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Items: 1 to 50 of 234

1.

Dysfunction of Cellular Proteostasis in Parkinson's Disease.

Lehtonen Š, Sonninen TM, Wojciechowski S, Goldsteins G, Koistinaho J.

Front Neurosci. 2019 May 10;13:457. doi: 10.3389/fnins.2019.00457. eCollection 2019. Review.

2.

Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms.

Oksanen M, Lehtonen S, Jaronen M, Goldsteins G, Hämäläinen RH, Koistinaho J.

Cell Mol Life Sci. 2019 Apr 23. doi: 10.1007/s00018-019-03111-7. [Epub ahead of print] Review.

PMID:
31016348
3.

Activation of P2X7 Receptors in Peritoneal and Meningeal Mast Cells Detected by Uptake of Organic Dyes: Possible Purinergic Triggers of Neuroinflammation in Meninges.

Nurkhametova D, Kudryavtsev I, Guselnikova V, Serebryakova M, Giniatullina RR, Wojciechowski S, Tore F, Rizvanov A, Koistinaho J, Malm T, Giniatullin R.

Front Cell Neurosci. 2019 Feb 13;13:45. doi: 10.3389/fncel.2019.00045. eCollection 2019.

4.

Long-term interleukin-33 treatment delays disease onset and alleviates astrocytic activation in a transgenic mouse model of amyotrophic lateral sclerosis.

Korhonen P, Pollari E, Kanninen KM, Savchenko E, Lehtonen Š, Wojciechowski S, Pomeshchik Y, Van Den Bosch L, Goldsteins G, Koistinaho J, Malm T.

IBRO Rep. 2019 Jan 11;6:74-86. doi: 10.1016/j.ibror.2019.01.005. eCollection 2019 Jun.

5.

Alzheimer's Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes.

Gynther M, Puris E, Peltokangas S, Auriola S, Kanninen KM, Koistinaho J, Huttunen KM, Ruponen M, Vellonen KS.

Pharm Res. 2018 Nov 28;36(1):17. doi: 10.1007/s11095-018-2546-7.

6.

PPARβ/δ-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1ΔE9 astrocytes.

Konttinen H, Gureviciene I, Oksanen M, Grubman A, Loppi S, Huuskonen MT, Korhonen P, Lampinen R, Keuters M, Belaya I, Tanila H, Kanninen KM, Goldsteins G, Landreth G, Koistinaho J, Malm T.

Glia. 2019 Jan;67(1):146-159. doi: 10.1002/glia.23534. Epub 2018 Nov 19.

PMID:
30453390
7.

CuII(atsm) Attenuates Neuroinflammation.

Choo XY, Liddell JR, Huuskonen MT, Grubman A, Moujalled D, Roberts J, Kysenius K, Patten L, Quek H, Oikari LE, Duncan C, James SA, McInnes LE, Hayne DJ, Donnelly PS, Pollari E, Vähätalo S, Lejavová K, Kettunen MI, Malm T, Koistinaho J, White AR, Kanninen KM.

Front Neurosci. 2018 Sep 24;12:668. doi: 10.3389/fnins.2018.00668. eCollection 2018.

8.

Generation of a human induced pluripotent stem cell line (LL008 1.4) from a familial Alzheimer's disease patient carrying a double KM670/671NL (Swedish) mutation in APP gene.

Oksanen M, Hyötyläinen I, Voutilainen J, Puttonen KA, Hämäläinen RH, Graff C, Lehtonen Š, Koistinaho J.

Stem Cell Res. 2018 Aug;31:181-185. doi: 10.1016/j.scr.2018.07.024. Epub 2018 Aug 1.

9.

HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage.

Loppi S, Kolosowska N, Kärkkäinen O, Korhonen P, Huuskonen M, Grubman A, Dhungana H, Wojciechowski S, Pomeshchik Y, Giordano M, Kagechika H, White A, Auriola S, Koistinaho J, Landreth G, Hanhineva K, Kanninen K, Malm T.

