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Items: 1 to 50 of 59

1.

Midlife Insulin Resistance as a Predictor for Late-Life Cognitive Function and Cerebrovascular Lesions.

Toppala S, Ekblad LL, Lötjönen J, Helin S, Hurme S, Johansson J, Jula A, Karrasch M, Koikkalainen J, Laine H, Parkkola R, Viitanen M, Rinne JO.

J Alzheimers Dis. 2019 Sep 23. doi: 10.3233/JAD-190691. [Epub ahead of print]

PMID:
31561373
2.

Association between Deep Gray Matter Changes and Neurocognitive Function in Mild Cognitive Impairment and Alzheimer's Disease: A Tensor-Based Morphometric MRI Study.

Tuokkola T, Karrasch M, Koikkalainen J, Parkkola R, Lötjönen J, Löyttyniemi E, Hurme S, Rinne JO.

Dement Geriatr Cogn Disord. 2019 Sep 12:1-11. doi: 10.1159/000502476. [Epub ahead of print]

PMID:
31514198
3.

Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER).

Stephen R, Liu Y, Ngandu T, Antikainen R, Hulkkonen J, Koikkalainen J, Kemppainen N, Lötjönen J, Levälahti E, Parkkola R, Pippola P, Rinne J, Strandberg T, Tuomilehto J, Vanninen R, Kivipelto M, Soininen H, Solomon A; FINGER study group.

Alzheimers Res Ther. 2019 Jun 4;11(1):53. doi: 10.1186/s13195-019-0506-z.

4.

Thalamic Atrophy Without Whole Brain Atrophy Is Associated With Absence of 2-Year NEDA in Multiple Sclerosis.

Hänninen K, Viitala M, Paavilainen T, Karhu JO, Rinne J, Koikkalainen J, Lötjönen J, Soilu-Hänninen M.

Front Neurol. 2019 May 3;10:459. doi: 10.3389/fneur.2019.00459. eCollection 2019.

5.

Impact of a clinical decision support tool on prediction of progression in early-stage dementia: a prospective validation study.

Bruun M, Frederiksen KS, Rhodius-Meester HFM, Baroni M, Gjerum L, Koikkalainen J, Urhemaa T, Tolonen A, van Gils M, Rueckert D, Dyremose N, Andersen BB, Lemstra AW, Hallikainen M, Kurl S, Herukka SK, Remes AM, Waldemar G, Soininen H, Mecocci P, van der Flier WM, Lötjönen J, Hasselbalch SG.

Alzheimers Res Ther. 2019 Mar 20;11(1):25. doi: 10.1186/s13195-019-0482-3.

6.

Automatically computed rating scales from MRI for patients with cognitive disorders.

Koikkalainen JR, Rhodius-Meester HFM, Frederiksen KS, Bruun M, Hasselbalch SG, Baroni M, Mecocci P, Vanninen R, Remes A, Soininen H, van Gils M, van der Flier WM, Scheltens P, Barkhof F, Erkinjuntti T, Lötjönen JMP; Alzheimer’s Disease Neuroimaging Initiative.

Eur Radiol. 2019 Sep;29(9):4937-4947. doi: 10.1007/s00330-019-06067-1. Epub 2019 Feb 22.

PMID:
30796570
7.

Detecting frontotemporal dementia syndromes using MRI biomarkers.

Bruun M, Koikkalainen J, Rhodius-Meester HFM, Baroni M, Gjerum L, van Gils M, Soininen H, Remes AM, Hartikainen P, Waldemar G, Mecocci P, Barkhof F, Pijnenburg Y, van der Flier WM, Hasselbalch SG, Lötjönen J, Frederiksen KS.

Neuroimage Clin. 2019;22:101711. doi: 10.1016/j.nicl.2019.101711. Epub 2019 Feb 4.

8.

Computer-assisted prediction of clinical progression in the earliest stages of AD.

Rhodius-Meester HFM, Liedes H, Koikkalainen J, Wolfsgruber S, Coll-Padros N, Kornhuber J, Peters O, Jessen F, Kleineidam L, Molinuevo JL, Rami L, Teunissen CE, Barkhof F, Sikkes SAM, Wesselman LMP, Slot RER, Verfaillie SCJ, Scheltens P, Tijms BM, Lötjönen J, van der Flier WM.

Alzheimers Dement (Amst). 2018 Oct 8;10:726-736. doi: 10.1016/j.dadm.2018.09.001. eCollection 2018.

9.

Impact of a Clinical Decision Support Tool on Dementia Diagnostics in Memory Clinics: The PredictND Validation Study.

