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Items: 8


Encoding, Consolidation, and Renormalization in Depression: Synaptic Homeostasis, Plasticity, and Sleep Integrate Rapid Antidepressant Effects.

Rantamäki T, Kohtala S.

Pharmacol Rev. 2020 Apr;72(2):439-465. doi: 10.1124/pr.119.018697. Review.


Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites.

Kohtala S, Theilmann W, Rosenholm M, Müller HK, Kiuru P, Wegener G, Yli-Kauhaluoma J, Rantamäki T.

Neuropharmacology. 2019 Oct;157:107684. doi: 10.1016/j.neuropharm.2019.107684. Epub 2019 Jun 25.


Commentary: Commonly Used Anesthesia/Euthanasia Methods for Brain Collection Differentially Impact MAPK Activity in Male and Female C57BL/6 Mice.

Kohtala S, Rantamäki T.

Front Cell Neurosci. 2019 May 28;13:219. doi: 10.3389/fncel.2019.00219. eCollection 2019. No abstract available.


Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation.

Leino S, Kohtala S, Rantamäki T, Koski SK, Rannanpää S, Salminen O.

BMC Neurosci. 2018 Nov 29;19(1):77. doi: 10.1186/s12868-018-0478-0.


Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses.

Kohtala S, Theilmann W, Rosenholm M, Penna L, Karabulut G, Uusitalo S, Järventausta K, Yli-Hankala A, Yalcin I, Matsui N, Wigren HK, Rantamäki T.

Mol Neurobiol. 2019 Jun;56(6):4163-4174. doi: 10.1007/s12035-018-1364-6. Epub 2018 Oct 4.


Isoflurane produces antidepressant effects and induces TrkB signaling in rodents.

Antila H, Ryazantseva M, Popova D, Sipilä P, Guirado R, Kohtala S, Yalcin I, Lindholm J, Vesa L, Sato V, Cordeira J, Autio H, Kislin M, Rios M, Joca S, Casarotto P, Khiroug L, Lauri S, Taira T, Castrén E, Rantamäki T.

Sci Rep. 2017 Aug 10;7(1):7811. doi: 10.1038/s41598-017-08166-9.


Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease.

Leikas JV, Kohtala S, Theilmann W, Jalkanen AJ, Forsberg MM, Rantamäki T.

J Neurochem. 2017 Aug;142(3):456-463. doi: 10.1111/jnc.14066. Epub 2017 Jun 14.


Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus.

Kohtala S, Theilmann W, Suomi T, Wigren HK, Porkka-Heiskanen T, Elo LL, Rokka A, Rantamäki T.

ACS Chem Neurosci. 2016 Jun 15;7(6):749-56. doi: 10.1021/acschemneuro.6b00002. Epub 2016 Apr 28.


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