Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 43

1.

Germination and Growth Analysis of Streptomyces lividans at the Single-Cell Level Under Varying Medium Compositions.

Koepff J, Sachs CC, Wiechert W, Kohlheyer D, Nöh K, Oldiges M, Grünberger A.

Front Microbiol. 2018 Nov 22;9:2680. doi: 10.3389/fmicb.2018.02680. eCollection 2018.

2.

A microfluidic co-cultivation platform to investigate microbial interactions at defined microenvironments.

Burmeister A, Hilgers F, Langner A, Westerwalbesloh C, Kerkhoff Y, Tenhaef N, Drepper T, Kohlheyer D, von Lieres E, Noack S, Grünberger A.

Lab Chip. 2018 Dec 18;19(1):98-110. doi: 10.1039/c8lc00977e.

PMID:
30488920
3.

Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but Nonculturable Escherichia coli K-12.

Vilhena C, Kaganovitch E, Grünberger A, Motz M, Forné I, Kohlheyer D, Jung K.

J Bacteriol. 2019 Jan 11;201(3). pii: e00610-18. doi: 10.1128/JB.00610-18. Print 2019 Feb 1.

PMID:
30420452
4.

Selective Pressure for Biofilm Formation in Bacillus subtilis: Differential Effect of Mutations in the Master Regulator SinR on Bistability.

Kampf J, Gerwig J, Kruse K, Cleverley R, Dormeyer M, Grünberger A, Kohlheyer D, Commichau FM, Lewis RJ, Stülke J.

MBio. 2018 Sep 4;9(5). pii: e01464-18. doi: 10.1128/mBio.01464-18.

5.

Natural biocide cocktails: Combinatorial antibiotic effects of prodigiosin and biosurfactants.

Hage-Hülsmann J, Grünberger A, Thies S, Santiago-Schübel B, Klein AS, Pietruszka J, Binder D, Hilgers F, Domröse A, Drepper T, Kohlheyer D, Jaeger KE, Loeschcke A.

PLoS One. 2018 Jul 19;13(7):e0200940. doi: 10.1371/journal.pone.0200940. eCollection 2018.

6.

Quantitative measurements in single-cell analysis: towards scalability in microbial bioprocess development.

Demling P, Westerwalbesloh C, Noack S, Wiechert W, Kohlheyer D.

Curr Opin Biotechnol. 2018 Dec;54:121-127. doi: 10.1016/j.copbio.2018.01.024. Epub 2018 Mar 27. Review.

PMID:
29597183
7.

Microbial single-cell analysis in picoliter-sized batch cultivation chambers.

Kaganovitch E, Steurer X, Dogan D, Probst C, Wiechert W, Kohlheyer D.

N Biotechnol. 2018 Dec 25;47:50-59. doi: 10.1016/j.nbt.2018.01.009. Epub 2018 Mar 14.

PMID:
29550523
8.

Quantitative modelling of nutrient-limited growth of bacterial colonies in microfluidic cultivation.

Hornung R, Grünberger A, Westerwalbesloh C, Kohlheyer D, Gompper G, Elgeti J.

J R Soc Interface. 2018 Feb;15(139). pii: 20170713. doi: 10.1098/rsif.2017.0713.

9.

Visualization of tandem repeat mutagenesis in Bacillus subtilis.

Dormeyer M, Lentes S, Ballin P, Wilkens M, Klumpp S, Kohlheyer D, Stannek L, Grünberger A, Commichau FM.

DNA Repair (Amst). 2018 Mar;63:10-15. doi: 10.1016/j.dnarep.2018.01.006. Epub 2018 Jan 31.

PMID:
29414049
10.

A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.

Vilhena C, Kaganovitch E, Shin JY, Grünberger A, Behr S, Kristoficova I, Brameyer S, Kohlheyer D, Jung K.

J Bacteriol. 2017 Dec 5;200(1). pii: e00536-17. doi: 10.1128/JB.00536-17. Print 2018 Jan 1.

11.