Bruun M, Frederiksen KS, Rhodius-Meester HFM, Baroni M, Gjerum L, Koikkalainen J, Urhemaa T, Tolonen A, van Gils M, Tong T, Guerrero R, Rueckert D, Dyremose N, Andersen BB, Simonsen AH, Lemstra A, Hallikainen M, Kurl S, Herukka SK, Remes AM, Waldemar G, Soininen H, Mecocci P, van der Flier WM, Lötjönen J, Hasselbalch SG.

Curr Alzheimer Res. 2019;16(2):91-101. doi: 10.2174/1567205016666190103152425.

PMID:
30605060
10.

Evaluating combinations of diagnostic tests to discriminate different dementia types.

Bruun M, Rhodius-Meester HFM, Koikkalainen J, Baroni M, Gjerum L, Lemstra AW, Barkhof F, Remes AM, Urhemaa T, Tolonen A, Rueckert D, van Gils M, Frederiksen KS, Waldemar G, Scheltens P, Mecocci P, Soininen H, Lötjönen J, Hasselbalch SG, van der Flier WM.

Alzheimers Dement (Amst). 2018 Aug 17;10:509-518. doi: 10.1016/j.dadm.2018.07.003. eCollection 2018.

11.

A Decision Support System for Diagnostics and Treatment Planning in Traumatic Brain Injury.

Umer A, Mattila J, Liedes H, Koikkalainen J, Lotjonen J, Katila A, Frantzen J, Newcombe V, Tenovuo O, Menon D, van Gils M.

IEEE J Biomed Health Inform. 2019 May;23(3):1261-1268. doi: 10.1109/JBHI.2018.2842717. Epub 2018 Jun 1.

PMID:
29993563
12.

Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier.

Tolonen A, Rhodius-Meester HFM, Bruun M, Koikkalainen J, Barkhof F, Lemstra AW, Koene T, Scheltens P, Teunissen CE, Tong T, Guerrero R, Schuh A, Ledig C, Baroni M, Rueckert D, Soininen H, Remes AM, Waldemar G, Hasselbalch SG, Mecocci P, van der Flier WM, Lötjönen J.

Front Aging Neurosci. 2018 Apr 25;10:111. doi: 10.3389/fnagi.2018.00111. eCollection 2018.

13.

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis.

Cajanus A, Hall A, Koikkalainen J, Solje E, Tolonen A, Urhemaa T, Liu Y, Haanpää RM, Hartikainen P, Helisalmi S, Korhonen V, Rueckert D, Hasselbalch S, Waldemar G, Mecocci P, Vanninen R, van Gils M, Soininen H, Lötjönen J, Remes AM.

Dement Geriatr Cogn Dis Extra. 2018 Feb 23;8(1):51-59. doi: 10.1159/000486849. eCollection 2018 Jan-Apr.

14.

Regional brain morphometry in patients with traumatic brain injury based on acute- and chronic-phase magnetic resonance imaging.

Ledig C, Kamnitsas K, Koikkalainen J, Posti JP, Takala RSK, Katila A, Frantzén J, Ala-Seppälä H, Kyllönen A, Maanpää HR, Tallus J, Lötjönen J, Glocker B, Tenovuo O, Rueckert D.

PLoS One. 2017 Nov 28;12(11):e0188152. doi: 10.1371/journal.pone.0188152. eCollection 2017.

15.

Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study.

Reijs BLR, Vos SJB, Soininen H, Lötjonen J, Koikkalainen J, Pikkarainen M, Hall A, Vanninen R, Liu Y, Herukka SK, Freund-Levi Y, Frisoni GB, Frölich L, Nobili F, Rikkert MO, Spiru L, Tsolaki M, Wallin ÅK, Scheltens P, Verhey F, Visser PJ.

J Alzheimers Dis. 2017;60(4):1387-1395. doi: 10.3233/JAD-170039.

PMID:
29036813
16.

Longitudinal changes in the brain in mild cognitive impairment: a magnetic resonance imaging study using the visual rating method and tensor-based morphometry.

Tuokkola T, Koikkalainen J, Parkkola R, Karrasch M, Lötjönen J, Rinne JO.

Acta Radiol. 2018 Aug;59(8):973-979. doi: 10.1177/0284185117734418. Epub 2017 Sep 27.

PMID:
28952780
17.

Five-class differential diagnostics of neurodegenerative diseases using random undersampling boosting.

Tong T, Ledig C, Guerrero R, Schuh A, Koikkalainen J, Tolonen A, Rhodius H, Barkhof F, Tijms B, Lemstra AW, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, Baroni M, Lötjönen J, Flier WV, Rueckert D.

