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Items: 1 to 50 of 52

1.

Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer.

Hokari S, Tamura Y, Kaneda A, Katsura A, Morikawa M, Murai F, Ehata S, Tsutsumi S, Ishikawa Y, Aburatani H, Kikuchi T, Miyazono K, Koinuma D.

Mol Oncol. 2019 Nov 29. doi: 10.1002/1878-0261.12608. [Epub ahead of print]

2.

The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.

Morikawa M, Mitani Y, Holmborn K, Kato T, Koinuma D, Maruyama J, Vasilaki E, Sawada H, Kobayashi M, Ozawa T, Morishita Y, Bessho Y, Maeda S, Ledin J, Aburatani H, Kageyama R, Maruyama K, Heldin CH, Miyazono K.

Sci Signal. 2019 Nov 12;12(607). pii: eaay4430. doi: 10.1126/scisignal.aay4430.

PMID:
31719172
3.

A comparative analysis of Smad-responsive motifs identifies multiple regulatory inputs for TGF-β transcriptional activation.

Itoh Y, Koinuma D, Omata C, Ogami T, Motizuki M, Yaguchi SI, Itoh T, Miyake K, Tsutsumi S, Aburatani H, Saitoh M, Miyazono K, Miyazawa K.

J Biol Chem. 2019 Oct 18;294(42):15466-15479. doi: 10.1074/jbc.RA119.009877. Epub 2019 Sep 3.

PMID:
31481467
4.

Palbociclib enhances activin-SMAD-induced cytostasis in estrogen receptor-positive breast cancer.

Harada M, Morikawa M, Ozawa T, Kobayashi M, Tamura Y, Takahashi K, Tanabe M, Tada K, Seto Y, Miyazono K, Koinuma D.

Cancer Sci. 2019 Jan;110(1):209-220. doi: 10.1111/cas.13841. Epub 2018 Nov 16.

5.

Intracellular and extracellular TGF-β signaling in cancer: some recent topics.

Miyazono K, Katsuno Y, Koinuma D, Ehata S, Morikawa M.

Front Med. 2018 Aug;12(4):387-411. doi: 10.1007/s11684-018-0646-8. Epub 2018 Jul 24. Review.

PMID:
30043220
6.

Long noncoding RNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype.

Kawasaki N, Miwa T, Hokari S, Sakurai T, Ohmori K, Miyauchi K, Miyazono K, Koinuma D.

Cancer Sci. 2018 Jul;109(7):2211-2220. doi: 10.1111/cas.13626. Epub 2018 May 29.

7.

Pancreatic tumor microenvironment confers highly malignant properties on pancreatic cancer cells.

Takahashi K, Ehata S, Koinuma D, Morishita Y, Soda M, Mano H, Miyazono K.

Oncogene. 2018 May;37(21):2757-2772. doi: 10.1038/s41388-018-0144-0. Epub 2018 Mar 7.

8.

TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.

Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, Morishita Y, Taguchi L, Morikawa M, Heldin CH, Noda T, Ehata S, Miyazono K, Koinuma D.

Cell Discov. 2018 Jan 9;4:1. doi: 10.1038/s41421-017-0001-2. eCollection 2018.

9.

Identification of a novel fusion gene HMGA2-EGFR in glioblastoma.

Komuro A, Raja E, Iwata C, Soda M, Isogaya K, Yuki K, Ino Y, Morikawa M, Todo T, Aburatani H, Suzuki H, Ranjit M, Natsume A, Mukasa A, Saito N, Okada H, Mano H, Miyazono K, Koinuma D.

Int J Cancer. 2018 Apr 15;142(8):1627-1639. doi: 10.1002/ijc.31179. Epub 2017 Dec 11.

10.

JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Sundqvist A, Morikawa M, Ren J, Vasilaki E, Kawasaki N, Kobayashi M, Koinuma D, Aburatani H, Miyazono K, Heldin CH, van Dam H, Ten Dijke P.

Nucleic Acids Res. 2018 Feb 16;46(3):1180-1195. doi: 10.1093/nar/gkx1190.

11.

ZEB1-regulated inflammatory phenotype in breast cancer cells.