Homogenizing bacterial cell factories: Analysis and engineering of phenotypic heterogeneity.

Binder D, Drepper T, Jaeger KE, Delvigne F, Wiechert W, Kohlheyer D, Grünberger A.

Metab Eng. 2017 Jul;42:145-156. doi: 10.1016/j.ymben.2017.06.009. Epub 2017 Jun 20. Review.

PMID:
28645641
12.

Coarse-graining bacteria colonies for modelling critical solute distributions in picolitre bioreactors for bacterial studies on single-cell level.

Westerwalbesloh C, Grünberger A, Wiechert W, Kohlheyer D, von Lieres E.

Microb Biotechnol. 2017 Jul;10(4):845-857. doi: 10.1111/1751-7915.12708. Epub 2017 Apr 3.

13.

Optogenetic Regulation of Tunable Gene Expression in Yeast Using Photo-Labile Caged Methionine.

Kusen PM, Wandrey G, Probst C, Grünberger A, Holz M, Meyer Zu Berstenhorst S, Kohlheyer D, Büchs J, Pietruszka J.

ACS Chem Biol. 2016 Oct 21;11(10):2915-2922. Epub 2016 Sep 12.

PMID:
27570879
14.

Image-Based Single Cell Profiling: High-Throughput Processing of Mother Machine Experiments.

Sachs CC, Grünberger A, Helfrich S, Probst C, Wiechert W, Kohlheyer D, Nöh K.

PLoS One. 2016 Sep 23;11(9):e0163453. doi: 10.1371/journal.pone.0163453. eCollection 2016.

15.
16.

Comparative Single-Cell Analysis of Different E. coli Expression Systems during Microfluidic Cultivation.

Binder D, Probst C, Grünberger A, Hilgers F, Loeschcke A, Jaeger KE, Kohlheyer D, Drepper T.

PLoS One. 2016 Aug 15;11(8):e0160711. doi: 10.1371/journal.pone.0160711. eCollection 2016.

17.

Light-Controlled Cell Factories: Employing Photocaged Isopropyl-β-d-Thiogalactopyranoside for Light-Mediated Optimization of lac Promoter-Based Gene Expression and (+)-Valencene Biosynthesis in Corynebacterium glutamicum.

Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger KE, Wendisch VF, Drepper T.

Appl Environ Microbiol. 2016 Sep 30;82(20):6141-6149. Print 2016 Oct 15.

18.

Silencing of cryptic prophages in Corynebacterium glutamicum.

Pfeifer E, Hünnefeld M, Popa O, Polen T, Kohlheyer D, Baumgart M, Frunzke J.

Nucleic Acids Res. 2016 Dec 1;44(21):10117-10131. Epub 2016 Aug 4.

19.

Photocaged Arabinose: A Novel Optogenetic Switch for Rapid and Gradual Control of Microbial Gene Expression.

Binder D, Bier C, Grünberger A, Drobietz D, Hage-Hülsmann J, Wandrey G, Büchs J, Kohlheyer D, Loeschcke A, Wiechert W, Jaeger KE, Pietruszka J, Drepper T.

Chembiochem. 2016 Feb 15;17(4):296-9. doi: 10.1002/cbic.201500609. Epub 2016 Jan 19.

PMID:
26677142
20.

Non-Invasive Microbial Metabolic Activity Sensing at Single Cell Level by Perfusion of Calcein Acetoxymethyl Ester.

Krämer CE, Singh A, Helfrich S, Grünberger A, Wiechert W, Nöh K, Kohlheyer D.

PLoS One. 2015 Oct 29;10(10):e0141768. doi: 10.1371/journal.pone.0141768. eCollection 2015.

21.

Spatiotemporal microbial single-cell analysis using a high-throughput microfluidics cultivation platform.

Grünberger A, Probst C, Helfrich S, Nanda A, Stute B, Wiechert W, von Lieres E, Nöh K, Frunzke J, Kohlheyer D.

Cytometry A. 2015 Dec;87(12):1101-15. doi: 10.1002/cyto.a.22779. Epub 2015 Sep 8.