Neuroimage Clin. 2017 Jun 12;15:613-624. doi: 10.1016/j.nicl.2017.06.012. eCollection 2017.

18.

Using the Disease State Fingerprint Tool for Differential Diagnosis of Frontotemporal Dementia and Alzheimer's Disease.

Muñoz-Ruiz MÁ, Hall A, Mattila J, Koikkalainen J, Herukka SK, Husso M, Hänninen T, Vanninen R, Liu Y, Hallikainen M, Lötjönen J, Remes AM, Alafuzoff I, Soininen H, Hartikainen P.

Dement Geriatr Cogn Dis Extra. 2016 Jul 22;6(2):313-329. eCollection 2016 May-Aug.

19.

Evaluation of motion-correction methods for dual-gated cardiac positron emission tomography/computed tomography imaging.

Klén R, Noponen T, Koikkalainen J, Lötjönen J, Thielemans K, Hoppela E, Sipilä H, Teräs M, Knuuti J.

Nucl Med Commun. 2016 Sep;37(9):956-68. doi: 10.1097/MNM.0000000000000539.

PMID:
27258990
20.

Differential diagnosis of neurodegenerative diseases using structural MRI data.

Koikkalainen J, Rhodius-Meester H, Tolonen A, Barkhof F, Tijms B, Lemstra AW, Tong T, Guerrero R, Schuh A, Ledig C, Rueckert D, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, van der Flier W, Lötjönen J.

Neuroimage Clin. 2016 Mar 5;11:435-449. doi: 10.1016/j.nicl.2016.02.019. eCollection 2016.

21.

Integrating Biomarkers for Underlying Alzheimer's Disease in Mild Cognitive Impairment in Daily Practice: Comparison of a Clinical Decision Support System with Individual Biomarkers.

Rhodius-Meester HF, Koikkalainen J, Mattila J, Teunissen CE, Barkhof F, Lemstra AW, Scheltens P, Lötjönen J, van der Flier WM.

J Alzheimers Dis. 2016;50(1):261-70. doi: 10.3233/JAD-150548.

PMID:
26577521
22.

Visual rating method and tensor-based morphometry in the diagnosis of mild cognitive impairment and Alzheimer's disease: a comparative magnetic resonance imaging study.

Tuokkola T, Koikkalainen J, Parkkola R, Karrasch M, Lötjönen J, Rinne JO.

Acta Radiol. 2016 Mar;57(3):348-55. doi: 10.1177/0284185115584656. Epub 2015 May 14.

PMID:
25977576
23.

Predicting progression from cognitive impairment to Alzheimer's disease with the Disease State Index.

Hall A, Mattila J, Koikkalainen J, Lötjonen J, Wolz R, Scheltens P, Frisoni G, Tsolaki M, Nobili F, Freund-Levi Y, Minthon L, Frölich L, Hampel H, Visser PJ, Soininen H.

Curr Alzheimer Res. 2015;12(1):69-79.

PMID:
25523428
24.

Firefighters' exposure to perfluoroalkyl acids and 2-butoxyethanol present in firefighting foams.

Laitinen JA, Koponen J, Koikkalainen J, Kiviranta H.

Toxicol Lett. 2014 Dec 1;231(2):227-32. doi: 10.1016/j.toxlet.2014.09.007. Epub 2014 Oct 17.

PMID:
25447453
25.

Generalizability of the disease state index prediction model for identifying patients progressing from mild cognitive impairment to Alzheimer's disease.

Hall A, Muñoz-Ruiz M, Mattila J, Koikkalainen J, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Lovestone S, Visser PJ, Lötjonen J, Soininen H; Alzheimer Disease Neuroimaging Initiative; AddNeuroMed consortium; DESCRIPA and Kuopio L-MCI.

J Alzheimers Dis. 2015;44(1):79-92. doi: 10.3233/JAD-140942.

PMID:
25201784
26.

Quantitative evaluation of disease progression in a longitudinal mild cognitive impairment cohort.

Runtti H, Mattila J, van Gils M, Koikkalainen J, Soininen H, Lötjönen J; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2014;39(1):49-61. doi: 10.3233/JAD-130359.

PMID:
24121959
27.

Comparing predictors of conversion to Alzheimer's disease using the disease state index.

Muñoz-Ruiz MÁ, Hall A, Mattila J, Koikkalainen J, Herukka SK, Vanninen R, Liu Y, Lötjönen J, Soininen H; Alzheimer’s Disease Neuroimaging Initiative.