Brain Behav Immun. 2018 Oct;73:670-681. doi: 10.1016/j.bbi.2018.07.021. Epub 2018 Jul 29.

PMID:
30063972
10.

Generation of a human induced pluripotent stem cell line from a patient with a rare A673T variant in amyloid precursor protein gene that reduces the risk for Alzheimer's disease.

Lehtonen Š, Höytyläinen I, Voutilainen J, Sonninen TM, Kuusisto J, Laakso M, Hämäläinen RH, Oksanen M, Koistinaho J.

Stem Cell Res. 2018 Jul;30:96-99. doi: 10.1016/j.scr.2018.05.014. Epub 2018 May 19.

11.

Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules.

Belt H, Koponen JK, Kekarainen T, Puttonen KA, Mäkinen PI, Niskanen H, Oja J, Wirth G, Koistinaho J, Kaikkonen MU, Ylä-Herttuala S.

Front Cardiovasc Med. 2018 Mar 14;5:16. doi: 10.3389/fcvm.2018.00016. eCollection 2018.

12.

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling.

Koivumäki JT, Naumenko N, Tuomainen T, Takalo J, Oksanen M, Puttonen KA, Lehtonen Š, Kuusisto J, Laakso M, Koistinaho J, Tavi P.

Front Physiol. 2018 Feb 7;9:80. doi: 10.3389/fphys.2018.00080. eCollection 2018.

13.

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation.

Dhungana H, Huuskonen MT, Jaronen M, Lemarchant S, Ali H, Keksa-Goldsteine V, Goldsteins G, Kanninen KM, Koistinaho J, Malm T.

J Neuroinflammation. 2017 Dec 4;14(1):237. doi: 10.1186/s12974-017-1010-7.

14.

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease.

Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen Š, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang SC, Kanninen KM, Hämäläinen RH, Koistinaho J.

Stem Cell Reports. 2017 Dec 12;9(6):1885-1897. doi: 10.1016/j.stemcr.2017.10.016. Epub 2017 Nov 16.

15.

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

Martiskainen H, Paldanius KMA, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M.

J Neuroinflammation. 2017 Nov 7;14(1):215. doi: 10.1186/s12974-017-0991-6.

16.

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer's Disease : Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla.

Vellonen KS, Ihalainen J, Boucau MC, Gosselet F, Picardat T, Gynther M, Kanninen KM, White AR, Malm T, Koistinaho J, Forsberg MM, Ruponen M.

Pharm Res. 2017 Dec;34(12):2652-2662. doi: 10.1007/s11095-017-2263-7. Epub 2017 Sep 26.

PMID:
28952054
17.

Loss of Cln5 causes altered neurogenesis in a mouse model of a childhood neurodegenerative disorder.

Savchenko E, Singh Y, Konttinen H, Lejavova K, Mediavilla Santos L, Grubman A, Kärkkäinen V, Keksa-Goldsteine V, Naumenko N, Tavi P, White AR, Malm T, Koistinaho J, Kanninen KM.

Dis Model Mech. 2017 Sep 1;10(9):1089-1100. doi: 10.1242/dmm.029165. Epub 2017 Jul 21.

18.

Creation of a library of induced pluripotent stem cells from Parkinsonian patients.

Holmqvist S, Lehtonen Š, Chumarina M, Puttonen KA, Azevedo C, Lebedeva O, Ruponen M, Oksanen M, Djelloul M, Collin A, Goldwurm S, Meyer M, Lagarkova M, Kiselev S, Koistinaho J, Roybon L.

NPJ Parkinsons Dis. 2016 Jun 2;2:16009. doi: 10.1038/npjparkd.2016.9. eCollection 2016.

19.

Retinal Degeneration In A Mouse Model Of CLN5 Disease Is Associated With Compromised Autophagy.

Leinonen H, Keksa-Goldsteine V, Ragauskas S, Kohlmann P, Singh Y, Savchenko E, Puranen J, Malm T, Kalesnykas G, Koistinaho J, Tanila H, Kanninen KM.