22.

Modeling and CFD simulation of nutrient distribution in picoliter bioreactors for bacterial growth studies on single-cell level.

Westerwalbesloh C, Grünberger A, Stute B, Weber S, Wiechert W, Kohlheyer D, von Lieres E.

Lab Chip. 2015 Nov 7;15(21):4177-86. doi: 10.1039/c5lc00646e. Epub 2015 Sep 8.

PMID:
26345659
23.

Vizardous: interactive analysis of microbial populations with single cell resolution.

Helfrich S, Azzouzi CE, Probst C, Seiffarth J, Grünberger A, Wiechert W, Kohlheyer D, Nöh K.

Bioinformatics. 2015 Dec 1;31(23):3875-7. doi: 10.1093/bioinformatics/btv468. Epub 2015 Aug 10.

PMID:
26261223
24.

Live cell imaging of SOS and prophage dynamics in isogenic bacterial populations.

Helfrich S, Pfeifer E, Krämer C, Sachs CC, Wiechert W, Kohlheyer D, Nöh K, Frunzke J.

Mol Microbiol. 2015 Nov;98(4):636-50. doi: 10.1111/mmi.13147. Epub 2015 Aug 22.

25.

Technical bias of microcultivation environments on single-cell physiology.

Dusny C, Grünberger A, Probst C, Wiechert W, Kohlheyer D, Schmid A.

Lab Chip. 2015 Apr 21;15(8):1822-34. doi: 10.1039/c4lc01270d.

PMID:
25710324
26.

Light-responsive control of bacterial gene expression: precise triggering of the lac promoter activity using photocaged IPTG.

Binder D, Grünberger A, Loeschcke A, Probst C, Bier C, Pietruszka J, Wiechert W, Kohlheyer D, Jaeger KE, Drepper T.

Integr Biol (Camb). 2014 Aug;6(8):755-65. doi: 10.1039/c4ib00027g.

PMID:
24894989
27.

Single-cell microfluidics: opportunity for bioprocess development.

Grünberger A, Wiechert W, Kohlheyer D.

Curr Opin Biotechnol. 2014 Oct;29:15-23. doi: 10.1016/j.copbio.2014.02.008. Epub 2014 Mar 16. Review.

PMID:
24642389
28.

Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains.

Mustafi N, Grünberger A, Mahr R, Helfrich S, Nöh K, Blombach B, Kohlheyer D, Frunzke J.

PLoS One. 2014 Jan 17;9(1):e85731. doi: 10.1371/journal.pone.0085731. eCollection 2014.

29.

Microfluidic picoliter bioreactor for microbial single-cell analysis: fabrication, system setup, and operation.

Gruenberger A, Probst C, Heyer A, Wiechert W, Frunzke J, Kohlheyer D.

J Vis Exp. 2013 Dec 6;(82):50560. doi: 10.3791/50560.

30.

Analysis of SOS-induced spontaneous prophage induction in Corynebacterium glutamicum at the single-cell level.

Nanda AM, Heyer A, Krämer C, Grünberger A, Kohlheyer D, Frunzke J.

J Bacteriol. 2014 Jan;196(1):180-8. doi: 10.1128/JB.01018-13. Epub 2013 Oct 25.

31.

Microfluidic growth chambers with optical tweezers for full spatial single-cell control and analysis of evolving microbes.

Probst C, Grünberger A, Wiechert W, Kohlheyer D.

J Microbiol Methods. 2013 Dec;95(3):470-6. doi: 10.1016/j.mimet.2013.09.002. Epub 2013 Sep 13.

PMID:
24041615
32.

Beyond growth rate 0.6: What drives Corynebacterium glutamicum to higher growth rates in defined medium.

Unthan S, Grünberger A, van Ooyen J, Gätgens J, Heinrich J, Paczia N, Wiechert W, Kohlheyer D, Noack S.

Biotechnol Bioeng. 2014 Feb;111(2):359-71. doi: 10.1002/bit.25103. Epub 2013 Sep 24.