Neurodegener Dis. 2014;13(2-3):200-2. doi: 10.1159/000354074. Epub 2013 Aug 22.

PMID:
23969422
28.

[11C]PIB, [18F]FDG and MR imaging in patients with mild cognitive impairment.

Brück A, Virta JR, Koivunen J, Koikkalainen J, Scheinin NM, Helenius H, Någren K, Helin S, Parkkola R, Viitanen M, Rinne JO.

Eur J Nucl Med Mol Imaging. 2013 Oct;40(10):1567-72. doi: 10.1007/s00259-013-2478-8. Epub 2013 Jun 26.

PMID:
23801168
29.

Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer's disease and mild cognitive impairment.

Muñoz-Ruiz MÁ, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka SK, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H.

J Alzheimers Dis. 2013;35(4):727-39. doi: 10.3233/JAD-122260.

PMID:
23455991
30.

Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted PredictAD tool.

Liu Y, Mattila J, Ruiz MÁ, Paajanen T, Koikkalainen J, van Gils M, Herukka SK, Waldemar G, Lötjönen J, Soininen H; Alzheimer's Disease Neuroimaging Initiative.

PLoS One. 2013;8(2):e55246. doi: 10.1371/journal.pone.0055246. Epub 2013 Feb 12.

31.

Automatic statistical shape analysis of cerebral asymmetry in 3D T1-weighted magnetic resonance images at vertex-level: application to neuroleptic-naïve schizophrenia.

Pepe A, Zhao L, Koikkalainen J, Hietala J, Ruotsalainen U, Tohka J.

Magn Reson Imaging. 2013 Jun;31(5):676-87. doi: 10.1016/j.mri.2012.10.021. Epub 2013 Jan 20.

PMID:
23337078
32.

Structural MRI in frontotemporal dementia: comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry.

Muñoz-Ruiz MÁ, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka SK, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H.

PLoS One. 2012;7(12):e52531. doi: 10.1371/journal.pone.0052531. Epub 2012 Dec 20.

33.

Optimizing the diagnosis of early Alzheimer's disease in mild cognitive impairment subjects.

Mattila J, Soininen H, Koikkalainen J, Rueckert D, Wolz R, Waldemar G, Lötjönen J.

J Alzheimers Dis. 2012;32(4):969-79. doi: 10.3233/JAD-2012-120934.

PMID:
22890102
34.

Improved classification of Alzheimer's disease data via removal of nuisance variability.

Koikkalainen J, Pölönen H, Mattila J, van Gils M, Soininen H, Lötjönen J; Alzheimer's Disease Neuroimaging Initiative.

PLoS One. 2012;7(2):e31112. doi: 10.1371/journal.pone.0031112. Epub 2012 Feb 13.

35.

Combination of biomarkers: PET [18F]flutemetamol imaging and structural MRI in dementia and mild cognitive impairment.

Thurfjell L, Lötjönen J, Lundqvist R, Koikkalainen J, Soininen H, Waldemar G, Brooks DJ, Vandenberghe R.

Neurodegener Dis. 2012;10(1-4):246-9. doi: 10.1159/000335381. Epub 2012 Feb 1.

PMID:
22301718
36.

Software tool for improved prediction of Alzheimer's disease.

Soininen H, Mattila J, Koikkalainen J, van Gils M, Hviid Simonsen A, Waldemar G, Rueckert D, Thurfjell L, Lötjönen J; Alzheimer’s Disease Neuroimaging Initiative.

Neurodegener Dis. 2012;10(1-4):149-52. doi: 10.1159/000332600. Epub 2011 Dec 9.

37.

Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease.

Wolz R, Julkunen V, Koikkalainen J, Niskanen E, Zhang DP, Rueckert D, Soininen H, Lötjönen J; Alzheimer's Disease Neuroimaging Initiative.

PLoS One. 2011;6(10):e25446. doi: 10.1371/journal.pone.0025446. Epub 2011 Oct 13.

38.

Design and application of a generic clinical decision support system for multiscale data.

Mattila J, Koikkalainen J, Virkki A, van Gils M, Lötjönen J; Alzheimer's Disease Neuroimaging Initiative.

IEEE Trans Biomed Eng. 2012 Jan;59(1):234-40. doi: 10.1109/TBME.2011.2170986. Epub 2011 Oct 10.

39.

A disease state fingerprint for evaluation of Alzheimer's disease.

Mattila J, Koikkalainen J, Virkki A, Simonsen A, van Gils M, Waldemar G, Soininen H, Lötjönen J; Alzheimer’s Disease Neuroimaging Initiative.

