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Items: 1 to 50 of 305

1.

Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course.

Lee JM, Botesteanu DA, Tomita Y, Yuno A, Lee MJ, Kohn EC, Annunziata CM, Matulonis U, MacDonald LA, Nair JR, Macneill KM, Trepel JB.

Oncol Lett. 2019 Oct;18(4):3914-3924. doi: 10.3892/ol.2019.10731. Epub 2019 Aug 7.

2.

Defining and targeting wild-type BRCA high-grade serous ovarian cancer: DNA repair and cell cycle checkpoints.

Ivy SP, Kunos CA, Arnaldez FI, Kohn EC.

Expert Opin Investig Drugs. 2019 Sep;28(9):771-785. doi: 10.1080/13543784.2019.1657403. Epub 2019 Aug 30.

PMID:
31449760
3.

A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1-3 inhibitor, cediranib, in recurrent women's cancers with biomarker analyses.

Zimmer AS, Nichols E, Cimino-Mathews A, Peer C, Cao L, Lee MJ, Kohn EC, Annunziata CM, Lipkowitz S, Trepel JB, Sharma R, Mikkilineni L, Gatti-Mays M, Figg WD, Houston ND, Lee JM.

J Immunother Cancer. 2019 Jul 25;7(1):197. doi: 10.1186/s40425-019-0680-3.

4.

Catalytic Nanoassemblies Formed by Short Peptides Promote Highly Enantioselective Transfer Hydrogenation.

Dolan MA, Basa PN, Zozulia O, Lengyel Z, Lebl R, Kohn EM, Bhattacharya S, Korendovych IV.

ACS Nano. 2019 Aug 27;13(8):9292-9297. doi: 10.1021/acsnano.9b03880. Epub 2019 Jul 22.

PMID:
31314486
5.

Radiopharmaceuticals for Persistent or Recurrent Uterine Cervix Cancer.

Kunos CA, Capala J, Kohn EC, Ivy SP.

Front Oncol. 2019 Jun 26;9:560. doi: 10.3389/fonc.2019.00560. eCollection 2019.

6.

Effects of Ionic Liquid Alkyl Chain Length on Denaturation of Myoglobin by Anionic, Cationic, and Zwitterionic Detergents.

Lee JY, Selfridge KM, Kohn EM, Vaden TD, Caputo GA.

Biomolecules. 2019 Jul 8;9(7). pii: E264. doi: 10.3390/biom9070264.

7.

Therapeutic levetiracetam monitoring during pregnancy: "mind the gap".

Berlin M, Barchel D, Gandelman-Marton R, Brandriss N, Blatt I, Ziv-Baran T, Neufeld MY, Dinavitser N, Kohn E, Shaniv D, De-Haan T, Ofek F, Koren G, Stepensky D, Berkovitch M.

Ther Adv Chronic Dis. 2019 May 27;10:2040622319851652. doi: 10.1177/2040622319851652. eCollection 2019.

8.

Phase I/Ib study of olaparib and carboplatin in heavily pretreated recurrent high-grade serous ovarian cancer at low genetic risk.

Lampert EJ, Hays JL, Kohn EC, Annunziata CM, Minasian L, Yu M, Gordon N, Sissung TM, Chiou VL, Figg WD, Houston N, Lee JM.

Oncotarget. 2019 Apr 23;10(30):2855-2868. doi: 10.18632/oncotarget.26869. eCollection 2019 Apr 23.

9.

Disease Labels and Clear Communication With Patients-A Rose by Any Other Name Would Smell as Sweet.

Kohn EC, Malik S.

JAMA Oncol. 2019 Jun 1;5(6):784-785. doi: 10.1001/jamaoncol.2019.0053. No abstract available.

PMID:
30896753
10.

Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.

Bast RC Jr, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ Jr, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L.

Cancer. 2019 Jun 15;125(12):1963-1972. doi: 10.1002/cncr.32004. Epub 2019 Mar 5.

PMID:
30835824
11.

