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Items: 37

1.

AAV Vectors for Efficient Gene Delivery to Rodent Hearts.

Lopez-Gordo E, Kohlbrenner E, Katz MG, Weber T.

Methods Mol Biol. 2019;1950:311-332. doi: 10.1007/978-1-4939-9139-6_19.

PMID:
30783983
2.

Intra-tracheal gene delivery of aerosolized SERCA2a to the lung suppresses ventricular arrhythmias in a model of pulmonary arterial hypertension.

Strauss B, Sassi Y, Bueno-Beti C, Ilkan Z, Raad N, Cacheux M, Bisserier M, Turnbull IC, Kohlbrenner E, Hajjar RJ, Hadri L, Akar FG.

J Mol Cell Cardiol. 2019 Feb;127:20-30. doi: 10.1016/j.yjmcc.2018.11.017. Epub 2018 Nov 28.

PMID:
30502350
3.

Enhancing atrial-specific gene expression using a calsequestrin cis-regulatory module 4 with a sarcolipin promoter.

Yoo J, Kohlbrenner E, Kim O, Hajjar RJ, Jeong D.

J Gene Med. 2018 Dec;20(12):e3060. doi: 10.1002/jgm.3060. Epub 2018 Dec 4.

PMID:
30393908
4.

Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension.

Watanabe S, Ishikawa K, Plataki M, Bikou O, Kohlbrenner E, Aguero J, Hadri L, Zarragoikoetxea I, Fish K, Leopold JA, Hajjar RJ.

Pulm Circ. 2018 Oct-Dec;8(4):2045894018799738. doi: 10.1177/2045894018799738. Epub 2018 Aug 21.

5.

FTO-Dependent N6-Methyladenosine Regulates Cardiac Function During Remodeling and Repair.

Mathiyalagan P, Adamiak M, Mayourian J, Sassi Y, Liang Y, Agarwal N, Jha D, Zhang S, Kohlbrenner E, Chepurko E, Chen J, Trivieri MG, Singh R, Bouchareb R, Fish K, Ishikawa K, Lebeche D, Hajjar RJ, Sahoo S.

Circulation. 2019 Jan 22;139(4):518-532. doi: 10.1161/CIRCULATIONAHA.118.033794.

PMID:
29997116
6.

A Calsequestrin Cis-Regulatory Motif Coupled to a Cardiac Troponin T Promoter Improves Cardiac Adeno-Associated Virus Serotype 9 Transduction Specificity.

Chamberlain K, Riyad JM, Garnett T, Kohlbrenner E, Mookerjee A, Elmastour F, Benard L, Chen J, VandenDriessche T, Chuah MK, Marian AJ, Hajjar RJ, Gurha P, Weber T.

Hum Gene Ther. 2018 Aug;29(8):927-937. doi: 10.1089/hum.2017.188. Epub 2018 May 9.

7.

Gene expression profile associated with postnatal development of pyramidal neurons in the human prefrontal cortex implicates ubiquitin ligase E3 in the pathophysiology of schizophrenia onset.

Kohlbrenner EA, Shaskan N, Pietersen CY, Sonntag KC, Woo TW.

J Psychiatr Res. 2018 Jul;102:110-117. doi: 10.1016/j.jpsychires.2018.03.013. Epub 2018 Apr 3.

8.

Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice.

Voit A, Patel V, Pachon R, Shah V, Bakhutma M, Kohlbrenner E, McArdle JJ, Dell'Italia LJ, Mendell JR, Xie LH, Hajjar RJ, Duan D, Fraidenraich D, Babu GJ.

Nat Commun. 2017 Oct 20;8(1):1068. doi: 10.1038/s41467-017-01146-7.

9.

Protein Phosphatase Inhibitor-1 Gene Therapy in a Swine Model of Nonischemic Heart Failure.

Watanabe S, Ishikawa K, Fish K, Oh JG, Motloch LJ, Kohlbrenner E, Lee P, Xie C, Lee A, Liang L, Kho C, Leonardson L, McIntyre M, Wilson S, Samulski RJ, Kranias EG, Weber T, Akar FG, Hajjar RJ.

J Am Coll Cardiol. 2017 Oct 3;70(14):1744-1756. doi: 10.1016/j.jacc.2017.08.013.

10.
11.

FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress.

Chaanine AH, Kohlbrenner E, Gamb SI, Guenzel AJ, Klaus K, Fayyaz AU, Nair KS, Hajjar RJ, Redfield MM.

Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1540-H1559. doi: 10.1152/ajpheart.00549.2016. Epub 2016 Sep 30.

12.

Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model.

Aguero J, Ishikawa K, Hadri L, Santos-Gallego CG, Fish KM, Kohlbrenner E, Hammoudi N, Kho C, Lee A, Ibáñez B, García-Alvarez A, Zsebo K, Maron BA, Plataki M, Fuster V, Leopold JA, Hajjar RJ.