J Alzheimers Dis. 2011;27(1):163-76. doi: 10.3233/JAD-2011-110365.

PMID:
21799247
40.

Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy.

Holmström M, Kivistö S, Heliö T, Jurkko R, Kaartinen M, Antila M, Reissell E, Kuusisto J, Kärkkäinen S, Peuhkurinen K, Koikkalainen J, Lötjönen J, Lauerma K.

J Cardiovasc Magn Reson. 2011 Jun 20;13:30. doi: 10.1186/1532-429X-13-30.

41.

Multi-template tensor-based morphometry: application to analysis of Alzheimer's disease.

Koikkalainen J, Lötjönen J, Thurfjell L, Rueckert D, Waldemar G, Soininen H; Alzheimer's Disease Neuroimaging Initiative.

Neuroimage. 2011 Jun 1;56(3):1134-44. doi: 10.1016/j.neuroimage.2011.03.029. Epub 2011 Mar 16.

42.

Serum lipidomics meets cardiac magnetic resonance imaging: profiling of subjects at risk of dilated cardiomyopathy.

Sysi-Aho M, Koikkalainen J, Seppänen-Laakso T, Kaartinen M, Kuusisto J, Peuhkurinen K, Kärkkäinen S, Antila M, Lauerma K, Reissell E, Jurkko R, Lötjönen J, Heliö T, Orešič M.

PLoS One. 2011 Jan 20;6(1):e15744. doi: 10.1371/journal.pone.0015744.

43.

Fast and robust extraction of hippocampus from MR images for diagnostics of Alzheimer's disease.

Lötjönen J, Wolz R, Koikkalainen J, Julkunen V, Thurfjell L, Lundqvist R, Waldemar G, Soininen H, Rueckert D; Alzheimer's Disease Neuroimaging Initiative.

Neuroimage. 2011 May 1;56(1):185-96. doi: 10.1016/j.neuroimage.2011.01.062. Epub 2011 Jan 31.

44.

Metabolome in progression to Alzheimer's disease.

Orešič M, Hyötyläinen T, Herukka SK, Sysi-Aho M, Mattila I, Seppänan-Laakso T, Julkunen V, Gopalacharyulu PV, Hallikainen M, Koikkalainen J, Kivipelto M, Helisalmi S, Lötjönen J, Soininen H.

Transl Psychiatry. 2011 Dec 13;1:e57. doi: 10.1038/tp.2011.55.

45.

Discovery and use of efficient biomarkers for objective disease state assessment in Alzheimer's disease.

van Gils M, Koikkalainen J, Mattila J, Herukka S, Lotjonen J, Soininen H.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:2886-9. doi: 10.1109/IEMBS.2010.5626311.

PMID:
21095977
46.

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis.

Mutch NJ, Koikkalainen JS, Fraser SR, Duthie KM, Griffin M, Mitchell J, Watson HG, Booth NA.

J Thromb Haemost. 2010 Sep;8(9):2017-24. doi: 10.1111/j.1538-7836.2010.03963.x.

47.

Differences in cortical thickness in healthy controls, subjects with mild cognitive impairment, and Alzheimer's disease patients: a longitudinal study.

Julkunen V, Niskanen E, Koikkalainen J, Herukka SK, Pihlajamäki M, Hallikainen M, Kivipelto M, Muehlboeck S, Evans AC, Vanninen R, Hilkka Soininen.

J Alzheimers Dis. 2010;21(4):1141-51.

PMID:
21504134
48.

Fast and robust multi-atlas segmentation of brain magnetic resonance images.

Lötjönen JM, Wolz R, Koikkalainen JR, Thurfjell L, Waldemar G, Soininen H, Rueckert D; Alzheimer's Disease Neuroimaging Initiative.

Neuroimage. 2010 Feb 1;49(3):2352-65. doi: 10.1016/j.neuroimage.2009.10.026. Epub 2009 Oct 24.

PMID:
19857578
49.

Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls.

Scheinin NM, Aalto S, Koikkalainen J, Lötjönen J, Karrasch M, Kemppainen N, Viitanen M, Någren K, Helin S, Scheinin M, Rinne JO.

Neurology. 2009 Oct 13;73(15):1186-92. doi: 10.1212/WNL.0b013e3181bacf1b. Epub 2009 Sep 2.

PMID:
19726751
50.

The need for comprehensive cardiac and neurologic assessment of lamin A/C mutation carriers.

Stöllberger C, Finsterer J.

Radiology. 2009 Apr;251(1):305-6; author reply 306. doi: 10.1148/radiol.2511081965. No abstract available.

PMID:
19332860

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