Gynecological Cancers Translational, Research Implementation, and Harmonization: Gynecologic Cancer InterGroup Consensus and Still Open Questions.

Bagnoli M, Shi TY, Gourley C, Speiser P, Reuss A, Nijman HW, Creutzberg CL, Scholl S, Negrouk A, Brady MF, Hasegawa K, Oda K, McNeish IA, Kohn EC, Oza AM, MacKay H, Millan D, Bennett K, Scott C, Mezzanzanica D.

Cells. 2019 Feb 26;8(3). pii: E200. doi: 10.3390/cells8030200.

12.

Overall survival and updated progression-free survival outcomes in a randomized phase II study of combination cediranib and olaparib versus olaparib in relapsed platinum-sensitive ovarian cancer.

Liu JF, Barry WT, Birrer M, Lee JM, Buckanovich RJ, Fleming GF, Rimel BJ, Buss MK, Nattam SR, Hurteau J, Luo W, Curtis J, Whalen C, Kohn EC, Ivy SP, Matulonis UA.

Ann Oncol. 2019 Apr 1;30(4):551-557. doi: 10.1093/annonc/mdz018.

PMID:
30753272
13.

Technology Applications: Use of Digital Health Technology to Enable Drug Development.

Liu JF, Lee JM, Strock E, Phillips R, Mari K, Killiam B, Bonam M, Milenkova T, Kohn EC, Ivy SP.

JCO Clin Cancer Inform. 2018 Dec;2:1-12. doi: 10.1200/CCI.17.00153.

14.

Heme Dissociation from Myoglobin in the Presence of the Zwitterionic Detergent N,N-Dimethyl-N-Dodecylglycine Betaine: Effects of Ionic Liquids.

Kohn EM, Lee JY, Calabro A, Vaden TD, Caputo GA.

Biomolecules. 2018 Oct 29;8(4). pii: E126. doi: 10.3390/biom8040126.

15.

Hysterectomy-corrected rates of endometrial cancer among women younger than age 50 in the United States.

Temkin SM, Kohn EC, Penberthy L, Cronin KA, Rubinsak L, Dickie LA, Minasian L, Noone AM.

Cancer Causes Control. 2018 May;29(4-5):427-433. doi: 10.1007/s10552-018-1018-z. Epub 2018 Mar 1.

PMID:
29497884
16.

Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: A NCI clinical trials planning meeting report.

Lheureux S, McCourt C, Rimel BJ, Duska L, Fleming G, Mackay H, Mutch D, Temkin SM, Lynn J, Kohn EC.

Gynecol Oncol. 2018 Feb 22. pii: S0090-8258(18)30124-0. doi: 10.1016/j.ygyno.2018.02.005. [Epub ahead of print] Review.

PMID:
29477660
17.

Editorial: New Approaches to Radiation-Therapeutic Agent Cancer Care for Women.

Kunos CA, Kohn EC.

Front Oncol. 2017 Nov 16;7:276. doi: 10.3389/fonc.2017.00276. eCollection 2017. No abstract available.

18.

Role of Cationic Side Chains in the Antimicrobial Activity of C18G.

Kohn EM, Shirley DJ, Arotsky L, Picciano AM, Ridgway Z, Urban MW, Carone BR, Caputo GA.

Molecules. 2018 Feb 4;23(2). pii: E329. doi: 10.3390/molecules23020329.

19.

Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study.

Lee JM, Nair J, Zimmer A, Lipkowitz S, Annunziata CM, Merino MJ, Swisher EM, Harrell MI, Trepel JB, Lee MJ, Bagheri MH, Botesteanu DA, Steinberg SM, Minasian L, Ekwede I, Kohn EC.

Lancet Oncol. 2018 Feb;19(2):207-215. doi: 10.1016/S1470-2045(18)30009-3. Epub 2018 Jan 18.

PMID:
29361470
20.

The new classifications of ovarian, fallopian tube, and primary peritoneal cancer and their clinical implications.

Duska LR, Kohn EC.

Ann Oncol. 2017 Nov 1;28(suppl_8):viii8-viii12. doi: 10.1093/annonc/mdx445. Review.