Sci Rep. 2017 May 9;7(1):1597. doi: 10.1038/s41598-017-01716-1.

20.

Collagen XIII secures pre- and postsynaptic integrity of the neuromuscular synapse.

Härönen H, Zainul Z, Tu H, Naumenko N, Sormunen R, Miinalainen I, Shakirzyanova A, Oikarainen T, Abdullin A, Martin P, Santoleri S, Koistinaho J, Silman I, Giniatullin R, Fox MA, Heikkinen A, Pihlajaniemi T.

Hum Mol Genet. 2017 Jun 1;26(11):2076-2090. doi: 10.1093/hmg/ddx101.

PMID:
28369367
21.

ADAMTS-4 in central nervous system pathologies.

Lemarchant S, Wojciechowski S, Vivien D, Koistinaho J.

J Neurosci Res. 2017 Sep;95(9):1703-1711. doi: 10.1002/jnr.24021. Epub 2017 Jan 13. Review.

PMID:
28084617
22.

Lack of collagen XV is protective after ischemic stroke in mice.

Dhungana H, Huuskonen MT, Pihlajaniemi T, Heljasvaara R, Vivien D, Kanninen KM, Malm T, Koistinaho J, Lemarchant S.

Cell Death Dis. 2017 Jan 12;8(1):e2541. doi: 10.1038/cddis.2016.456.

23.

The Copper bis(thiosemicarbazone) Complex CuII(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu.

Huuskonen MT, Tuo QZ, Loppi S, Dhungana H, Korhonen P, McInnes LE, Donnelly PS, Grubman A, Wojciechowski S, Lejavova K, Pomeshchik Y, Periviita L, Kosonen L, Giordano M, Walker FR, Liu R, Bush AI, Koistinaho J, Malm T, White AR, Lei P, Kanninen KM.

Neurotherapeutics. 2017 Apr;14(2):519-532. doi: 10.1007/s13311-016-0504-9.

24.

Aβ and Inflammatory Stimulus Activate Diverse Signaling Pathways in Monocytic Cells: Implications in Retaining Phagocytosis in Aβ-Laden Environment.

Savchenko E, Malm T, Konttinen H, Hämäläinen RH, Guerrero-Toro C, Wojciechowski S, Giniatullin R, Koistinaho J, Magga J.

Front Cell Neurosci. 2016 Dec 5;10:279. eCollection 2016.

25.

Perineuronal nets in neurodegeneration.

Lemarchant S, Wojciechowski S, Koistinaho J.

Oncotarget. 2016 Nov 29;7(48):78224-78225. doi: 10.18632/oncotarget.13420. No abstract available.

26.

Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy.

Huuskonen MT, Loppi S, Dhungana H, Keksa-Goldsteine V, Lemarchant S, Korhonen P, Wojciechowski S, Pollari E, Valonen P, Koponen J, Takashima A, Landreth G, Goldsteins G, Malm T, Koistinaho J, Kanninen KM.

Sci Rep. 2016 Sep 14;6:33176. doi: 10.1038/srep33176.

27.

Deletion of Nuclear Factor kappa B p50 Subunit Decreases Inflammatory Response and Mildly Protects Neurons from Transient Forebrain Ischemia-induced Damage.

Rolova T, Dhungana H, Korhonen P, Valonen P, Kolosowska N, Konttinen H, Kanninen K, Tanila H, Malm T, Koistinaho J.

Aging Dis. 2015 Nov 23;7(4):450-65. doi: 10.14336/AD.2015.1123. eCollection 2016 Aug.

28.

Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA-responsive cells in fragile X syndrome.

Achuta VS, Grym H, Putkonen N, Louhivuori V, Kärkkäinen V, Koistinaho J, Roybon L, Castrén ML.

Dev Neurobiol. 2017 Apr;77(4):438-453. doi: 10.1002/dneu.22419. Epub 2016 Jul 28.

29.

Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.