J Am Coll Cardiol. 2016 May 3;67(17):2032-46. doi: 10.1016/j.jacc.2016.02.049.

13.

Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling.

Bénard L, Oh JG, Cacheux M, Lee A, Nonnenmacher M, Matasic DS, Kohlbrenner E, Kho C, Pavoine C, Hajjar RJ, Hulot JS.

Circulation. 2016 Apr 12;133(15):1458-71; discussion 1471. doi: 10.1161/CIRCULATIONAHA.115.020678. Epub 2016 Mar 2.

14.

High-dose chloroquine is metabolically cardiotoxic by inducing lysosomes and mitochondria dysfunction in a rat model of pressure overload hypertrophy.

Chaanine AH, Gordon RE, Nonnenmacher M, Kohlbrenner E, Benard L, Hajjar RJ.

Physiol Rep. 2015 Jul;3(7). pii: e12413. doi: 10.14814/phy2.12413.

15.

Restraint of the G2/M transition by the SR/RRM family mRNA shuttling binding protein SNXAHRB1 in Aspergillus nidulans.

James SW, Banta T, Barra J, Ciraku L, Coile C, Cuda Z, Day R, Dixit C, Eastlack S, Giang A, Goode J, Guice A, Huff Y, Humbert S, Kelliher C, Kobie J, Kohlbrenner E, Mwambutsa F, Orzechowski A, Shingler K, Spell C, Anglin SL.

Genetics. 2014 Oct;198(2):617-33. doi: 10.1534/genetics.114.167445. Epub 2014 Aug 7.

16.

Effect of bortezomib on the efficacy of AAV9.SERCA2a treatment to preserve cardiac function in a rat pressure-overload model of heart failure.

Chaanine AH, Nonnenmacher M, Kohlbrenner E, Jin D, Kovacic JC, Akar FG, Hajjar RJ, Weber T.

Gene Ther. 2014 Apr;21(4):379-386. doi: 10.1038/gt.2014.7. Epub 2014 Feb 27.

17.

SUMO-1 gene transfer improves cardiac function in a large-animal model of heart failure.

Tilemann L, Lee A, Ishikawa K, Aguero J, Rapti K, Santos-Gallego C, Kohlbrenner E, Fish KM, Kho C, Hajjar RJ.

Sci Transl Med. 2013 Nov 13;5(211):211ra159. doi: 10.1126/scitranslmed.3006487.

18.

Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension.

Hadri L, Kratlian RG, Benard L, Maron BA, Dorfmüller P, Ladage D, Guignabert C, Ishikawa K, Aguero J, Ibanez B, Turnbull IC, Kohlbrenner E, Liang L, Zsebo K, Humbert M, Hulot JS, Kawase Y, Hajjar RJ, Leopold JA.

Circulation. 2013 Jul 30;128(5):512-23. doi: 10.1161/CIRCULATIONAHA.113.001585. Epub 2013 Jun 26.

19.

Cardiac surgical delivery of the sarcoplasmic reticulum calcium ATPase rescues myocytes in ischemic heart failure.

Fargnoli AS, Katz MG, Yarnall C, Isidro A, Petrov M, Steuerwald N, Ghosh S, Richardville KC, Hillesheim R, Williams RD, Kohlbrenner E, Stedman HH, Hajjar RJ, Bridges CR.

Ann Thorac Surg. 2013 Aug;96(2):586-95. doi: 10.1016/j.athoracsur.2013.04.021. Epub 2013 Jun 15.

20.

Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure.

Chaanine AH, Gordon RE, Kohlbrenner E, Benard L, Jeong D, Hajjar RJ.

Circ Heart Fail. 2013 May;6(3):572-83. doi: 10.1161/CIRCHEARTFAILURE.112.000200. Epub 2013 Mar 18.

21.

Quantification of AAV particle titers by infrared fluorescence scanning of coomassie-stained sodium dodecyl sulfate-polyacrylamide gels.

Kohlbrenner E, Henckaerts E, Rapti K, Gordon RE, Linden RM, Hajjar RJ, Weber T.

Hum Gene Ther Methods. 2012 Jun;23(3):198-203. doi: 10.1089/hgtb.2012.049. Epub 2012 Jul 20.

22.

CXCR4 gene transfer prevents pressure overload induced heart failure.

Larocca TJ, Jeong D, Kohlbrenner E, Lee A, Chen J, Hajjar RJ, Tarzami ST.

J Mol Cell Cardiol. 2012 Aug;53(2):223-32. doi: 10.1016/j.yjmcc.2012.05.016. Epub 2012 Jun 3.

23.

Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure.

Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L, Hulot JS, Kohlbrenner E, Hajjar RJ, Peters NS, Korchev YE, Macleod KT, Harding SE, Gorelik J.