21.

Clinical trials in gynecologic oncology: Past, present, and future.

Annunziata CM, Kohn EC.

Gynecol Oncol. 2018 Feb;148(2):393-402. doi: 10.1016/j.ygyno.2017.11.026. Epub 2017 Dec 6. Review.

22.

Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials.

MacKay HJ, Levine DA, Bae-Jump VL, Bell DW, McAlpine JN, Santin A, Fleming GF, Mutch DG, Nephew KP, Wentzensen N, Goodfellow PJ, Dorigo O, Nijman HW, Broaddus R, Kohn EC.

Oncotarget. 2017 Aug 3;8(48):84579-84594. doi: 10.18632/oncotarget.19961. eCollection 2017 Oct 13. Review.

23.

Phase I/Ib study of olaparib and carboplatin in women with triple negative breast cancer.

Lee JM, Hays JL, Chiou VL, Annunziata CM, Swisher EM, Harrell MI, Yu M, Gordon N, Sissung TM, Ji J, Figg WD, Minasian L, Lipkowitz S, Wood BJ, Doroshow J, Kohn EC.

Oncotarget. 2017 Mar 25;8(45):79175-79187. doi: 10.18632/oncotarget.16577. eCollection 2017 Oct 3.

24.

The HRD Decision-Which PARP Inhibitor to Use for Whom and When.

Kohn EC, Lee JM, Ivy SP.

Clin Cancer Res. 2017 Dec 1;23(23):7155-7157. doi: 10.1158/1078-0432.CCR-17-2186. Epub 2017 Oct 3.

25.

The 'Pushmi-Pullyu' of DNA REPAIR: Clinical Synthetic Lethality.

Ivy SP, de Bono J, Kohn EC.

Trends Cancer. 2016 Nov;2(11):646-656. doi: 10.1016/j.trecan.2016.10.014. Epub 2016 Nov 23. Review.

26.

Population pharmacokinetic analyses of the effect of carboplatin pretreatment on olaparib in recurrent or refractory women's cancers.

Peer CJ, Lee JM, Roth J, Rodgers L, Nguyen J, Annunziata CM, Minasian L, Kohn EC, Figg WD.

Cancer Chemother Pharmacol. 2017 Jul;80(1):165-175. doi: 10.1007/s00280-017-3346-1. Epub 2017 Jun 2.

27.

Whence High-Grade Serous Ovarian Cancer.

Kohn EC, Ivy SP.

Am Soc Clin Oncol Educ Book. 2017;37:443-448. doi: 10.14694/EDBK_174718. Review.

PMID:
28561656
28.

Drug development and registration: Challenges and opportunities in ovarian cancer.

Ivy SP, Kohn EC.

Cancer. 2017 Jul 15;123(14):2597-2599. doi: 10.1002/cncr.30645. Epub 2017 May 12. No abstract available.

29.

Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study.

Lee JM, Cimino-Mathews A, Peer CJ, Zimmer A, Lipkowitz S, Annunziata CM, Cao L, Harrell MI, Swisher EM, Houston N, Botesteanu DA, Taube JM, Thompson E, Ogurtsova A, Xu H, Nguyen J, Ho TW, Figg WD, Kohn EC.

J Clin Oncol. 2017 Jul 1;35(19):2193-2202. doi: 10.1200/JCO.2016.72.1340. Epub 2017 May 4.

30.

PARP Inhibitors: The Cornerstone of DNA Repair-Targeted Therapies.

del Rivero J, Kohn EC.

Oncology (Williston Park). 2017 Apr 15;31(4):265-73. Review.

31.

Apoptosis is augmented in high-grade serous ovarian cancer by the combined inhibition of Bcl-2/Bcl-xL and PARP.

Yokoyama T, Kohn EC, Brill E, Lee JM.

Int J Oncol. 2017 Mar 15. doi: 10.3892/ijo.2017.3914. [Epub ahead of print]

32.

The Situation Awareness Weighted Network (SAWN) model and method: Theory and application.

