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Items: 1 to 50 of 162

1.

Non-Cell-Autonomous Neurotoxicity in Parkinson's Disease Mediated by Astroglial α-Synuclein.

Chai M, Kohyama J.

Stem Cell Reports. 2019 Feb 12;12(2):183-185. doi: 10.1016/j.stemcr.2019.01.011.

2.

Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression.

Nakatsukasa H, Oda M, Yin J, Chikuma S, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Yamanaka S, Takamura-Enya T, Lu Q, Yoshimura A.

Int Immunol. 2019 Feb 6. doi: 10.1093/intimm/dxz008. [Epub ahead of print]

PMID:
30726915
3.

Treatment with a Gamma-Secretase Inhibitor Promotes Functional Recovery in Human iPSC- Derived Transplants for Chronic Spinal Cord Injury.

Okubo T, Nagoshi N, Kohyama J, Tsuji O, Shinozaki M, Shibata S, Kase Y, Matsumoto M, Nakamura M, Okano H.

Stem Cell Reports. 2018 Dec 11;11(6):1416-1432. doi: 10.1016/j.stemcr.2018.10.022. Epub 2018 Nov 29.

4.

Selective Ablation of Tumorigenic Cells Following Human Induced Pluripotent Stem Cell-Derived Neural Stem/Progenitor Cell Transplantation in Spinal Cord Injury.

Kojima K, Miyoshi H, Nagoshi N, Kohyama J, Itakura G, Kawabata S, Ozaki M, Iida T, Sugai K, Ito S, Fukuzawa R, Yasutake K, Renault-Mihara F, Shibata S, Matsumoto M, Nakamura M, Okano H.

Stem Cells Transl Med. 2019 Mar;8(3):260-270. doi: 10.1002/sctm.18-0096. Epub 2018 Nov 28.

5.

Concise Review: Laying the Groundwork for a First-In-Human Study of an Induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury.

Tsuji O, Sugai K, Yamaguchi R, Tashiro S, Nagoshi N, Kohyama J, Iida T, Ohkubo T, Itakura G, Isoda M, Shinozaki M, Fujiyoshi K, Kanemura Y, Yamanaka S, Nakamura M, Okano H.

Stem Cells. 2019 Jan;37(1):6-13. doi: 10.1002/stem.2926. Epub 2018 Nov 12. Review.

PMID:
30371964
6.

T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease.

Tabata Y, Imaizumi Y, Sugawara M, Andoh-Noda T, Banno S, Chai M, Sone T, Yamazaki K, Ito M, Tsukahara K, Saya H, Hattori N, Kohyama J, Okano H.

Stem Cell Reports. 2018 Nov 13;11(5):1171-1184. doi: 10.1016/j.stemcr.2018.09.006. Epub 2018 Oct 18.

7.

Chromatin remodeler CHD7 regulates the stem cell identity of human neural progenitors.

Chai M, Sanosaka T, Okuno H, Zhou Z, Koya I, Banno S, Andoh-Noda T, Tabata Y, Shimamura R, Hayashi T, Ebisawa M, Sasagawa Y, Nikaido I, Okano H, Kohyama J.

Genes Dev. 2018 Jan 15;32(2):165-180. doi: 10.1101/gad.301887.117. Epub 2018 Feb 9.

8.

Insufficient sleep syndrome: An unrecognized but important clinical entity.

Kohyama J, Anzai Y, Ono M, Kishino A, Tamanuki K, Takada K, Inoue K, Horiuchi M, Hatai Y.

Pediatr Int. 2018 Apr;60(4):372-375. doi: 10.1111/ped.13519. Epub 2018 Feb 28.

PMID:
29337407
9.

CHARGE syndrome modeling using patient-iPSCs reveals defective migration of neural crest cells harboring CHD7 mutations.

Okuno H, Renault Mihara F, Ohta S, Fukuda K, Kurosawa K, Akamatsu W, Sanosaka T, Kohyama J, Hayashi K, Nakajima K, Takahashi T, Wysocka J, Kosaki K, Okano H.

Elife. 2017 Nov 28;6. pii: e21114. doi: 10.7554/eLife.21114.

10.

Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation.

Someya K, Nakatsukasa H, Ito M, Kondo T, Tateda KI, Akanuma T, Koya I, Sanosaka T, Kohyama J, Tsukada YI, Takamura-Enya T, Yoshimura A.

Int Immunol. 2017 Aug 1;29(8):365-375. doi: 10.1093/intimm/dxx049.

11.

Low immunogenicity of mouse induced pluripotent stem cell-derived neural stem/progenitor cells.