Lemarchant S, Dunghana H, Pomeshchik Y, Leinonen H, Kolosowska N, Korhonen P, Kanninen KM, García-Berrocoso T, Montaner J, Malm T, Koistinaho J.

Glia. 2016 Sep;64(9):1492-507. doi: 10.1002/glia.23017. Epub 2016 Jun 15.

PMID:
27301579
30.

Inhibition of Excessive Oxidative Protein Folding Is Protective in MPP(+) Toxicity-Induced Parkinson's Disease Models.

Lehtonen Š, Jaronen M, Vehviläinen P, Lakso M, Rudgalvyte M, Keksa-Goldsteine V, Wong G, Courtney MJ, Koistinaho J, Goldsteins G.

Antioxid Redox Signal. 2016 Sep 10;25(8):485-97. doi: 10.1089/ars.2015.6402. Epub 2016 Jun 15.

PMID:
27139804
31.

Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.

Liddell JR, Lehtonen S, Duncan C, Keksa-Goldsteine V, Levonen AL, Goldsteins G, Malm T, White AR, Koistinaho J, Kanninen KM.

J Neuroinflammation. 2016 Feb 26;13:49. doi: 10.1186/s12974-016-0515-9.

32.

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J.

Mol Neurodegener. 2016 Feb 8;11:15. doi: 10.1186/s13024-016-0080-9. No abstract available.

33.

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.

Lemarchant S, Pomeshchik Y, Kidin I, Kärkkäinen V, Valonen P, Lehtonen S, Goldsteins G, Malm T, Kanninen K, Koistinaho J.

Mol Neurodegener. 2016 Jan 25;11:10. doi: 10.1186/s13024-016-0078-3. Erratum in: Mol Neurodegener. 2016;11:15.

34.

Generation of Functional Neuromuscular Junctions from Human Pluripotent Stem Cell Lines.

Puttonen KA, Ruponen M, Naumenko N, Hovatta OH, Tavi P, Koistinaho J.

Front Cell Neurosci. 2015 Dec 8;9:473. doi: 10.3389/fncel.2015.00473. eCollection 2015.

35.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Maysami S, Wong R, Pradillo JM, Denes A, Dhungana H, Malm T, Koistinaho J, Orset C, Rahman M, Rubio M, Schwaninger M, Vivien D, Bath PM, Rothwell NJ, Allan SM.

J Cereb Blood Flow Metab. 2016 Mar;36(3):596-605. doi: 10.1177/0271678X15606714. Epub 2015 Sep 30.

36.

Exosomes as new diagnostic tools in CNS diseases.

Kanninen KM, Bister N, Koistinaho J, Malm T.

Biochim Biophys Acta. 2016 Mar;1862(3):403-10. doi: 10.1016/j.bbadis.2015.09.020. Epub 2015 Oct 20. Review. No abstract available.

37.

Applications of the Keap1-Nrf2 system for gene and cell therapy.

Kanninen KM, Pomeshchik Y, Leinonen H, Malm T, Koistinaho J, Levonen AL.

Free Radic Biol Med. 2015 Nov;88(Pt B):350-361. doi: 10.1016/j.freeradbiomed.2015.06.037. Epub 2015 Jul 8. Review.

PMID:
26164630
38.

Immunomodulation by interleukin-33 is protective in stroke through modulation of inflammation.

Korhonen P, Kanninen KM, Lehtonen Š, Lemarchant S, Puttonen KA, Oksanen M, Dhungana H, Loppi S, Pollari E, Wojciechowski S, Kidin I, García-Berrocoso T, Giralt D, Montaner J, Koistinaho J, Malm T.

Brain Behav Immun. 2015 Oct;49:322-36. doi: 10.1016/j.bbi.2015.06.013. Epub 2015 Jun 22.

PMID:
26111431
39.

Neuroinflammation in Alzheimer's disease.

Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.

Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5. Review.

40.

ER stress and unfolded protein response in amyotrophic lateral sclerosis-a controversial role of protein disulphide isomerase.

Jaronen M, Goldsteins G, Koistinaho J.