Circ Heart Fail. 2012 May 1;5(3):357-65. doi: 10.1161/CIRCHEARTFAILURE.111.964692. Epub 2012 Mar 28.

24.

An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide.

Bolognin S, Blanchard J, Wang X, Basurto-Islas G, Tung YC, Kohlbrenner E, Grundke-Iqbal I, Iqbal K.

Acta Neuropathol. 2012 Jan;123(1):133-51. doi: 10.1007/s00401-011-0908-x. Epub 2011 Nov 15.

25.

Neutralizing antibodies against AAV serotypes 1, 2, 6, and 9 in sera of commonly used animal models.

Rapti K, Louis-Jeune V, Kohlbrenner E, Ishikawa K, Ladage D, Zolotukhin S, Hajjar RJ, Weber T.

Mol Ther. 2012 Jan;20(1):73-83. doi: 10.1038/mt.2011.177. Epub 2011 Sep 13.

26.

Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats.

Chemaly ER, Hadri L, Zhang S, Kim M, Kohlbrenner E, Sheng J, Liang L, Chen J, K-Raman P, Hajjar RJ, Lebeche D.

J Mol Cell Cardiol. 2011 Aug;51(2):144-55. doi: 10.1016/j.yjmcc.2011.04.006. Epub 2011 Apr 23.

27.

SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure.

Lyon AR, Bannister ML, Collins T, Pearce E, Sepehripour AH, Dubb SS, Garcia E, O'Gara P, Liang L, Kohlbrenner E, Hajjar RJ, Peters NS, Poole-Wilson PA, Macleod KT, Harding SE.

Circ Arrhythm Electrophysiol. 2011 Jun;4(3):362-72. doi: 10.1161/CIRCEP.110.961615. Epub 2011 Mar 15.

28.

The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment.

Wang X, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K.

FASEB J. 2010 Nov;24(11):4420-32. doi: 10.1096/fj.10-158477. Epub 2010 Jul 22.

29.

Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors.

Zeltner N, Kohlbrenner E, Clément N, Weber T, Linden RM.

Gene Ther. 2010 Jul;17(7):872-9. doi: 10.1038/gt.2010.27. Epub 2010 Mar 25.

30.

Transcriptional analysis of the adeno-associated virus integration site.

Dutheil N, Henckaerts E, Kohlbrenner E, Linden RM.

J Virol. 2009 Dec;83(23):12512-25. doi: 10.1128/JVI.01754-09. Epub 2009 Sep 16.

31.

Site-specific integration of adeno-associated virus involves partial duplication of the target locus.

Henckaerts E, Dutheil N, Zeltner N, Kattman S, Kohlbrenner E, Ward P, Clément N, Rebollo P, Kennedy M, Keller GM, Linden RM.

Proc Natl Acad Sci U S A. 2009 May 5;106(18):7571-6. doi: 10.1073/pnas.0806821106. Epub 2009 Apr 16.

32.

Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.

Quesada O, Gurda B, Govindasamy L, McKenna R, Kohlbrenner E, Aslanidi G, Zolotukhin S, Muzyczka N, Agbandje-McKenna M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Dec 1;63(Pt 12):1073-6. Epub 2007 Nov 30.

33.

Structure of adeno-associated virus serotype 8, a gene therapy vector.

Nam HJ, Lane MD, Padron E, Gurda B, McKenna R, Kohlbrenner E, Aslanidi G, Byrne B, Muzyczka N, Zolotukhin S, Agbandje-McKenna M.

J Virol. 2007 Nov;81(22):12260-71. Epub 2007 Aug 29.

34.

Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5.

DiMattia M, Govindasamy L, Levy HC, Gurda-Whitaker B, Kalina A, Kohlbrenner E, Chiorini JA, McKenna R, Muzyczka N, Zolotukhin S, Agbandje-McKenna M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt 10):917-21. Epub 2005 Sep 30.

35.

Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8.

Lane MD, Nam HJ, Padron E, Gurda-Whitaker B, Kohlbrenner E, Aslanidi G, Byrne B, McKenna R, Muzyczka N, Zolotukhin S, Agbandje-McKenna M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jun 1;61(Pt 6):558-61. Epub 2005 Jun 1.

36.

Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system.

Kohlbrenner E, Aslanidi G, Nash K, Shklyaev S, Campbell-Thompson M, Byrne BJ, Snyder RO, Muzyczka N, Warrington KH Jr, Zolotukhin S.

Mol Ther. 2005 Dec;12(6):1217-25. Epub 2005 Oct 6.

37.

Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats.

Shklyaev S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Campbell-Thompson M, Crawford J, Shek EW, Scarpace PJ, Zolotukhin S.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14217-22. Epub 2003 Nov 14.

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