelin WG Jr.

Science. 2019 Mar 15;363(6432):1217-1222. doi: 10.1126/science.aaw1026. Epub 2019 Mar 14.

PMID:
30872525
12.

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease.

Laitakari A, Ollonen T, Kietzmann T, Walkinshaw G, Mennerich D, Izzi V, Haapasaari KM, Myllyharju J, Serpi R, Dimova EY, Koivunen P.

Redox Biol. 2019 Apr;22:101145. doi: 10.1016/j.redox.2019.101145. Epub 2019 Feb 19.

13.

Swallowing-related quality of life after free flap surgery due to cancer of the head and neck.

Lahtinen S, Koivunen P, Ala-Kokko T, Kaarela O, Laurila P, Liisanantti JH.

Eur Arch Otorhinolaryngol. 2019 Mar;276(3):821-826. doi: 10.1007/s00405-018-05264-w. Epub 2018 Dec 28.

14.

Short- and long-term mortality and causes of death after reconstruction of cancers of the head and neck with free flaps.

Lahtinen S, Koivunen P, Ala-Kokko T, Kaarela O, Ohtonen P, Laurila P, Liisanantti JH.

Br J Oral Maxillofac Surg. 2019 Jan;57(1):21-28. doi: 10.1016/j.bjoms.2018.12.004. Epub 2018 Dec 21.

PMID:
30583873
15.

Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism.

Koivunen P, Kietzmann T.

Trends Mol Med. 2018 Dec;24(12):1021-1035. doi: 10.1016/j.molmed.2018.10.004. Epub 2018 Nov 1. Review.

PMID:
30391126
16.

Gestational Diabetes Prevalence at Moderate and High Altitude.

Euser AG, Hammes A, Ahrendsen JT, Neshek B, Weitzenkamp DA, Gutierrez J, Koivunen P, Julian CG, Moore LG.

High Alt Med Biol. 2018 Dec;19(4):367-372. doi: 10.1089/ham.2018.0012. Epub 2018 Oct 3.

17.

Surgical quality assurance in head and neck cancer trials: an EORTC Head and Neck Cancer Group position paper based on the EORTC 1420 'Best of' and 24954 'larynx preservation' study.

Simon C, Caballero C, Gregoire V, Thurnher D, Koivunen P, Ceruse P, Spriano G, Nicolai P, Licitra L, Machiels JP, Hamoir M, Andry G, Mehanna H, Hunter KD, Dietz A, René Leemans C.

Eur J Cancer. 2018 Nov;103:69-77. doi: 10.1016/j.ejca.2018.07.140. Epub 2018 Sep 11. Review.

PMID:
30216847
18.

Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism.

Määttä J, Sissala N, Dimova EY, Serpi R, Moore LG, Koivunen P.

Sci Rep. 2018 Sep 11;8(1):13583. doi: 10.1038/s41598-018-31908-2. Erratum in: Sci Rep. 2020 Mar 3;10(1):4260.

19.

Quality of life after free flap surgery for cancer of the head and neck in patients with or without postoperative complications.

Lahtinen S, Koivunen P, Ala-Kokko T, Laurila P, Kaarela O, Liisanantti JH.

Eur Arch Otorhinolaryngol. 2018 Oct;275(10):2575-2584. doi: 10.1007/s00405-018-5103-4. Epub 2018 Aug 24.

PMID:
30143854
20.

Complications and outcome after free flap surgery for cancer of the head and neck.

Lahtinen S, Koivunen P, Ala-Kokko T, Kaarela O, Ohtonen P, Laurila P, Liisanantti JH.

Br J Oral Maxillofac Surg. 2018 Oct;56(8):684-691. doi: 10.1016/j.bjoms.2018.07.009. Epub 2018 Aug 11.

PMID:
30107953
21.

Transoral Robotic Surgery in the Nordic Countries: Current Status and Perspectives.

Mäkitie AA, Keski-Säntti H, Markkanen-Leppänen M, Bäck L, Koivunen P, Ekberg T, Sandström K, Laurell G, von Beckerath M, Nilsson JS, Wahlberg P, Greiff L, Norberg Spaak L, Kjærgaard T, Godballe C, Rikardsen O, Channir HI, Rubek N, von Buchwald C.