PMID:
23996851
33.

Taking control over control: use of product sensing in single cells to remove flux control at key enzymes in biosynthesis pathways.

Schendzielorz G, Dippong M, Grünberger A, Kohlheyer D, Yoshida A, Binder S, Nishiyama C, Nishiyama M, Bott M, Eggeling L.

ACS Synth Biol. 2014 Jan 17;3(1):21-9. doi: 10.1021/sb400059y. Epub 2013 Jul 15.

PMID:
23829416
34.

Beyond growth rate 0.6: Corynebacterium glutamicum cultivated in highly diluted environments.

Grünberger A, van Ooyen J, Paczia N, Rohe P, Schiendzielorz G, Eggeling L, Wiechert W, Kohlheyer D, Noack S.

Biotechnol Bioeng. 2013 Jan;110(1):220-8. doi: 10.1002/bit.24616. Epub 2012 Aug 13.

PMID:
22890752
35.

The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids.

Mustafi N, Grünberger A, Kohlheyer D, Bott M, Frunzke J.

Metab Eng. 2012 Jul;14(4):449-57. doi: 10.1016/j.ymben.2012.02.002. Epub 2012 Feb 15.

PMID:
22583745
36.

A disposable picolitre bioreactor for cultivation and investigation of industrially relevant bacteria on the single cell level.

Grünberger A, Paczia N, Probst C, Schendzielorz G, Eggeling L, Noack S, Wiechert W, Kohlheyer D.

Lab Chip. 2012 May 8;12(11):2060-8. doi: 10.1039/c2lc40156h. Epub 2012 Apr 17.

PMID:
22511122
37.

A prefilled, ready-to-use electrophoresis based lab-on-a-chip device for monitoring lithium in blood.

Floris A, Staal S, Lenk S, Staijen E, Kohlheyer D, Eijkel J, van den Berg A.

Lab Chip. 2010 Jul 21;10(14):1799-806. doi: 10.1039/c003899g. Epub 2010 Jun 7.

PMID:
20532263
38.

Integrated electrokinetic sample focusing and surface plasmon resonance imaging system for measuring biomolecular interactions.

Krishnamoorthy G, Carlen ET, Kohlheyer D, Schasfoort RB, van den Berg A.

Anal Chem. 2009 Mar 1;81(5):1957-63. doi: 10.1021/ac802668z.

PMID:
19186980
39.

Synchronized, continuous-flow zone electrophoresis.

Zalewski DR, Kohlheyer D, Schlautmann S, Gardeniers HJ.

Anal Chem. 2008 Aug 15;80(16):6228-34. doi: 10.1021/ac800567n. Epub 2008 Jul 12.

PMID:
18620428
40.

Bubble-free operation of a microfluidic free-flow electrophoresis chip with integrated Pt electrodes.

Kohlheyer D, Eijkel JC, Schlautmann S, van den Berg A, Schasfoort RB.

Anal Chem. 2008 Jun 1;80(11):4111-8. doi: 10.1021/ac800275c. Epub 2008 Apr 25.

PMID:
18435546
41.

Miniaturizing free-flow electrophoresis - a critical review.

Kohlheyer D, Eijkel JC, van den Berg A, Schasfoort RB.

Electrophoresis. 2008 Mar;29(5):977-93. doi: 10.1002/elps.200700725. Review.

PMID:
18232029
42.

Microfluidic high-resolution free-flow isoelectric focusing.

Kohlheyer D, Eijkel JC, Schlautmann S, van den Berg A, Schasfoort RB.

Anal Chem. 2007 Nov 1;79(21):8190-8. Epub 2007 Sep 29.

PMID:
17902700
43.

Free-flow zone electrophoresis and isoelectric focusing using a microfabricated glass device with ion permeable membranes.

Kohlheyer D, Besselink GA, Schlautmann S, Schasfoort RB.

Lab Chip. 2006 Mar;6(3):374-80. Epub 2006 Jan 26.

PMID:
16511620

Supplemental Content

Loading ...
Support Center