Katsura A, Tamura Y, Hokari S, Harada M, Morikawa M, Sakurai T, Takahashi K, Mizutani A, Nishida J, Yokoyama Y, Morishita Y, Murakami T, Ehata S, Miyazono K, Koinuma D.

Mol Oncol. 2017 Sep;11(9):1241-1262. doi: 10.1002/1878-0261.12098. Epub 2017 Jul 11.

12.

RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.

Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D.

Oncogene. 2017 Aug 31;36(35):5083. doi: 10.1038/onc.2017.191. Epub 2017 Jun 12.

13.

Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.

Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, Todo T, Morikawa M, Aburatani H, Koinuma D, Iwata C, Miyazono K.

Oncogene. 2017 Aug 31;36(35):4963-4974. doi: 10.1038/onc.2017.112. Epub 2017 May 1.

PMID:
28459464
14.

Dynamics of chromatin accessibility during TGF-β-induced EMT of Ras-transformed mammary gland epithelial cells.

Arase M, Tamura Y, Kawasaki N, Isogaya K, Nakaki R, Mizutani A, Tsutsumi S, Aburatani H, Miyazono K, Koinuma D.

Sci Rep. 2017 Apr 26;7(1):1166. doi: 10.1038/s41598-017-00973-4.

15.

Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.

Vasilaki E, Morikawa M, Koinuma D, Mizutani A, Hirano Y, Ehata S, Sundqvist A, Kawasaki N, Cedervall J, Olsson AK, Aburatani H, Moustakas A, Miyazono K, Heldin CH.

Sci Signal. 2016 Aug 23;9(442):ra84. doi: 10.1126/scisignal.aag3232.

PMID:
27555661
16.

RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma.

Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, Miyazono K, Koinuma D.

Oncogene. 2016 Sep 22;35(38):5000-9. doi: 10.1038/onc.2016.35. Epub 2016 Feb 29. Erratum in: Oncogene. 2017 Jun 12;:.

17.

Mutational Landscape and Antiproliferative Functions of ELF Transcription Factors in Human Cancer.

Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, Kataoka K, Yasuda T, Yamaguchi H, Fukumura K, Yamato A, Soda M, Sai E, Yamashita Y, Asakage T, Miyazaki Y, Kurokawa M, Miyazono K, Nimer SD, Yamasoba T, Mano H.

Cancer Res. 2016 Apr 1;76(7):1814-24. doi: 10.1158/0008-5472.CAN-14-3816. Epub 2016 Feb 26.

18.

BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.

Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K.

Stem Cell Reports. 2016 Jan 12;6(1):64-73. doi: 10.1016/j.stemcr.2015.12.004.

19.

The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma.

Mizutani A, Koinuma D, Seimiya H, Miyazono K.

Oncogene. 2016 Jul 7;35(27):3514-23. doi: 10.1038/onc.2015.412. Epub 2015 Nov 2.

20.

Smad4 Decreases the Population of Pancreatic Cancer-Initiating Cells through Transcriptional Repression of ALDH1A1.

Hoshino Y, Nishida J, Katsuno Y, Koinuma D, Aoki T, Kokudo N, Miyazono K, Ehata S.

Am J Pathol. 2015 May;185(5):1457-70. doi: 10.1016/j.ajpath.2015.01.011. Epub 2015 Mar 11.

21.

EZH2 promotes progression of small cell lung cancer by suppressing the TGF-β-Smad-ASCL1 pathway.

Murai F, Koinuma D, Shinozaki-Ushiku A, Fukayama M, Miyaozono K, Ehata S.

Cell Discov. 2015 Sep 22;1:15026. doi: 10.1038/celldisc.2015.26. eCollection 2015.

22.

A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

Isogaya K, Koinuma D, Tsutsumi S, Saito RA, Miyazawa K, Aburatani H, Miyazono K.

Cell Res. 2014 Aug;24(8):994-1008. doi: 10.1038/cr.2014.97. Epub 2014 Jul 25.

23.

Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells.

Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H, Miyazono K, Koinuma D.

Cancer Sci. 2014 Aug;105(8):974-82. doi: 10.1111/cas.12454. Epub 2014 Jul 25.

24.

Epithelial to mesenchymal transition in murine tracheal allotransplantation: an immunohistochemical observation.