Kalloniatis A, Ali I, Neville T, La P, Macleod I, Zuparic M, Kohn E.

Appl Ergon. 2017 May;61:178-196. doi: 10.1016/j.apergo.2017.02.002. Epub 2017 Feb 14.

PMID:
28237016
33.

Long-Term Responders on Olaparib Maintenance in High-Grade Serous Ovarian Cancer: Clinical and Molecular Characterization.

Lheureux S, Lai Z, Dougherty BA, Runswick S, Hodgson DR, Timms KM, Lanchbury JS, Kaye S, Gourley C, Bowtell D, Kohn EC, Scott C, Matulonis U, Panzarella T, Karakasis K, Burnier JV, Gilks CB, O'Connor MJ, Robertson JD, Ledermann J, Barrett JC, Ho TW, Oza AM.

Clin Cancer Res. 2017 Aug 1;23(15):4086-4094. doi: 10.1158/1078-0432.CCR-16-2615. Epub 2017 Feb 21.

34.

Words matter: Restoring respect and dignity when referring to individuals with cancer.

Ellis LM, Blanke CD, Kohn EC.

Cancer. 2017 Jul 1;123(13):2390-2391. doi: 10.1002/cncr.30625. Epub 2017 Feb 9. No abstract available.

35.

Ectopic Expression of Mouse Melanopsin in Drosophila Photoreceptors Reveals Fast Response Kinetics and Persistent Dark Excitation.

Yasin B, Kohn E, Peters M, Zaguri R, Weiss S, Schopf K, Katz B, Huber A, Minke B.

J Biol Chem. 2017 Mar 3;292(9):3624-3636. doi: 10.1074/jbc.M116.754770. Epub 2017 Jan 24.

36.

Fifth Ovarian Cancer Consensus Conference of the Gynecologic Cancer InterGroup (GCIG): clinical trial design for rare ovarian tumours.

Leary AF, Quinn M, Fujiwara K, Coleman RL, Kohn E, Sugiyama T, Glasspool R, Ray-Coquard I, Colombo N, Bacon M, Zeimet A, Westermann A, Gomez-Garcia E, Provencher D, Welch S, Small W, Millan D, Okamoto A, Stuart G, Ochiai K; participants of the Fifth Ovarian Cancer Consensus Conference.

Ann Oncol. 2017 Apr 1;28(4):718-726. doi: 10.1093/annonc/mdw662.

37.

Microcirculatory changes during cardiac surgery with cardiopulmonary bypass.

Prestes I, Riva J, Bouchacourt JP, Kohn E, López A, Hurtado FJ.

Rev Esp Anestesiol Reanim. 2016 Nov;63(9):513-518. doi: 10.1016/j.redar.2016.03.005. Epub 2016 Apr 16. English, Spanish.

PMID:
27095670
38.

The generalizability of NCI-sponsored clinical trials accrual among women with gynecologic malignancies.

Mishkin G, Minasian LM, Kohn EC, Noone AM, Temkin SM.

Gynecol Oncol. 2016 Dec;143(3):611-616. doi: 10.1016/j.ygyno.2016.09.026. Epub 2016 Sep 30.

PMID:
27697287
39.

Sequence-Specific Pharmacokinetic and Pharmacodynamic Phase I/Ib Study of Olaparib Tablets and Carboplatin in Women's Cancer.

Lee JM, Peer CJ, Yu M, Amable L, Gordon N, Annunziata CM, Houston N, Goey AK, Sissung TM, Parker B, Minasian L, Chiou VL, Murphy RF, Widemann BC, Figg WD, Kohn EC.

Clin Cancer Res. 2017 Mar 15;23(6):1397-1406. doi: 10.1158/1078-0432.CCR-16-1546. Epub 2016 Sep 23.

40.

Gynecologic Cancers: Emerging Novel Strategies for Targeting DNA Repair Deficiency.

Kristeleit RS, Miller RE, Kohn EC.