Front Oncol. 2018 Jul 27;8:289. doi: 10.3389/fonc.2018.00289. eCollection 2018.

22.

Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases.

Laukka T, Myllykoski M, Looper RE, Koivunen P.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3081-3092. doi: 10.1016/j.jmb.2018.06.048. Epub 2018 Jul 5.

PMID:
29981745
23.

Risk factors for periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome: a case-control study.

Kettunen S, Lantto U, Koivunen P, Tapiainen T, Uhari M, Renko M.

Eur J Pediatr. 2018 Aug;177(8):1201-1206. doi: 10.1007/s00431-018-3175-1. Epub 2018 May 25.

PMID:
29799086
24.

Cause-specific mortality in patients with head and neck cancer: Long-term follow-up of a population-based cohort from 1986 to 2012 accounting for competing risks.

Väisänen JA, Alho OP, Koivunen PT, Läärä E.

Oral Oncol. 2018 Apr;79:20-26. doi: 10.1016/j.oraloncology.2018.02.008. Epub 2018 Feb 22.

PMID:
29598946
25.

USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner.

Richter K, Paakkola T, Mennerich D, Kubaichuk K, Konzack A, Ali-Kippari H, Kozlova N, Koivunen P, Haapasaari KM, Jukkola-Vuorinen A, Teppo HR, Dimova EY, Bloigu R, Szabo Z, Kerkelä R, Kietzmann T.

Mol Cancer Res. 2018 Jun;16(6):1000-1012. doi: 10.1158/1541-7786.MCR-17-0452. Epub 2018 Mar 15. Erratum in: Mol Cancer Res. 2018 Nov;16(11):1815. Kippari, Heidi Ali [corrected to Ali-Kippari, Heidi].

26.

Comorbidity of PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenitis) patients: a case control study.

Lantto U, Kettunen S, Tapiainen T, Koivunen P, Uhari M, Renko M.

Clin Exp Rheumatol. 2018 Nov-Dec;36(6 Suppl 115):129-134. Epub 2018 Feb 27.

PMID:
29533751
27.

Predictive factors of a beneficial quality of life outcome in patients undergoing primary sinonasal surgery: a population-based prospective cohort study.

Alakärppä AI, Koskenkorva TJ, Koivunen PT, Alho OP.

Eur Arch Otorhinolaryngol. 2018 May;275(5):1139-1147. doi: 10.1007/s00405-018-4918-3. Epub 2018 Feb 28.

PMID:
29492664
28.

Inflammatory Biomarkers During Bacterial Acute Rhinosinusitis.

Autio TJ, Koskenkorva T, Koivunen P, Alho OP.

Curr Allergy Asthma Rep. 2018 Feb 21;18(2):13. doi: 10.1007/s11882-018-0761-2. Review.

PMID:
29464415
29.

Kinetic Analysis of HIF Prolyl Hydroxylases.

Koivunen P, Myllyharju J.

Methods Mol Biol. 2018;1742:15-25. doi: 10.1007/978-1-4939-7665-2_2.

PMID:
29330786
30.

The management and survival outcomes of nasopharyngeal cancer in the Nordic countries<sup/>.

Mäkitie A, Ruuskanen M, Bentzen J, Brun E, Gebre-Medhin M, Friesland S, Marsk E, Hammarstedt-Nordenvall L, Gille E, Reizenstein J, Adell G, Farnebo L, Rzepecki J, Haugen H, Söderström K, Zackrisson B, Bergström S, Lödén B, Cederblad L, Laurell G, Smeland E, Folkvard Evensen J, Lund JÅ, Tøndel H, Karlsdottir Å, Jóhannsson J, Johansen J, Kristensen CA, Jensen K, Andersen LJ, Koivunen P, Korpela M, Voutilainen L, Wigren T, Minn H, Joensuu H, Overgaard J, Saarilahti K.