Konoeda C, Koinuma D, Morishita Y, Sano A, Nagayama K, Motomura N, Kakimi K, Miyazono K, Nakajima J, Nicolls MR, Murakawa T.

Transplant Proc. 2013 Jun;45(5):1797-801. doi: 10.1016/j.transproceed.2012.11.024.

25.

Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.

Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D, Kato M.

J Biol Chem. 2013 Jul 12;288(28):20658-67. doi: 10.1074/jbc.M113.450478. Epub 2013 Jun 4.

26.

Specific interactions between Smad proteins and AP-1 components determine TGFβ-induced breast cancer cell invasion.

Sundqvist A, Zieba A, Vasilaki E, Herrera Hidalgo C, Söderberg O, Koinuma D, Miyazono K, Heldin CH, Landegren U, Ten Dijke P, van Dam H.

Oncogene. 2013 Aug 1;32(31):3606-15. doi: 10.1038/onc.2012.370. Epub 2012 Aug 27.

PMID:
22926518
27.

Genome-wide mechanisms of Smad binding.

Morikawa M, Koinuma D, Miyazono K, Heldin CH.

Oncogene. 2013 Mar 28;32(13):1609-15. doi: 10.1038/onc.2012.191. Epub 2012 May 21. Review.

28.

Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.

Ishii R, Isogaya K, Seto A, Koinuma D, Watanabe Y, Arisaka F, Yaguchi S, Ikushima H, Dohmae N, Miyazono K, Miyazawa K, Ishitani R, Nureki O.

EMBO J. 2012 May 30;31(11):2541-52. doi: 10.1038/emboj.2012.77. Epub 2012 Mar 27.

29.

TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells.

Kawata M, Koinuma D, Ogami T, Umezawa K, Iwata C, Watabe T, Miyazono K.

J Biochem. 2012 Feb;151(2):205-16. doi: 10.1093/jb/mvr136. Epub 2011 Dec 7.

PMID:
22161143
30.

Tumor-promoting functions of transforming growth factor-β in progression of cancer.

Miyazono K, Ehata S, Koinuma D.

Ups J Med Sci. 2012 May;117(2):143-52. doi: 10.3109/03009734.2011.638729. Epub 2011 Nov 24. Review.

31.

TGF-β drives epithelial-mesenchymal transition through δEF1-mediated downregulation of ESRP.

Horiguchi K, Sakamoto K, Koinuma D, Semba K, Inoue A, Inoue S, Fujii H, Yamaguchi A, Miyazawa K, Miyazono K, Saitoh M.

Oncogene. 2012 Jun 28;31(26):3190-201. doi: 10.1038/onc.2011.493. Epub 2011 Oct 31.

32.

RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.

Koinuma D, Shinozaki M, Nagano Y, Ikushima H, Horiguchi K, Goto K, Chano T, Saitoh M, Imamura T, Miyazono K, Miyazawa K.

J Biol Chem. 2011 Sep 16;286(37):32502-12. doi: 10.1074/jbc.M111.227561. Epub 2011 Jul 27.

33.

ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif.

Morikawa M, Koinuma D, Tsutsumi S, Vasilaki E, Kanki Y, Heldin CH, Aburatani H, Miyazono K.

Nucleic Acids Res. 2011 Nov 1;39(20):8712-27. doi: 10.1093/nar/gkr572. Epub 2011 Jul 15.

34.

Cell type-specific target selection by combinatorial binding of Smad2/3 proteins and hepatocyte nuclear factor 4alpha in HepG2 cells.

Mizutani A, Koinuma D, Tsutsumi S, Kamimura N, Morikawa M, Suzuki HI, Imamura T, Miyazono K, Aburatani H.

J Biol Chem. 2011 Aug 26;286(34):29848-60. doi: 10.1074/jbc.M110.217745. Epub 2011 Jun 6.

35.

Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.

Ehata S, Johansson E, Katayama R, Koike S, Watanabe A, Hoshino Y, Katsuno Y, Komuro A, Koinuma D, Kano MR, Yashiro M, Hirakawa K, Aburatani H, Fujita N, Miyazono K.

Oncogene. 2011 Apr 7;30(14):1693-705. doi: 10.1038/onc.2010.546. Epub 2010 Dec 6.