Itakura G, Ozaki M, Nagoshi N, Kawabata S, Nishiyama Y, Sugai K, Iida T, Kashiwagi R, Ookubo T, Yastake K, Matsubayashi K, Kohyama J, Iwanami A, Matsumoto M, Nakamura M, Okano H.

Sci Rep. 2017 Oct 11;7(1):12996. doi: 10.1038/s41598-017-13522-w.

12.

Fail-Safe System against Potential Tumorigenicity after Transplantation of iPSC Derivatives.

Itakura G, Kawabata S, Ando M, Nishiyama Y, Sugai K, Ozaki M, Iida T, Ookubo T, Kojima K, Kashiwagi R, Yasutake K, Nakauchi H, Miyoshi H, Nagoshi N, Kohyama J, Iwanami A, Matsumoto M, Nakamura M, Okano H.

Stem Cell Reports. 2017 Mar 14;8(3):673-684. doi: 10.1016/j.stemcr.2017.02.003. Epub 2017 Mar 2.

13.

Whole-Genome DNA Methylation Analyses Revealed Epigenetic Instability in Tumorigenic Human iPS Cell-Derived Neural Stem/Progenitor Cells.

Iida T, Iwanami A, Sanosaka T, Kohyama J, Miyoshi H, Nagoshi N, Kashiwagi R, Toyama Y, Matsumoto M, Nakamura M, Okano H.

Stem Cells. 2017 May;35(5):1316-1327. doi: 10.1002/stem.2581. Epub 2017 Feb 23.

14.

Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Different Oxygen and Medium Conditions.

Yamazaki K, Fukushima K, Sugawara M, Tabata Y, Imaizumi Y, Ishihara Y, Ito M, Tsukahara K, Kohyama J, Okano H.

J Biomol Screen. 2016 Dec;21(10):1054-1064. doi: 10.1177/1087057116661291. Epub 2016 Aug 19.

PMID:
28139961
15.

Evaluation of the immunogenicity of human iPS cell-derived neural stem/progenitor cells in vitro.

Ozaki M, Iwanami A, Nagoshi N, Kohyama J, Itakura G, Iwai H, Nishimura S, Nishiyama Y, Kawabata S, Sugai K, Iida T, Matsubayashi K, Isoda M, Kashiwagi R, Toyama Y, Matsumoto M, Okano H, Nakamura M.

Stem Cell Res. 2017 Mar;19:128-138. doi: 10.1016/j.scr.2017.01.007. Epub 2017 Jan 19.

16.

Good daily habits during the early stages of life determine success throughout life.

Kohyama J.

Sleep Sci. 2016 Jul-Sep;9(3):153-157. doi: 10.1016/j.slsci.2016.09.002. Epub 2016 Oct 5. Review.

17.

Changeability of the fully methylated status of the 15q11.2 region in induced pluripotent stem cells derived from a patient with Prader-Willi syndrome.

Okuno H, Nakabayashi K, Abe K, Ando T, Sanosaka T, Kohyama J, Akamatsu W, Ohyama M, Takahashi T, Kosaki K, Okano H.

Congenit Anom (Kyoto). 2017 Jul;57(4):96-103. doi: 10.1111/cga.12206. Epub 2017 Mar 22.

PMID:
28004416
18.

Possible neuronal mechanisms of sleep disturbances in patients with autism spectrum disorders and attention-deficit/hyperactivity disorder.

Kohyama J.

Med Hypotheses. 2016 Dec;97:131-133. doi: 10.1016/j.mehy.2016.11.001. Epub 2016 Nov 5.

PMID:
27876121
19.

Steroid therapy ameliorated cataplexy in three children with recent-onset of narcolepsy.

Miyata R, Hayashi M, Kohyama J, Honda M.

Sleep Med. 2017 Jan;29:86-87. doi: 10.1016/j.sleep.2016.01.024. Epub 2016 Sep 29. No abstract available.

PMID:
27765531
20.

Pretreatment with a γ-Secretase Inhibitor Prevents Tumor-like Overgrowth in Human iPSC-Derived Transplants for Spinal Cord Injury.

Okubo T, Iwanami A, Kohyama J, Itakura G, Kawabata S, Nishiyama Y, Sugai K, Ozaki M, Iida T, Matsubayashi K, Matsumoto M, Nakamura M, Okano H.

Stem Cell Reports. 2016 Oct 11;7(4):649-663. doi: 10.1016/j.stemcr.2016.08.015. Epub 2016 Sep 22.

21.

Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases.

Sugai K, Fukuzawa R, Shofuda T, Fukusumi H, Kawabata S, Nishiyama Y, Higuchi Y, Kawai K, Isoda M, Kanematsu D, Hashimoto-Tamaoki T, Kohyama J, Iwanami A, Suemizu H, Ikeda E, Matsumoto M, Kanemura Y, Nakamura M, Okano H.