Acta Oncol. 2018 Apr;57(4):557-560. doi: 10.1080/0284186X.2017.1408961. Epub 2017 Dec 5. No abstract available.

PMID:
29202641
31.

The TET enzymes.

Koivunen P, Laukka T.

Cell Mol Life Sci. 2018 Apr;75(8):1339-1348. doi: 10.1007/s00018-017-2721-8. Epub 2017 Nov 28. Review.

PMID:
29184981
32.

Epidemiological and treatment-related factors contribute to improved outcome of oropharyngeal squamous cell carcinoma in Finland.

Jouhi L, Halme E, Irjala H, Saarilahti K, Koivunen P, Pukkila M, Hagström J, Haglund C, Lindholm P, Hirvikoski P, Vaittinen S, Ellonen A, Tikanto J, Blomster H, Laranne J, Grénman R, Mäkitie A, Atula T.

Acta Oncol. 2018 Apr;57(4):541-551. doi: 10.1080/0284186X.2017.1400688. Epub 2017 Nov 17.

PMID:
29145765
33.

Total or subtotal glossectomy with laryngeal preservation: a national study of 29 patients.

Keski-Säntti H, Bäck L, Lassus P, Koivunen P, Kinnunen I, Blomster H, Mäkitie AA, Aro K.

Eur Arch Otorhinolaryngol. 2018 Jan;275(1):191-197. doi: 10.1007/s00405-017-4789-z. Epub 2017 Nov 8.

PMID:
29119320
34.

Integrin alpha 10, CD44, PTEN, cadherin-11 and lactoferrin expressions are potential biomarkers for selecting patients in need of central nervous system prophylaxis in diffuse large B-cell lymphoma.

Lemma SA, Kuusisto M, Haapasaari KM, Sormunen R, Lehtinen T, Klaavuniemi T, Eray M, Jantunen E, Soini Y, Vasala K, Böhm J, Salokorpi N, Koivunen P, Karihtala P, Vuoristo J, Turpeenniemi-Hujanen T, Kuittinen O.

Carcinogenesis. 2017 Aug 1;38(8):812-820. doi: 10.1093/carcin/bgx061.

35.

Outcome of nasopharyngeal carcinoma in Finland: A nationwide study.

Ruuskanen M, Grenman R, Leivo I, Vahlberg T, Mäkitie A, Saarilahti K, Wigren T, Korpela M, Voutilainen L, Koivunen P, Irjala H, Minn H.

Acta Oncol. 2018 Feb;57(2):251-256. doi: 10.1080/0284186X.2017.1346378. Epub 2017 Jul 7. Erratum in: Acta Oncol. 2018 Feb;57(2):304.

PMID:
28686479
36.

HER2 regulates cancer stem-like cell phenotype in ALK translocated NSCLC.

Honkanen T, Wilenius E, Koivunen P, Koivunen JP.

Int J Oncol. 2017 Aug;51(2):599-606. doi: 10.3892/ijo.2017.4048. Epub 2017 Jun 21.

PMID:
28656214
37.

Exploring effects of remote ischemic preconditioning in a pig model of hypothermic circulatory arrest.

Herajärvi J, Anttila T, Dimova EY, Laukka T, Myllymäki M, Haapanen H, Olenchock BA, Tuominen H, Puistola U, Karihtala P, Kiviluoma K, Koivunen P, Anttila V, Juvonen T.

Scand Cardiovasc J. 2017 Aug;51(4):233-241. doi: 10.1080/14017431.2017.1319574. Epub 2017 Apr 24.

PMID:
28434264
38.

Update on hypoxia-inducible factors and hydroxylases in oxygen regulatory pathways: from physiology to therapeutics.

Ratcliffe P, Koivunen P, Myllyharju J, Ragoussis J, Bovée JV, Batinic-Haberle I, Vinatier C, Trichet V, Robriquet F, Oliver L, Gardie B.

Hypoxia (Auckl). 2017 Mar 15;5:11-20. doi: 10.2147/HP.S127042. eCollection 2017. Review.

39.

Structural basis of homo- and heterotrimerization of collagen I.

