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Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy.

Koch PD, Rodell CB, Kohler RH, Pittet MJ, Weissleder R.

Cell Chem Biol. 2020 Jan 16;27(1):94-104.e5. doi: 10.1016/j.chembiol.2019.12.007. Epub 2020 Jan 2.


Imaging of Tie2 with a Fluorescently Labeled Small Molecule Affinity Ligand.

Koch PD, Ahmed MS, Kohler RH, Li R, Weissleder R.

ACS Chem Biol. 2020 Jan 17;15(1):151-157. doi: 10.1021/acschembio.9b00724. Epub 2019 Dec 13.


LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects.

Liao HW, Garris C, Pfirschke C, Rickelt S, Arlauckas S, Siwicki M, Kohler RH, Weissleder R, Sundvold-Gjerstad V, Sveinbjørnsson B, Rekdal Ø, Pittet MJ.

Cell Stress. 2019 Oct 14;3(11):348-360. doi: 10.15698/cst2019.11.204.


TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018 Aug;2(8):578-588. doi: 10.1038/s41551-018-0236-8. Epub 2018 May 21.


A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart.

Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre AD, Nahrendorf M, Weissleder R.

Bioconjug Chem. 2019 Mar 20;30(3):733-740. doi: 10.1021/acs.bioconjchem.8b00882. Epub 2019 Jan 18.


Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages.

Arlauckas SP, Garren SB, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R.

Theranostics. 2018 Nov 12;8(21):5842-5854. doi: 10.7150/thno.26888. eCollection 2018.


Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.

Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ.

Immunity. 2018 Dec 18;49(6):1148-1161.e7. doi: 10.1016/j.immuni.2018.09.024. Epub 2018 Dec 11.


Modular Nanoparticulate Prodrug Design Enables Efficient Treatment of Solid Tumors Using Bioorthogonal Activation.

Miller MA, Mikula H, Luthria G, Li R, Kronister S, Prytyskach M, Kohler RH, Mitchison T, Weissleder R.

ACS Nano. 2018 Dec 26;12(12):12814-12826. doi: 10.1021/acsnano.8b07954. Epub 2018 Dec 14.


Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin.

Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA.

ACS Nano. 2018 Dec 26;12(12):12015-12029. doi: 10.1021/acsnano.8b04338. Epub 2018 Dec 11.


TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy.

Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R.

Nat Biomed Eng. 2018;2:578-588. Epub 2018 May 21.


Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease.

Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R.

Chem Commun (Camb). 2017 Dec 19;54(1):42-45. doi: 10.1039/c7cc07581b.


IRF3 and type I interferons fuel a fatal response to myocardial infarction.

King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP Jr, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R.

Nat Med. 2017 Dec;23(12):1481-1487. doi: 10.1038/nm.4428. Epub 2017 Nov 6.


Imaging the emergence and natural progression of spontaneous autoimmune diabetes.

Mohan JF, Kohler RH, Hill JA, Weissleder R, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7776-E7785. doi: 10.1073/pnas.1707381114. Epub 2017 Aug 24.


Nano-palladium is a cellular catalyst for in vivo chemistry.

Miller MA, Askevold B, Mikula H, Kohler RH, Pirovich D, Weissleder R.

Nat Commun. 2017 Jul 12;8:15906. doi: 10.1038/ncomms15906.


Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts.

Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R.

Sci Transl Med. 2017 May 31;9(392). pii: eaal0225. doi: 10.1126/scitranslmed.aal0225.


In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy.

Arlauckas SP, Garris CS, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ.

Sci Transl Med. 2017 May 10;9(389). pii: eaal3604. doi: 10.1126/scitranslmed.aal3604.


Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging.

Mikula H, Stapleton S, Kohler RH, Vinegoni C, Weissleder R.

Theranostics. 2017 Mar 6;7(5):1257-1265. doi: 10.7150/thno.18238. eCollection 2017.


Fluorescent vinblastine probes for live cell imaging.

Meimetis LG, Giedt RJ, Mikula H, Carlson JC, Kohler RH, Pirovich DB, Weissleder R.

Chem Commun (Camb). 2016 Aug 2;52(64):9953-6. doi: 10.1039/c6cc04129a.


Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle.

Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R.

Sci Transl Med. 2015 Nov 18;7(314):314ra183. doi: 10.1126/scitranslmed.aac6522.


Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug.

Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R.

Nat Commun. 2015 Oct 27;6:8692. doi: 10.1038/ncomms9692.


Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression.

Kim E, Yang KS, Kohler RH, Dubach JM, Mikula H, Weissleder R.

Bioconjug Chem. 2015 Aug 19;26(8):1513-8. doi: 10.1021/acs.bioconjchem.5b00152. Epub 2015 Jun 9.


Single cell resolution in vivo imaging of DNA damage following PARP inhibition.

Yang KS, Kohler RH, Landon M, Giedt R, Weissleder R.

Sci Rep. 2015 May 18;5:10129. doi: 10.1038/srep10129.


In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.

Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ.

Nat Methods. 2015 Jun;12(6):577-85. doi: 10.1038/nmeth.3363. Epub 2015 Apr 13.


Population dynamics of islet-infiltrating cells in autoimmune diabetes.

Magnuson AM, Thurber GM, Kohler RH, Weissleder R, Mathis D, Benoist C.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1511-6. doi: 10.1073/pnas.1423769112. Epub 2015 Jan 20.


Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.

Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R.

Sci Transl Med. 2014 Nov 5;6(261):261ra152. doi: 10.1126/scitranslmed.3009318.


Ultrafluorogenic coumarin-tetrazine probes for real-time biological imaging.

Meimetis LG, Carlson JC, Giedt RJ, Kohler RH, Weissleder R.

Angew Chem Int Ed Engl. 2014 Jul 14;53(29):7531-4. doi: 10.1002/anie.201403890. Epub 2014 Jun 10.


In vivo imaging of multidrug resistance using a third generation MDR1 inhibitor.

Sprachman MM, Laughney AM, Kohler RH, Weissleder R.

Bioconjug Chem. 2014 Jun 18;25(6):1137-42. doi: 10.1021/bc500154c. Epub 2014 May 14.


Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.

Turetsky A, Kim E, Kohler RH, Miller MA, Weissleder R.

Sci Rep. 2014 Apr 24;4:4782. doi: 10.1038/srep04782.


Effect of small-molecule modification on single-cell pharmacokinetics of PARP inhibitors.

Thurber GM, Reiner T, Yang KS, Kohler RH, Weissleder R.

Mol Cancer Ther. 2014 Apr;13(4):986-95. doi: 10.1158/1535-7163.MCT-13-0801. Epub 2014 Feb 19.


Platinum compounds for high-resolution in vivo cancer imaging.

Miller MA, Askevold B, Yang KS, Kohler RH, Weissleder R.

ChemMedChem. 2014 Jun;9(6):1131-5. doi: 10.1002/cmdc.201300502. Epub 2014 Feb 6.


A photoactivatable drug-caged fluorophore conjugate allows direct quantification of intracellular drug transport.

Agasti SS, Laughney AM, Kohler RH, Weissleder R.

Chem Commun (Camb). 2013 Dec 7;49(94):11050-11052. doi: 10.1039/c3cc46089d.


Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo.

Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R.

Nat Commun. 2013;4:1504. doi: 10.1038/ncomms2506.


Dual imaging and photoactivated nanoprobe for controlled cell tracking.

Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder R.

Small. 2013 Jan 28;9(2):222-7. doi: 10.1002/smll.201201007. Epub 2012 Sep 21.


Imaging therapeutic PARP inhibition in vivo through bioorthogonally developed companion imaging agents.

Reiner T, Lacy J, Keliher EJ, Yang KS, Ullal A, Kohler RH, Vinegoni C, Weissleder R.

Neoplasia. 2012 Mar;14(3):169-77.


Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog.

Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R.

Proc Natl Acad Sci U S A. 2011 Aug 2;108(31):12815-20. doi: 10.1073/pnas.1109859108. Epub 2011 Jul 18.


Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.

Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ.

Cancer Res. 2011 Jul 1;71(13):4608-16. doi: 10.1158/0008-5472.CAN-11-0412. Epub 2011 Jun 28.


Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging.

Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1933-9. doi: 10.1161/ATVBAHA.110.206342. Epub 2010 Aug 5.


Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.

Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E.

Eur Heart J. 2010 Aug;31(16):1975-84. doi: 10.1093/eurheartj/ehq237. Epub 2010 Jul 2.


Near-infrared fluorescent probe for imaging of pancreatic beta cells.

Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R.

Bioconjug Chem. 2010 Jul 21;21(7):1362-8. doi: 10.1021/bc100184w.


Intravital molecular imaging of small-diameter tissue-engineered vascular grafts in mice: a feasibility study.

Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer JE, Aikawa E.

Tissue Eng Part C Methods. 2010 Aug;16(4):597-607. doi: 10.1089/ten.TEC.2009.0466.


Identification of splenic reservoir monocytes and their deployment to inflammatory sites.

Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ.

Science. 2009 Jul 31;325(5940):612-6. doi: 10.1126/science.1175202.


Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle.

Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton AP, Waterman P, Figueiredo JL, Kohler RH, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ.

Neoplasia. 2009 May;11(5):459-68, 2 p following 468.


Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease.

Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R.

Circulation. 2009 Apr 7;119(13):1785-94. doi: 10.1161/CIRCULATIONAHA.108.827972. Epub 2009 Mar 23.


Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.

Aikawa E, Nahrendorf M, Figueiredo JL, Swirski FK, Shtatland T, Kohler RH, Jaffer FA, Aikawa M, Weissleder R.

Circulation. 2007 Dec 11;116(24):2841-50. Epub 2007 Nov 26.


Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor.

Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R.

Circulation. 2007 May 1;115(17):2292-8. Epub 2007 Apr 9.


Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.

Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA.

J Biomed Opt. 2006 Mar-Apr;11(2):021009.


GFP imaging: methodology and application to investigate cellular compartmentation in plants.

Hanson MR, Köhler RH.

J Exp Bot. 2001 Apr;52(356):529-39. Review.


Active protein transport through plastid tubules: velocity quantified by fluorescence correlation spectroscopy.

Köhler RH, Schwille P, Webb WW, Hanson MR.

J Cell Sci. 2000 Nov;113 ( Pt 22):3921-30.


Plastid tubules of higher plants are tissue-specific and developmentally regulated.

Köhler RH, Hanson MR.

J Cell Sci. 2000 Jan;113 ( Pt 1):81-9.

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