PMID:
21132002
36.

Arkadia--beyond the TGF-β pathway.

Miyazono K, Koinuma D.

J Biochem. 2011 Jan;149(1):1-3. doi: 10.1093/jb/mvq133. Epub 2010 Nov 25.

PMID:
21109559
37.

Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells.

Nagano Y, Koinuma D, Miyazawa K, Miyazono K.

J Biochem. 2010 Apr;147(4):545-54. doi: 10.1093/jb/mvp202. Epub 2009 Dec 2.

PMID:
19959502
38.

Promoter-wide analysis of Smad4 binding sites in human epithelial cells.

Koinuma D, Tsutsumi S, Kamimura N, Imamura T, Aburatani H, Miyazono K.

Cancer Sci. 2009 Nov;100(11):2133-42. doi: 10.1111/j.1349-7006.2009.01299.x. Epub 2009 Jul 23.

39.

Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins.

Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T.

J Biol Chem. 2009 Mar 6;284(10):6109-15. doi: 10.1074/jbc.M804659200. Epub 2009 Jan 4.

40.

SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nagasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Miyazawa K, Inazawa J, Miyazono K, Imamura T.

J Biol Chem. 2009 Jan 30;284(5):3334-44. doi: 10.1074/jbc.M808989200. Epub 2008 Dec 1.

41.

Chromatin immunoprecipitation on microarray analysis of Smad2/3 binding sites reveals roles of ETS1 and TFAP2A in transforming growth factor beta signaling.

Koinuma D, Tsutsumi S, Kamimura N, Taniguchi H, Miyazawa K, Sunamura M, Imamura T, Miyazono K, Aburatani H.

Mol Cell Biol. 2009 Jan;29(1):172-86. doi: 10.1128/MCB.01038-08. Epub 2008 Oct 27.

42.

Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts.

Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T.

Bone. 2009 Jan;44(1):53-60. doi: 10.1016/j.bone.2008.09.013. Epub 2008 Oct 7.

PMID:
18950738
43.

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.

Fukunaga E, Inoue Y, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T.

J Biol Chem. 2008 Dec 19;283(51):35660-7. doi: 10.1074/jbc.M710496200. Epub 2008 Oct 16.

44.

Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling.

Nagano Y, Mavrakis KJ, Lee KL, Fujii T, Koinuma D, Sase H, Yuki K, Isogaya K, Saitoh M, Imamura T, Episkopou V, Miyazono K, Miyazawa K.

J Biol Chem. 2007 Jul 13;282(28):20492-501. Epub 2007 May 16.

45.

[TGF-beta signaling].

Imamura T, Koinuma D.

Tanpakushitsu Kakusan Koso. 2006 Aug;51(10 Suppl):1277-81. Review. Japanese. No abstract available.

PMID:
16922387
46.

[Bone formation and inflammation].

Koinuma D, Imamura T.

Nihon Rinsho. 2005 Sep;63(9):1523-8. Review. Japanese.

PMID:
16164206
47.

Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis.

Watanabe M, Ebina M, Orson FM, Nakamura A, Kubota K, Koinuma D, Akiyama K, Maemondo M, Okouchi S, Tahara M, Matsumoto K, Nakamura T, Nukiwa T.

Mol Ther. 2005 Jul;12(1):58-67.

48.

[TGF-beta family (TGF-beta, activin, BMP)].

Koinuma D, Imamura T, Miyazono K.

Nihon Rinsho. 2005 Apr;63 Suppl 4:215-9. Review. Japanese. No abstract available.

PMID:
15861659
49.

Vaccination of dendritic cells loaded with interleukin-12-secreting cancer cells augments in vivo antitumor immunity: characteristics of syngeneic and allogeneic antigen-presenting cell cancer hybrid cells.

Suzuki T, Fukuhara T, Tanaka M, Nakamura A, Akiyama K, Sakakibara T, Koinuma D, Kikuchi T, Tazawa R, Maemondo M, Hagiwara K, Saijo Y, Nukiwa T.

Clin Cancer Res. 2005 Jan 1;11(1):58-66.

50.

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7.

Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K.

EMBO J. 2003 Dec 15;22(24):6458-70.

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