Sharma U, Carrique L, Vadon-Le Goff S, Mariano N, Georges RN, Delolme F, Koivunen P, Myllyharju J, Moali C, Aghajari N, Hulmes DJ.

Nat Commun. 2017 Mar 10;8:14671. doi: 10.1038/ncomms14671.

40.

The feasibility of NBI in patients with suspected upper airway lesions: A multicenter study.

Bäck LJJ, Rekola J, Raittinen L, Halme E, Pietarinen P, Keski-Säntti H, Aaltonen LM, Mäkitie AA, Raappana A, Tikanto J, Schrey A, Grenman R, Laranne J, Koivunen P, Irjala H.

Laryngoscope. 2017 Aug;127(8):1821-1825. doi: 10.1002/lary.26526. Epub 2017 Feb 22.

PMID:
28224618
41.

Recurrent acute otitis media detracts from health-related quality of life.

Kujala T, Alho OP, Kristo A, Uhari M, Renko M, Pokka T, Koivunen P.

J Laryngol Otol. 2017 Feb;131(2):128-137. doi: 10.1017/S0022215116009944. Epub 2017 Jan 11.

PMID:
28073387
42.

Predictive factors and treatment outcome of laryngeal carcinoma recurrence.

Haapaniemi A, Väisänen J, Atula T, Alho OP, Mäkitie A, Koivunen P.

Head Neck. 2017 Mar;39(3):555-563. doi: 10.1002/hed.24642. Epub 2016 Nov 30.

PMID:
27902867
43.

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition in cardiometabolic diseases.

Koivunen P, Serpi R, Dimova EY.

Pharmacol Res. 2016 Dec;114:265-273. doi: 10.1016/j.phrs.2016.11.003. Epub 2016 Nov 8. Review.

PMID:
27832958
44.

Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.

Myllymäki MNM, Määttä J, Dimova EY, Izzi V, Väisänen T, Myllyharju J, Koivunen P, Serpi R.

Mol Cell Biol. 2017 Jan 4;37(2). pii: e00529-16. doi: 10.1128/MCB.00529-16. Print 2017 Jan 15.

45.

Longitudinal analysis of inflammatory biomarkers during acute rhinosinusitis.

Autio TJ, Koskenkorva T, Leino TK, Koivunen P, Alho OP.

Laryngoscope. 2017 Feb;127(2):E55-E61. doi: 10.1002/lary.26344. Epub 2016 Oct 18.

PMID:
27753120
46.

Long-Term Outcome of Classic and Incomplete PFAPA (Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Adenitis) Syndrome after Tonsillectomy.

Lantto U, Koivunen P, Tapiainen T, Renko M.

J Pediatr. 2016 Dec;179:172-177.e1. doi: 10.1016/j.jpeds.2016.08.097. Epub 2016 Sep 28.

PMID:
27692464
47.

Imaging follow-up study of acute rhinosinusitis.

Autio TJ, Koskenkorva T, Närkiö M, Leino TK, Koivunen P, Alho OP.

Laryngoscope. 2016 Sep;126(9):1965-70. doi: 10.1002/lary.25843. Epub 2016 Jan 4.

PMID:
27557439
48.

Quality of life before and after sinonasal surgery: a population-based matched cohort study.

Alakärppä AI, Koskenkorva TJ, Koivunen PT, Alho OP.

Eur Arch Otorhinolaryngol. 2017 Feb;274(2):795-802. doi: 10.1007/s00405-016-4272-2. Epub 2016 Aug 23.

PMID:
27554663
49.
50.

Lack of P4H-TM in mice results in age-related retinal and renal alterations.

Leinonen H, Rossi M, Salo AM, Tiainen P, Hyvärinen J, Pitkänen M, Sormunen R, Miinalainen I, Zhang C, Soininen R, Kivirikko KI, Koskelainen A, Tanila H, Myllyharju J, Koivunen P.

Hum Mol Genet. 2016 Sep 1;25(17):3810-3823. doi: 10.1093/hmg/ddw228. Epub 2016 Jul 27.

PMID:
27466183

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