Mol Brain. 2016 Sep 19;9(1):85. doi: 10.1186/s13041-016-0265-8.

22.

Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions.

Isoda M, Kohyama J, Iwanami A, Sanosaka T, Sugai K, Yamaguchi R, Matsumoto T, Nakamura M, Okano H.

Neurosci Res. 2016 Sep;110:18-28. doi: 10.1016/j.neures.2016.04.003. Epub 2016 Apr 13.

PMID:
27083781
23.

Neural Basis of Brain Dysfunction Produced by Early Sleep Problems.

Kohyama J.

Brain Sci. 2016 Jan 29;6(1). pii: E5. doi: 10.3390/brainsci6010005. Review.

24.

Safe and efficient method for cryopreservation of human induced pluripotent stem cell-derived neural stem and progenitor cells by a programmed freezer with a magnetic field.

Nishiyama Y, Iwanami A, Kohyama J, Itakura G, Kawabata S, Sugai K, Nishimura S, Kashiwagi R, Yasutake K, Isoda M, Matsumoto M, Nakamura M, Okano H.

Neurosci Res. 2016 Jun;107:20-9. doi: 10.1016/j.neures.2015.11.011. Epub 2016 Jan 22.

25.

Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury.

Kawabata S, Takano M, Numasawa-Kuroiwa Y, Itakura G, Kobayashi Y, Nishiyama Y, Sugai K, Nishimura S, Iwai H, Isoda M, Shibata S, Kohyama J, Iwanami A, Toyama Y, Matsumoto M, Nakamura M, Okano H.

Stem Cell Reports. 2016 Jan 12;6(1):1-8. doi: 10.1016/j.stemcr.2015.11.013. Epub 2015 Dec 24.

26.

A boy infant with sleep related rhythmic movement disorder showing arm banging.

Kohyama J, Takano T.

Sleep Sci. 2014 Sep;7(3):181-3. doi: 10.1016/j.slsci.2014.09.014. Epub 2014 Sep 27.

27.

Disease staging as a measure of disease severity.

Kohyama J, Fujitani S, Umesato Y, Kataoka H.

J Med Dent Sci. 2015 Jun 24;62(2):25-32. doi: 10.11480/620201.

PMID:
26183830
28.

[A nationwide survey on the uses of melatonin and ramelteon in Japanese children].

Fukumizu M, Hayashi M, Miyajima T, Ishizaki A, Tanaka H, Kohyama J.

No To Hattatsu. 2015 Jan;47(1):23-7. Japanese.

PMID:
25803907
29.

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus.

Matsuda T, Murao N, Katano Y, Juliandi B, Kohyama J, Akira S, Kawai T, Nakashima K.

Nat Commun. 2015 Mar 9;6:6514. doi: 10.1038/ncomms7514.

30.

The possible long-term effects of early-life circadian rhythm disturbance on social behavior.

Kohyama J.

Expert Rev Neurother. 2014 Jul;14(7):745-55. doi: 10.1586/14737175.2014.927735. Epub 2014 Jun 6. Review.

PMID:
24902476
31.

Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors.

Zhou Z, Kohda K, Ibata K, Kohyama J, Akamatsu W, Yuzaki M, Okano HJ, Sasaki E, Okano H.

Mol Brain. 2014 Apr 3;7:24. doi: 10.1186/1756-6606-7-24.

32.

[Circadian rhythm disruption and human development].

Kohyama J.

Nihon Rinsho. 2013 Dec;71(12):2082-8. Review. Japanese.

PMID:
24437259
33.

Sleep education in pediatric residency programs: a cross-cultural look.

Mindell JA, Bartle A, Ahn Y, Ramamurthy MB, Huong HT, Kohyama J, Li AM, Ruangdaraganon N, Sekartini R, Teng A, Goh DY.

BMC Res Notes. 2013 Apr 3;6:130. doi: 10.1186/1756-0500-6-130.

34.

PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies.

Iwanami A, Gini B, Zanca C, Matsutani T, Assuncao A, Nael A, Dang J, Yang H, Zhu S, Kohyama J, Kitabayashi I, Cavenee WK, Cloughesy TF, Furnari FB, Nakamura M, Toyama Y, Okano H, Mischel PS.

Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4339-44. doi: 10.1073/pnas.1217602110. Epub 2013 Feb 25.

35.

Chromatin accessibility at a STAT3 target site is altered prior to astrocyte differentiation.

Urayama S, Semi K, Sanosaka T, Hori Y, Namihira M, Kohyama J, Takizawa T, Nakashima K.