Am Soc Clin Oncol Educ Book. 2016;35:e259-68. doi: 10.14694/EDBK_159086. Review.

41.

Confronting the Care Delivery Challenges Arising from Precision Medicine.

Kohn EC, Ivy SP.

Front Oncol. 2016 Apr 27;6:106. doi: 10.3389/fonc.2016.00106. eCollection 2016. Review.

42.

Cediranib, a pan-VEGFR inhibitor, and olaparib, a PARP inhibitor, in combination therapy for high grade serous ovarian cancer.

Ivy SP, Liu JF, Lee JM, Matulonis UA, Kohn EC.

Expert Opin Investig Drugs. 2016;25(5):597-611. doi: 10.1517/13543784.2016.1156857. Epub 2016 Mar 16. Review.

PMID:
26899229
43.

Challenges and Opportunities for Immunotherapies in Gynecologic Cancers.

Lee JM, Ivy SP, Kohn EC.

Oncology (Williston Park). 2016 Jan;30(1):67-9. No abstract available.

44.

Pharmacodynamic markers and clinical results from the phase 2 study of the SMAC mimetic birinapant in women with relapsed platinum-resistant or -refractory epithelial ovarian cancer.

Noonan AM, Bunch KP, Chen JQ, Herrmann MA, Lee JM, Kohn EC, O'Sullivan CC, Jordan E, Houston N, Takebe N, Kinders RJ, Cao L, Peer CJ, Figg WD, Annunziata CM.

Cancer. 2016 Feb 15;122(4):588-597. doi: 10.1002/cncr.29783. Epub 2015 Nov 13.

45.

To Treat or Not to Treat: The Use of Hormone Replacement Therapy in Patients With Ovarian Cancer.

Lipkowitz S, Kohn EC.

J Clin Oncol. 2015 Dec 10;33(35):4127-8. doi: 10.1200/JCO.2015.63.6670. Epub 2015 Oct 5. No abstract available.

PMID:
26438113
46.

Power-Assisted Liposuction Versus Tissue Resection for the Isolation of Adipose Tissue-Derived Mesenchymal Stem Cells: Phenotype, Senescence, and Multipotency at Advanced Passages.

Barzelay A, Levy R, Kohn E, Sella M, Shani N, Meilik B, Entin-Meer M, Gur E, Loewenstein A, Barak A.

Aesthet Surg J. 2015 Sep;35(7):NP230-40. doi: 10.1093/asj/sjv055.

PMID:
26319084
47.

Development of a multiparameter flow cytometric assay as a potential biomarker for homologous recombination deficiency in women with high-grade serous ovarian cancer.

Lee JM, Gordon N, Trepel JB, Lee MJ, Yu M, Kohn EC.

J Transl Med. 2015 Jul 22;13:239. doi: 10.1186/s12967-015-0604-z.

48.

Does one size fit all? The updated ovarian cancer staging: Still a work in progress.

Duska LR, Kohn EC.

Cancer. 2015 Oct 1;121(19):3384-6. doi: 10.1002/cncr.29521. Epub 2015 Jun 25. No abstract available.

49.

Ovarian cancer treatment: The end of empiricism?

Lheureux S, Karakasis K, Kohn EC, Oza AM.

Cancer. 2015 Sep 15;121(18):3203-11. doi: 10.1002/cncr.29481. Epub 2015 Jun 10. Review.

50.

CECs and IL-8 Have Prognostic and Predictive Utility in Patients with Recurrent Platinum-Sensitive Ovarian Cancer: Biomarker Correlates from the Randomized Phase-2 Trial of Olaparib and Cediranib Compared with Olaparib in Recurrent Platinum-Sensitive Ovarian Cancer.

Lee JM, Trepel JB, Choyke P, Cao L, Sissung T, Houston N, Yu M, Figg WD, Turkbey IB, Steinberg SM, Lee MJ, Ivy SP, Liu JF, Matulonis UA, Kohn EC.

Front Oncol. 2015 Jun 1;5:123. doi: 10.3389/fonc.2015.00123. eCollection 2015.

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