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Items: 10


An unusual genomic variant of pancreatic ductal adenocarcinoma with an indolent clinical course.

Kohutek ZA, Rosati LM, Hong J, Poling J, Attiyeh MA, Makohon-Moore A, Herman JM, Iacobuzio-Donahue CA.

Cold Spring Harb Mol Case Stud. 2017 Jul 5;3(4). pii: a001701. doi: 10.1101/mcs.a001701. Print 2017 Jul.


Transcriptional Mechanisms of Resistance to Anti-PD-1 Therapy.

Ascierto ML, Makohon-Moore A, Lipson EJ, Taube JM, McMiller TL, Berger AE, Fan J, Kaunitz GJ, Cottrell TR, Kohutek ZA, Favorov A, Makarov V, Riaz N, Chan TA, Cope L, Hruban RH, Pardoll DM, Taylor BS, Solit DB, Iacobuzio-Donahue CA, Topalian SL.

Clin Cancer Res. 2017 Jun 15;23(12):3168-3180. doi: 10.1158/1078-0432.CCR-17-0270. Epub 2017 Feb 13.


Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer.

Makohon-Moore AP, Zhang M, Reiter JG, Bozic I, Allen B, Kundu D, Chatterjee K, Wong F, Jiao Y, Kohutek ZA, Hong J, Attiyeh M, Javier B, Wood LD, Hruban RH, Nowak MA, Papadopoulos N, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA.

Nat Genet. 2017 Mar;49(3):358-366. doi: 10.1038/ng.3764. Epub 2017 Jan 16.


Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer.

Zhong Y, Macgregor-Das A, Saunders T, Whittle MC, Makohon-Moore A, Kohutek ZA, Poling J, Herbst BT, Javier BM, Cope L, Leach SD, Hingorani SR, Iacobuzio-Donahue CA.

Clin Cancer Res. 2017 Mar 15;23(6):1607-1620. doi: 10.1158/1078-0432.CCR-15-1615. Epub 2016 Sep 16.


Long-term Impact of Androgen-deprivation Therapy on Cardiovascular Morbidity After Radiotherapy for Clinically Localized Prostate Cancer.

Kohutek ZA, Weg ES, Pei X, Shi W, Zhang Z, Kollmeier MA, Zelefsky MJ.

Urology. 2016 Jan;87:146-52. doi: 10.1016/j.urology.2015.08.029. Epub 2015 Oct 22.


Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases.

Kohutek ZA, Yamada Y, Chan TA, Brennan CW, Tabar V, Gutin PH, Yang TJ, Rosenblum MK, Ballangrud Å, Young RJ, Zhang Z, Beal K.

J Neurooncol. 2015 Oct;125(1):149-56. doi: 10.1007/s11060-015-1881-3. Epub 2015 Aug 26.


Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma.

Rodić N, Steranka JP, Makohon-Moore A, Moyer A, Shen P, Sharma R, Kohutek ZA, Huang CR, Ahn D, Mita P, Taylor MS, Barker NJ, Hruban RH, Iacobuzio-Donahue CA, Boeke JD, Burns KH.

Nat Med. 2015 Sep;21(9):1060-4. doi: 10.1038/nm.3919. Epub 2015 Aug 10.


FDG-PET maximum standardized uptake value is prognostic for recurrence and survival after stereotactic body radiotherapy for non-small cell lung cancer.

Kohutek ZA, Wu AJ, Zhang Z, Foster A, Din SU, Yorke ED, Downey R, Rosenzweig KE, Weber WA, Rimner A.

Lung Cancer. 2015 Aug;89(2):115-20. doi: 10.1016/j.lungcan.2015.05.019. Epub 2015 May 28.


ADAM-10-mediated N-cadherin cleavage is protein kinase C-alpha dependent and promotes glioblastoma cell migration.

Kohutek ZA, diPierro CG, Redpath GT, Hussaini IM.

J Neurosci. 2009 Apr 8;29(14):4605-15. doi: 10.1523/JNEUROSCI.5126-08.2009.


Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion.

Amos S, Mut M, diPierro CG, Carpenter JE, Xiao A, Kohutek ZA, Redpath GT, Zhao Y, Wang J, Shaffrey ME, Hussaini IM.

Cancer Res. 2007 Nov 1;67(21):10241-51.

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