Cell Struct Funct. 2013;38(1):55-66. Epub 2013 Feb 26.

36.

[Analysis of parent-child sleeping and living habits related to later bedtimes in children].

Shinkoda H, Suetsugu Y, Asami E, Kato N, Kohyama J, Uchimura N, Chishaki A, Nishioka K, Okubo I, Matsumoto K, Nanbu Y, Kaku T.

Fukuoka Igaku Zasshi. 2012 Jan;103(1):12-23. Japanese.

PMID:
22423499
37.

Prenatal diagnosis of xeroderma pigmentosum group A in Japan.

Moriwaki S, Yamashita Y, Nakamura S, Fujita D, Kohyama J, Takigawa M, Ohmichi M.

J Dermatol. 2012 Jun;39(6):516-9. doi: 10.1111/j.1346-8138.2011.01425.x. Epub 2011 Dec 14.

PMID:
22168765
38.

Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging.

Zeng Y, Tan M, Kohyama J, Sneddon M, Watson JB, Sun YE, Xie CW.

J Neurosci. 2011 Dec 7;31(49):17800-10. doi: 10.1523/JNEUROSCI.3878-11.2011. Retraction in: J Neurosci. 2013 Dec 11;33(50):19735.

39.

Neurochemical and neuropharmacological aspects of circadian disruptions: an introduction to asynchronization.

Kohyama J.

Curr Neuropharmacol. 2011 Jun;9(2):330-41. doi: 10.2174/157015911795596522.

40.

Sleep education in medical school curriculum: a glimpse across countries.

Mindell JA, Bartle A, Wahab NA, Ahn Y, Ramamurthy MB, Huong HT, Kohyama J, Ruangdaraganon N, Sekartini R, Teng A, Goh DY.

Sleep Med. 2011 Oct;12(9):928-31. doi: 10.1016/j.sleep.2011.07.001. Epub 2011 Sep 16.

PMID:
21924951
41.

Give children and adolescents the gift of a good night's sleep: a call to action.

Mindell JA, Owens J, Alves R, Bruni O, Goh DY, Hiscock H, Kohyama J, Sadeh A.

Sleep Med. 2011 Mar;12(3):203-4. doi: 10.1016/j.sleep.2011.01.003. No abstract available.

PMID:
21316296
42.

Sleep, serotonin, and suicide in Japan.

Kohyama J.

J Physiol Anthropol. 2011;30(1):1-8. Review.

43.

Sleep characteristics of young children in Japan: internet study and comparison with other Asian countries.

Kohyama J, Mindell JA, Sadeh A.

Pediatr Int. 2011 Oct;53(5):649-655. doi: 10.1111/j.1442-200X.2010.03318.x.

PMID:
21199167
44.

Sleep debt and serotonin. A response to a comment on my hypothesis.

Kohyama J.

Med Hypotheses. 2011 Feb;76(2):304. doi: 10.1016/j.mehy.2010.11.027. Epub 2010 Dec 21. No abstract available.

PMID:
21177043
45.

Sleep health and asynchronization.

Kohyama J.

Brain Dev. 2011 Mar;33(3):252-9. doi: 10.1016/j.braindev.2010.09.006. Review.

PMID:
20937552
46.

Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury.

Abematsu M, Tsujimura K, Yamano M, Saito M, Kohno K, Kohyama J, Namihira M, Komiya S, Nakashima K.

J Clin Invest. 2010 Sep;120(9):3255-66. doi: 10.1172/JCI42957. Epub 2010 Aug 16.

47.

[Report of the 3rd meeting of Japanese child sleep association].

Kohyama J, Taniike M.

No To Hattatsu. 2010 May;42(3):220-3. Review. Japanese. No abstract available.

PMID:
23858582
48.

More sleep will bring more serotonin and less suicide in Japan.

Kohyama J.

Med Hypotheses. 2010 Sep;75(3):340. doi: 10.1016/j.mehy.2010.03.035. Epub 2010 Apr 14. No abstract available.

PMID:
20395059
49.

BMP-induced REST regulates the establishment and maintenance of astrocytic identity.

Kohyama J, Sanosaka T, Tokunaga A, Takatsuka E, Tsujimura K, Okano H, Nakashima K.

J Cell Biol. 2010 Apr 5;189(1):159-70. doi: 10.1083/jcb.200908048. Epub 2010 Mar 29.

50.

Parental behaviors and sleep outcomes in infants and toddlers: a cross-cultural comparison.

Mindell JA, Sadeh A, Kohyama J, How TH.

Sleep Med. 2010 Apr;11(4):393-9. doi: 10.1016/j.sleep.2009.11.011.

PMID:
20223706

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