Front Cell Neurosci. 2014 Dec 2;8:402. doi: 10.3389/fncel.2014.00402. eCollection 2014. Review.

41.

Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice With Contusion Spinal Cord Injury.

Pomeshchik Y, Puttonen KA, Kidin I, Ruponen M, Lehtonen S, Malm T, Åkesson E, Hovatta O, Koistinaho J.

Cell Transplant. 2015;24(9):1799-812. doi: 10.3727/096368914X684079. Epub 2014 Sep 8.

PMID:
25203632
42.

Behavioral and neuropathological consequences of transient global ischemia in APP/PS1 Alzheimer model mice.

Kemppainen S, Hämäläinen E, Miettinen PO, Koistinaho J, Tanila H.

Behav Brain Res. 2014 Dec 15;275:15-26. doi: 10.1016/j.bbr.2014.08.050. Epub 2014 Sep 1.

PMID:
25192639
43.

Interleukin-33 treatment reduces secondary injury and improves functional recovery after contusion spinal cord injury.

Pomeshchik Y, Kidin I, Korhonen P, Savchenko E, Jaronen M, Lehtonen S, Wojciechowski S, Kanninen K, Koistinaho J, Malm T.

Brain Behav Immun. 2015 Feb;44:68-81. doi: 10.1016/j.bbi.2014.08.002. Epub 2014 Aug 18.

PMID:
25153903
44.

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis.

Pollari E, Goldsteins G, Bart G, Koistinaho J, Giniatullin R.

Front Cell Neurosci. 2014 May 13;8:131. doi: 10.3389/fncel.2014.00131. eCollection 2014. Review.

45.

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis.

Vehviläinen P, Koistinaho J, Gundars G.

Front Cell Neurosci. 2014 May 9;8:126. doi: 10.3389/fncel.2014.00126. eCollection 2014. Review.

46.

Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses?

Grubman A, Pollari E, Duncan C, Caragounis A, Blom T, Volitakis I, Wong A, Cooper J, Crouch PJ, Koistinaho J, Jalanko A, White AR, Kanninen KM.

Metallomics. 2014 Apr;6(4):932-43.

PMID:
24804307
47.

Nrf2 regulates neurogenesis and protects neural progenitor cells against Aβ toxicity.

Kärkkäinen V, Pomeshchik Y, Savchenko E, Dhungana H, Kurronen A, Lehtonen S, Naumenko N, Tavi P, Levonen AL, Yamamoto M, Malm T, Magga J, Kanninen KM, Koistinaho J.

Stem Cells. 2014 Jul;32(7):1904-16. doi: 10.1002/stem.1666.

48.

Susceptibility to focal and global brain ischemia of Alzheimer mice displaying aβ deposits: effect of immunoglobulin.

Heikkinen R, Malm T, Heikkilä J, Muona A, Tanila H, Koistinaho M, Koistinaho J.

Aging Dis. 2014 Apr 1;5(2):76-87. doi: 10.14336/AD.2014.050076. eCollection 2014 Apr.

49.

Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder.

Grubman A, Lidgerwood GE, Duncan C, Bica L, Tan JL, Parker SJ, Caragounis A, Meyerowitz J, Volitakis I, Moujalled D, Liddell JR, Hickey JL, Horne M, Longmuir S, Koistinaho J, Donnelly PS, Crouch PJ, Tammen I, White AR, Kanninen KM.

Acta Neuropathol Commun. 2014 Feb 28;2:25. doi: 10.1186/2051-5960-2-25.

50.

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury.

Lemarchant S, Pruvost M, Hébert M, Gauberti M, Hommet Y, Briens A, Maubert E, Gueye Y, Féron F, Petite D, Mersel M, do Rego JC, Vaudry H, Koistinaho J, Ali C, Agin V, Emery E, Vivien D.

Neurobiol Dis. 2014 Jun;66:28-42. doi: 10.1016/j.nbd.2014.02.005. Epub 2014 Feb 25.

PMID:
24576594

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